Tag: M.W:200-300

98303-20-9, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 98303-20-9, Name is 1-(tert-Butoxycarbonyl)piperidine-2-carboxylic acid, molecular formula is C11H19NO4. In a Article, authors is Nikulnikov, Mikhail£¬once mentioned of 98303-20-9

A convenient preparation of diastereomerically pure, diversely substituted piperazine-2,5-diones from n-protected -amino acids

The products of the Ugi reaction of various N-tert-butoxycarbonyl-protected -amino acids, aldehydes, amines and tert-butyl isocyanide, after tert-butoxycarbonyl deprotection, undergo efficient microwave-assisted cyclization in acetic acid to give diastereomerically pure, racemic piperazine-2,5-diones. The formation of a single diastereomer is rationalized via an enolization equilibration process in acetic acid at high temperature which enriches the product mixture in the more stable diastereomer. The relative stereochemistry of the products are confirmed by NOESY experiments and are consistent with molecular mechanics calculations. Georg Thieme Verlag Stuttgart New York.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. 98303-20-9, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 98303-20-9, in my other articles.

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H18474N – PubChem

 

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬ 858643-92-2, Which mentioned a new discovery about 858643-92-2

[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AS PDE2 INHIBITORS

The present invention relates to novel [1,2,4]triazolo[1,5-a]pyrimidin-yl derivatives as inhibitors of phosphodiesterase 2 (PDE2). The invention is also directed to pharmaceutical compositions comprising the compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which PDE2 is involved, such as neurological and psychiatric disorders.

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, 858643-92-2, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 858643-92-2

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Piperidine – Wikipedia,
Piperidine | C5H18036N – PubChem

 

Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In a patent, 205059-24-1, molecular formula is C14H27N3O2, introducing its new discovery., 205059-24-1

A deuterated II of phenyl compounds of preparation method and its crystalline form (by machine translation)

The invention of the formula (A) preparation method of the compound and its crystalline form, the invention also discloses the formula (A) compound of the pharmaceutical composition of the crystal, and the use of the composition in the treatment of diseases related to the ALK method. (by machine translation)

205059-24-1, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 205059-24-1

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Piperidine – Wikipedia,
Piperidine | C5H21780N – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, 19977-51-6, such as the rate of change in the concentration of reactants or products with time.In a article, authors is Monira, Shirajum, mentioned the application of 19977-51-6, Name is 1-(3-Bromoprop-2-ynyl)piperidine, molecular formula is C8H12BrN

Oxidative-addition of the N-H bond of saccharin (sacH) to a triosmium centre: Synthesis, structure and reactivity of Os3(CO)10(mu-H)(mu-sac) This paper is dedicated to Professor Kazi Azam on the occasion of his retirement. A talented scientist, true gentleman, and inspiration to generations of students at Jahangirnager University.

Saccharin (sacH) is a widely-used sweetener and consequently its chemistry has been extensively studied, but here we report a rare example of its reactivity towards a multinuclear metal centre. Lightly-stabilized Os3(CO)10-n(NCMe)n (n = 1, 2) react with sacH to afford Os3(CO)10(mu-H) (mu-sac) (1) in which the sac ligand bridges an osmium-osmium vector via nitrogen and the carbonylic oxygen (mu-N,O). The reactivity of 1 towards monodentate phosphines, PR3 (R = Ph, Th, Fu), has been investigated. Carbonyl substitution affords both mono- and bis-phosphine substituted derivatives Os3(CO)9(PR3) (mu-H) (mu-sac) (2) and Os3(CO)8(PR3)2(mu-H) (mu-sac) (3) respectively. In the mono-substituted derivatives, the phosphine occupies an equatorial position on the osmium that is directly bonded to the carbonylic oxygen of saccharinate, while in the bis-(phosphine) substituted derivatives the second phosphine is bound to the remote osmium also occupying an equatorial site. In all complexes the saccharinate ligand remains in the bidentate N,O coordination mode thus playing a directing spectator role in these reactions.

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Piperidine – Wikipedia,
Piperidine | C5H15029N – PubChem

 

147636-36-0, One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time.In a article, authors is Mao, Runze, mentioned the application of 147636-36-0, Name is 1-Tosylpiperidine-4-carboxylic acid, molecular formula is C13H17NO4S

Cross-Coupling of Alkyl Redox-Active Esters with Benzophenone Imines: Tandem Photoredox and Copper Catalysis

Alkyl amines are an important class of organic compounds in medicinal and materials chemistry. Until now very have been very few methods for the synthesis of alkyl amines by metal-catalyzed cross-coupling of alkyl electrophiles with nitrogen nucleophiles. Described here is an approach to employ tandem photoredox and copper catalysis to enable the cross-coupling of alkyl N-hydroxyphthalimide esters, readily derived from alkyl carboxylic acids, with benzophenone-derived imines. Hydrolysis of the coupling products furnish alkylated primary amines. Primary, secondary, and tertiary alkyl groups can be transferred, and the coupling tolerates a diverse set of functional groups. The method allows rapid functionalization of natural products and drugs, and can be used to expedite syntheses of pharmaceuticals from readily available chemical feedstocks.

