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Benzamidine derivatives of the following formulae or analogs thereof, i. e., pharmaceutically acceptable salts thereof, are provided. These compounds or salts thereof have a blood-coagulation inhibiting effect based on an excellent effect of inhibiting the action of activated blood coagulation factor X, and they are useful as anticoagulants.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H19107N – PubChem

 

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The present invention relates to modified amino acids of general formula 1wherein A, Z, X, n, m, R, R2, R3, R4 and R11 are defined as in claims 1 to 5, their tautomers, their diastereomers, their enantiomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, pharmaceutical compositions containing these compounds, the use thereof and processes for preparing them as well as their use for the production and purification of antibodies and as labelled compounds in RIA- and ELISA assays and as diagnostic or analytical aids in neurotransmitter research.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H18733N – PubChem

 

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The present invention refers to fluorescein derivative, and manufacturing method of using the same number and pH sensor […], formula 1 or formula 2 exhibits said to fluorescein derivative represented; [Formula 1] , [Formula 2] (by machine translation)

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H16894N – PubChem

 

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Application of 143900-43-0, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 143900-43-0, Name is (R)-tert-Butyl 3-hydroxypiperidine-1-carboxylate, molecular formula is C10H19NO3. In a Article,once mentioned of 143900-43-0

Through virtual screening, we identified the lead compound MCL1020, which exhibited modest CHK1 inhibitory activity. Then a series of 5-(pyrimidin-2-ylamino)picolinonitrile derivatives as CHK1 inhibitors were discovered by further rational optimization. One promising molecule, (R)-17, whose potency was one of the best, had an IC50 of 0.4 nM with remarkable selectivity (>4300-fold CHK1 vs. CHK2). Compound (R)-17 effectively inhibited the growth of malignant hematopathy cell lines especially Z-138 (IC50: 0.013 muM) and displayed low affinity for hERG (IC50 > 40 muM). Moreover, (R)-17 significantly suppressed the tumor growth in Z-138 cell inoculated xenograft model (20 mg/kg I.V., TGI = 90.29%) as a single agent with body weight unaffected. Taken together, our data demonstrated compound (R)-17 could be a promising drug candidate for the treatment of hematologic malignancies.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H14636N – PubChem

 

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The invention relates to compounds corresponding to formula (I): In which Ar1, Ar2, Q, Y, Z, Alk?, k and m are as defined herein. The invention further relates to their preparations, intermediates therefor and their therapeutic uses.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H19474N – PubChem

 

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Application of 3515-49-9, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 3515-49-9, Name is 3-(Piperidin-4-ylmethyl)-1H-indole, molecular formula is C14H18N2. In a Patent,once mentioned of 3515-49-9

The invention provides compounds of formula (I) wherein m, R1, n, R2, q, X, Y, R3, R4, R5, R6, R7and R8 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H16912N – PubChem

 

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Carbon nitride (CN)-supported nanosized palladium particles, Pd-CN, have been found to be an active catalyst system for the amination of aryl and pyridyl chloride moieties in the presence of dialkyl amine under mild reaction conditions. The recyclability study of the reaction shows the stable performance of the catalyst without a significant loss of catalytic activity for a couple of cycles.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H15338N – PubChem

 

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The invention relates to compounds of the general formula (I) STR1 and physiologically acceptable salts, N-oxides, hydrates and bioprecursors thereof, in which Y represents =O, =S, =CHNO2 or =NR3 where R3 represents hydrogen, nitro, cyano, lower alkyl, aryl, lower alkylsulphonyl or arylsulphonyl; R1 and R2, which may be the same or different, each represent hydrogen lower alkyl, cycloalkyl, lower alkenyl, aralkyl, hydroxy, lower trifluoroalkyl, lower alkyl substituted by hydroxy, lower alkoxy, amine, lower alkylamino or dialkylamino, or R1 and R2 together with the nitrogen atom to which they are attached form a 5 to 7 membered heterocyclic ring which may contain other heteroatoms or the group STR2 where R4 represents hydrogen or lower alkyl; Q represents a furan or thiophen ring in which incorporation into the rest of the molecule is through bonds at the 2- and 5-positions, or a benzene ring in which incorporation into the rest of the molecule is through bonds at the 1- and 3- or 1- and 4-positions; X represents –CH2, –O– or –S–; n represents zero, 1 or 2; m represents 2, 3 or 4; Alk represents a straight chain alkylene group of 1 to 3 carbon atoms; (except that n is not zero when X is oxygen and Q is a furan or thiophen ring system) q represents 2, 3 or 4 or can additionally represent zero or 1 when E is a –CH2 -group; p represents zero, 1 or 2; E represents –CH2 –, –O– or –S–; and Z represents a monocyclic 5 or 6 membered carbocyclic or heterocyclic aromatic ring which may be optionally substituted by one or more groups or Z represents the group STR3 where Q’ represents any of the rings defined for Q; Alk’ represents any of the groups defined for Alk; and R5 and R6, which may be the same or different, each represent any of the groups defined for R1 and R2 ; (except that p is not zero when E is oxygen and Q’ or Z is a furan or thiophen ring system). The compounds of formula (I) show pharmacological activity as selective histamine H2 -antagonists.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H19469N – PubChem

 

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Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent, name: N-butyl-N-methyl-piperidinium bromide, Which mentioned a new discovery about 94280-72-5

Addition of a small amount of water was found to induce the lignin solubilizing ability in several polar ionic liquids which showed no lignin solubility in the absence of water. Similarly, addition of water was found to enhance lignin solubility in many polar ionic liquids. Though addition of water lowered the proton accepting ability of these ionic liquids, their proton donating ability was found to increase. The lignin dissolution by ionic liquids was newly found to be a function of both the proton accepting ability and proton donating ability of the ionic liquids. Water is a poor solvent for polysaccharides, and water addition has therefore been confirmed to be effective to improve the selective extraction yield of lignin from cedar powder under mild conditions.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H19154N – PubChem

 

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A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, name: 3-(Piperidin-4-ylmethyl)-1H-indole, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 3515-49-9, Name is 3-(Piperidin-4-ylmethyl)-1H-indole, molecular formula is C14H18N2. In a Review, authors is Caminade, Anne-Marie,once mentioned of 3515-49-9

Dendrimers are hyperbranched macromolecules having a perfectly defined and multifunctionalized structure, constituted of branches emanating radially from a central core. The structure of dendrimers is particularly modular, and can incorporate in different parts coordination complexes. In this review, we will present the interplay between dendrimers and coordination chemistry in three main fields: catalysis, materials, and biology. Most of the examples will be taken from the work done with phosphorus-containing dendrimers, but the pioneering work carried out with other dendrimers will be also presented. One of the major improvements that metallodendrimers have afforded concerning catalysis is their easy recovery and reuse, bridging the gap between homogeneous and heterogeneous catalysis. Another major improvement concerns the ?dendritic effect? which can afford impressive outcomes concerning the increase of yield and of enantioselectivity, together with a decrease of the leaching of metals, and consequently of waste. Dendrimers can be used also for the synthesis and stabilization of metallic nanoparticles, for the modification of metallic surfaces at the nanometric scale, and for the synthesis of mesoscopically ordered hybrid materials. Finally metallodendrimers have high potency against cancerous cell lines, and they appear to operate via a different mechanism of action compared with native metallodrugs, opening new avenues for the search of improved anti-cancer agents.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H16982N – PubChem