Tag: M.W:200-300

Related Products of 77542-18-8, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.77542-18-8, Name is 1-Ethyl-1-methyl-4-oxopiperidin-1-ium iodide, molecular formula is C8H16INO. In a Patent，once mentioned of 77542-18-8

A compound having a partial structure represented by the formula (A) (wherein ring Xa represents a nitrogen-containing ring and R represents optionally substituted amino) or a salt thereof. The compound or salt is highly effective in regulating neuromedin U receptors and is useful as a preventive/therapeutic agent for hypertension, etc.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 77542-18-8

Reference：
Piperidine – Wikipedia,
Piperidine | C5H21746N – PubChem

Related Products of 77542-18-8, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.77542-18-8, Name is 1-Ethyl-1-methyl-4-oxopiperidin-1-ium iodide, molecular formula is C8H16INO. In a Article，once mentioned of 77542-18-8

Animal models suggest that the chemokine ligand 2/CC-chemokine receptor 2 (CCL2/CCR2) axis plays an important role in the development of inflammatory diseases. However, CCR2 antagonists have failed in clinical trials because of a lack of efficacy. We previously described a new approach for the design of CCR2 antagonists by the use of structure’kinetics relationships (SKRs). Herein we report new findings on the structure’affinity relationships (SARs) and SKRs of the reference compound MK- 0483, its diastereomers, and its structural analogues as CCR2 antagonists. The SARs of the 4-arylpiperidine group suggest that lipophilic hydrogen-bond-accepting substituents at the 3- position are favorable. However, the SKRs suggest that a lipophilic group with a certain size is desired [e.g., 3-Br: Ki= 2.8 nm, residence time (tres)=243 min; 3-iPr: Ki=3.6 nm, tres= 266 min]. Alternatively, additional substituents and further optimization of the molecule, while keeping a carboxylic acid at the 3-position, can also prolong tres; this was most prominently observed in MK-0483 (Ki=1.2 nm, tres=724 min) and a close analogue (Ki=7.8 nm) with a short residence time.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 77542-18-8

Reference：
Piperidine – Wikipedia,
Piperidine | C5H21740N – PubChem

Application of 6574-15-8, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.6574-15-8, Name is 1-(4-Nitrophenyl)piperidine, molecular formula is C11H14N2O2. In a Article，once mentioned of 6574-15-8

Pyridin-2-ol-N-oxide was designed as an efficient ligand for the coupling reaction of aryl iodides, aryl bromides and aryl chlorides, respectively, with primary amines, cyclic secondary amines or N-containing heterocycles at room or moderate temperature. The catalytic system showed great functional groups tolerance and excellent selective reactivity.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Application of 6574-15-8, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 6574-15-8

Reference：
Piperidine – Wikipedia,
Piperidine | C5H15306N – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， HPLC of Formula: C11H18N2O2, Which mentioned a new discovery about 91419-52-2

A series of 6-cyclic aliphatic amino-7-nitro-3,4-dihydroquinoline-2(1H)-ones were prepared and tested for platelet aggregation inhibitory effect, cardiotonic activity and chronotropic activity. These compounds appeared to show selective inhibitory activity against platelet aggregation. Among them, 6-(4-ethoxycarbonylpiperidino)-7-nitro-3,4-dihydroquinoline-2(1H)-one (22f) showed the most potent inhibitory activity and high selectivity. A divergent synthetic route to 6-cyclic aliphatic amino-7-nitro-3,4-dihydroquinoline-2(1H)-one derivatives has also been investigated.

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, HPLC of Formula: C11H18N2O2, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 91419-52-2

Reference：
Piperidine – Wikipedia,
Piperidine | C5H15857N – PubChem

Related Products of 73874-95-0, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 73874-95-0, Name is tert-Butyl piperidin-4-ylcarbamate,introducing its new discovery.

A compound of formula (I) wherein A, X, Y, Z, R1 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function

If you’re interested in learning more about 153-94-6, below is a message from the blog Manager. Related Products of 73874-95-0

Reference：
Piperidine – Wikipedia,
Piperidine | C5H14450N – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， Product Details of 84163-13-3, Which mentioned a new discovery about 84163-13-3

The present invention relates to stable polymorphic form of paliperidone and process for its preparation. The chemical name of Paliperidone (I) is 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one. Formula (I): Paliperidone is useful as anti-psychotic agent in the treatment of psychotic disorders. Paliperidone is available in market under brand name INVEGA.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 84163-13-3, help many people in the next few years.Product Details of 84163-13-3

Reference：
Piperidine – Wikipedia,
Piperidine | C5H20991N – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， Safety of (R)-tert-Butyl (piperidin-3-ylmethyl)carbamate, Which mentioned a new discovery about 879275-33-9

A series of chiral lactam carboxamides of aminomethylpiperidine were synthesized and investigated for the collagen induced in vitro anti-platelet efficacy and collagen plus epinephrine induced in vivo pulmonary thromboembolism. The compound 31a (30 muM/kg) displayed a remarkable antithrombotic efficacy (60% protection) which was sustained for more than 24 h and points to its excellent bioavailability. The compounds 31a (IC50 = 6.6 muM) and 32a (IC50 = 37 muM), as well as their racemic mixture 28i (IC50 = 16 muM) significantly inhibited collagen-induced human platelet aggregation in vitro. Compound 34c displayed dual mechanism of action against both collagen (IC50 = 3.3 muM) and U46619 (IC50 = 2.7 muM) induced platelet aggregation. The pharmacokinetic study of 31a indicated very faster absorption, prolonged and constant systemic exposure and thereby exhibiting better therapeutic response.

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, Safety of (R)-tert-Butyl (piperidin-3-ylmethyl)carbamate, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 879275-33-9

Reference：
Piperidine – Wikipedia,
Piperidine | C5H16740N – PubChem

Synthetic Route of 143900-44-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.143900-44-1, Name is (S)-tert-Butyl 3-hydroxypiperidine-1-carboxylate, molecular formula is C10H19NO3. In a Patent，once mentioned of 143900-44-1

The present invention relates to inhibitors of 11-beta hydroxyl steroid dehydrogenase type 1 and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-beta hydroxyl steroid dehydrogenase type l, as exemplified by formula (I)

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 143900-44-1 is helpful to your research. Synthetic Route of 143900-44-1

Reference：
Piperidine – Wikipedia,
Piperidine | C5H14514N – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， HPLC of Formula: C14H17NO4, Which mentioned a new discovery about 10314-98-4

We have developed a series of cyclic amine-containing benzimidazole carboxamide poly(ADP-ribose)polymerase (PARP) inhibitors, with good PARP-1 enzyme potency, as well as cellular potency. These efforts led to the identification of a lead preclinical candidate, 10b, 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide (A-620223). 10b displayed very good potency against both the PARP-1 enzyme with a Ki of 8 nM and in a whole cell assay with an EC50 of 3 nM. 10b is aqueous soluble, orally bioavailable across multiple species, and demonstrated good in vivo efficacy in a B16F10 subcutaneous murine melanoma model in combination with temozolomide (TMZ) and in an MX-1 breast xenograph model in combination with cisplatin.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 10314-98-4, help many people in the next few years.HPLC of Formula: C14H17NO4

Reference：
Piperidine – Wikipedia,
Piperidine | C5H21449N – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Application In Synthesis of 8-Boc-2,8-Diazaspiro[4.5]decane, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 236406-39-6, Name is 8-Boc-2,8-Diazaspiro[4.5]decane, molecular formula is C13H24N2O2. In a Article, authors is Iwata, Masaaki，once mentioned of 236406-39-6

New synthetic routes to N-(omega-tosyloxyalkyl)phthalimides (2) were developed and the synthetic utility of 2 as alkylating reagents was exemplified in the open-chain polyamine synthesis involving the “self-proliferative” process.

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about is helpful to your research. Application In Synthesis of 8-Boc-2,8-Diazaspiro[4.5]decane

Reference：
Piperidine – Wikipedia,
Piperidine | C5H19622N – PubChem