Tag: M.W:200-300

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Product Details of 388077-74-5, 388077-74-5, Name is 1-Boc-2-piperidinamide, molecular formula is C11H20N2O3, belongs to piperidines compound. In a document, author is Kaygusuz, Ozge, introduce the new discover.

The reactions of hexachlorocyclotriphosphazene with piperidine, N-(1-naphthyl)ethylenediamine and 2-(2-hydroxyethylamino)ethanol. Antimicrobial activities of iminodiethoxy-substituted cyclotriphosphazene derivatives

A series of cyclotriphosphazene derivatives (5-16) were synthesized from the reactions of hexachlorocyclotriphosphazene (1, N3P3Cl6) with piperidine (2),N-(1-naphthyl)ethylenediamine (3) and 2-(2-hydroxyethylamino)ethanol (4). Of the synthesized compounds, 2-piperidino-2,4,4,6,6-pentachlorocyclotri phosphazatriene, N3P3Cl5[N-(C5H10)] (5); 2,4-piperidino-2,4,6,6-tetrachlorocyclo triphosphazatriene, N3P3Cl4[N-(C5H10)](2)(6); 2,4,6-piperidino-2,4,6-trichlorocyclo triphosphazatriene, N3P3Cl3[N-(C5H10)](3)(7); 2,2,4,6-piperidino-4,6-dichlorocyclotri phosphazatriene, N3P3Cl2[N-(C5H10)](4)(8); the 2,4,6,6-tetrachloro-2,4-non-gem-N-(1-naphthyl)ethylendiamino)-cyclotri phosphazatriene, N3P3Cl4[NH-(CH2)(2)-NH-(C10H7)](2)(9); and the 2,2,4,4,6,6-trispiro-2,2 ‘-iminodiethoxy-cyclotriphosphazatriene, N3P3[O-(CH2)(2)-NH-(CH2)(2)O](3)(14) derivatives are reported for the first time, others (10-13,15and16) were previously reported. The derived compounds (5-16) were structurally elucidated by elemental analysis and spectral data of(1)H and(31)P NMR and TLC-MS. Water-soluble hexachlorocyclotriphosphazene derivatives (10-16) were screened for their antimicrobial activities against three human pathogens;Escherichia coliW3110,Staphylococcus aureusATCC 25923, andCandida albicansATCC 10231 and compounds10,12, and16found to exhibit significant antimicrobial activities against the indicated microorganism.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 388077-74-5. Product Details of 388077-74-5.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

In an article, author is Canfield, Jeremy R., once mentioned the application of 34737-89-8, Recommanded Product: 34737-89-8, Name is 1-Benzyl-3-methylpiperidin-4-one, molecular formula is C13H17NO, molecular weight is 203.28, MDL number is MFCD00044806, category is piperidines. Now introduce a scientific discovery about this category.

Fentanyl Detection Using Eosin Y Paper Assays(,)

Eosin Y is a potential new color test for use in detecting illicit drugs that has not been extensively studied. In the present study, a variety of drugs of abuse and fentanyl analogues were tested to determine which drugs will bind to eosin Y, which functional groups are capable of binding and eliciting a color change, and a mechanism for eosin Y binding to fentanyl. Further, these agents were combined with common cutting agents and other drugs of abuse in order to determine the fentanyl detection limit in a drug mixture using an eosin Y test strip. Additionally, cobalt thiocyanate was used to determine whether the combination of cobalt thiocyanate and eosin Y has the potential to identify fentanyl. Through the testing performed, we concluded that (i) Eosin Y is capable of detecting low amounts of fentanyl down to 1%, (ii) Eosin Y binds to select tertiary amines to produce an orange to pink color change, and (iii) Eosin Y binds to the nonpiperidine ring nitrogen of fentanyl as a primary binding site and the piperidine ring nitrogen as a secondary binding site. While the cobalt thiocyanate assay detected 1% fentanyl in some of the mixtures, eosin Y detected 1% fentanyl in all mixtures. Finally, eosin Y was able to detect fentanyl in forensic case samples containing heroin and various cutting agents. Based on our results, eosin Y has the potential to screen for fentanyl and fentanyl analogues and can detect fentanyl in low amounts when mixed with common cutting agents.

If you are interested in 34737-89-8, you can contact me at any time and look forward to more communication. Recommanded Product: 34737-89-8.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 88495-54-9, Name is (S)-1-(tert-Butoxycarbonyl)piperidine-3-carboxylic acid, molecular formula is C11H19NO4. In an article, author is Liu, Huixia,once mentioned of 88495-54-9, Application In Synthesis of (S)-1-(tert-Butoxycarbonyl)piperidine-3-carboxylic acid.

Crystal structure of 5-methyl-3-phenyl-1-tosyl-1,2,3,4-tetrahydropyridine, C19H21NO2S

C19H21NO2S, orthorhombic, Pbca (no. 61), a =16.792(5) angstrom, b = 9.153(3) angstrom, c = 22.809(6) angstrom, V = 3505.8(16) angstrom(3), Z = 8, R-gt(F) = 0.0622, wR(ref)(F-2) = 0.1494, T = 296(2) K.

Interested yet? Keep reading other articles of 88495-54-9, you can contact me at any time and look forward to more communication. Application In Synthesis of (S)-1-(tert-Butoxycarbonyl)piperidine-3-carboxylic acid.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Formula: C14H18N4, 401566-79-8, Name is 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine, SMILES is CC1=NN(C2=CC=CC=C2)C(N3CCNCC3)=C1, belongs to piperidines compound. In a document, author is Philip, Rose Mary, introduce the new discover.

Applications of tert-butanesulfinamide in the synthesis of N-heterocycles via sulfinimines

Chiral sulfinamides are among the best known chiral auxiliaries in the stereoselective synthesis of amines and their derivatives. The most extensively used enantiopure tert-butanesulfinamide emerged as the gold standard among many others over the last two decades. The present review attempts to provide an overview of tert-butanesulfinamide mediated asymmetric N-heterocycle synthesis via sulfinimines and covers literature from 2010-2020. This methodology offers general access to structurally diverse piperidines, pyrrolidines, azetidines, and their fused derivatives that represent the structural motif of many natural products and therapeutically applicable compounds.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 401566-79-8. Formula: C14H18N4.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 827026-45-9, Name is 3-(4-Nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione, molecular formula is C13H11N3O5. In an article, author is Vereshchagin, A. N.,once mentioned of 827026-45-9, Product Details of 827026-45-9.

Stereoselective multicomponent synthesis of (2RS,6SR)-2,6-diaryl-3,3,5,5-tetracyanopiperidines

Multicomponent reaction between alkylidenemalononitriles, formaldehyde, and ammonium acetate upon reflux in alcohols gives stereoselectively 2,6-diaryl-3,3,5,5-tetracyanopiperidines in 6592% yields. In this process, ammonium acetate acts as both a catalyst and a source of nitrogen for the piperidine ring.

Interested yet? Keep reading other articles of 827026-45-9, you can contact me at any time and look forward to more communication. Product Details of 827026-45-9.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Synthetic Route of 34737-89-8, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 34737-89-8, Name is 1-Benzyl-3-methylpiperidin-4-one, SMILES is O=C1C(C)CN(CC2=CC=CC=C2)CC1, belongs to piperidines compound. In a article, author is Degorce, Sebastien L., introduce new discover of the category.

Lowering Lipophilicity by Adding Carbon: One-Carbon Bridges of Morpholines and Piperazines

In this article, we report our investigation of a phenomenon by which bridging morpholines across the ring with one-carbon tethers leads to a counterintuitive reduction in lipophilicity. This effect was also found to occur in piperazines and piperidines and lowered the measured log D-7.4 of the bridged molecules by as much as -0.8 relative to their unbridged counterparts. As lowering lipophilicity without introducing additional heteroatoms can be desirable, we believe this potentially provides a useful tactic to improve the drug-like properties of molecules containing morpholine-, piperazine-, and piperidine-like motifs.

Synthetic Route of 34737-89-8, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 34737-89-8.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

401566-79-8, Name is 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine, molecular formula is C14H18N4, Application In Synthesis of 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine, belongs to piperidines compound, is a common compound. In a patnet, author is Feng, Yangyang, once mentioned the new application about 401566-79-8.

Aerobic intramolecular aminothiocyanation of unactivated alkenes promoted by in situ generated iodine thiocyanate

Aerobic intramolecular aminothiocyanation of unactivated alkenes has been developed by in situ generated iodine thiocyanate under open-flask conditions. This protocol provides a concise and efficient method for synthesizing SCN-containing pyrrolidine, piperidine and indoline derivatives with isolated yields of up to 87%. Furthermore, mixing iodine and sodium thiocyanate with oxygen afforded iodine thiocyanate (ISCN) and dithiocyanatoiodate [I(SCN)(2)](-) which were testified by liquid chromatography mass spectrometry. A mechanistic investigation indicates that iodonium ion and sulfonium ion intermediates might be involved in this transformation. (C)2018 Elsevier Ltd. All rights reserved.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 401566-79-8 help many people in the next few years. Application In Synthesis of 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 827026-45-9, Name is 3-(4-Nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione, molecular formula is C13H11N3O5. In an article, author is Tosan, Fatemeh,once mentioned of 827026-45-9, Category: piperidines.

Synthesis and antithrombotic activity of 1-benzyl-N ‘-benzylidenepiperidine-3-carbohydrazide derivatives

Platelet aggregation inhibition and interfering with clot formation are essential tools for antithrombotic therapy and there is a need for discovering new antithrombotic agents. In this study, we synthesized a series of benzylidenepiperidine-3-carbohydrazide derivatives (1f-11f), bearing various selected substituents on both the piperidine ring nitrogen and the hydrazide nitrogen. The synthesized compounds were characterized by FTIR, (HNMR)-H-1 spectroscopic techniques, CHN/O elemental analysis and electrospray ionization mass spectra. All new 1-benzyl-N0-benzylidenepiperidine-3-carbohydrazides were evaluated for their antiplatelet aggregation activities (against platelet aggregation induced by AA, ADP and collagen separately) and anticoagulant activities [protrombin time (PT) and partial thromboplastin time (PTT)]. Antiplatelet aggregation activity of the new derivatives was measured using human plasma on an APACT 4004 aggregometer. All the compounds were mainly effective on ADP pathway of platelet aggregation compared with collagen and AA pathways. The most potent compound on platelet aggregation induced by ADP is compound 2f with 87% aggregation inhibition activity at 0.5 mmol/l concentration. The synthesized compounds were further investigated for their anticoagulant action via the two PT and PTT models. They all showed higher PT and PTT values compared with the blank control sample. The most potent compounds are 5f, 6f, 7f and 1f. All compounds were obtained in good yield and further evaluated for their antiplatelet and anticoagulant activity. Copyright (C) 2020 Wolters Kluwer Health, Inc. All rights reserved.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Reference of 2873-29-2, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 2873-29-2, Name is (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate, SMILES is O=C(OC[C@@H]1[C@@H](OC(C)=O)[C@H](OC(C)=O)C=CO1)C, belongs to piperidines compound. In a article, author is Ding, Xiang-Feng, introduce new discover of the category.

Organocatalytic Asymmetric Formal Aza-[3+3]Cyclo-additions of 3-Aminobenzofuran with alpha,beta-Unsaturated Aldehydes

An organocatalytic asymmetric formal aza-[3+3]cycloaddition of readily available N-Tosyl-3-aminobenzofuran with alpha,beta-unsaturated aldehydes was developed for the first time. This method enables the facile synthesis of biologically active and synthetically challenging polysubstituted fused benzofuran derivatives bearing two stereocenters in high yields with excellent diastereo-, and enantioselectivity (up to >20 : 1 dr, and >99% ee).

Reference of 2873-29-2, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 2873-29-2.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Electric Literature of 105812-81-5, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 105812-81-5, Name is (3S,4R)-4-(4-Fluorophenyl)-3-hydroxymethyl-1-methylpiperidine, SMILES is CN1C[C@@H](CO)[C@H](C2=CC=C(F)C=C2)CC1, belongs to piperidines compound. In a article, author is Zhou, Shiyang, introduce new discover of the category.

The antagonistic activity of H 1 receptor antagonists as medicinal foods

At present, there are many kinds of H1 receptor antagonists as medicinal foods in clinical application, which can be divided into ethylenediamine antagonist, aminoether antagonist, propylamine antagonist, tricyclic antagonist, piperazine antagonist and piperidine antagonist according to their chemical structures. Herein, the research progresses of allergic reactions of histamine H1 receptor antagonists as medicinal foods were reviewed, and the important aspects of design, synthesis and biological activity of various new compounds were expounded.

Electric Literature of 105812-81-5, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 105812-81-5.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem