Tag: M.W:200-300

73874-95-0, In heterogeneous catalysis, the catalyst is in a different phase from the reactants. At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 73874-95-0, name is tert-Butyl piperidin-4-ylcarbamate. In an article£¬Which mentioned a new discovery about 73874-95-0

Arylsulfonamide derivatives of (aryloxy)ethylpiperidines as selective 5-HT7 receptor antagonists and their psychotropic properties

A series of alkyl/arylsulfonamide derivatives of (aryloxy)ethylpiperidines as highly potent 5-HT7 receptor antagonists has been developed through structure-based design on the previously identified compound PZ-766. This resulted in highly potent antagonist 10 (3-fluoro-N-(1-{2-[(propan-2-yl)phenoxy]ethyl}piperidin-4-yl)-benzenesulfonamide) which was more active in vivo than PZ-766 and SB-269970 in forced swim test in mice (MED = 2.5 mg kg-1), and displayed comparable effects to SB-269970 in four-plate test in mice (MED = 1.25 mg kg-1) and novel object recognition test in rats (MED = 1 mg kg-1). The results highlight the antidepressant, anxiolytic and pro-cognitive potential of the arylsulfonamide derivatives of (aryloxy)ethylpiperidines with 5-HT7 receptor antagonist properties and warrant further studies to explore their therapeutic potential for the treatment of CNS disorders.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 73874-95-0 is helpful to your research. 73874-95-0

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Piperidine – Wikipedia,
Piperidine | C5H14401N – PubChem

 

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 67686-01-5, name is (1-Benzylpiperidin-4-yl)methanol, introducing its new discovery. 67686-01-5

ETHER DERIVATIVES OF ALKYL PIPERIDINES AND PYRROLIDINES AS ANTIPSYCHOTIC AGENTS

Novel unsaturated ether derivatives of alkyl piperidine and pyrrolidine compounds, pharmaceutical compositions containing them, methods of preparation and methods of using these compounds as antipsychotic agents are disclosed.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.67686-01-5, you can also check out more blogs about67686-01-5

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Piperidine | C5H15236N – PubChem

 

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 137076-22-3, name is tert-Butyl 4-formylpiperidine-1-carboxylate, introducing its new discovery. 137076-22-3

SUBSTITUTED CYCLOPROPYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS, AND METHODS OF TREATMENT

Substituted cyclopropyl compounds of the formula I: and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.137076-22-3, you can also check out more blogs about137076-22-3

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Piperidine | C5H16273N – PubChem

 

146667-84-7, Name is tert-Butyl 3-(2-hydroxyethyl)piperidine-1-carboxylate, belongs to piperidines compound, is a common compound. 146667-84-7. In an article, authors is Akwabi-Ameyaw, Adwoa, once mentioned the new application about 146667-84-7.

Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064

Starting from the known FXR agonist GW 4064 1a, a series of stilbene replacements were prepared. The 6-substituted 1-naphthoic acid 1b was an equipotent FXR agonist with improved developability parameters relative to 1a. Analog 1b also reduced the severity of cholestasis in the ANIT acute cholestatic rat model.

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Piperidine | C5H18597N – PubChem

 

73874-95-0, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In a patent, 73874-95-0, molecular formula is C10H20N2O2, introducing its new discovery.

NOVEL 1-BENZYL-4-PIPERIDINAMINES THAT ARE USEFUL IN THE TREATMENT OF COPD AND ASTHMA

The invention provides 1-benzyl-4-piperidinamines of the general formula (I), processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are useful in the treatment of respiratory diseses such as chronic obstructive pulmonary disease and asthma. The compounds are inhibitors of the CCRl receptor.

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Piperidine – Wikipedia,
Piperidine | C5H14010N – PubChem

 

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.137076-22-3, Name is tert-Butyl 4-formylpiperidine-1-carboxylate, molecular formula is C11H19NO3, introducing its new discovery., 137076-22-3

SnAP reagents for the synthesis of piperazines and morpholines

Substituted piperazines and morpholines are valuable structural motifs in biologically active compounds, but are not easily prepared by contemporary cross-coupling approaches. In this report, we introduce SnAP reagents for the transformation of aldehydes into N-unprotected piperazines and morpholines. This approach offers simple, mild conditions compatible with aromatic, heteroaromatic, aliphatic, and glyoxylic aldehydes and provides mono- and disubstituted N-heterocycles in a single step.

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Piperidine – Wikipedia,
Piperidine | C5H16268N – PubChem

 

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn¡¯t involve a screen. 3515-49-9, C14H18N2. A document type is Article, introducing its new discovery. 3515-49-9

The influence of lateral substituents on the mesophase behaviour of banana-shaped mesogens. Part II

New materials are presented, derived from the original banana compounds where the first smectic phases with polar switching (SmCP) were detected. Our results demonstrate that the introduction of lateral substituents on the central ring (F, Cl, CN, NO2, CH3) and/or on the terminal rings (Cl, Br, CH3) can significantly change the mesophase behaviour. The influence of such substituents is much more pronounced than in comparable calamitic compounds. The clearing temperatures are more or less depressed depending on the number, position and type of lateral substituents. In most cases the laterally substituted compounds form SmCPA phases. Of basic and theoretical interest are compounds where substituents (e.g. 4-cyano; 4,6-dichloro) on the central core enhance the bending angle giving rise to polymorphism variants with conventional smectic and nematic phases as well as “banana phases”: N-SmCPA; SmA-SmCPA; SmA-SmC-SmCPA; SmA-SmAPA-SmCPA. The last mentioned phase sequence has not been reported for single compounds up to now. Furthermore, the pool of materials allows us to compare the significant influence of lateral halogen atoms F, Cl, Br on the mesophase behaviour of bent-core mesogens for the first time. Nevertheless, up to now it has not been possible to predict the mesophase behaviour of bent core mesogens on the basis of the molecular architecture. The Royal Society of Chemistry 2005.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! Read on for other articles about 3131-52-0!, 3515-49-9

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Piperidine – Wikipedia,
Piperidine | C5H16953N – PubChem

 

25519-78-2, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 25519-78-2, Name is (4-Fluorophenyl)(piperidin-4-yl)methanone hydrochloride,introducing its new discovery.

4-aroylpiperidines and 4-(alpha-hydroxyphenyl)piperidines as selective sigma-1 receptor ligands: Synthesis, preliminary pharmacological evaluation and computational studies

Background: Sigma (sigma) receptors are membrane-bound proteins characterised by an unusual promiscuous ability to bind a wide variety of drugs and their high affinity for typical neuroleptic drugs, such as haloperidol, and their potential as alternative targets for antipsychotic agents. Sigma receptors display diverse biological activities and represent potential fruitful targets for therapeutic development in combating many human diseases. Therefore, they present an interesting avenue for further exploration. It was our goal to evaluate the potential of ring opened spipethiane (1) analogues as functional ligands (agonists) for sigma receptors by chemical modification. Results: Chemical modification of the core structure of the lead compound, (1), by replacement of the sulphur atom with a carbonyl group, hydroxyl group and 3-bromobenzylamine with the simultaneous presence of 4-fluorobenzoyl replacing the spirofusion afforded novel potent sigma-1 receptor ligands 7a-f, 8a-f and 9d-e. The sigma-1 receptor affinities of 7e, 8a and 8f were slightly lower than that of 1 and their selectivities for this receptor two to threefold greater than that of 1. Conclusions: It was found that these compounds have higher selectivities for sigma-1 receptors compared to 1. Quantitatitive structure-activity relationship studies revealed that sigma-1 binding is driven by hydrophobic interactions. Graphical abstract Identified pharmacophore features for sigma binding.

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Piperidine | C5H20298N – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1029413-55-5,tert-Butyl 4-(4-amino-1H-pyrazol-1-yl)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

Compound 48-b (250 mg, 0.68 mmol) and compound 32-c (181 mg, 0.68 mmol) were dissolved in N,N-dimethylformamide (3 mL), and potassium carbonate (281 mg, 2.37 mmol), 2-dicyclohexylphosphino-2?,6?-diisopropoxy-1,1?-biphenyl (58 mg, 0.13 mmol) and tris(dibenzylideneacetone)dipalladium (136 mg, 0.24 mmol) were added. The reaction solution was heated to 110 C. and stirred for 16 hours under nitrogen gas atmosphere. After cooling to room temperature, the reaction mixture was partitioned between ethyl acetate (100 mL) and water (100 mL). The organic phase was dried over anhydrous sodium sulfate, filtered and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel TLC preparative plate (petroleum ether: ethyl acetate=1:1) to give 48-a as a pale yellow solid (75 mg, yield 18%). LC-MS (ESI): m/z=599[M+H]+.

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Reference£º
Patent; GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.; XU, Zusheng; ZHANG, Nong; WANG, Tinghan; SUN, Qingrui; WANG, Yuguang; (90 pag.)US2018/208604; (2018); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.163271-08-7,tert-Butyl (4-methylpiperidin-4-yl)carbamate,as a common compound, the synthetic route is as follows.

To a solution of 3-(benzyloxy)-5-bromo-2-(2,3-dichlorophenyl)pyrazine (90.0 mg, 220 muetaiotaomicron, 1 equiv) in toluene (1 mL) was added ter/-butyl(4-methylpiperidin-4-yl)carbamate (70.5 mg, 329 muiotaetaomicron, 1.5 equiv), NaOt-Bu (42.2 mg, 439 muiotaetaomicron, 2 equiv), [l-(2- diphenylphosphanyl-l-naphthyl)-2-naphthyl]-diphenyl-phosphane (137 mg, 219 muiotaetaomicron, 1 equiv) and Pd2(dba)3 (10.0 mg, 11.0 mumol, 0.05 equiv). The reaction mixture was then warmed to 90 C and stirred for 1 hour. The reaction mixture was then filtered and concentrated under reduced pressure. The residue was purified by silica gel chromatography to give fer/-butyl(l-(6- (benzyloxy)-5-(2,3-dichlorophenyl)pyrazin-2-yl)-4-methylpiperidin-4-yl)carbamate (100 mg, 184 mupiiotaomicron, 83.8% yield) as a white solid.

163271-08-7, 163271-08-7 tert-Butyl (4-methylpiperidin-4-yl)carbamate 19691370, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; REVOLUTION MEDICINES, INC.; JOGALEKAR, Ash; WON, Walter; KOLTUN, Elena S.; GILL, Adrian; MELLEM, Kevin; AAY, Naing; BUCKL, Andreas; SEMKO, Christopher; KISS, Gert; (496 pag.)WO2018/13597; (2018); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem