Tag: M.W:200-300

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Formula: C13H11N3O5, 827026-45-9, Name is 3-(4-Nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione, molecular formula is C13H11N3O5, belongs to piperidines compound. In a document, author is Wang, Fanghui, introduce the new discover.

Preparation and study of spirocyclic cationic side chain functionalized polybiphenyl piperidine anion exchange membrane

Research on the ion conductivity and mechanical stability of anion exchange membranes (AEMs) has achieved great progress, it is more urgent to prepare AEMs with high alkali stability. Azaspimcyclic cations are among the most alkali-stable cations. In this study, a synthesized long-chain 3-(3-(1-(8-bromooctyl) piperidin-4-yl) propyl)-6-azaspiro [5.5] undecan-6-ium bromide(BOP-ASU) cation was introduced into a portion of a piperidine ring on a PBP backbone to prepare PBP-BOP-ASU, and AEMs based on PBP-ASU and PBP-BOP-ASU were prepared. The structure of each product was characterized (1H NMR, MS), and the prepared anion exchange membrane was also characterized using micromorphology (SEM, TEM, AFM) and performance tests (TGA, WU, SR, ion conductivity, alkali stability). The PBP-BOP-ASU (8% membrane) showed the highest ion conductivity (117.43 mS/cm) at 80 degrees C. In addition, it showed excellent alkali stability in a test environment of 2 M NaOH solution at 80 degrees C for 1400 h. Moreover, the introduction of side chain spiro cations could improve the microscopic phase separation structure of the AEMs, and it also increased their ionic conductivity, thus ensuring the potential for their application in anion exchange membrane fuel cells.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 827026-45-9. Formula: C13H11N3O5.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Application of 105812-81-5, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 105812-81-5, Name is (3S,4R)-4-(4-Fluorophenyl)-3-hydroxymethyl-1-methylpiperidine, SMILES is CN1C[C@@H](CO)[C@H](C2=CC=C(F)C=C2)CC1, belongs to piperidines compound. In a article, author is Dorostkar-Ahmadi, Nadieh, introduce new discover of the category.

1,8-Diazabicyclo [5.4.0]undec-7-ene Catalyzed Synthesis of Some New 7-Alkyl-6-oxo-1H-pyrazolo[3,4-b]pyridine-5-carbonitriles

Starting from 5-chloro-1,3-diphenyl-1H-pyrazole-4-carbaldehyde, the synthesis of some new bicyclic 7-alkyl-6-oxo-1,3-diphenyl-6,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carbonitriles catalyzed by 1,8-diazabicyclo [5.4.0] undec-7-ene (DBU) is described. Knoevenagel condensation reaction of 5-chloro-1, 3-diphenyl-1H-pyrazole-4-carbaldehyde with ethyl cyanoacetate in refluxing ethanol containing a few drops of piperidine afforded the (Z)-ethyl 3-(5-chloro-1,3-diphenyl-1H-pyrazol-4-yl)-2-cyanoacrylate. Treatment of this compound with primary alkyl amines in the presence of DBU as a catalyst in dimethylformamide at reflux temperature gave new 7-alkyl-6-oxo-1,3-diphenyl-6,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carbonitriles in high yields. All synthetic compounds were characterized on the basis of their spectral and microanalytical data. The correct stereoisomer of the Knoevenagel product was confirmed with comparison of the experimental and calculated H-1 nuclear magnetic resonance (NMR) and C-13 NMR chemical shifts using density functional theory calculations at the B3LYP/6-31+G(d,p) level of theory. [GRAPHICS] .

Application of 105812-81-5, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 105812-81-5 is helpful to your research.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 119515-38-7, Name is sec-Butyl 2-(2-hydroxyethyl)piperidine-1-carboxylate, formurla is C12H23NO3. In a document, author is Su, Qian-Qian, introducing its new discovery. SDS of cas: 119515-38-7.

Field-induced slow magnetic relaxation in low-spin S=1/2 mononuclear osmium(v) complexes

Photochemical reactions of (PPh4)[Os-VI(N)(L)(CN)(3)] (NO2-OsN) with piperidine and pyrrolidine afforded two osmium(v) hydrazido compounds, (PPh4)[Os-V(L)(CN)(3)(NNC5H10)] ([PPh4]1) and (PPh4)[Os-V(L)(CN)(3)(NNC4H8)] ([PPh4]2), respectively. Their structures consist of isolated, mononuclear distorted octahedral osmium anions that are well-separated from each other by PPh4+. Their low spin S = 1/2 and L = 1 ground state was confirmed by magnetometry and DFT calculations. Interestingly, both compounds exhibit slow magnetic relaxation under a bias dc-field. These osmium(v) complexes are potentially useful building-blocks for the construction of molecule-based architectures with interesting magnetic properties. In contrast, the structurally related (PPh4)[Os-III(L)(CN)(3)(NH3)] ([PPh4]3), which also has a low-spin S = 1/2 ground state but with a different electronic configuration (5d(5)), does not exhibit slow magnetic relaxation, due to the absence of any orbital moment (L = 0). Furthermore, the structurally different osmium(v) hydrazido compound reported by Meyer, [Os-V(tpy)(Cl)(2)(NNC5H10)](PF6) (4[PF6]), also does not exhibit slow magnetic relaxation due possibly to a change in magnetic anisotropy from axial for [PPh4]1 and [PPh4]2 to planar.

If you are hungry for even more, make sure to check my other article about 119515-38-7, SDS of cas: 119515-38-7.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter.388077-74-5, Name is 1-Boc-2-piperidinamide, SMILES is O=C(C1N(C(OC(C)(C)C)=O)CCCC1)N, belongs to piperidines compound. In a document, author is Pratibha, introduce the new discover, Category: piperidines.

Autocombustion-Promoted Synthesis of Lanthanum Iron Oxide: Application as Heterogeneous Catalyst for Synthesis of Piperidines, Substituted Amines and Light-Assisted Degradations

An autocombustion technique was adopted to synthesize the Perovskite structured Lanthanum iron oxide nanoparticles (LaFeO3, abbreviated as LFO NPs). This technique offered lots of benefits such as short reaction time along with quick heating rate. LFO NPs were fabricated at different calcination temperatures (300-800 degrees C) through the aid of sucrose as chelating agent. The prepared LFO NPs were well characterized by various techniques like X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), Vibrating sample magnetometer (VSM), Ultraviolet-Visible spectroscopy (UV-Vis), Brunauer-Emmett-Teller (BET), X-ray Photo-Electron Spectroscopy (XPS) and Transmission electron microscopy (TEM) which affirmed that highly crystalline LFO NPs were obtained at 700 degrees C. Subsequently, the catalytic activity of the LFO NPs was surveyed for three independent approaches: (i) for the synthesis of functionalized piperidines through activation of carbonyl groups in the reacting partners (ii) for the sunlight-assisted mineralization of health hazardous food colorant, Allura Red AC (iii) for the hydrogenation of nitro aromatic compounds (NACs) using NaBH4(sodium borohydride) as source of hydrogen in aqueous medium at room temperature.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 388077-74-5 is helpful to your research. Category: piperidines.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 388077-74-5, Name is 1-Boc-2-piperidinamide, molecular formula is C11H20N2O3. In an article, author is Lazewska, Dorota,once mentioned of 388077-74-5, HPLC of Formula: C11H20N2O3.

Rational design of new multitarget histamine H-3 receptor ligands as potential candidates for treatment of Alzheimer’s disease

Design and development of multitarget-directed ligands (MTDLs) has become a very important approach in the search of new therapies for Alzheimer’s disease (AD). In our present research, a number of xanthone derivatives were first designed using a pharmacophore model for histamine H-3 receptor (H3R) antagonists/inverse agonists, and virtual docking was then performed for the enzyme acetylcholinesterase. Next, 23 compounds were synthesised and evaluated in vitro for human H3R (hH(3)R) affinity and inhibitory activity on cholinesterases. Most of the target compounds showed hH(3)R affinities in nanomolar range and exhibited cholinesterase inhibitory activity with IC50 values in submicromolar range. Furthermore, the inhibitory effects of monoamine oxidases (MAO) A and B were investigated. The results showed low micromolar and selective human MAO B (hMAO B) inhibition. Two azepane derivatives, namely 23 (2-(5-(azepan-1-yl)pentyloxy)-9H-xanthen-9-one) and 25 (2-(5-(azepan-1-yl)pentyloxy)-7-chloro-9H-xanthen-9-one), were especially very promising and showed high affinity for hH(3)R (K-i = 170 nM and 100 nM respectively) and high inhibitory activity for acetylcholinesterase (IC50 = 180 nM and 136 nM respectively). Moreover, these compounds showed moderate inhibitory activity for butyrylcholinesterase (IC50 = 880 nM and 394 nM respectively) and hMAO B (IC50 = 775 nM and 897 nM respectively). Furthermore, molecular docking studies were performed for hH(3)R, human cholinesterases and hMAO B to describe the mode of interactions with these biological targets. Next, the two most promising compounds 23 and 25 were selected for in vivo studies. The results showed significant memory-enhancing effect of compound 23 in dizocilpine-induced amnesia in rats in two tests: step-through inhibitory avoidance paradigm (SIAP) and transfer latency paradigm time (TLPT). In addition, favourable analgesic effects of compound 23 were observed in neuropathic pain models. Therefore, compound 23 is a particularly promising structure for further design of new MTDLs for AD. (C) 2020 Elsevier Masson SAS. All rights reserved.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 388077-74-5, Name is 1-Boc-2-piperidinamide, SMILES is O=C(C1N(C(OC(C)(C)C)=O)CCCC1)N, belongs to piperidines compound. In a document, author is Zhang, Zhengyu, introduce the new discover, Quality Control of 1-Boc-2-piperidinamide.

Synthesis of pyridopyrimidine derivatives based on benzenesulfonyl acetonitrile compounds via a one-pot sequential four-component domino reaction and microwave-mediated molecular cyclization

A concise, rapid and highly efficient method for the one-pot synthesis of novel pyridopyrimidine derivatives has been demonstrated by the four-component domino reaction of aromatic aldehyde, benzenesulfonyl acetonitrile, 1,1-dimethylthio-2-nitroethylene and 1,3-propanediamine, using piperidine as a catalyst and ethanol as solvent under microwave irradiation. This methodology was established with many advantages, including higher reaction yields, broad substrate scopes, experimental simplicity, short time and utility of easily available starting materials. The synthesized compounds are confirmed by H-1 NMR, IR and HR-ESI-MS.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 388077-74-5 is helpful to your research. Quality Control of 1-Boc-2-piperidinamide.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Synthetic Route of 143900-44-1, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 143900-44-1, Name is (S)-tert-Butyl 3-hydroxypiperidine-1-carboxylate, SMILES is O=C(N1C[C@@H](O)CCC1)OC(C)(C)C, belongs to piperidines compound. In a article, author is Vereshchagin, Anatoly N., introduce new discover of the category.

Stereoselective one-pot synthesis of polycyanosubstituted piperidines

An effective and facile multicomponent method for the synthesis of polysubstituted piperidines is described. The Michael-Mannich type cascade of benzylidenemalononitriles with aromatic aldehydes and ammonium acetate or aqueous ammonia provides convenient access to the stereoselective synthesis of 3,3,5,5-tetracyano-2,4,6-triarylpiperidines in good to excellent yields in one-pot manner. Ammonium acetate or aqueous ammonia plays a role both as a catalyst and as a nitrogen source. It is established that the reaction proceeds via sequence of equilibriums and a competitive mechanisms are implemented. [GRAPHICS] .

Synthetic Route of 143900-44-1, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 143900-44-1.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 188111-79-7, Name is (R)-1-Boc-3-Aminopiperidine, molecular formula is , belongs to piperidines compound. In a document, author is Savkov, Boris Y., Product Details of 188111-79-7.

Unusual Synthesis of Triosmium Carbene Clusters by Tandem Activation of Chlorohydrocarbons and Heterocyclic Amines

Reactions of the [Os3H2(CO)(10)] cluster complex (1) with six-membered heterocyclic amines (morpholine, thiomorpholine, piperidine) and halohydrocarbons (CH2Cl2, ClHC=CHCl, CH2=CCl2) at similar to 25 degrees C have been studied. Two main types of products are formed in all studied reactions. One product is carbene cluster [Os-3(mu-H)(mu-Cl){eta(1)-C(CH3)N(CH2CH2)(2)X}(CO)(9)] (X=O, S, CH2) (3, 3 a and 3 b). Second product is cluster containing enamine ligand [Os-3(mu-H){mu-CH=CHN(C2CH2)(2)X)}(2)(CO)(10)] (X=O, S, CH2) (2, 2 a and 2 b). The carbene ligand is assembled on a cluster, from three organic molecules, thus representing the first example of carbene ligands formed in this way. Clusters with carbene ligand exist as two stable isomers (rotamers hindered towards the Os-C bond), as confirmed by NMR studies and conformational analysis. We have found that in reactions of cluster 1 with acyclic amines containing an oxygen atom in gamma-position (likely morpholine in CH2Cl2), only complexes with bridging enamine ligands are formed. Compounds 2 a, 2 b, 3 and 3 b are characterized by single-crystal X-ray diffraction.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 188111-79-7, in my other articles. Product Details of 188111-79-7.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 105812-81-5, Name is (3S,4R)-4-(4-Fluorophenyl)-3-hydroxymethyl-1-methylpiperidine, formurla is C13H18FNO. In a document, author is Li, Mingfeng, introducing its new discovery. Name: (3S,4R)-4-(4-Fluorophenyl)-3-hydroxymethyl-1-methylpiperidine.

Cu-Catalyzed Enantioselective Reductive Coupling of 1,3-Dienes and Aldimines

Catalytic chemo- and enantioselective generation of 1,3-disubstituted allyl-Cu complexes from a Cu-H addition to 1,3-dienes followed by in situ reactions with aldimines to construct homoallylic amines is presented. The method is distinguished by an unprecedented pathway to generate enantiomerically enriched allyl-Cu species, allowing reactions with a wide range of aldimines in high chemo-, site-, diastereo-, and enantioselectivity. Functionalization provides useful building blocks that are otherwise difficult to access.

If you are hungry for even more, make sure to check my other article about 105812-81-5, Name: (3S,4R)-4-(4-Fluorophenyl)-3-hydroxymethyl-1-methylpiperidine.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

In an article, author is Darweesh, Ahmed F., once mentioned the application of 3056-33-5, Product Details of 3056-33-5, Name is N2,9-Diacetylguanine, molecular formula is C9H9N5O3, molecular weight is 235.19, MDL number is MFCD00142116, category is piperidines. Now introduce a scientific discovery about this category.

Investigation of the reactivity of (1H-benzo[d]imidazol-2-yl)acetonitrile and (benzo[d]thiazol-2-yl)acetonitrile as precursors for novel bis(benzo[4,5]imidazo[1,2-a]pyridines) and bis(benzo[4,5]thiazolo[3,2-a]pyridines)

A synthesis of novel bis(benzo[4,5]imidazo[1,2-a]pyridines)viathe reaction of the appropriate bis(aldehyde) with 2-(1H-benzo[d]imidazol-2-yl)acetonitrile and malononitrile in ethanol at reflux in the presence of piperidine was reported. On the other hand, attempted synthesis of bis(benzo[4,5]thiazolo[3,2-a]pyridines) by a three-component reaction of the appropriate bis-aldehyde with malononitrile and (benzo[d]thiazol-2-yl)acetonitrile under similar reaction conditions was unsuccessful. The reactions gave instead the corresponding novel bis(benzo[d]thiazol-2-yl)acrylonitriles.

If you are interested in 3056-33-5, you can contact me at any time and look forward to more communication. Product Details of 3056-33-5.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem