Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.214834-18-1,tert-Butyl 4-carbamothioylpiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

55 mg (1.5 mmol) of 4-thiocarbamoyl-piperidine-1-tert-butyl carboxylate is added to a suspension of 57 mg (0.15 mmol) of 8-(2-bromo-acetyl)-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate in 3 mL of ethanol. The mixture is stirred at 90 C. for 3 hours then the mixture is cooled to room temperature. Triethylamine (2 mmol) is added, then the solvent is evaporated and the product is purified by chromatography on silica (chloroform/methanol/triethylamine 8/2/1). After drying, 11 mg (17%) of 4-oxo-8-(2-piperidin-4-yl-thiazol-4-yl)-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate is obtained in the form of a beige solid.LCMS (IE, m/z): (M+1) 423.241H-NMR: deltaH ppm 400 MHz, DMSO11.76 (1H, bs, NH), 9.76 (1H, d, CHarom), 8.00 (1H, s, CHarom), 7.95 (1H, dd, CHarom), 7.74 (1H, s, CHarom), 7.44 (1H, d, CHarom), 4.35 (2H, q, CH2), 3.35-3.30 (1H, m, CHpiper), 3.16-3.10 (2H, m, 2¡ÁCHpiper), 2.80-2.72 (2H, m, 2¡ÁCHpiper), 2.13-2.06 (2H, m, 2¡ÁCHpiper), 1.77-1.68 (2H, m, 2¡ÁCHpiper), 1.36 (3H, t, CH3).

214834-18-1, The synthetic route of 214834-18-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Pierre Fabre Medicament; US2009/42876; (2009); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.216854-23-8,(S)-tert-Butyl piperidin-3-ylcarbamate,as a common compound, the synthetic route is as follows.

216854-23-8, To a solution of l-chloro-7-methoxyisoquinoline-6-carbonitrile (218 mg) in DIPEA (4.0 mL) was added compound 1 (300 mg). The mixture was stirred at 120 C for 8 h. The title compound 2 was obtained as a yellow solid (170 mg, yield 45%) after standard work up procedure.

As the paragraph descriping shows that 216854-23-8 is playing an increasingly important role.

Reference£º
Patent; SYNBLIA THERAPEUTICS, INC.; XIE, Yinong; BABISS, Lee, E.; (89 pag.)WO2019/89422; (2019); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.614730-97-1,1-Boc-4-Fluoro-4-(hydroxymethyl)piperidine,as a common compound, the synthetic route is as follows.

614730-97-1, To a mixture of tert-butyl 4-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate (30 g, 129 mmol, prepared as described in the synthesis of AMI04) and NaH (3.09 g, 129 mmol) in THF (500 mL) was added iodomethane (41.9 g, 295 mmol) at room temperature, and then the mixture was stirred at 25 C for 12 h, The reaction mixture was diluted with water and extracted with EtOAc. The combined organic phases were washed with water and brine. The organic fraction was dried over Na2SO4, filtered, and concentrated under vacuum. The residue was purified on a silica gel column eluted with petroleum ether/EtOAc=2:1 to give 4- fluoro-4-(methoxymethyl)piperidine-1-carboxylate (25 g, 101 mmol, 79% yield).

614730-97-1 1-Boc-4-Fluoro-4-(hydroxymethyl)piperidine 22248400, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; ABBVIE S.A.R.L; GALAPAGOS NV; AKKARI, Rhalid; ALVEY, Luke Jonathan; BOCK, Xavier Marie; BROWN, Brian S.; CLAES, Pieter Isabelle Roger; COWART, Marlon D.; DE LEMOS, Elsa; DESROY, Nicolas; DUTHION, Beranger; GFESSER, Gregory A.; GOSMINI, Romain Luc Marie; HOUSSEMAN, Christopher Gaetan; JANSEN, Koen Karel; JI, Jianguo; KYM, Philip R.; LEFRANCOIS, Jean-Michel; MAMMOLITI, Oscar; MENET, Christel Jeanne Marie; MERAYO, Nuria Merayo; NEWSOME, Gregory John Robert; PALISSE, Adeline Marie Elise; PATEL, Sachin V.; PIZZONERO, Mathieu Rafael; SHRESTHA, Anurupa; SWIFT, Elizabeth C.; VAN DER PLAS, Steven Emiel; WANG, Xueqing; DE BLIECK, Ann; (1004 pag.)WO2017/60874; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.309956-78-3,(R)-tert-Butyl piperidin-3-ylcarbamate,as a common compound, the synthetic route is as follows.

2) A mixture of 13.8 g (50 mmol) of 6-chloro-1- (2-isocyaninyl) -3-methylpyrimidine-2,4- (1H, 3H) -dione(R) -3-tert-butyloxycarbonylaminopiperidine (11.0 g, 55 mmol)Potassium carbonate 17.3 g (125 mmol) was mixed in DMF at 65 C,After the reaction,add water,Then extracted with dichloromethane,concentrate,N-hexane washing,(R) -tert-butyl-1- (3- (2-isocyaninyl) -1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidine- Yl) piperidin-3-ylcarbamate (21.6 g)The yield was 98.2%Purity 99.20%., 309956-78-3

The synthetic route of 309956-78-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Qingdao Chenda Biological Technology Co., Ltd.; Chen, Linghao; (8 pag.)CN105837557; (2016); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.479630-08-5,1-Boc-4-(2-Ethoxycarbonyl-acetyl)piperidine,as a common compound, the synthetic route is as follows.

Tert-butyl 4-(3-ethoxy-3-oxopropanoyl)piperidine-l -carboxylate (818 mg, 2.27 mmol), 4-methyl-lH- pyrazolo[3,4-b]pyridin-3-amine (224 mg, 1.51 mmol) and potassium phosphate (642 mg, 3.02 mmol) were suspended in l-methoxy-2-propanol (8 ml) in a 20 ml microwave vial. The vial was capped and the mixture was heated in a microwave to 180C for 15 min. The reaction mixture was diluted with water and neutralized (pH 6) by the addition of IN HC1. The resulting solid was filtrated, washed with ethyl acetate and water and dried under vacuo. The solid was stirred in a mixture of water, ammonia and acetonitrile. The solid was filtered off and the filtrate was purified by preparative HPLC (Method 2A) to yield the title compound (40 mg, 7% of theory). LC-MS (Method 3B): Rt = 1.75 min, MS (ESIPos): m/z = 384 [M+H]+

479630-08-5, As the paragraph descriping shows that 479630-08-5 is playing an increasingly important role.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; HASSFELD, Jorma; KINZEL, Tom; KOeBBERLING, Johannes; CANCHO-GRANDE, Yolanda; BEYER, Kristin; ROeHRIG, Susanne; KOeLLNBERGER, Maria; SPERZEL, Michael; BURKHARDT, Nils; SCHLEMMER, Karl-Heinz; STEGMANN, Christian; SCHUHMACHER, Joachim; WERNER, Matthias; ELLERMANN, Manuel; WO2015/67549; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, the author is Calderwood, David J and a compound is mentioned, 236406-39-6, 8-Boc-2,8-Diazaspiro[4.5]decane, introducing its new discovery. 236406-39-6

Pyrrolo[2,3-d]pyrimidines containing diverse N-7 substituents as potent inhibitors of Lck.

A series of pyrrolo[2,3-d]pyrimidines was synthesized and evaluated as inhibitors of Lck. Lck accommodates a diverse set of substituents at N-7. Altering the substituent at N-7 provided compound 13, an orally available lck inhibitor which inhibited TCR mediated IL-2 production after oral dosing.

236406-39-6, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 236406-39-6

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Piperidine – Wikipedia,
Piperidine | C5H19818N – PubChem

 

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 52722-86-8, Name is 1-(2-Hydroxyethyl)-2,2,6,6-tetramethylpiperidin-4-ol. In a document type is Article, introducing its new discovery., 52722-86-8

Dry micro-polymeric inoculant of Azospirillum brasilense is useful for producing mesquite transplants for reforestation of degraded arid zones

Massive clear-cutting of wild stands of mesquite trees in the Mexican part of the Sonoran Desert result from high demand for this wood by the charcoal industry. Consequently, there is a need to develop techniques for reforestation of this tree in the desert and maintain its natural diversity at the same time. An outdoor nursery procedure to produce mesquite transplants from diversely originated seeds for reforestation of arid zones was developed. This procedure involved: 1) inoculation of the seedlings in the nursery with the plant growth-promoting bacteria (PGPB) Azospirillum brasilense immobilized in dry microbeads of alginate, and 2) developing a reliable way to monitor plant development and aerial volume in the nursery for the entire growth period of seven months before transplantation. Dry microbeads containing the PGPB and maintained at room temperature were tested for survival of bacteria for up to seven months. These dry microbeads maintained sufficient population levels of A. brasilense to inoculate the plant for the entire period. Inoculation with the PGPB enhanced all growth parameters of the plants, including biomass, aerial volume, root system, and chlorophyll pigments, but not the auxiliary photosynthetic pigments. The PGPB was specifically identified colonizing the roots of the transplants by fluorescent in situ hybridization for the entire growth period. Measuring a few simple parameters allowed development of a workable model for plant growth. This model was confirmed by data obtained from sacrificed plants whose parameters were measured directly. This study shows that outdoor nursery cultivation of inoculated mesquite transplants is feasible.

Interested yet? Keep reading other articles of 244-63-3!, 52722-86-8

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Piperidine – Wikipedia,
Piperidine | C5H14876N – PubChem

 

221532-96-3, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In a patent, 221532-96-3, molecular formula is C17H26N2O2, introducing its new discovery.

2-(substituted-phenyl)amino-imidazoline derivatives

This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: where:R1 is a group represented by formula (A), (B) or (C); and other substituents as defined in the specification, and their pharmaceutically acceptable salts or crystal forms thereof; and pharmaceutical compositions containing them; and methods for their use as therapeutic agents.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.221532-96-3, you can also check out more blogs about221532-96-3

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Piperidine – Wikipedia,
Piperidine | C5H22811N – PubChem

 

236406-39-6, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.236406-39-6, Name is 8-Boc-2,8-Diazaspiro[4.5]decane, molecular formula is C13H24N2O2. In a article£¬once mentioned of 236406-39-6

The Reaction of Lithium Phenylacetylide and Phenyllithium with N-(omega-Bromoalkyl)phthalimides

Lithium phenylacetylide reacted with short-chain N-(omega-bromoalkyl)phathalimides 1b and 1c to give tricyclic products 2b and 2c in moderate yields.Likewise, tricyclic products 3a-c were obtained when short-chain imides 1a-c were treated with phenyllithium.When longer-chain imides 1d-f in this series were treated with lithium phenylacetylide only tertiary alcohols 4d-f could be isolated.Partial hydrogenation of 2b and 2c yielded the corresponding alkenes 5b and 5c, products which corroborated the structural assignment of 2b and 2c.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.236406-39-6. In my other articles, you can also check out more blogs about 236406-39-6

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Piperidine – Wikipedia,
Piperidine | C5H19651N – PubChem

 

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.126501-70-0, Name is 1-(2,2,2-Trifluoroacetyl)piperidine-4-carboxylic acid, molecular formula is C8H10F3NO3, introducing its new discovery., 126501-70-0

Fluorous Boc (FBoc) carbamates: New amine protecting groups for use in fluorous synthesis

The first fluorous variants of the Boc (tert-butyloxycarbonyl) group have been prepared and tested for their suitability as nitrogen protecting groups. A group with two fluorous chains and an ethylene spacer, (RfCH2CH2)2(CH3)COC(O)-, was readily attached to a representative amine but was difficult to cleave. In contrast, groups with two fluorous chains and a propylene spacer, (RfCH2CH2CH2)2-(CH3) COC(O)-, or one fluorous chain and an ethylene spacer, (RfCH2CH2)(CH3)2COC(O)-, were readily formed and cleaved. The fluorous alcohol component of the FBoc group can be removed by evaporation and can be recovered and reused. The utility of the new FBoc group (C8F17CH2CH2)(CH3) 2COC(O)- was demonstrated in 16 and 96 compound library synthesis exercises. Separations can be achieved either by manual, parallel fluorous solid-phase extraction, or automated, serial fluorous chromatography. The results provide additional confirmation of the value of “light” fluorous synthesis techniques, and the new fluorous Boc groups expand the applicability of fluorous synthesis techniques to many classes of nitrogen-containing organic compounds.

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Piperidine – Wikipedia,
Piperidine | C5H17959N – PubChem