147636-36-0, If you are hungry for even more, make sure to check my other article about 147636-36-0

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Piperidine – Wikipedia,
Piperidine | C5H22708N – PubChem

 

932035-01-3, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 932035-01-3, molcular formula is C13H24N2O4, introducing its new discovery.

NOVEL PYRIDINE DERIVATIVES

The invention relates to a compound of formula (I) wherein A1, A2 and R1 to R6 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, 932035-01-3, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 932035-01-3

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Piperidine – Wikipedia,
Piperidine | C5H22143N – PubChem

 

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬ 91419-52-2, Which mentioned a new discovery about 91419-52-2

FUSED RING COMPOUNDS

Provided are fused ring compounds of Formula (I), Formula (II), or Formula (III), as further detailed herein, which are used for the inhibition of Ras proteins, as well as compositions comprising these compounds and methods treatment by their administration.

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, 91419-52-2, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 91419-52-2

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Piperidine – Wikipedia,
Piperidine | C5H15806N – PubChem

 

10314-98-4, In heterogeneous catalysis, the catalyst is in a different phase from the reactants. At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 10314-98-4, name is N-Cbz-4-Piperidinecarboxylic acid. In an article£¬Which mentioned a new discovery about 10314-98-4

Discovery and preclinical profile of teneligliptin (3-[(2S,4S)-4-[4-(3- methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl] thiazolidine): A highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

Dipeptidyl peptidase IV (DPP-4) inhibition is suitable mechanism for once daily oral dosing regimen because of its low risk of hypoglycemia. We explored linked bicyclic heteroarylpiperazines substituted at the gamma-position of the proline structure in the course of the investigation of l-prolylthiazolidines. The efforts led to the discovery of a highly potent, selective, long-lasting and orally active DPP-4 inhibitor, 3-[(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5- yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl]thiazolidine (8g), which has a unique structure characterized by five consecutive rings. An X-ray co-crystal structure of 8g in DPP-4 demonstrated that the key interaction between the phenyl ring on the pyrazole and the S2 extensive subsite of DPP-4 not only boosted potency, but also increased selectivity. Compound 8g, at 0.03 mg/kg or higher doses, significantly inhibited the increase of plasma glucose levels after an oral glucose load in Zucker fatty rats. Compound 8g (teneligliptin) has been approved for the treatment of type 2 diabetes in Japan.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 10314-98-4 is helpful to your research. 10314-98-4

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Piperidine – Wikipedia,
Piperidine | C5H21529N – PubChem

 

158407-04-6, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In a patent, 158407-04-6, molecular formula is C11H20BrNO2, introducing its new discovery.

6-PHENYLPYRIMIDINONES AS PIM MODULATORS

A compound having Formula I or II (Formula I) or (Formula II), or a pharmaceutically acceptable salt thereof, wherein X, Z, R1, R2, R11 and R12 are as defined in the specification; pharmaceutical compositions thereof; and methods of use thereof.

158407-04-6, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 158407-04-6

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Piperidine – Wikipedia,
Piperidine | C5H22575N – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. 477600-70-7. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 477600-70-7

Chiral piperidine compound of preparation method and chiral resolving agent recovery mechanically method (by machine translation)

The invention discloses a chiral piperidine compound of preparation method and chiral resolving agent of the recycled method, the invention takes the 1 – benzyl – 4 – methyl – 3 – piperidine alcohol as the starting material, halo, armor amination, chiral separation of reaction such as preparation into (3 R, 4 R) – N, 4 – dimethyl – 1 – (phenyl methyl) – 3 – amino piperdine double-hydrochloric acid salt product, at the same time will split the stock solution of alkali treatment, in accordance with the refined after the purification of the recovered response requires the ((2 R, 3 R) – 2, 3 – double-[(4 – methyl benzoyl) oxy] succinic acid product. The invention has the beneficial effect that: 1, short synthetic route, all intermediate purity is easy to control, beneficial control of impurity content; 2, each step reaction process simple and convenient operation, and at the same time a large amount of chiral resolving agent can be recycled, the production cost is reduced at the same time reduce the amount of the solid waste, and is suitable for large-scale industrial production. (by machine translation)

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 477600-70-7 is helpful to your research. 477600-70-7

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Piperidine – Wikipedia,
Piperidine | C5H17690N – PubChem