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Continuing medicinal chemistry studies to identify spiropiperidine-derived NPY Y5 receptor antagonists are described. Aryl urea derivatives of a variety of spiropiperidines were tested for their NPY Y5 receptor binding affinities. Of the spiropiperidines so far examined, spiro[3-oxoisobenzofurane-1(3H),4?-piperidine] was a useful scaffold for producing orally active NPY Y5 receptor antagonists. Oral administration of 5c significantly inhibited the Y5 agonist-induced food intake in rats with a minimum effective dose of 3 mg/kg. In addition, this compound was efficacious in decreasing body weight in diet-induced obese mice.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H15129N – PubChem

 

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The invention discloses a method for supporting france for cloth starting material N – ((3 R, 4 R) – 4 – methyl – 1 – benzyl – 3 – piperidinyl) – N – methyl – 7 – paratoluene sulfonyl – 7 H – pyrrolo [2, 3 – D] pyrimidine – 4 – amine (I) synthetic method, specific steps are as follows: to 4 – methyl pyridine as the starting material, with the benzyl chloride undergo nucleophilic substitution by the 4 – methyl – 1 – phenylmethyl – pyridine hydrochloride, under the action of the sodium borohydride reduction reaction, borohydrite – oxidation reaction, hydroxy oxidation, the introduction of the reductive amination of the stereo selectivity of the two chiral center, through a readily available and inexpensive chiral acid (L – DTTA) splitting, to obtain optically pure intermediates (3 R, 4 R) – (1 – benzyl – 4 – methyl – piperidin – 3 – yl) – methylamine, and finally with the 4 – chloro pyrrolo pyrimidine condensation is obtained. The whole method raw materials are easy, simple operation, after treatment is easy, and the cost is low. (by machine translation)

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H15118N – PubChem

 

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Reference of 129888-60-4, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.129888-60-4, Name is tert-Butyl 3-((methylsulfonyl)oxy)piperidine-1-carboxylate, molecular formula is C11H21NO5S. In a Article,once mentioned of 129888-60-4

The A-values of the acetamido and the acetoxy group were determined by low-temperature 1H-n.m.r. spectroscopy.The limiting values for the relevant vicinal coupling constants of the newly prepared trans- (22) and cis-5-acetoxy-2-(1-hydroxy-1-methylethyl)tetrahydropyran (24) were obtained at room temperature.The attractive gauche effect of AcNH-3 and AcO-3 in piperidines, piperidinium trifluoroacetates, and tetrahydropyrans was investigated by 1H-n.m.r. spectroscopy both at low temperature (integrals) and at room temperature (band widths and coupling constants).The results obtained at low temperature are more reliable.The position of the conformational equilibrium of N-(3-piperidyl)acetamide (11), N-(1-methyl-3-piperidyl)acetamide (12), and N-(tetrahydropyran-3-yl)acetamide (17) depends strongly upon the nature of the solvent and, in apolar solvents, upon the concentration.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H22647N – PubChem

 

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This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (?Formula One?).

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Piperidine – Wikipedia,
Piperidine | C5H17867N – PubChem

 

Brief introduction of Methyl 1-benzyl-4-hydroxypiperidine-4-carboxylate

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The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H20759N – PubChem

 

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The invention provides compounds of general formula (I) wherein A, B, p, w, x, y, and z are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

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Piperidine – Wikipedia,
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Simple exploration of tert-Butyl 1,8-diazaspiro[4.5]decane-8-carboxylate

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Reference of 937729-06-1, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.937729-06-1, Name is tert-Butyl 1,8-diazaspiro[4.5]decane-8-carboxylate, molecular formula is C13H24N2O2. In a article,once mentioned of 937729-06-1

Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of monoacylglycerol lipase (MAGL). Furthermore, the subject compounds and compositions are useful for the treatment of pain.

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Piperidine – Wikipedia,
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The present invention relates to novel substituted spirotetronic acids (I) in which R1 and R2, together with the carbon atom to which they are bonded, form a group of the formula (1), (2), (3) or (4), whereby * represents the carbon atom to which R1 and R2 are bonded, to methods for their preparation, their use for the treatment and/or prophylaxis of diseases, as well as their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, in particular of retroviral disorders, in people and/or animals.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H20753N – PubChem

 

Top Picks: new discover of tert-Butyl 2-ethynylpiperidine-1-carboxylate

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In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 255864-58-5, name is tert-Butyl 2-ethynylpiperidine-1-carboxylate, introducing its new discovery. Recommanded Product: tert-Butyl 2-ethynylpiperidine-1-carboxylate

A study concerning the gold(I)-catalyzed rearrangement of propargylic tert-butylcarbamates into 5-methylene-1,3-oxazolidin-2-ones is described. The mild reaction conditions employed allow the efficient synthesis of a variety of these structures, which would be less conveniently obtained using other reported methods. Georg Thieme Verlag Stuttgart.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H15593N – PubChem

 

Archives for Chemistry Experiments of 1150618-39-5

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Quality Control of: tert-Butyl (6-methylpiperidin-3-yl)carbamate, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 1150618-39-5, in my other articles.

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The invention relates to bicyclic compounds of formulas I and I’, and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Quality Control of: tert-Butyl (6-methylpiperidin-3-yl)carbamate, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 1150618-39-5, in my other articles.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H17052N – PubChem