Tag: M.W:200-300

Synthetic Route of C3H4Br2O2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2,3-Dibromopropionic acid, is researched, Molecular C3H4Br2O2, CAS is 600-05-5, about Development of a bifunctional crosslinking agent with potential for the preparation of immunotoxins. Author is McKenzie, Julie A.; Raison, Robert L.; Rivett, Donald E..

A new protein crosslinking agent 2,3-dibromopropionyl-N-hydroxysuccinimide ester, was synthesized and characterized. The potential use of this compound as a temperature-controllable heterobifunctional crosslinking agent was investigated using model systems and its reactivity compared with that of chlorambucil-N-hydroxysuccinimide ester. The coupling of 14C-labeled phenylethylamine to lysozyme was used to illustrate the feasibility of the use of this crosslinking agent for the synthesis of immunotoxins.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Recommanded Product: 1-Boc-4-(Aminomethyl)piperidine. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1-Boc-4-(Aminomethyl)piperidine, is researched, Molecular C11H22N2O2, CAS is 144222-22-0, about A successful search for new, efficient, and silver-free manufacturing processes for key platinum(II) intermediates applied in antibody-drug conjugate (ADC) production. Author is Merkul, Eugen; Sijbrandi, Niels J.; Aydin, Ibrahim; Muns, Joey A.; Peters, Ruud J. R. W.; Laarhoven, Paul; Houthoff, Hendrik-Jan; van Dongen, Guus A. M. S..

A silver-free amination procedure, here called “”complexation””, was developed to obtain a class of Pt(II) complexes bearing a payload (such as a diagnostic or a therapeutic moiety). These complexes are crucial intermediates for the efficient development and production of antibody-drug conjugates (ADCs) based on a novel Pt(II)-based linker technol. We termed this metal-organic linker, [ethylenediamineplatinum(II)]2+, “”Lx””. The present, newly developed procedure is a greener alternative for the classically applied activation reaction of Pt-halido complexes with silver salts, followed by amination. The crucial finding is that the leaving ligand of the classical process, chloride, can now be replaced by its higher homolog iodide. This not only decisively improved the manufacturing process of the intermediate, but also was found to be key to a more efficient conjugation procedure, i.e. a subsequent step in which this intermediate is coupled to an antibody. The new process allowed upscaling to be readily realized and the desired intermediate was successfully manufactured on a multigram scale. The obtained Ag-free procedure can be generalized and has a great potential to be applied for other Pt(II) complexes of high importance, such as anti-cancer therapeutics.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 144222-22-0, is researched, Molecular C11H22N2O2, about Discovery of a Bromodomain and Extraterminal Inhibitor with a Low Predicted Human Dose through Synergistic Use of Encoded Library Technology and Fragment Screening, the main research direction is dimethylpyridone benzimidazole compound preparation BET protein inhibitor.Computed Properties of C11H22N2O2.

The bromodomain and extraterminal (BET) family of bromodomain-containing proteins are important regulators of the epigenome through their ability to recognize N-acetyl lysine (KAc) post-translational modifications on histone tails. These interactions have been implicated in various disease states and, consequently, disruption of BET-KAc binding has emerged as an attractive therapeutic strategy with a number of small mol. inhibitors now under investigation in the clinic. However, until the utility of these advanced candidates is fully assessed by these trials, there remains scope for the discovery of inhibitors from new chemotypes with alternative physicochem., pharmacokinetic, and pharmacodynamic profiles. Herein, we describe the discovery of a candidate-quality dimethylpyridone benzimidazole compound which originated from the hybridization of a dimethylphenol benzimidazole series, identified using encoded library technol., with an N-Me pyridone series identified through fragment screening. Optimization via structure- and property-based design led to I-BET469, which possesses favorable oral pharmacokinetic properties, displays activity in vivo, and is projected to have a low human efficacious dose.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 600-05-5, is researched, SMILESS is O=C(O)C(Br)CBr, Molecular C3H4Br2O2Journal, Hayastani Kimiakan Handes called Reactions of triphenylphosphine with vinylpyridinium salts, Author is Khachikyan, R. D.; Davtyan, S. L.; Tovmasyan, N. V.; Indzhikyan, M. G., the main research direction is pyridinium salt vinyl preparation nucleophilic addition triphenylphosphine.Electric Literature of C3H4Br2O2.

The reaction of triphenylphosphine with N-vinylpyridinium chloride leads to the formation of 1,2-bis(triphenylphosphonio)ethane dichloride via nucleophilic addition of phosphine to the external double bond. The similar reaction with N-vinyl-3,5-dibromopyridinium bromide or chloride gave the mixtures of 1,2-bis(triphenylphosphonio)ethane dihalides and 3,5-dibromo-2-(β-triphenylphosphonioethyl)pyridine halide. The second product could be formed as the result of electrophilic substitution reaction of the initially formed nucleophilic addition product.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Li, Lun; Liu, Yu-Cheng; Shi, Hang published the article 《Nickel-Catalyzed Enantioselective α-Alkenylation of N-Sulfonyl Amines: Modular Access to Chiral α-Branched Amines》. Keywords: allylic amine preparation enantioselective diastereoselective; sulfonyl amine alkyne alkenylation nickel catalyst.They researched the compound: 1-Boc-4-(Aminomethyl)piperidine( cas:144222-22-0 ).Computed Properties of C11H22N2O2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:144222-22-0) here.

Herein, an atom-economical, modular method for nickel-catalyzed enantioselective α-alkenylation of readily available linear N-sulfonyl amines RS(O)2NHCH2R1 (R = Me, 2,4,6-trimethylphenyl, 4-methoxyphenyl, etc.; R1 = Et, Ph, thiophen-2-yl, etc.) with alkynes R2CCR3 (R2 = trimethylsilyl, Ph, 4-methylphenyl, etc.; R3 = 3-methylbutyl, Ph, naphthalen-2-yl, etc.) to afford a wide variety of allylic amines RS(O)2NHCH(R1)C(R2)=CH(R3) without the need for exogenous oxidants, reductants, or activating reagents was described. The method provides a platform for constructing chiral α-branched amines, as well as derivatives such as α-amino amides I and β-amino alcs. 2,4,6-(CH3)3C6H2S(O)2NHCH(R1)CH(R2)OH, which can be conveniently accessed from the newly introduced alkene. Based on the generality, versatility, and high atom economy of this method, the method will have broad synthetic utility.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 600-05-5, is researched, Molecular C3H4Br2O2, about Reaction of α,β-dibromopropionic acid nitrile with sodium diethyl phosphite, the main research direction is bromopropionitrile addition sodium ethyl phosphite.Computed Properties of C3H4Br2O2.

BrCH2CHBrCN and (EtO)2PONa in Et2O gave (EtO)2PHO, O P(O)(OEt)2]2, and (EtO)2P(O)CH2CH2CN, which was hydrolyzed to the acid and converted to the anilide. (EtO)2P(O)CH:CHCN in Et2O added to (EtO)2PHO in (EtO)2PONa, after refluxing 18 hr and hydrolyzing the ester, gave (HO)2P(O)CH2CH2CO2H. BrCH2CHBrCO2Me and (EtO)2PONa in Et2O gave (EtO)2PHO, (EtO)2P(O)CH2CH2CO2Me, O[P(O)(OEt)2]2 and (EtO)3PO.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Esters of α, β-dibromopropionic acid, published in 1945, which mentions a compound: 600-05-5, Name is 2,3-Dibromopropionic acid, Molecular C3H4Br2O2, SDS of cas: 600-05-5.

The following esters of α, β-dibromopropionic acid were prepared in 60-5% yields by treating mixtures of the acid with the appropriate alc. and HCl with ice-cooling, followed by standing at room temperature, separation, and washing with water (b60-5, b., d420, nD20 given): Me 129-30°, 203-5°, 1.9333, 1.5127; Et 137-8°, 214-16°, 1.7966, 1.5007; Pr 149-50°, 221-4°, 1.6799, 1.4950; iso-Pr 143-6°, 210-14°, 1.6459, 1.4903; Bu 163-4°, 236-9°, 1.6107, 1.4890; iso-Bu 155-6°, 230-2°, 1.5783, 1.4882; iso-Am 165-9°, 240-4°, 1.5149, 1.4871; allyl 148-50°, 218-21°, 1.7412, 1.5126.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2,3-Dibromopropionic acid, is researched, Molecular C3H4Br2O2, CAS is 600-05-5, about Dissociation of halogen-substituted propionic acids in water-acetonitrile solvent mixtures. Substituent effects.Name: 2,3-Dibromopropionic acid.

The pK values of AcOH, EtCO2H and halogen-substituted EtCO2H in H2O/MeCN mixtures were determined at 25° by potentiometric titration The values for α-Cl-, β-Cl-, α-Br-, β-Br-, β-I-, α,α-di-Cl-, α,β-di-Cl-, α,β-di-Br-propionic acid, AcOH and EtCO2H in aqueous mixtures containing 0, 20, 40, 60 and 80 weight% MeCN are reported. The substituent effects on acidity are discussed.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Reaction of dihalopropionic acids and their nitriles with tertiary amines, published in 2004, which mentions a compound: 600-05-5, mainly applied to amine tertiary dehydrohalogenation dihalopropionic acid dihalopropionitrile; pyridine vinylation dihalopropionic acid; haloacrylic acid preparation; vinylpyridinium halide preparation, Recommanded Product: 600-05-5.

The reaction of 2,3-dichloro- and 2,3-dibromopropionic acid and the corresponding nitriles with tertiary aliphatic amines gave dehydrohalogenation products and amine hydrohalides. When pyridine was used, 1-vinylpyridinium halides were obtained.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1-Boc-4-(Aminomethyl)piperidine, is researched, Molecular C11H22N2O2, CAS is 144222-22-0, about Design, synthesis, biological evaluation and molecular docking study of novel thieno[3,2-d]pyrimidine derivatives as potent FAK inhibitors.Safety of 1-Boc-4-(Aminomethyl)piperidine.

A series of 2,7-disubstituted thieno[3,2-d]pyrimidine derivatives I [R1 = 2-methoxy, 3-acetyl, 3-methylsulfonyl, etc.], II [R2 = methylcarbamoyl, piperidine-3-carbonylamino, diethoxyphosphorylmethyl, etc.], III [R3 = H, Me, ethoxy, etc.; R4 = H, fluoro, methyl; R5 = H, fluoro] and IV [R6 = pyrrolidin-3-yl, tetrahydro-2H-pyran-4-yl, piperidin-3-ylmethyl, etc.] were synthesized and evaluated as novel focal adhesion kinase (FAK) inhibitors. The novel 2,7-disubstituted thieno[3,2-d]pyrimidine scaffold was designed as a new kinase inhibitor platform that mimics the bioactive conformation of the well-known diaminopyrimidine motif. Most of the compounds potently suppressed the enzymic activities of FAK and potently inhibited the proliferation of U-87MG, A-549 and MDA-MB-231 cancer cell lines. Among these derivatives, the optimized compound III [R3 = R5 = H, R4 = fluoro] potently inhibited the enzyme (IC50 = 28.2 nM) and displayed stronger potency than TAE-226 in U-87MG, A-549 and MDA-MB-231 cells, with IC50 values of 0.16, 0.27, and 0.19μM, resp. Compound III [R3 = R5 = H, R4 = fluoro] also exhibited relatively less cytotoxicity (IC50 = 3.32μM) toward a normal human cell line, HK2. According to the flow cytometry results, compound III [R3 = R5 = H, R4 = fluoro] induced the apoptosis of MDA-MB-231 cells in a dose-dependent manner and effectively arrested MDA-MB-231 cells in G0/G1 phase. Further investigations revealed that compound III [R3 = R5 = H, R4 = fluoro] potently suppressed the migration of MDA-MB-231 cells. Collectively, these data support the further development of compound III [R3 = R5 = H, R4 = fluoro] as a lead compound for FAK-targeted anticancer drug discovery.

From this literature《Design, synthesis, biological evaluation and molecular docking study of novel thieno[3,2-d]pyrimidine derivatives as potent FAK inhibitors》,we know some information about this compound(144222-22-0)Safety of 1-Boc-4-(Aminomethyl)piperidine, but this is not all information, there are many literatures related to this compound(144222-22-0).

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem