Tag: M.W:200-300

Synthetic Route of 71233-25-5, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 71233-25-5, Name is 1-tert-Butyl 4-ethyl 3-oxopiperidine-1,4-dicarboxylate, molecular formula is C13H21NO5. In a Patent£¬once mentioned of 71233-25-5

MODULATORS OF AMYLOID BETA

The present invention relates to novel compounds of formula I and therapeutically acceptable salts thereof, their pharmaceutical compositions, processes for making them and their use as therapeutic methods for treatment and/or prevention of various diseases. In particular the invention relates to compounds, which inhibit the Ab40 and Ab42 production, increase the Ab37 and Ab38 production and maintain the Notch signaling and will be used for treatment and/or prevention of Ab-related pathologies such as Alzheimer’s disease. Downs syndrome and b-amyloid angiopathy, such as but not limited to cerebral amyloid angiopathy, hereditary cerebral hemorrhage, disorders associated with cognitive impairment, such as but not limited to MCI (“mild cognitive impairment”), Alzheimer’s disease, memory loss, attention deficit symptoms associated with Alzheimer’s disease, neurodegeneration associated with diseases such as Alzheimer’s disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson’s disease, progressive supranuclear palsy or cortical basal degeneration

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Synthetic Route of 71233-25-5, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 71233-25-5, in my other articles.

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H21798N – PubChem

 

Electric Literature of 142247-38-9, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 142247-38-9, Name is 4-(1-(tert-Butoxycarbonyl)piperidin-4-yl)butanoic acid, molecular formula is C14H25NO4. In a Article£¬once mentioned of 142247-38-9

Synthesis of heterocycle-modified betulinic acid derivatives as antitumor agents

Abstract A series of novel heterocycle-modified betulinic acid (BA) derivatives were synthesized and investigated for their activity against the growth of eight non-drug resistant and one multidrug-resistant tumor cell line using a sulforhodamine B (SRB) assay. The most active compound 17 showed an average IC50 1.19 muM, which was about 20 times more potent than the lead compound BA. It is amazing that for most synthetic saturated N-heterocycle derivatives, MCF-7/ADR was the most sensitive tumor cells, especially 17 showed the most potent antitumor activity (IC50 = 0.33 muM) on this multidrug-resistant tumor cell line, that was 117 times more potent than BA. Most of the tested compounds displayed less toxic on human fibroblasts (HAF) in comparison with the tumor cell lines. The cytometry and transwell migration assays were used to test the ability of 17 to induce apoptosis and inhibit metastasis on tumor cell lines respectively.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Electric Literature of 142247-38-9, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 142247-38-9, in my other articles.

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Piperidine – Wikipedia,
Piperidine | C5H21874N – PubChem

 

Chemistry is an experimental science, Safety of Benzyl 4-hydroxypiperidine-1-carboxylate, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 95798-23-5, Name is Benzyl 4-hydroxypiperidine-1-carboxylate

Pyridyl-and pyrimidyl-heterocyclic compounds inhibiting oxido squalene-cyclase

This invention concerns heterocyclic derivatives which are useful in inhibiting oxido-squalene cyclase, processes for their preparation and pharmaceutical compositions containing them. The present invention is also concerned with heterocyclic derivatives capable of inhibiting cholesterol biosynthesis and hence in lowering cholesterol levels in blood plasma. The present invention also relates to methods of using such heterocyclic derivatives in treating or preventing diseases and medical conditions such as hypercholesterolemia, atherosclerosis and other medical conditions associated with elevated cholesterol levels. In formula (I): G is selected from CH or N; R1 is selected from hydrogen, halogeno, (1-6C)alkyl, halogeno(1-6C)alkyl, cyano, nitro, (1-6C)alkoxycarbonyl, and NR3R4 wherein R3 and R4 are independently selected from hydrogen and (1-6C)alkyl, and wherein up to 3 R1 groups may be present; T1 is selected from CH or N; T2 and T2 are independently selected from N and CR, wherein R is selected from hydrogen, hydroxyl and (C1-4)alkyl and wherein either ring containing T2 or T3 is optionally substituted with an oxo group; R2 is selected from hydrogen or (1-4C)alkyl; Q is selected from SO2, CO and CH2; AR is selected from a five or six-membered heterocycle containing up to 3 heteroatoms selected from nitrogen, oxygen and sulphur, phenyl, phenyl (2-6)alkenyl and naphthyl in which any Ar group is optionally substituted by one or more substituents selected from (1-6C)alkyl, halogeno, halogeno (1-6C)alkyl, (1-6C)alkoxy, (1-6C)alkoxycarbonyl, cyano, (1-6C)alkylamido, nitro, NR3R4 wherein R3 and R4 are independently selected from hydrogen and (1-4C)alkyl; provided that both T2 and T3 are not N and that when T2 is CR then T1 is not CH.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Safety of Benzyl 4-hydroxypiperidine-1-carboxylate, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 95798-23-5, in my other articles.

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H19123N – PubChem

 

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬ Safety of tert-Butyl 4-(2-oxoethyl)piperidine-1-carboxylate, Which mentioned a new discovery about 142374-19-4

Enantioselective Formal alpha-Methylation and alpha-Benzylation of Aldehydes by Means of Photo-organocatalysis

Detailed herein is the photochemical organocatalytic enantioselective alpha-alkylation of aldehydes with (phenylsulfonyl)alkyl iodides. The chemistry relies on the direct photoexcitation of enamines to trigger the formation of reactive carbon-centered radicals from iodosulfones, while the ground-state chiral enamines provide effective stereochemical control over the radical trapping process. The phenylsulfonyl moiety, acting as a redox auxiliary group, facilitates the generation of radicals. In addition, it can eventually be removed under mild reducing conditions to reveal methyl and benzyl groups.

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, Safety of tert-Butyl 4-(2-oxoethyl)piperidine-1-carboxylate, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 142374-19-4

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H18149N – PubChem

 

Chemistry is an experimental science, 56346-57-7, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 56346-57-7, Name is (4-Fluorophenyl)(piperidin-4-yl)methanone

PROCESS FOR THE PREPARATION OF DARUNAVIR

The present invention provides a cost effective and industrially feasible process for preparation of Darunavir (I). Also described is the novel salt of intermediate 4-Amino-N- ((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzene sulfonamide acid salt (VIII) and its use in the preparation of Darunavir. Formula (I) and (VII).

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. 56346-57-7, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 56346-57-7, in my other articles.

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H15417N – PubChem

 

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬ 236406-39-6, Which mentioned a new discovery about 236406-39-6

Synthesis and biological evaluation of 2,4-diaminoquinazoline derivatives as novel heat shock protein 90 inhibitors

Novel 2,4-diaminoquinazoline derivatives originating from a virtual screening approach were designed, synthesized and their biological activities as heat shock protein 90 (Hsp90) inhibitors were evaluated. The prepared compounds exhibited significant anti-proliferative activities against DU-145, HT-29, HCT-116, A375P and MCF-7 cancer cell lines. The selected compounds were tested against Her2, a client protein of Hsp90, and showed significant reduction in Her2 protein expression. Compound 6b was found the most potent, reduced Her2 protein expression levels and induced Hsp70 protein expression levels significantly.

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, 236406-39-6, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 236406-39-6

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H19615N – PubChem

 

346593-03-1, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 346593-03-1, Name is tert-Butyl 2,2-dimethyl-4-oxopiperidine-1-carboxylate,introducing its new discovery.

POLYCARBONATE RESIN

The present invention relates to a polycarbonate resin containing, in the molecule, a structure represented by the following formula (1):wherein X has a structure represented by any one of the following formulae (2) to (4):wherein each of R1 to R4 independently represents a hydrogen atom or an organic group having a carbon number of 1 to 30; the organic group may have an arbitrary substituent, and any two or more members of R1 to R4 may combine with each other to form a ring, which is excellent in heat resistance, transparency, light resistance, weather resistance and mechanical strength.

If you¡¯re interested in learning more about 50541-93-0, below is a message from the blog Manager. 346593-03-1

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Piperidine – Wikipedia,
Piperidine | C5H18004N – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.324769-03-1,(3S,5R)-1-Benzyl-3,5-dimethylpiperidin-4-one,as a common compound, the synthetic route is as follows.

Phenyllithium in diisopropyl ether (2 M, 34.5 mL, 690 mmol) was added dropwise to a stirred solution of (3R,5S)-1-benzyl-3,5-dimethylpiperidin-4-one, from preparation 14 (10.0 g, 46 mmol) in anhydrous diethyl ether (150 mL) at -78 C. The mixture was stirred for a further 30 minutes at -78 C., before saturated aqueous ammonium chloride solution (10 mL) was added and the mixture was allowed to warm to room temperature. The organic layer was separated, washed with water (3¡Á200 mL) and dried over sodium sulfate, and then filtered. The solvent was then evaporated to give the crude (3R,4s,5S)-1-benzyl-3,5-dimethyl-4-phenylpiperidin-4-ol (12.8 g) as a white solid. The crude compound was >95% pure by 1H NMR and used directly in preparation 21. LC-MS (ESI+): 296 (M+H); 11H NMR (400 MHz, CD3OD) delta 0.51 (d, 6H), 2.18 (m, 2H), 2.30 (m, 2H), 2.42 (m, 2H), 3.6 (s, 2H), 7.15 (m, 1H), 7.35 (m, 9H)., 324769-03-1

As the paragraph descriping shows that 324769-03-1 is playing an increasingly important role.

Reference£º
Patent; Pfizer Inc; US2005/176772; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.135634-18-3,(2,4-Difluorophenyl)(piperidin-4-yl)methanone oxime hydrochloride,as a common compound, the synthetic route is as follows.

Potassium hydroxide (27 g) was added to 600 mL of methanol and added(2,4-difluorophenyl) – (4-piperidinyl) methanone oxime hydrochloride (55 g)Heating reaction for about 2.5 hours. Cold to room temperature, add appropriate amount of anhydrous MgSO4, stirring about 1h. The filtrate was concentrated under reduced pressure. Join500 mL of acetone, stirred at room temperature for about 0.5 h, filtered, the filtrate stirred into the hydrochloric acid to pH = 2 ~ 3, filter, dry, white solidBody 35g. The methanol content is 0.4%.

135634-18-3, The synthetic route of 135634-18-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Beijing Pharmaceutical Group Co., Ltd.; Wang Qichang; Liu Moyi; Liu Qingliang; Zou Jiang; Yang Yan; (9 pag.)CN106831742; (2017); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.92235-39-7,(S)-tert-Butyl (2-oxopiperidin-3-yl)carbamate,as a common compound, the synthetic route is as follows.

92235-39-7, A. Preparation of 1,1-dimethylethyl [(3S)-1-[2-oxo-2-(1-pyrrolidinyl)ethyl]-2-oxo-3-piperidinyl]carbamate. Lithium bis(trimethylsilyl)amide (1 N in THF, 18.9 mL, 18.9 mmol) in THF (9 mL) was added dropwise over 35 min to a solution of 1,1-dimethylethyl ((3S)-2-oxo-3-piperidinyl)carbamate (2.0 g, 9.3 mmol) in THF (160 mL) stirring at ambient temperature under argon. After stirring at ambient temperature for 15 min the reaction was cooled to 0 C. and a solution of 1-(bromoacetyl)pyrrolidine (2.0 g, 10.4 mmol) in THF (27 mL) was then added over 60 min. After stirring at 0 C. for 2 h, the reaction was quenched with 10% KHSO4 and transferred to a separatory funnel with ethyl acetate. The mixture was washed with 10% KHSO4 and brine, dried over magnesium sulfate and concentrated in vacuo to afford 4.0 g of crude product. Column chromatography (silica, acetonitrile) afforded 1,1-dimethylethyl [(3S)-1-[2-oxo-2-(1-pyrrolidinyl)ethyl]-2-oxo-3-piperidinyl]carbamate (2.0 g, 66%): 1H-NMR (CDCl3) delta 5.36 (m, 1H), 4.14 (d, J=14.1 Hz, 1H), 4.00 (m, 1 H), 3.71 (d, J=14.1 Hz, 1 H), 3.41-3.24 (m, 6 H), 2.31 (m, 1 H), 1.91-1.70 (m, 6 H), 1.61 (m, 1 H), 1.42 (s, 9 H); 13C-NMR (CDCl3) delta 170.0, 165.6, 155.6, 79.0, 51.5, 49.3, 48.6, 45.6, 45.5, 28.1, 27.6, 25.9, 23.8, 20.6.

The synthetic route of 92235-39-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Stein, Philip D.; O’Connor, Stephen P.; Shi, Yan; Li, Chi; US2002/25957; (2002); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem