Tag: M.W:200-300

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Hussein, A. M., once mentioned the application of 477600-74-1, Name is N-Methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, molecular formula is C13H19N5, molecular weight is 245.3235, MDL number is MFCD09878608, category is piperidines. Now introduce a scientific discovery about this category, Recommanded Product: N-Methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine.

beta-Oxo andides in Heterocyclic Synthesis: Novel Synthesis of Polyfunctionally Pyridines, Pyrimidines and Benzothiazole Derivatives

ACETOACETANILIDE derivative 1 was reacted with aromatic aldehydes 2 to yield the arylidine derivatives 3 and 6a, b. The IIantzsch amides 7a,b were prepared by the one-pot cyclization reaction of a mixture of 2 moles of 1, aqueous ammonia and aromatic aldehydes. Treatment of 1 with ethanol containing equivalent amount of piperidine or morpholine furnished the isolable products 8a and 8b. Compound 1 underwent interamolecular heterocyclization on boiling conc. sulfuric acid, afforded 9. Also, the reaction of compound 1 with hydroxylamine hydrochloride in ethanol and sodium acetate afforded the oxime derivative 10. Furthermore, reactions of compound 1 with o-aminothiophenol furnished 11. Reactions of 1 with arylidine derivatives give compounds 13 and 16a-d. Treatment of compound 16d with elemental sulfur afforded the thieno[3,4-c]pyridine derivative 18. Treatment of 16a with hydrazine hydrate in boiling ethanol afforded the pyrazolo[3,4-b]pyridine derivatives 19. Also, compound 16a was reacted with ethylchloroacetate giving 20. Compound 20 was cyclized into the corresponding thieno[2,3-b]-pyridine derivative 21 upon boiling with ethanol containing a few drops of sodium ethoxide solution. Furthermore, compound 1 readily reacted with cyanothioacetamide to yield compound 22. Fusion of compound 1 with malononitrile over melting point without solvent in presence of ammonium acetate or refluxing in ethanolic piperidine afforded the pyridone 23a. Also, the pyridone derivative 23b was obtained by reacting compound 1 with cyanoacetamide. The reaction of acetoacetanilide 1 with co-bromoacetophenones afforded 28a,b. Treatment of 1 with benzoyl and ethoxy carbonyl isothiocyanates afforded the pyrimidine derivatives 30a,b. The reaction of 1 with aminopyrazole gave the pyrazolopyrimidine 33. Coupling of 1 with diazonium salt of compounds 34a,b yielding 37a,b.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Synthetic Route of 3056-33-5, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 3056-33-5, Name is N2,9-Diacetylguanine, SMILES is CC(=O)NC1=NC2=C(N=CN2C(C)=O)C(=O)N1, belongs to piperidines compound. In a article, author is Nowicka, Anna, introduce new discover of the category.

SYNTHESIS AND IN VITRO ANTIPROLIFERATIVE ACTIVITY OF NOVEL MANNICH BASES-2-ARYLIDENEAMINOBENZIMIDAZOLES DERIVATIVES

A new class of Mannich bases 5-16, 20-21, derivatives of 2-amino-1H-benzimidazole, were obtained in the condensation of Schiff bases 2-4 with selected secondary or primary amines: N-phcnylpiperazinc, 1-(2-pyridyl)piperazine, morpholine, piperidine, 2-chloroaniline, benzylamine and formaldehyde in ethanol. In reaction of 2-bromobenzylideneaminobenzimidazole with primary amines: o-chloroaniline and benzylamine carried out in room temperature 1-hydroxymethy1-2-(2-bromobenzylideneamino)benzimidazole (19) was obtained. In next step compound 19 with primary amines in boiling ethanol with catalytic amount of Triflate gave Mannich bases of various chemical structures. The structures 5-21 were confirmed by the results of elementary analysis and their IR, H-1, C-13-NMR spectra and mathematical optimalizations. All 20 compounds were screened against the cells of MV4-11 human leukemia. Selected 8 compounds with the highest activity (IC50 lower than 10 mu g/mL) were tested towards human breast (T47D), lung (A549) and colon (LoVo) cancer cells and normal mouse fibroblasts (BALB/3T3). Cisplatin was used as a control drug. Selected types of cancer are the examples of diseases frequently afflicted people worldwide.

Synthetic Route of 3056-33-5, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 3056-33-5 is helpful to your research.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 2873-29-2, Name is (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate, molecular formula is , belongs to piperidines compound. In a document, author is Yadav, Nagendra Nath, Category: piperidines.

Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles

Bicyclic aziridinium ions were generated by the removal of an appropriate leaving group through internal nucleophilic attack by nitrogen atom in the aziridine ring. The utility of bicyclic aziridinium ions, specifically 1-azoniabicyclo[3.1.0]hexane and 1-azoniabicyclo[4.1.0]heptane tosylate highlighted in the aziridine ring openings by the nucleophile with the release of the ring strain to yield the corresponding ring-expanded azaheterocycles such as pyrrolidine, piperidine and azepane with diverse substituents on the ring in regio- and stereospecific manner. Herein, we report a simple and convenient method for the preparation of the stable 1-azabicyclo[4.1.0]heptane tosylate followed by selective ring opening via a nucleophilic attack either at the bridge or at the bridgehead carbon to yield piperidine and azepane rings, respectively. This synthetic strategy allowed us to prepare biologically active natural products containing piperidine and azepane motif including sedamine, allosedamine, fagomine and balanol in highly efficient manner.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 2873-29-2, in my other articles. Category: piperidines.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 14691-89-5, Name is 4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl, molecular formula is , belongs to piperidines compound. In a document, author is de Oliveira, Isadora M., Formula: C11H21N2O2*.

Copper(I)/succinic acid cooperatively catalyzed one-pot synthesis of organoselenium-propargylamines via A(3)-coupling

Selenium propargylamines were synthesized via an A(3)-coupling approach using piperidine, p-methoxybenzaldehyde, and trimethylsilyl selenium-acetylene, catalyzed by copper(i) chloride and succinic acid as an additive, in good to excellent yields. This method is advantageous in that desilylation of the trimethylsilyl selenium-acetylene occurs in situ. The reaction time was monitored by FTIR studies and a probable mechanism is described. Scale-up was also performed in satisfactory yield. These selenium propargylamines could be hydrohalogenated to synthesize halovinyl selenides. The stereochemistry was determined by treatment with n-butyllithium and the coupling constant (J) values in H-1 NMR spectra. The vinyl selenides were employed in Sonogashira cross-coupling reactions to produce the corresponding enynes, with yields ranging from moderate to good.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 14691-89-5, in my other articles. Formula: C11H21N2O2*.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 401566-79-8, Name is 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine, formurla is C14H18N4. In a document, author is Dooley, Charles J., III, introducing its new discovery. Recommanded Product: 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine.

Using the Competing Enantioselective Conversion Method to Assign the Absolute Configuration of Cyclic Amines with Bode’s Acylation Reagents

The competing enantioselective conversion (CEC) method is a quick and reliable means to determine absolute configuration. Previously, Bode’s chiral acylated hydroxamic acids were used to determine the stereochemistry of primary amines, as well as cyclic and acyclic secondary amines. The enantioselective acylation has been evaluated for 4-, 5-, and 6-membered cyclic secondary amines, including medicinally relevant compounds. The limitations of the method were studied through computational analysis and experimental results. Piperidines with substituents at the 2-position did not behave well unless the axial conformer was energetically accessible, which is consistent with the transition state geometries proposed by Bode and Kozlowski. Control experiments were performed to investigate the cause of degrading selectivity under the CEC reaction conditions. The present study expands the scope of the CEC method for secondary amines and provides a better understanding of the reaction profile.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 34737-89-8, Name is 1-Benzyl-3-methylpiperidin-4-one, SMILES is O=C1C(C)CN(CC2=CC=CC=C2)CC1, belongs to piperidines compound. In a document, author is Geary, Gemma C., introduce the new discover, Recommanded Product: 34737-89-8.

Densely functionalised spirocyclic oxetane-piperidine scaffolds for drug discovery

A spirocyclic, sp(3)-atom rich oxetane-containing scaffold was synthesised in just two steps via a gold catalysed propargylic alcohol rearrangement. The key gold cyclisation can be undertaken on a 40 g scale allowing the preparation of 419 lead-like compounds based on the scaffold for the European Lead Factory. (C) 2017 Elsevier Ltd. All rights reserved.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 34737-89-8 is helpful to your research. Recommanded Product: 34737-89-8.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Recommanded Product: N2,9-Diacetylguanine, 3056-33-5, Name is N2,9-Diacetylguanine, SMILES is CC(=O)NC1=NC2=C(N=CN2C(C)=O)C(=O)N1, belongs to piperidines compound. In a document, author is Masson, Guillaume, introduce the new discover.

Azetidiniums: Ring-Expansion to Pyrrolidines, Piperidines, Azepanes, and Azocanes

The 4-membered ring in bicyclic azetidiniums, e.g. 1-azabicyclo[2.n.0]alkanes (n= 1-4), can be efficiently transformed to larger rings. This minireview focuses on the ring-expansion of these azetidiniums to five- and eight-membered nitrogen containing heterocycles (pyrrolidines, piperidines, azepanes and azocanes). The ring-expansion is induced by nucleophiles which can be internal nucleophiles (leaving groups), or external nucleophiles.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 3056-33-5. Recommanded Product: N2,9-Diacetylguanine.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Related Products of 4005-49-6, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 4005-49-6, Name is N-(7H-Purin-6-yl)benzamide, SMILES is O=C(NC1=C2NC=NC2=NC=N1)C3=CC=CC=C3, belongs to piperidines compound. In a article, author is Kamble, Rohit B., introduce new discover of the category.

Synthesis of key intermediate for (+)-tofacitinib through Co-III(salen)-catalyzed two stereocentered hydrolytic kinetic resolution of (+/-)-methyl-3-(oxiran-2-yl)butanoate

An enantiopure piperidine, a key intermediate for the synthesis of (+)-tofacitinib, has been achieved in high optical purity (98% ee) from readily available crotyl alcohol. The key steps involved is a Co-III(salen)-OAc-catalyzed two stereocentered hydrolytic kinetic resolution of (+/-)-methyl-3-(oxiran-2-yl)butanoate.

Related Products of 4005-49-6, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 4005-49-6.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 14691-89-5, Name is 4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl, SMILES is CC1(C)CC(NC(C)=O)CC(C)(C)N1[O], belongs to piperidines compound. In a document, author is Aziz-ur-Rehman, introduce the new discover, Application In Synthesis of 4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl.

Synthesis of some new propanamide derivatives bearing 4-piperidinyl-1,3,4-oxadiazole, and their evaluation as promising anticancer agents

Purpose: To sequentially synthesize piperidine-4-carboxylic acid ethyl ester-appended 1,3,4-oxadiazole hybrids and to evaluate them as anticancer agents. Methods: Ethyl 1-[(4-methylphenyl)sulfonyl]-4-piperidinecarboxylate (1) was synthesized from 4-methylbenzenesulfonylchloride (a) and ethyl 4-piperidinecarboxylate (b) Compound (1) was converted into ethyl 1-[(4-methylphenyl)sulfonyl]-4-piperidine carbohydrazides (2) and 5-{1-[(4-methylphenyl)sulfonyl]-4-piperidinyl}-1,3,4-oxadiazole-2-thiol (3) respectively. A variety of aryl amine (4a-l) were treated with 2-bromopropionylbromide to synthesize an array of propanamide (5a-l). Finally, 5-{1-[(4-methylphenyl)sulfonyl]-4-piperidinyl}-1,3,4-oxadiazole-2-thiol (3) and propanamides (5a-l) were reacted to synthesize target compounds (6a-l) Purity compounds 6a-l was confirmed by spectroscopic techniques like (H-1-NMR), (C-13-NMR) and EI-MS. To determine their anticancer potential, the change in absorbance of mixture and cell line before and after incubation was determined Results: All the compounds 6a-l were successfully synthesized in 73-85 % yield. Compounds 6h, 6j and 6e have low ICso (+/- SD) values of 20 12 +/- 6 20, 10 84 +/- 4 2 and 24 57 +/- 1.62 mu M to act as strong anticancer agents relative to doxorubicin (0.92 +/- 0.1 mu M) used as a reference. Conclusion: The synthesized propanamide derivatives bearing 4-piperidinyl-1,3,4-oxadiazole are potential anticancer agents, but further studies, especially in vivo, are required to ascertain their therapeutic usefulness.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 14691-89-5 is helpful to your research. Application In Synthesis of 4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 119515-38-7, Name is sec-Butyl 2-(2-hydroxyethyl)piperidine-1-carboxylate, molecular formula is C12H23NO3. In an article, author is Savanur, Hemantkumar M.,once mentioned of 119515-38-7, Recommanded Product: 119515-38-7.

Libraries of C-5 Substituted Imidazoles and Oxazoles by Sequential Van Leusen (VL)-Suzuki, VL-Heck and VL-Sonogashira in Imidazolium-ILs with Piperidine-Appended-IL as Base

Facile access to diverse C5-substituted imidazoles and oxazoles via sequential Van Leusen-Suzuki, Van Leusen-Heck, and Van Leusen-Sonogashira protocols, employing imidazolium-ILs as solvents along with piperidine-appended imidazolium [PAIM][NTf2] as task-specific basic IL has been demonstrated, in a high-yielding one-pot method, starting with readily available aldimines (for imidazole) or aldehydes (for oxazole) and tosylmethylisocyanide (Tos-MIC), under mild conditions with potential for recycling and reuse of the IL solvent. The scope of the method is supported 49 examples.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem