More research is needed about (R)-tert-Butyl piperidin-3-ylcarbamate

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Molecular modeling of unbound tricyclic guanine scaffolds indicated that they can serve as effective bioisosteric replacements of xanthines. This notion was further confirmed by a combination of X-ray crystallography and SAR studies, indicating that tricyclic guanine DPP4 inhibitors mimic the binding mode of xanthine inhibitors, exemplified by linagliptin. Realization of the bioisosteric relationship between these scaffolds potentially will lead to a wider application of cyclic guanines as xanthine replacements in drug discovery programs for a variety of biological targets. Newly designed DPP4 inhibitors achieved sub-nanomolar potency range and demonstrated oral activity in vivo in mouse glucose tolerance test.

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Extracurricular laboratory:new discovery of N-Cbz-2-Piperidinecarboxylic acid

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The present invention provides 4H,6H-5-oxa-2,3,10b-triaza-benzo[e]azulenes, which act as V1a receptor modulators, and in particular as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use as medicaments. The active compounds of the present invention are useful as therapeutics acting peripherally and centrally in the conditions of dysmenorrhea, male or female sexual dysfunction, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, anxiety, depressive disorders, obsessive compulsive disorder, autistic spectrum disorders, schizophrenia, and aggressive behavior.

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Some scientific research about 3-(1-((Benzyloxy)carbonyl)piperidin-4-yl)propanoic acid

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Novel pyridazinamines having antirhinoviral activity, compositions containing these compounds as active ingredient, and a method of inhibiting combating or preventing the growth of viruses in warm-blooded animals suffering from diseases caused by these viruses.

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The Absolute Best Science Experiment for 3-Boc-3,9-diazaspiro[5.5]undecane Hydrochloride

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A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, category: piperidines, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 236406-47-6, Name is 3-Boc-3,9-diazaspiro[5.5]undecane Hydrochloride, molecular formula is C14H27ClN2O2. In a Patent, authors is ,once mentioned of 236406-47-6

The present invention relates to compounds of formula (I) that are metallo-beta-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with beta-lactam antibiotics for overcoming resistance.

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Archives for Chemistry Experiments of N-Cbz-4-Piperidinecarboxylic acid

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An object of the present invention is to provide a compound having a superior CH24H inhibitory action, which is useful as an agent for the prophylaxis or treatment of epilepsy, neurodegenerative disease and the like. The present invention relates to a compound represented by the formula: wherein each symbol is as defined in the specification, or a salt thereof.

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Awesome and Easy Science Experiments about 8-Boc-2,8-Diazaspiro[4.5]decane

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The invention discloses a such as chemical structural formula I and II shown in the N – [(dihydrobenzofuran – 7 – yloxy) alkyl] – 2 – aryloxy amide derivatives: Wherein R is selected from: hydrogen, C1 – C2 Alkyl, C3 – C4 C straight chain alkyl or3 – C4 Branched alkyl; n selected from: 1, 2, 3, 4, 5, 6; Y1 Is selected from: hydrogen, C1 – C2 Alkyl, fluorine, chlorine, bromine or iodine; Y2 Is selected from: hydrogen, C1 – C2 Alkyl, fluoro, chloro, bromo, iodo, trifluoromethyl or trifluoroethyl; Y3 Is selected from: hydrogen, C1 – C2 Alkyl, fluorine, chlorine, bromine or iodine. N – [(dihydrobenzofuran -7 – oxy) alkyl] -2 – aryloxy amide derivatives for the preparation of herbicide in the application. (by machine translation)

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The important role of (R)-tert-Butyl 3-(hydroxymethyl)piperidine-1-carboxylate

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The invention relates to novel antibacterial compounds of formula (I). Said compounds are of interest, inter alia, as topoisomerase IV (topo IV) and DNA gyrase inhibitors.

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Top Picks: new discover of (4-Fluorophenyl)(piperidin-4-yl)methanone hydrochloride

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Novel thienopyrimidine-2,4-dione piperidine derivatives and novel furo[3,4-d]pyrimidine-2,4-dione piperidine derivatives are described. The novel piperidine derivatives are selective serotonin antagonists and alpha adrenergic blocking agents with cardiovascular, gastrointestinal and central nervous system activites.

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New explortion of 143900-43-0

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The present invention relates to novel thienopyhmidine compounds of general formula (I), pharmaceutical compositions comprising these compounds and their therapeutic use for the prophylaxis and/or treatment of diseases which can be influenced by the inhibition of the kinase activity of Mnk1 and/or Mnk2 (Mnk2a or Mnk2b) and/or variants thereof.

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Some scientific research about tert-Butyl piperidin-4-ylcarbamate

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The invention discloses a process for preparing 4 – Boc – amino piperidine method, comprises the following steps: N – benzyl – 4 – piperidone in under the acid catalysis with orthoformate in alcoholic solution react to form a ketal, then with the tert-butyl carbamate reaction of the imine, then imine by Pd/C catalytic hydrogenation reduction to obtain 4 – Boc – amino piperidine. The method the synthetic route is brief, raw materials are easy, low cost, simple and convenient operation, the reaction yield is high, product separation and purification, it has very good application prospect. (by machine translation)

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