Tag: M.W:200-300

72551-53-2, Ethyl 1-benzylpiperidine-3-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(l-Benzylpipeiidin-3-yl)methanol; To a solution of ethyl l-benzylpiperidine-3-carboxylate (1.0 g) in tetrahydrofuran (10 mL) at 5C under argon was added a IM solution of lithium aluminium hydride (4.04 mL) dropwise. The mixture was stirred for 1 hour at 5C and then quenched by the dropwise addition of ethyl acetate (5 mL). The mixture was warmed to room temperature and dichloromethane (150 mL) was added followed by saturated aqueous sodium potassium tartrate (50 mL). The mixture was stirred vigorously overnight. The layers were separated EPO and the organic layer was dried over magnesium sulfate and evaporated to give the title compound as a colourless oil (0.82 g, 99%).

72551-53-2, 72551-53-2 Ethyl 1-benzylpiperidine-3-carboxylate 2736370, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/67401; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.142851-03-4,Ethyl N-Boc-piperidine-4-carboxylate,as a common compound, the synthetic route is as follows.

Intermediate 63: 4-Hydrazinocarbonyl-piperidine-1-carboxylic acid tert-butyl esterTo a stirred solution of 1-ferf-butyl 4-ethylpiperidine-1 ,4-dicarboxylate (10 g, 38.9 mmol, 1.0 eq) in EtOH (100 mL) was added hydrazine hydrate (18.67g, 389 mmol, 10 eq.) and the mixture was refluxed for 8 h. The reaction was cooled to room temperature and evaporation of the solvent gave a viscous liquid which was dissolved in CH2CI2, washed with water (3 x 50 mL) then brine (50 mL). The organic layers were combined, dried over Na2S04, the solvent evaporated leaving a yellowish oil, which upon addition of a few drops of acetonitrile and re-evaporation, yielded the title compound (8.6 g, 35.3 mmol) MS (m/z, MH-): 242.2., 142851-03-4

142851-03-4 Ethyl N-Boc-piperidine-4-carboxylate 2758812, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; NOVARTIS AG; CHEN, Zhuoliang; CHEUNG, Atwood, Kim; CHIN, Donovan, Noel; FAN, Jianmei; MILLER-MOSLIN, Karen, Marie; SHULTZ, Michael, David; SMITH, Troy, D.; TOMLINSON, Ronald, Charles; TOURE, Bakary-Barry; VISSER, Michael, Scott; WO2013/12723; (2013); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

358789-72-7, 4-((1-Methylpiperidin-4-yl)oxy)aniline is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example No. 163Preparation of (8- ethoxy-2H-pyrazolo [3, 4-c] quinolin-4-yl) – [4- (l-methyl-piperidin-4-yloxy) -phenyl] -amine4-chloro-8-methoxy-2- (4 -methoxybenzyl) -2H-pyrazolo [3 , 4 – c]quinoline (0.16 mmol) and 4- ( (l-methylpiperidin-4- yl) oxy) aniline (2 eq.,0.3 mmol) were suspended in MeOH (dry, 3mL) in a microwave vial (2-5mL) , HC1 in dioxane (4M, 3 drops) was added. The reaction mixture was irradiated in a microwave reactor for 5 min at 140C. The reaction mixture was evaporated and used without further purification. The residue was dissolved in TFA (3mL) . The reaction mixture was irradiated in a microwave reactor for 5 min at 140C. The reaction mixture was concentrated and purified by semi- preparative HPLC-MS and freeze dried from water/t-BuOH 4/1. exact mass: 403.2399 g/molHPLC-MS: analytical method Crt: 1.460 min – found mass: 404.2 (m/z+H), 358789-72-7

358789-72-7 4-((1-Methylpiperidin-4-yl)oxy)aniline 16765164, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; ORIGENIS GMBH; ALMSTETTER, Michael; THORMANN, Michael; TREML, Andreas; KOESTLER, Roland; YEHIA, Nasser; WO2012/143143; (2012); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10315-06-7,Methyl 1-benzylpiperidine-4-carboxylate,as a common compound, the synthetic route is as follows.

Dried to 30L jacketed reactor was slowly purged with nitrogen, the 1.87kg1-benzyl-4-piperidine carboxylic acid methyl ester (8mol) and 2.0kg of toluene into a reactor, with stirring, cooled to an internal temperature of -5 . The resulting red aluminum – morpholine complex (approximately 8.8mol) was dropped to control the reaction temperature at 0 , 1 mixture liquid is completed, 0 reaction was continued for 30min. Was added slowly prepared 4N sodium hydroxide solution (containing 1.1kgNaOH), control the internal temperature not higher than 20 , the addition was completed, stirring was stopped, the organic layer was washed with water (11.0kg / times, 4 times), organic layer was concentrated under reduced pressure at 75 deg.] C and concentrated until no solvent was distilled off to give 1-benzyl-4-piperidine carbaldehyde 1.57kg, as a pale yellow oily liquid. Yield: 96.5%. HPLC: 99.03%

10315-06-7, The synthetic route of 10315-06-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Shanghai Goldentree Resin Powder Co., Ltd.; Zhu, Ben; (8 pag.)CN105693596; (2016); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.495414-81-8,1-tert-Butyl 4-ethyl 4-(cyanomethyl)piperidine-1,4-dicarboxylate,as a common compound, the synthetic route is as follows.,495414-81-8

B) tert-butyl 1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate To a mixture of 1-tert-butyl 4-ethyl 4-(cyanomethyl)piperidine-1,4-dicarboxylate (2.5 g), cobalt(II) chloride hexahydrate (1.0 g) and methanol (50 mL) was added sodium borohydride (1.6 g) under ice-cooling, and the mixture was stirred under ice-cooling for 2 hr, and then at room temperature for 2 days, and then 60C for 1 hr. 28% Aqueous ammonia was added thereto, the precipitate was removed by filtration, and the filtrate was extract with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate) to give the title compound (1.1 g). 1H NMR (300 MHz, DMSO-d6) delta 1.25-1.35 (2H, m), 1.40 (9H, s), 1.45-1.58 (2H, m), 1.90-1.98 (2H, m), 2.90 (2H, brs), 3.16 (2H, t, J = 7.2 Hz), 3.76-3.86 (2H, m), 7.56 (1H, brs).

The synthetic route of 495414-81-8 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Takeda Pharmaceutical Company Limited; KOIKE, Tatsuki; KAJITA, Yuichi; YOSHIKAWA, Masato; IKEDA, Shuhei; KIMURA, Eiji; HASUI, Tomoaki; NISHI, Toshiya; FUKUDA, Hiromi; EP2933247; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.301225-58-1,tert-Butyl 4-(propylamino)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

Step A 4-(N-(N-(4-Nitrobenzyl)carbamoyl)-N-(prop-1-yl)amino)-piperidinetrifluoroacetate The title compound was prepared by the reaction of 4-(N-(prop-1-yl)amino)-1-tert-butoxycarbonylpiperidine (prepared by the method described in Example 1, Step A, using 1-propylamine in place of methylamine) with (4-nitrobenzyl)isocyanate (prepared from phosgene and (4-nitrobenzyl)amine), followed by treatment of the product with 50% TFA in CH2Cl2 to remove the tert-butoxycarbonyl group, affording the title compound. ESI-MS: 321.2 (M+H)., 301225-58-1

301225-58-1 tert-Butyl 4-(propylamino)piperidine-1-carboxylate 22458258, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; Merck & Co., Inc.; US6399619; (2002); B1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

885279-92-5,885279-92-5, 1-Boc-1,8-diaza-spiro[4.5]decane is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A 100-mL round-bottom flask was charged with 4-nitrophenyl 3-acetamido-1H- pyrazole-1-carboxylate (2.32 g, 7.99 mmol, 1.50 equiv), DCM (20 mL), tert-butyl 1,8- diazaspiro[4.5]decane-1-carboxylate (1.28 g, 5.33 mmol, 1.00 equiv), and triethylamine (1.62 g, 16.0 mmol, 3.00 equiv). The resulting solution was stirred overnight at room temperature and quenched with water (50 mL). The resulting solution was extracted with DCM (2 x 80 mL) and the organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was chromatographed on a silica gel column to provide 1.90 g (61% yield) of tert-butyl 8-(3 -acetamido- 1 H-pyrazole- 1 -carbonyl)- 1,8 – diazaspiro[4.5]decane-1-carboxylate as a yellow oil. LCMS (ESI, m/z): 392 [M+H].

885279-92-5 1-Boc-1,8-diaza-spiro[4.5]decane 34178602, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; ABIDE THERAPEUTICS, INC.; WEBER, Olivia D.; SHAGHAFI, Michael B.; GRICE, Cheryl A.; JONES, Todd K.; (274 pag.)WO2017/87854; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

1158759-06-8, tert-Butyl 3-amino-3-methylpiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To 3.15 ml 1M lithium aluminium hydride in THF was added at 5-10 C. drop-wise a solution of 225 mg (1.05 mmol) rac-3-amino-3-methyl-piperidine-1-carboxylic acid tert-butyl ester in 4 ml dry THF. The reaction mixture was heated to 65 C. for 1 h. The turbid reaction solution was cooled with an ice bath and below 12 C., were added drop-wise 0.13 ml water, 0.32 ml 2N NaOH and further 0.19 ml water. The suspension was diluted with tert-butyl methyl ether, dried over sodium sulfate, filtered and acidified with 2N HCl in diethyl ether. Evaporation provided 210 mg of the title compound as a colourless semisolid. MS (m/e): 129.3 (M+H)., 1158759-06-8

The synthetic route of 1158759-06-8 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Kolczewski, Sabine; Pinard, Emmanuel; Stalder, Henri; US2010/197715; (2010); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

108612-54-0, tert-Butyl methyl(piperidin-4-yl)carbamate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Reference Example 50; [l-(2-ChIoro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-yImethyl)-piperidin-4- yl]-methyl-carbamic acid tert-butyl ester; To a solution of 6-bromomethyl-2-chloro-4-morpholin-4-yl-tMeno[352- djpyrimidine (85 mg, 0.244 mmol) in DMF (2 mL) were added water (13 muL), methyl-piperidin-4-yl-carbamic acid tert-butyl ester (105 mg, 0.489 mmol) and cesium carbonate (159 mg, 0.489 mmol). The resulting mixture was stirred at RT for 18 h. The reaction mixture was loaded onto an Isolute.(R). SCX-2 cartridge, washed with MeOH then eluted with 2 M NH3 in MeOH. The resultant residue was purified by column chromatography to give the title compound as a pale brown solid (73 mg, 62 percent).[M + H]+ 482.2, 108612-54-0

As the paragraph descriping shows that 108612-54-0 is playing an increasingly important role.

Reference：
Patent; PIRAMED LIMITED; WO2007/122410; (2007); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

24686-78-0, 1-Benzoylpiperidin-4-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 74A 1-benzoyl-4-piperidinecarbonitrile A mixture of 1-benzoyl-4-piperidone (2.0 g, 9.8 mmol), tosylmethyl isocyanide (2.5 g, 12.8 mmol) and ethanol (1.0 mL, 17.1 mmol) in 30 mL DME was cooled in an ethanol/ice bath, and potassium tert-butoxide was added at such a rate to maintain the reaction temperature at <10° C. The cold bath was removed, and the reaction was allowed to stir overnight at room temperature. The solids were removed by filtration, rinsed with DME, and the filtrate was evaporated. The residue was dissolved in EtOAc, washed with water and brine, dried (MgSO4), filtered through silica gel, and concentrated to give 2.14 g (66percent) of a slightly yellow oil., 24686-78-0

Big data shows that 24686-78-0 is playing an increasingly important role.

Reference：
Patent; Henkin; Jack; Davidson; Donald J.; US6150362; (2000); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem