Tag: M.W=150-200

Wei, Ying published the artcileDegradation of enrofloxacin in aqueous by DBD plasma and UV: Degradation performance, mechanism and toxicity assessment, Formula: C9H17NO, the publication is Chemical Engineering Journal (Amsterdam, Netherlands) (2022), 431(Part_3), 133360, database is CAplus.

Enrofloxacin (ENRO) as a highly toxic antibiotic poses great threats to human health and environmental safety. In this study, a novel technol. of coupling dielec. barrier discharge (DBD) and UV was investigated to efficiently degrade ENRO in aqueous, and had a higher degradation rate. The ENRO degradation rate achieved approx. 93.9% at 30 min, and approx. 1.20 g kWh-1 of energy yield (G50) was observed for the combined system. The addition of H₂O₂ and K₂S₂O₄ improved the ENRO degradation due to the generation of ·OH and ·SO₄^2-. In the presence of NO₃-, the ENRO degradation played a tendency to promote first and then decrease, and the presence of SO₄^2-resulted in the pos. effect, while the neg. effect was shown in the presence of Cl^– and CO₃^2-. The trapping experiment indicated that ·OH played an important part in the ENRO degradation The addition of UV into the DBD system decreased H₂O₂ concentration in deionized water, and increased ·OH concentration The DFT anal. showed the degradation mechanisms of ENRO at a mol. level. The degradation of ENRO mainly involved the oxidation of the piperazine group, the removal of Et acetate and the substitution of the F atom. The toxicity of ENRO and its degradation intermediates was evaluated.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C40H35N7O8, Formula: C9H17NO.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

He, Suisui published the artcileSpatiotemporally controlled O₂ and singlet oxygen self-sufficient nanophotosensitizers enable the in vivo high-yield synthesis of drugs and efficient hypoxic tumor therapy, HPLC of Formula: 826-36-8, the publication is Chemical Science (2020), 11(33), 8817-8827, database is CAplus and MEDLINE.

Carrying out the in vivo syntheses of drugs toxic to tumors based on the specific features of the tumor microenvironment is critical for ensuring specific antitumor efficacy. However, achieving in situ high-yield synthetic toxic drugs from non-toxic agents and reducing their drug resistance in hypoxic tumors remain challenges. Herein we created a tumor-microenvironment-responsive porous Pt/Pt(IV) methylene blue coordination polymer nanoshuttle (Pt/PtMBCPNS) photosensitizer with spatiotemporally controlled O₂ and singlet oxygen (¹O₂) self-sufficient for the in vivo high-yield synthesis of drugs and efficient hypoxic tumor therapy. After being endocytosed, the nanophotosensitizer as a cascade catalyst was observed to effectively catalyze the conversion of endogenous H₂O₂ to O₂, and was hence found to play a dual role in the enhanced tumor therapy. PtMBCPNSs, upon being irradiated with red light, efficiently converted O₂ into ¹O₂. Subsequently, ¹O₂ oxidized non-toxic 1,5-dihydroxynaphthalene to form the anticancer agent juglone with a high yield. In addition, O₂ was found to be able to improve the hypoxic microenvironment without light irradiation, thus enhancing the antitumor efficacy of the produced drugs and reducing drug resistance. As a result, by enhancing the synergistic effect of the treatment, this nanophotosensitizer significantly inhibited the growth of tumors and avoided damage to normal tissues/organs. Collectively, this work highlights a robust nanoplatform with the spatiotemporally controlled in vivo high-yield synthesis of drugs and generation of O₂ to help overcome the current limitations of chem.-based therapies against hypoxic tumors.

Chemical Science published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C9H17NO, HPLC of Formula: 826-36-8.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Yang, Guang published the artcileType I macrophage activator photosensitizer against hypoxic tumors, Product Details of C9H17NO, the publication is Chemical Science (2021), 12(44), 14773-14780, database is CAplus and MEDLINE.

Photodynamic immunotherapy has emerged as a promising strategy to treat cancer. However, the hypoxic nature of most solid tumors and notoriously immunosuppressive tumor microenvironment could greatly compromise the efficacy of photodynamic immunotherapy. To address this challenge, we rationally synthesized a type I photosensitizer of TPA-DCR nanoparticles (NPs) with aggregation-enhanced reactive oxygen species generation via an oxygen-independent pathway. We demonstrated that the free radicals produced by TPA-DCR NPs could reprogram M0 and M2 macrophages into an anti-tumor state, which is not restricted by the hypoxic conditions. The activated M1 macrophages could further induce the immunogenic cell death of cancer cells by secreting pro-inflammatory cytokines and phagocytosis. In addition, in vivo anti-tumor experiments revealed that the TPA-DCR NPs could further trigger tumor immune response by re-educating tumor-associated macrophages toward M1 phenotype and promoting T cell infiltration. Overall, this work demonstrates the design of type I organic photosensitizers and mechanistic investigation of their superior anti-tumor efficacy. The results will benefit the exploration of advanced strategies to regulate the tumor microenvironment for effective photodynamic immunotherapy against hypoxic tumors.

Chemical Science published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C20H12N2O2, Product Details of C9H17NO.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Tan, Yixuan published the artcileFacile construction of fluorescent C₇₀-COOH nanoparticles with advanced antibacterial and anti-biofilm photodynamic activity, HPLC of Formula: 826-36-8, the publication is Journal of Photochemistry and Photobiology, B: Biology (2022), 112507, database is CAplus and MEDLINE.

Photodynamic antibacterial therapy has been considered as one of the most promising treatments to alleviate the spread of multidrug resistant bacterial pathogens. Given the hypoxic environment of infectious tissues, photosensitizers with reduced oxygen-demand could exhibit superiority upon irradiation Herein reported is a novel C70-based photosensitizers synthesized by the facile one-step thiol-ene reaction. Various characterization techniques were employed to confirm the structural, photoluminescent properties, photostability and biocompatibility of the as-synthesized C70-COOH nanoparticles. Furthermore, they were capable of efficiently producing reactive oxygen species following both the type I and II mechanistic pathways, thus still generating adequate free radicals under hypoxic condition. Therefore, they could approach and destroy the bacterial cell membrane in the presence of visible light, thereby causing cytoplasmic leakage and eventually achieving broad-spectrum inactivation of four representative bacterial strains. Especially, methicillin-resistant Staphylococcus aureus (MRSA) were completely eliminated after merely 10 min irradiation, and the formation of its corresponding biofilm were also greatly inhibited by C70-COOH nanoparticles. These results provide new insights and opportunities for the development of hypoxia-tolerant fullerene-based photosensitizers to combat multidrug resistant bacterial and related infections.

Journal of Photochemistry and Photobiology, B: Biology published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C20H12N2O2, HPLC of Formula: 826-36-8.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Wang, Shule published the artcileSynergistic effects in the copyrolysis of municipal sewage sludge digestate and salix: Reaction mechanism, product characterization and char stability, Computed Properties of 826-36-8, the publication is Applied Energy (2021), 116687, database is CAplus.

Anaerobic digestion is a practical process for recovering energy and materials from sewage sludge. However, land disposal of the derived digestate results in environmental problems, such as eutrophication and salinization. Copyrolysis of sewage sludge digestate and lignocellulosic biomass produces a high-quality oil, a diluted hazardous component of biochar. This study investigates the copyrolysis behavior of lignocellulosic biomass and sludge digestate with different blending ratios using bench-scale experiments Compared to individual feedstock pyrolysis, copyrolysis shows a higher energy distribution in the liquid product and a lower energy distribution in the char and gas product. The highest energy yield with respect to the organic fraction of liquid product is observed in the copyrolysis case, corresponding to 36.4% of the total energy in the feedstock. The interaction between the sludge digestate and lignocellulosic biomass is studied through product characterizations, mechanistic investigations and char stability assessments. The liquid products in the copyrolysis cases show a relatively high abundance of esters, aliphatic hydrocarbons, pyridines and pyrroles. The reaction pathways of proteins, lipids and carbohydrates are investigated. Two synergistic reaction pathways are proposed. The char stability and nitrogen distribution are investigated. According to the results, the synergistic interaction between feedstocks enhances the quality and energy yield of the liquid biofuel. The char product from copyrolysis has higher potential for use as a carbon sink and fertilizer.

Applied Energy published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C15H20O6, Computed Properties of 826-36-8.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Hu, Erfeng published the artcilePyrolysis behaviors of anaerobic digestion residues in a fixed-bed reactor with rapid infrared heating, HPLC of Formula: 826-36-8, the publication is Environmental Science and Pollution Research (2022), 29(34), 51815-51826, database is CAplus and MEDLINE.

Fast pyrolysis via rapid IR heating may significantly enhance the heat transfer and suppress the secondary reaction of the volatiles. The effects of various pyrolysis temperatures on pyrolysis behaviors of anaerobic digestion residues (ADR) were studied in this research utilizing a fixed-bed reactor equipped with rapid IR heating (IH), as well as to compare the pyrolysis products produced by rapid IR heating (IH) to those produced by conventional elec. heating (EH). Thermogravimetric anal. revealed that pyrolysis of ADR occurred in three decomposition stages. The results of pyrolysis experiments showed that increasing temperature first raised the bio-oil yield for IH and EH, peaking at 500-600°C, but thereafter decreased the yield. In contrast to the findings achieved with EH, IR heating (IH) presented a greater overall bio-oil yield but a lower gas yield. The bio-oil produced by IH increased from 8.35 weight% at 400°C to 12.56 weight% at 500°C before dropping to 11.22 weight% at 700°C. Gaseous products produced by IH have a higher heating value than those generated by EH. Nitrogenous compounds, ketones, and phenols make up the majority of the bio-oil. In the IH bio-oil, nitrogen compounds rose with increasing temperature, while those varied slightly in the EH bio-oil. The phenols content in IH bio-oil was much more than that of EH, exhibiting values of 8.63% and 2.95%, resp. The findings of the FTIR spectra of biochar indicated that as the temperature increased, the chains of aliphatic side professedly reduced and the structure of biochar became considerably ordered for both heating techniques. The Raman spectra of IH biochar showed that the ratio of AG/AD rose progressively from 0.17 to 0.20 as pyrolysis temperature rose from 500 to 700°C.

Environmental Science and Pollution Research published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C9H17NO, HPLC of Formula: 826-36-8.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Li, Ning published the artcileCorrelation of active sites to generated reactive species and degradation routes of organics in peroxymonosulfate activation by Co-loaded carbon, Related Products of piperidines, the publication is Environmental Science & Technology (2021), 55(23), 16163-16174, database is CAplus and MEDLINE.

Peroxymonosulfate (PMS)-based advanced oxidation processes (PMS-AOPs) as an efficient strategy for organic degradation are highly dependent on catalyst design and structured active sites. However, the identification of the active sites and their relationship with reaction mechanisms for organic degradation are not fully understood for a composite catalyst due to the complex structure. Herein, we developed a family of Co encapsulated in N-doped carbons (Co-PCN) with tailored types and contents of active sites via manipulated pyrolysis for PMS activation and ciprofloxacin (CIP) degradation, focusing on the correlation of active sites to generated reactive species and degradation routes of organics The structure-function relationships between the different active sites in Co-PCN catalysts and reactive oxygen species (ROS), as well as bond breaking position of CIP, were revealed through regression anal. and d. functional theory calculation Co-N_x, O-C=O, C=O, graphitic N, and defects in Co-PCN stimulate the generation of ¹O₂ for oxidizing the C-C bond in the piperazine ring of CIP into C=O. The substitution of F by OH and hydroxylation of the piperazine ring might be induced by SO₄^â€? and ^{â€?/sup>OH, whose formation was affected by C-O, Co(0), Co-N_x, graphitic N, and defects. The findings provided new insights into reaction mechanisms in PMS-AOP systems and rational design of catalysts for ROS-oriented degradation of pollutants.}

Environmental Science & Technology published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C9H17NO, Related Products of piperidines.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Chen, Qiumeng published the artcileSize-controllable Fe-N/C single-atom nanozyme with exceptional oxidase-like activity for sensitive detection of alkaline phosphatase, Recommanded Product: 2,2,6,6-Tetramethylpiperidin-4-one, the publication is Sensors and Actuators, B: Chemical (2020), 127511, database is CAplus.

Nanozymes become currently a frontier of chem. research. However, exploiting a novel nanozyme with high activity, good stability and reproducibility is challenging. Here, size-controllable Fe-N/C nanozymes containing exclusive single Fe atoms coordinated Fe-N_x sites were succesfully prepared through a facile pyrolysis of size controllable Fe-Zn ZIFs precursors. The Fe-N/C nanozymes exhibit exceptional high oxidase-mimicking activity able to catalyze oxidation of colorless 3,3′,5,5′-tetramethylbenzidine (TMB) by dissolved oxygen to generate blue product. Their catalytic activities can be regulated by modulating the molar ratios of methanol to metal salts (e.g., Fe and Zn) through which the size controllable Fe-Zn ZIFs precursors are obtained. Upon introduction of ascorbic acid (AA) into Fe-N/C/TMB system, complete inhibition of TMB oxidation was observed, resulting in significant decline in absorbance with a clear color change. In the presence of alk. phosphatase (ALP), ascorbic acid 2-phosphate (AAP) is hydrolyzed to produce AA. When coupled with AAP, a novel colorimetric biosensor platform was fabricated for ALP activity screening in the range of 0.05 U/L-100 U/L (four orders of magnitude) with an ultra-low limit of detection of 0.02 U/L. The work provides a promising strategy to rationally design the transition metal-N/C single-atom nanozyme with high oxidase-like activity.

Sensors and Actuators, B: Chemical published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C9H17NO, Recommanded Product: 2,2,6,6-Tetramethylpiperidin-4-one.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Liu, Shikai published the artcileAn all-in-one theranostic nanoplatform based on upconversion dendritic mesoporous silica nanocomposites for synergistic chemodynamic/photodynamic/gas therapy, Formula: C9H17NO, the publication is Nanoscale (2020), 12(47), 24146-24161, database is CAplus and MEDLINE.

Gasotransmitters with high therapeutic efficacy and biosafety have been drawing the attention of researchers. Nevertheless, how to effectively deliver gases to and precisely control their generation at the lesion as well as integrate them with other therapies to realize precision therapy have remained elusive. Herein, we report a versatile Cu2+-initiated nitric oxide (NO) nanocomposite for multimodal imaging-guided synergistic chemodynamic/photodynamic/gas therapy. After the nanomedicine was ingested by tumor cells, the acidic tumor microenvironment accelerated the decompn of CuO2 and simultaneously triggered the Fenton-like catalytic reaction of Cu2+ and H2O2 to produce highly toxic OH. By virtue of the NO generation and glutathione depletion, UMNOCC-PEG can relieve the antioxidant capacity and hypoxia of the tumor to improve the efficiency of chemodynamic therapy (CDT) and photodynamic therapy (PDT). Importantly, NO and reactive oxygen species (ROS) can generate reactive nitrogen species (RNS), which can result in DNA damage, further improving the therapeutic effect (cell apoptosis rate up to 93.4%). Moreover, the inherent properties of lanthanide ions endow UMNOCC-PEG with upconversion luminescence (UCL), CT and MRI trimodal imaging capability, achieving precise cancer treatment. By taking advantage of these features, the strategy developed here may provide a promising application foreground to conquer malignant tumors.

Nanoscale published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C9H17NO, Formula: C9H17NO.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Liu, Li published the artcileActivation of peroxymonosulfate with CuCo₂O₄@kaolin for efficient degradation of phenacetin, Name: 2,2,6,6-Tetramethylpiperidin-4-one, the publication is Chemical Engineering Journal (Amsterdam, Netherlands) (2020), 126014, database is CAplus.

CuCo₂O₄@kaolin was successfully synthesized by a sol-gel method and used as a heterogeneous catalyst to activate peroxymonosulfate (PMS) for the degradation of phenacetin (PNT). The results demonstrated that 10 mg/L PNT was completely decomposed by 1 mM PMS activated with 0.1 g/L CuCo₂O₄@kaolin within 15 min at initial pH 7. CuCo₂O₄@kaolin exhibited the best excellent catalytic performance among the tested catalysts, and the pseudo-first-order rate constants of PNT degradation were CuCo₂O₄@kaolin (0.40 min^-1) > CuCo₂O₄ (0.22 min^-1) > Co₃O₄@kaolin (0.10 min^-1) > CuO@kaolin (0.08 min^-1) > kaolin (0.02 min^-1). CuCo₂O₄@kaolin also possessed superior stability, and the degradation efficiency of PNT declined from 100% in the first round to 80% in the fourth round. Nevertheless, a simple calcinating treatment (20 min) after the third round could restore its catalytic activity substantially and 95% removal of PNT was realized, 15% higher compared to without treatment. ^·OH, SO₄^·-, and ¹O₂ were the reactive oxygen species driving the PNT degradation Based on the results mentioned above, characterizations of CuCo₂O₄@kaolin, and intermediates of PNT degradation, the possible pathways and underlying mechanisms of the PNT degradation in the CuCo₂O₄@kaolin/PMS system were deduced. CuCo₂O₄@kaolin/PMS had a universal degradation potential toward various organic pollutants, and the degradation efficiencies of sulfisoxazole, p-nitrophenol, chloramphenicol, and 2,4,6-Trichlorophenol reached 95-100% within 5-45 min. Thus, this work provides a novel and efficient PMS activator through an eco-friendly synthetic route, and it may be put into practice to degrade organic matter in wastewater.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C9H17NO, Name: 2,2,6,6-Tetramethylpiperidin-4-one.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem