Tag: M.W:200-300

Chemistry is an experimental science, Safety of 4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 14691-89-5, Name is 4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl, molecular formula is C11H21N2O2*, belongs to piperidines compound. In a document, author is Nakhate, Akhil V..

Cu2O nanoparticles supported hydrothermal carbon microspheres as catalyst for propargylamine synthesis

Cu2O nanoparticles supported on hydrothermal carbon microsphere (HTC) have been synthesized by hydro thermal synthesis followed by chemical reduction method. The prepared catalyst was used for propargylamine synthesis from the coupling of phenyl acetylene with benzaldehyde and piperidine. In this protocol, biomass derived D-glucose was used as carbon source for the synthesis of carbon microspheres by hydrothermal treatment and CuCl2 center dot 6H(2)O as a copper precursor. The activity of Cu2O@HTC was compared with different catalysts such as CuFe2O4, CuCl2 center dot 2H(2)O, commercial CuO, and Cu2O. Among them Cu2O@HTC exhibited the best activity and selectivity for propargylamine synthesis. The catalyst was well characterized by several analytical techniques such as SEM, XRD, FTIR, TEM, ICP-AES, and XPS analysis before and after 5th reuse. The effect of various parameters was studied including solvent, catalyst loading, mole ratio and temperature of the reaction to achieve the best yield at 60 degrees C and 1.5 x 10 (-3)g/cm(3) catalyst loading. Notably, Cu2O@HTC was recycled five times and found to be robust.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 14691-89-5, in my other articles. Safety of 4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Application of 3056-33-5, Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. The appropriate choice of redox mediator can avoid electrode passivation and overpotential. 3056-33-5, Name is N2,9-Diacetylguanine, SMILES is CC(=O)NC1=NC2=C(N=CN2C(C)=O)C(=O)N1, belongs to piperidines compound. In a article, author is Hussain, Javeena, introduce new discover of the category.

Synthesis and characterization of a new class of phenothiazine molecules with 10H-substituted morpholine & piperidine derivatives: A structural insight

A series of 10H-substituted phenothiazine-based molecules were prepared by the base-catalyzed reactions. The synthesized compounds are characterized by Mass spectroscopy, NMR, and SCXRD to examine the role of different functional groups involved in the intermolecular interactions and conformational geometries. The crystal packing of the compounds is governed by O-H center dot center dot center dot O, C-H center dot center dot center dot O, and pi-pi interactions. A complete understanding of the intermolecular interactions is studied employing the Hirshfeld analysis, 2D Fingerprint plot. Furthermore, the density functional theory (DFT/B3LYP) method at the 6-311++G(d,p) basis set was performed to support and compare experimental & theoretical geometrical parameters of phenothiazine derivatives. (C) 2020 Elsevier B.V. All rights reserved.

Application of 3056-33-5, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 3056-33-5 is helpful to your research.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Electric Literature of 19916-73-5, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 19916-73-5, Name is 6-(Benzyloxy)-7H-purin-2-amine, SMILES is C3=NC1=C(C(=NC(=N1)N)OCC2=CC=CC=C2)[NH]3, belongs to piperidines compound. In a article, author is Waddell, Lachlan J. N., introduce new discover of the category.

Asperidine B: Total synthesis and structure correction

A synthesis of the proposed structure of asperidine B is reported, involving a tandem hydroformylation-condensation reaction, a diastereoselective dihydroxylation and the addition of an organozinc reagent to an iminium ion. As the spectroscopic data for the synthetic material is not in agreement with that of the natural product, the structure of asperidine B is reassigned as (+)-preussin. (C) 2020 Elsevier Ltd. All rights reserved.

Electric Literature of 19916-73-5, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 19916-73-5.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Synthetic Route of 401566-79-8, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 401566-79-8, Name is 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine, SMILES is CC1=NN(C2=CC=CC=C2)C(N3CCNCC3)=C1, belongs to piperidines compound. In a article, author is Yamaguchi-Sasaki, Toru, introduce new discover of the category.

Design and Synthesis of 2-(1-Alkylaminoalkyl)pyrazolo[1,5-a]pyrimidines as New Respiratory Syncytial Virus Fusion Protein Inhibitors

Respiratory syncytial virus (RSV) is one of the most common causes of lower respiratory tract infections and a significant pathogen for both adults and children. Although two drugs have been approved for the treatment of RSV infections, the low therapeutic index of these drugs have led pharmaceutical companies to develop safe and effective small-molecule anti-RSV drugs. The pyrazolo[1,5-a]pyrimidine series of compounds containing a piperidine ring at the 2-position of the pyrazolo[1,5-a]pyrimidine scaffold are known as candidate RSV fusion (F) protein inhibitor drugs, such as presatovir and P3. The piperidine ring has been revealed to facilitate the formation of an appropriate dihedral angle between the pyrazolo[1,5-a]pyrimidine scaffold and the plane of the amide bond for exertion of anti-RSV activity. A molecular-dynamic study on newly designed compounds with an acyclic chain instead of the piperidine ring proposed and demonstrated a new series of pyrazolo[1,5-a]pyrimidine derivatives, such as 9c with a 1-methyaminopropyl moiety, showing similar dihedral angle distributions to those in presatovir. Compound 9c exhibited potent anti-RSV activity with an EC50 value of below 1 nM, which was similar to that of presatovir. A subsequent optimization study on the benzene ring of 9c led to the potent RSV F protein inhibitor 14f with an EC50 value of 0.15 nM. The possibility of improving the biological properties of anti-RSV agents by modification at the 7-position of pyrazolo[1,5-a]pyrimidine is also discussed.

Synthetic Route of 401566-79-8, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 401566-79-8 is helpful to your research.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Electric Literature of 34737-89-8, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 34737-89-8, Name is 1-Benzyl-3-methylpiperidin-4-one, SMILES is O=C1C(C)CN(CC2=CC=CC=C2)CC1, belongs to piperidines compound. In a article, author is Mu, Changhua, introduce new discover of the category.

Activation by Oxidation: Ferrocene-Functionalized Ru(II)-Arene Complexes with Anticancer, Antibacterial, and Antioxidant Properties

Organometallic Ru(II)-cymene complexes linked to ferrocene (Fc) via nitrogen heterocycles have been synthesized and studied as cytotoxic agents. These compounds are analogues of Ru(II)-arene piano-stool anticancer complexes such as RAPTA-C. The Ru center was coordinated by pyridine, imidazole, and piperidine with 0-, 1-, or 2-carbon bridges to Fc to give six bimetallic, dinuclear compounds, and the properties of these complexes were compared with their non-Fc-functionalized parent compounds. Crystal structures for five of the compounds, their Ru-cymene parent compounds, and an unusual trinuclear compound were determined. Cyclic voltammetry was used to determine the formal M-III/II potentials of each metal center of the Ru-cymene-Fc complexes, with distinct one-electron waves observed in each case. The Fc-functionalized complexes were found to exhibit good cytotoxicity against HT29 human colon adenocarcinoma cells, whereas the parent compounds were inactive. Similarly, antibacterial activity from the Ru-cymene-Fc compounds was observed against Bacillus subtilis, but not from the unfunctionalized complexes. In both cases, the IC50 values correlated quantitatively with the Fc(+/0) reduction potentials. This is consistent with more facile oxidation to give ferrocenium, and subsequent generation of toxic reactive oxygen species, leading to greater cytotoxicity. The antioxidant properties of the complexes were quantified by a 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay. EC50 values indicate that linking of the Ru and Fc centers promotes antioxidant activity.

Electric Literature of 34737-89-8, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 34737-89-8.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 10465-81-3, Name is Diazene-1,2-diylbis(piperidin-1-ylmethanone), SMILES is O=C(/N=N/C(N1CCCCC1)=O)N2CCCCC2, belongs to piperidines compound. In a document, author is Tikhov, Rabdan M., introduce the new discover, Safety of Diazene-1,2-diylbis(piperidin-1-ylmethanone).

Construction of piperidine-2,4-dione-type azaheterocycles and their application in modern drug development and natural product synthesis

The current review summarizes the latest achievements in the synthesis of piperidine-2,4-dione-type azaheterocycles. Two main groups traditional (carbonyl compound transformations) and novel (anionic enolate rearrangements) of complementary methods for the simple and effective preparation of structurally diverse compounds in racemic and enantiopure forms have been reported. Due to the specific structure and appropriate reactivity profiles of dione-type molecules, they are a convenient modern platform for the construction of functionalized piperidine-type systems possessing high synthetic and medicinal potential. This potential is successfully realized by the creation of highly active pharmaceutically relevant compounds and the synthesis of natural products.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 10465-81-3 is helpful to your research. Safety of Diazene-1,2-diylbis(piperidin-1-ylmethanone).

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Application of 4005-49-6, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 4005-49-6, Name is N-(7H-Purin-6-yl)benzamide, SMILES is O=C(NC1=C2NC=NC2=NC=N1)C3=CC=CC=C3, belongs to piperidines compound. In a article, author is Li, Hui, introduce new discover of the category.

Antidiabetic compounds 8a, 8b, 8k, and 9h enhance insulin secretion: activity and mechanism

Purpose This study primarily investigated the effects of hypoglycemic compounds (Imeglimin derivatives) on insulin secretion in type 2 diabetes mellitus (T2DM), and further explored the possible mechanism underlying these effects. Methods Firstly, Metformin was used as the initiating compound to synthesize three sets of derivatives which contained Imeglimin structure core. At the cellular level, we screened compounds with better effect on the activity of insulin receptor tyrosine protein kinase (IFcTPK) after the islet beta cells were treated with the compounds of different concentrations. The insulin secretion was assessed using radioimmunoassay and the cytotoxicity to islet beta cells was evaluated by means of MTT assay following treatment with the compounds. The Ca2+-related mechanism by which these compounds promote insulin secretion was elucidated with whole cell recordings from current-clamp mode. Results Totally, 48 synthesized compounds were generated, wherein 10 compounds could increase the activity of IFcTPK in HIT-T15 cells better among these compounds. The modified Imeglimin, especially in the structure of hydrophilic hydroxyl or piperidine rings, could improve the activity of the compound to promote insulin secretion. Furthermore, the compounds 8a, 8b, 8k, and 9h revealed high insulin secretion-promoting activity. These compounds enhanced insulin secretion in islet beta cells by repressing the ATP-sensitive K(+) and voltage-gated K+ pathway. Conclusions Our findings indicate that the hypoglycemic compounds 8a, 8b, 8k, and 9h confer better promotive effect on insulin secretion, which provides a reference for the development of drugs with better hypoglycemic activity.

Application of 4005-49-6, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 4005-49-6 is helpful to your research.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 34737-89-8, Name is 1-Benzyl-3-methylpiperidin-4-one, SMILES is O=C1C(C)CN(CC2=CC=CC=C2)CC1, belongs to piperidines compound. In a document, author is Namera, Dipti L., introduce the new discover, HPLC of Formula: C13H17NO.

Arylidene analogues as selective COX-2 inhibitors: synthesis, characterization,in silicoandin vitrostudies

Pyrazole derivatives are known to be as non-steroidal anti-inflammatory drugs (NSAID).Celecoxibis the pioneer sulfonamide being pyrazole derivative COX-2 inhibitors, which used to treat pain and inflammation; they may also have a role in cancer prevention. In the present investigation, a series of arylidene analogues (NDP-4011toNDP-4016) were synthesized by the condensation of 4-(3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl) benzenesulfonamide (I) with various substituted aromatic aldehydes in ethanol using a catalytic amount of piperidine. All the synthesized compounds were well characterized by IR,H-1 NMR,C-13 NMR and mass spectrometry. The cytotoxicity of synthesized compounds was tested on theNRK-52Ecell line. From whichNDP-4011,NDP-4012,NDP-4013,NDP-1015andNDP-4016were found to have higher cytotoxicity whereasNDP-4014showed less cytotoxicity compared toCelecoxib. Thein silicopharmacokinetic parameters of compounds were evaluated to check their candidature as a drug. Molecular docking was carried out on COX-2 structures, which revealed thatNDP-4011toNDP-4016targets allosteric binding site similar to the binding mode of the selective COX inhibitorCelecoxib. Furthermore, results ofin vitroCOX-2 inhibition assay supports arylidene analogues as COX-2 inhibitors.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 34737-89-8 is helpful to your research. HPLC of Formula: C13H17NO.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Synthetic Route of 827026-45-9, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 827026-45-9, Name is 3-(4-Nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione, SMILES is [O-][N+](=O)C1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1, belongs to piperidines compound. In a article, author is Wakiyama, Yoshinari, introduce new discover of the category.

Synthesis and SARs of novel lincomycin derivatives Part 5: optimization of lincomycin analogs exhibiting potent antibacterial activities by chemical modification at the 6-and 7-positions

In order to modify lincomycin at the C-6 and C-7 positions, we prepared target molecules, which have substituted pipecolinic acid at the 6-amino group and a para-substituted phenylthio group at the C-7 position, in application of palladium-catalyzed cross-coupling as a key reaction. As the result of structure-activity relationship (SAR) studies at the 6-position, analogs possessing 4′-cis-(cyclopropylmethyl) piperidine showed significantly strong antibacterial activities against Streptococcus pneumoniae and Streptococcus pyogenes with an erm gene. On the basis of SAR, we further synthesized novel analogs possessing 4′-cis-(cyclopropylmethyl) piperidine by transformation of a C-7 substituent. Consequently, novel derivatives possessing a paraheteroaromatic-phenylthio group at the C-7 position exhibited significantly strong activities against S. pneumoniae and S. pyogenes with an erm gene even when compared with those of telithromycin. Finally, in vivo efficacy of selected two derivatives was evaluated in a rat pulmonary infection model with resistant S. pneumoniae with erm + mef genes. One of them exhibited strong and constant in vivo efficacy in this model, and both compounds showed strong in vivo efficacy against resistant S. pneumoniae with a mef gene.

Synthetic Route of 827026-45-9, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 827026-45-9 is helpful to your research.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

4005-49-6, Name is N-(7H-Purin-6-yl)benzamide, molecular formula is C12H9N5O, belongs to piperidines compound, is a common compound. In a patnet, author is dos Santos, Nathalia M., once mentioned the new application about 4005-49-6, COA of Formula: C12H9N5O.

3-Hydroxy-piperidinyl-N-benzyl-acyl-arylhydrazone derivatives reduce neuropathic pain and increase thermal threshold mediated by opioid system

Here in, we report the preparation and evaluation of four 3-hydroxy-piperidine-N-benzyl-aryl-acylhydrazone derivatives (6a-d) for their potential antinociceptive activity. In the tail flick test, compounds 6a and 6d exhibited a significant increase in the latency time of the animals, in comparison to the control group. These two compounds also showed a significant increase in the nociceptive threshold from 1 to 6 h after treatment in the CCI neuropathic pain model. In both cases, the antinociceptive activity was blocked by naloxone, suggesting an opioid mechanism of action, but without sedative or motor coordination effects.

If you¡¯re interested in learning more about 4005-49-6. The above is the message from the blog manager. COA of Formula: C12H9N5O.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem