Tag: M.W:200-300

Raman, S. Venkata; Chandrakumar, N. published an article about the compound: 2,3-Dibromopropionic acid( cas:600-05-5,SMILESS:O=C(O)C(Br)CBr ).COA of Formula: C3H4Br2O2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:600-05-5) through the article.

A simple novel approach is described for pure-phase multidimensional NMR with retention of quadrature information by introducing an offset term in the evolutionary Hamiltonian. This achieved by a reference frequency shift during the evolution period. The method was used to obtain the 2D COSY spectrum of 2,3-dibromopropionic acid in CDCl3 and the spectra of 2-aminoethanol in D2O.

《Pure-phase multidimensional NMR by reference-frequency shift (RFS)》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(2,3-Dibromopropionic acid)COA of Formula: C3H4Br2O2.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: tert-Butyl ((1S,2S)-2-hydroxycyclohexyl)carbamate(SMILESS: O=C(OC(C)(C)C)N[C@@H]1[C@@H](O)CCCC1,cas:145166-06-9) is researched.Computed Properties of C3H4Br2O2. The article 《Highly enantioselective direct organocatalytic α-chlorination of ketones》 in relation to this compound, is published in Angewandte Chemie, International Edition. Let’s take a look at the latest research on this compound (cas:145166-06-9).

A C2-sym. diamine I served as the organocatalyst in an asym. α-chlorination reaction of simple ketones. Optically active α-chloro ketones were formed with excellent enantioselectivities using N-chlorosuccinimide (NCS) as the chlorine source. These products have broad synthetic utility, in particular for pharmaceutical applications.

Different reactions of this compound(tert-Butyl ((1S,2S)-2-hydroxycyclohexyl)carbamate)Safety of tert-Butyl ((1S,2S)-2-hydroxycyclohexyl)carbamate require different conditions, so the reaction conditions are very important.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-Boc-4-(Aminomethyl)piperidine(SMILESS: NCC1CCN(C(OC(C)(C)C)=O)CC1,cas:144222-22-0) is researched.Safety of tert-Butyl ((1S,2S)-2-hydroxycyclohexyl)carbamate. The article 《Syntheses and Binding Testing of N1-Alkylamino-Substituted 2-Aminobenzimidazole Analogues Targeting the Hepatitis C Virus Internal Ribosome Entry Site*》 in relation to this compound, is published in Australian Journal of Chemistry. Let’s take a look at the latest research on this compound (cas:144222-22-0).

A series of 2-aminobenzimidazole analogs have been synthesized and tested for binding to a previously established RNA target for viral translation inhibitors in the internal ribosome entry site (IRES) of the hepatitis C virus (HCV). Synthesis of new inhibitor compounds followed a highly convergent strategy which allowed for incorporation of diverse tertiary amino substituents in high overall yields (eight-steps, 4-22%). Structure-activity relationship (SAR) studies focussed on the tertiary amine substituent involved in hydrogen bonding with the RNA backbone at the inhibitor binding site. The SAR study was further correlated with in silico docking experiments Analogous compounds showed promising activities (half maximal effective concentration, EC50: 21-89μM). Structures of the synthesized analogs and a correlation to their mode of binding, provided the opportunity to explore parameters required for selective targeting of the HCV IRES at the subdomain IIa which acts as an RNA conformational switch in HCV translation.

Different reactions of this compound(1-Boc-4-(Aminomethyl)piperidine)Synthetic Route of C11H22N2O2 require different conditions, so the reaction conditions are very important.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Safety of tert-Butyl ((1S,2S)-2-hydroxycyclohexyl)carbamate. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: tert-Butyl ((1S,2S)-2-hydroxycyclohexyl)carbamate, is researched, Molecular C11H21NO3, CAS is 145166-06-9, about Discovery and structure-activity relationships of 4-aminoquinazoline derivatives, a novel class of opioid receptor like-1 (ORL1) antagonists.

Synthesis and structure-activity relationship studies of a series of 4-aminoquinazoline derivatives led to the identification of (1 R,2 S)-17, N-[(1R,2S)-2-({2-[(4-chlorophenyl)carbonyl]amino-6-methylquinazolin-4-yl}amino)cyclohexyl]guanidine dihydrochloride, as a highly potent ORL1 antagonist with up to 3000-fold selectivity over the μ, δ, and κ opioid receptors. Mol. modeling clarified the structural factors contributing to the high affinity and selectivity of (1 R,2 S)-17.

Different reactions of this compound(tert-Butyl ((1S,2S)-2-hydroxycyclohexyl)carbamate)Safety of tert-Butyl ((1S,2S)-2-hydroxycyclohexyl)carbamate require different conditions, so the reaction conditions are very important.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Safety of tert-Butyl ((1S,2S)-2-hydroxycyclohexyl)carbamate. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: tert-Butyl ((1S,2S)-2-hydroxycyclohexyl)carbamate, is researched, Molecular C11H21NO3, CAS is 145166-06-9, about Enzymatic method of preparation of optically active trans-2-amino cyclohexanol derivatives. Author is Ursini, A.; Maragni, P.; Bismara, C.; Tamburini, B..

Supported Lipase Amano PS-D catalyzes the resolution of (±)-trans-2-[(tert-butoxycarbonyl)amino]cyclohexanol by a selective acylation reaction. Using the supported enzyme gave a much faster reaction compared to existing methodol. on similar substrates. A variety of acylating agents were investigated, with vinyl acetate providing the most practical and convenient procedure.

Different reactions of this compound(tert-Butyl ((1S,2S)-2-hydroxycyclohexyl)carbamate)Safety of tert-Butyl ((1S,2S)-2-hydroxycyclohexyl)carbamate require different conditions, so the reaction conditions are very important.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Delsuc, Marc A.; Levy, George C. published an article about the compound: 2,3-Dibromopropionic acid( cas:600-05-5,SMILESS:O=C(O)C(Br)CBr ).Quality Control of 2,3-Dibromopropionic acid. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:600-05-5) through the article.

The deconvolution of J-coupling patterns in NMR by iterative maximum entropy processing is demonstrated. Both the in-phase and the antiphase coupling patterns are considered. The deconvolution of the coupling pattern, either for one value of the coupling constant or for a range of coupling constants is shown. The method can be used for improving the signal-to-noise ratio for known coupling patterns by removing the coupling structure, as well as for extracting coupling constants from an unknown spectrum. Examples are shown both in ID (dimensional) NMR and in slicewise processing of 2D spectra.

《The application of maximum entropy processing to the deconvolution of coupling patterns in NMR》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(2,3-Dibromopropionic acid)Quality Control of 2,3-Dibromopropionic acid.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1-Boc-4-(Aminomethyl)piperidine, is researched, Molecular C11H22N2O2, CAS is 144222-22-0, about Design and Synthesis of a Highly Selective and In Vivo-Capable Inhibitor of the Second Bromodomain of the Bromodomain and Extra Terminal Domain Family of Proteins.Product Details of 144222-22-0.

Pan-bromodomain and extra terminal domain (BET) inhibitors interact equipotently with the eight bromodomains of the BET family of proteins and have shown profound efficacy in a number of in vitro phenotypic assays and in vivo pre-clin. models in inflammation or oncol. A number of these inhibitors have progressed to the clinic where pharmacol.-driven adverse events have been reported. To better understand the contribution of each domain to their efficacy and improve their safety profile, selective inhibitors are required. This article discloses the profile of GSK046, also known as iBET-BD2(I), a highly selective inhibitor of the second bromodomains of the BET proteins that has undergone extensive pre-clin. in vitro and in vivo characterization.

《Design and Synthesis of a Highly Selective and In Vivo-Capable Inhibitor of the Second Bromodomain of the Bromodomain and Extra Terminal Domain Family of Proteins》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(1-Boc-4-(Aminomethyl)piperidine)Product Details of 144222-22-0.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Related Products of 144222-22-0. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 1-Boc-4-(Aminomethyl)piperidine, is researched, Molecular C11H22N2O2, CAS is 144222-22-0, about Discovery of Adamantane Carboxamides as Ebola Virus Cell Entry and Glycoprotein Inhibitors. Author is Plewe, Michael B.; Sokolova, Nadezda V.; Gantla, Vidyasagar Reddy; Brown, Eric R.; Naik, Shibani; Fetsko, Alexandra; Lorimer, Donald D.; Dranow, David M.; Smutney, Hayden; Bullen, Jameson; Sidhu, Rana; Master, Arshil; Wang, Junru; Kallel, E. Adam; Zhang, Lihong; Kalveram, Birte; Freiberg, Alexander N.; Henkel, Greg; McCormack, Ken.

We identified and explored the structure-activity-relationship (SAR) of an adamantane carboxamide chem. series of Ebola virus (EBOV) inhibitors. Selected analogs exhibited half-maximal inhibitory concentrations (EC50 values) of ~10-15 nM in vesicular stomatitis virus (VSV) pseudotyped EBOV (pEBOV) infectivity assays, low hundred nanomolar EC50 activity against wild type EBOV, aqueous solubility >20 mg/mL, and attractive metabolic stability in human and nonhuman liver microsomes. X-ray cocrystallog. characterizations of a lead compound with the EBOV glycoprotein (GP) established the EBOV GP as a target for direct compound inhibitory activity and further provided relevant structural models that may assist in identifying optimized therapeutic candidates.

《Discovery of Adamantane Carboxamides as Ebola Virus Cell Entry and Glycoprotein Inhibitors》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(1-Boc-4-(Aminomethyl)piperidine)Related Products of 144222-22-0.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Vinyl polymers. X. Polymers of the α-haloacrylic acids and their derivatives》. Authors are Marvel, C. S.; Dec, Joseph; Cooke, H. G. Jr.; Cowan, John Charles.The article about the compound:2,3-Dibromopropionic acidcas:600-05-5,SMILESS:O=C(O)C(Br)CBr).HPLC of Formula: 600-05-5. Through the article, more information about this compound (cas:600-05-5) is conveyed.

cf. C. A. 34, 7863.8. Passing Cl into a mixture of 2265 g. tech. Me acrylate and 1 l. MeOH at a temperature below 40° for 5-6 h. gives 85% of the Me ester (I) of III, b21 72-5°; Br gives 85-8% of the Me ester (II) of IV, b22 96-8°. Refluxing 175 g. of I and 500 cc. 20% HCl for 5 h. and extracting with 3 100-cc. portions of CHCl3 give a 65% yield of crude ClCH2CHClCO2H (III); II gives 72% of BrCH2CHBrCO2H (IV) on hydrolysis with 48% HBr. With SOCl2 III gives 53% of the acid chloride (V), b16 52-4°, and IV gives 77% of the acid chloride (VI), b18 81-4°. With excess of the proper alc. (heating at 100° for 10 min.) V gives the following esters of III: sec-Bu, b25 65-6°, nD20 1.4423, d2020 1.150, 88%; cyclohexyl, b2 95-7°, nD20 1.4752, 91%; β-chloroethyl, b22 123-6°, nD20 1.4739. VI gives the esters of IV: sec-Bu, b26 130-5°, nD20 1.4855, d2020 130-2°, 89%; cyclohexyl, b2 130-2°, nD20 1.5139, 93%. PhOH and C5H5N with V yield 41% of the Ph ester of III, b18 130-5°, nD20 1.5262; VI gives 45.5% of the Ph ester of IV, b2 132-5°, nD20 1.5598. The α-haloacrylates were prepared by heating about 0.07 mol of the above esters and 0.10 mol of quinoline, quinaldine or PhNEt2 at 100° for 10 min. in a N atm. α-Chloroacrylic esters: Et, b18 51-3°, nD20 1.4384, 81%; sec-Bu, b23 73-3.5°, nD20 1.4360, 58%; cyclohexyl, b2 51-2°, nD20 1.4735, 69%; Ph, b8 91-3°, nD20 1.5808, 25%; β-chloroethyl, b20 94-6°, nD20 1.4729, 45%. α-Bromoacrylic esters: sec-Bu, b23 80-2°, nD20 1.4660, d2020 1.303, 72%; cyclohexyl, b4 100-6°, nD20 1.4954, 54%; Ph, b2 95-6°, nD20 1.5480, 46%. These esters polymerize on standing at room temperature for 2-3 wk, on heating at 100° for 20-30 min., by the action of UV light for 6-8 h., in the presence of Bz2O2, etc. In bulk polymerization experiments clear, hard glassy products were obtained; the polymers precipitated from dioxane by ether or alc. are white powders. Poly-α-chloroacrylic esters: Et, decomposes 160-70°, n25 1.502; sec-Bu, decomposes 160-5°, n25 1.500; cyclohexyl, decomposes 210-35°, n25 1.532; Ph, decomposes 160-8°; β-chloroethyl, decomposes 230-40°, n25 1.533. α-Br derivatives: Et, decomposes 125-30°; sec-Bu, decomposes 150-60°, n25 1.542; cyclohexyl, decomposes 140-50°, n25 1.547; Ph, decomposes 175-85°, n25 1.612. CH2:CClCO2H (VII) results in 62% yield by adding dropwise 110 g. of I to 275 g. Ba(OH)2.8H2O and 500 cc. H2O, stirring 2 h. and adding 62.5 g. concentrated H2SO4 in 125 cc. H2O, extracting with 5 200-cc. portions of ether containing hydroquinone and crystallizing from petr. ether. CH2:CBrCO2H (VIII) similarly results in 70% yield from II. Illumination of 75 g. VII in 500 cc. anhydrous ether for 3 days gives 55 g. of the polymer (IX), m. about 300°; it is soluble in cold H2O and forms clear, tough films. Addition of 0.1 g. Bz2O2 to 10 g. VII at 70° causes polymerization in 15 min. (5.5 g. of IX); boiling 10 g. IX with 50 cc. H2O gives a gel, hardening to an easily pulverizable mass, which analyzes for C3H2O2; it is apparently a cross-linked lactone with some HO groups. Dropwise addition of 25 g. of ClCH2CHClCOCl to 25 g. of PhNEt2 at 85° and 70-80 mm. gives 37% of the chloride, of VII, b78 45-8°, nD20 1.4689; illumination in CCl4 for 3 days gives 67% of the polymer, m. 210-25°; the film from 1 g. in 10 cc. H2O resembles that of IX. The polymer of VIII is relatively unstable and loses HBr rapidly at room temperature ClCH2CH2COCl (50 g.) and 35 g. HOC2H4Cl give 62 g. (92%) of β-chloroethyl β-chloropropionate, b20 109-11°, nD20 1.4600; treatment with quinoline at 150-60° for 20 min. gives 53% of β-chloroethyl acrylate, b20 64-6°, nD20 1.4490; the polymer is a soft rubbery material which did not harden on longer illumination.

《Vinyl polymers. X. Polymers of the α-haloacrylic acids and their derivatives》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(2,3-Dibromopropionic acid)HPLC of Formula: 600-05-5.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Related Products of 600-05-5. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2,3-Dibromopropionic acid, is researched, Molecular C3H4Br2O2, CAS is 600-05-5, about Bifunctional catalysts. V. Reconjugation of Δ5-cholestenone. Author is Kergomard, A.; Renard, M. F..

Dihaloacetic and -propionic acids catalyze the reconjugation of cholest-5-en-3-one (I). The reconjugation of I is also catalyzed by mixtures of triethylamine and phenols. The acid catalysis involves 2 mols. acid/mol. I, and the distance between the active sites (carbonyl O and C-5) is 5 Å. The enthalpy and entropy of activation are 11 ± 2 kcal/mole and -38 ± 4esu for I in benzene containing trichloroacetic acid.

《Bifunctional catalysts. V. Reconjugation of Δ5-cholestenone》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(2,3-Dibromopropionic acid)Related Products of 600-05-5.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem