M.W=150-200 | Page 17 of 23 | Heterocyclic Building Blocks-piperidine

Tadic, Djordje team published research on Molecules in 2022 | 2403-88-5

2403-88-5, 2,2,6,6-Tetramethyl-4-piperidinol(TEMPO) is a useful research compound. Its molecular formula is C9H19NO and its molecular weight is 157.25 g/mol. The purity is usually 95%.
TEMPO is an intermediate used in the preparation of Piperidinyloxy free radical derivatives.
TEMPO is an organic compound that acts as a radical scavenger. It is stable in the presence of water and air and can be used for the inhibition of bacterial growth. TEMPO reacts with reactive intermediates to form non-reactive substances and terminate chain reactions. This process is optimal at temperatures between 0°C and 40°C and pH values between 3.5 and 7.5. TEMPO has been shown to inhibit the growth of bacteria by reacting with reactive molecules such as amines, chlorides, or low energy radicals in aqueous solution. TEMPO also has genotoxic activity that inhibits DNA synthesis in bacterial cells through oxidation of guanine residues on DNA molecules., Recommanded Product: 2,2,6,6-Tetramethyl-4-piperidinol

Piperidine is an organic compound with the molecular formula (CH2)5NH. This heterocyclic amine consists of a six-membered ring containing five methylene bridges (–CH2–) and one amine bridge (–NH–). 2403-88-5, formula is C9H19NO, Name is 2,2,6,6-Tetramethyl-4-piperidinol. It is a colorless liquid with an odor described as objectionable, and typical of amines. Recommanded Product: 2,2,6,6-Tetramethyl-4-piperidinol.

Tadic, Djordje;Manasfi, Rayana;Bertrand, Marine;Sauvetre, Andres;Chiron, Serge research published 《 Use of Passive and Grab Sampling and High-Resolution Mass Spectrometry for Non-Targeted Analysis of Emerging Contaminants and Their Semi-Quantification in Water》, the research content is summarized as follows. Different groups of organic micropollutants including pharmaceuticals and pesticides have emerged in the environment in the last years, resulting in a rise in environmental and human health risks. In order to face up and evaluate these risks, there is an increasing need to assess their occurrence in the environment. Therefore, many studies in the past couple of decades were focused on the improvements in organic micropollutants′ extraction efficiency from the different environmental matrixes, as well as their mass spectrometry detection parameters and acquisition modes. This paper presents different sampling methodologies and high-resolution mass spectrometry-based non-target screening workflows for the identification of pharmaceuticals, pesticides, and their transformation products in different kinds of water (domestic wastewater and river water). Identification confidence was increased including retention time prediction in the workflow. The applied methodol., using a passive sampling technique, allowed for the identification of 85 and 47 contaminants in the wastewater effluent and river water, resp. Finally, contaminants′ prioritization was performed through semi-quantification in grab samples as a fundamental step for monitoring schemes.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Tahir, Mudassir Hussain team published research on Journal of Analytical and Applied Pyrolysis in 2021 | 2403-88-5

Application of C9H19NO, 2,2,6,6-Tetramethyl-4-piperidinol(TEMPO) is a useful research compound. Its molecular formula is C9H19NO and its molecular weight is 157.25 g/mol. The purity is usually 95%.
TEMPO is an intermediate used in the preparation of Piperidinyloxy free radical derivatives.
TEMPO is an organic compound that acts as a radical scavenger. It is stable in the presence of water and air and can be used for the inhibition of bacterial growth. TEMPO reacts with reactive intermediates to form non-reactive substances and terminate chain reactions. This process is optimal at temperatures between 0°C and 40°C and pH values between 3.5 and 7.5. TEMPO has been shown to inhibit the growth of bacteria by reacting with reactive molecules such as amines, chlorides, or low energy radicals in aqueous solution. TEMPO also has genotoxic activity that inhibits DNA synthesis in bacterial cells through oxidation of guanine residues on DNA molecules., 2403-88-5.

Piperidine was first reported in 1850 by the Scottish chemist Thomas Anderson and again, independently, in 1852 by the French chemist 2403-88-5, formula is C9H19NO, Name is 2,2,6,6-Tetramethyl-4-piperidinol. Auguste Cahours, who named it. Both of them obtained piperidine by reacting piperine with nitric acid. Application of C9H19NO.

Tahir, Mudassir Hussain;Irfan, Rana Muhammad;Cheng, Xingxing;Ahmad, Muhammad Sajjad;Jamil, Muhammad;Shah, Tanveer-Ul- Hassan;Karim, Abdul;Ashraf, Rizwan;Haroon, Muhammad research published 《 Mango peel as source of bioenergy, bio-based chemicals via pyrolysis, thermodynamics and evolved gas analyses》, the research content is summarized as follows. Waste biomass is one of the promising feedstocks for bioenergy generation in present era. The aim of present study is to demonstrate Mango peel as a source of bioenergy, bio-based chem. and phenols productions via pyrolysis, thermodn. and evolved gas analyses. Therefore, samples were characterized through thermogravimetric analyzer, Fourier transform IR spectrometry (FTIR) and pyrolysis-gas chromatog./mass spectrometry (Py-GC/MS). Pyrolysis experiments were carried out at different heating rates i.e. 10, 20 and 30 °Cmin^-1 and thermodn. parameters were calculated using different kinetic models. The apparent activation energy was found in range of 88 kJ mol^-1 to 304 kJ mol^-1 with all kinetic models. Evolved gaseous anal. was performed though out pyrolysis and between three temperature intervals for qual. and quant. anal. of pyrolytic compounds Similarly, effect of temperature and heating rate on pyrolytic compounds concentrations were also carried out. Release of several chems., aromatics compounds and high phenols concentration i.e. 21.01% via Py/GC-MS confirms its potential for bioenergy, bio-based chems. productions and anti-oxidant characteristics associated with phenolic compounds

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Takajo, Tokuko team published research on Chemical & Pharmaceutical Bulletin in 2020 | 2403-88-5

Formula: C9H19NO, 2,2,6,6-Tetramethyl-4-piperidinol(TEMPO) is a useful research compound. Its molecular formula is C9H19NO and its molecular weight is 157.25 g/mol. The purity is usually 95%.
TEMPO is an intermediate used in the preparation of Piperidinyloxy free radical derivatives.
TEMPO is an organic compound that acts as a radical scavenger. It is stable in the presence of water and air and can be used for the inhibition of bacterial growth. TEMPO reacts with reactive intermediates to form non-reactive substances and terminate chain reactions. This process is optimal at temperatures between 0°C and 40°C and pH values between 3.5 and 7.5. TEMPO has been shown to inhibit the growth of bacteria by reacting with reactive molecules such as amines, chlorides, or low energy radicals in aqueous solution. TEMPO also has genotoxic activity that inhibits DNA synthesis in bacterial cells through oxidation of guanine residues on DNA molecules., 2403-88-5.

Takajo, Tokuko;Kurihara, Yoshinori;Iwase, Kodai;Miyake, Daiki;Tsuchida, Kazunori;Anzai, Kazunori research published 《 Basic investigations of singlet oxygen detection systems with ESR for the measurement of singlet oxygen quenching activities》, the research content is summarized as follows. Singlet oxygen (¹O₂) is highly oxidative and exerts strong cytotoxic effects. We tried to establish the best combination of a singlet oxygen generation system and a detection method with ESR, for measurement of the quenching activities of various substances. The photosensitizing reaction of rose bengal or thermal decomposition of 4-methyl-1,4-etheno-2,3-benzodioxin-1(4H)-propanoic acid (endoperoxide, EP) was used for the generation of ¹O₂, and a sterically hindered secondary amine, 2,2,6,6-tetramethyl-4-piperidone (TEMPD) or 2,2,6,6-tetramethyl-4-piperidinol (TEMP-OH), was used as the ¹O₂ detection probe. These secondary amines were oxidized by ¹O₂ to form stable nitroxide radicals, which were detectable by ESR. TEMPD was found to be readily oxidized by air, causing large background signals in comparison with TEMP-OH. The ESR signal obtained by the irradiation of rose bengal with visible light in the presence of TEMP-OH consisted of two kinds of nitroxide radical overlapping. In contrast, only a single nitroxide signal was observed when TEMP-OH was reacted with ¹O₂ generated from EP. Therefore, the best combination should be EP as the ¹O₂ generator and TEMP-OH as the detection probe. When using this combination, we found that the concentrations of some organic solvents such as DMSO and acetonitrile should be kept constant for reliable quantification, because the concentrations of organic solvents affect the ESR signal intensity.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Tan, Chaoqun team published research on Chemical Engineering Journal (Amsterdam, Netherlands) in 2020 | 2403-88-5

Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst: C5H5N + 3 H2 → C5H10NH. 2403-88-5, formula is C9H19NO, Name is 2,2,6,6-Tetramethyl-4-piperidinol. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol. Application of C9H19NO.

Tan, Chaoqun;Xu, Tianhui;He, Huan;Xu, Qinglong;Fang, Chao;Du, Erdeng;Deng, Jing;Chu, Wenhai research published 《 Bimetallic oxychloride as an efficient oxone activator: Radical and non-radical oxidation of non-steroidal anti-inflammatory drugs》, the research content is summarized as follows. A novel iron-cobalt mixed oxychloride (CoFeOCl) nanosheet, with a plane size in the ranges of 0.2-1.0 μm and a thickness of 30-40 nm, was manufactured firstly and employed as catalyst for peroxymonosulfate (PMS) activation. The CoFeOCl/PMS system exhibits excellent catalytic activity for non-steroidal anti-inflammatory drugs removal at buffered pH 5.5-8.5 with extremely low catalyst dosage (0.03 g/L). The mechanism of PMS activation by CoFeOCl indicated that ·OH and ¹O₂ played a key role at pH 5.5-7.0 and pH 8.5 resp., and O^–₂· was involved for all pHs. The cycle of Co²⁺-Co³⁺ and Fe²⁺-Fe³⁺ were answerable to ·OH and ¹O₂ generation. Furthermore, CoFeOCl/PMS pre-oxidation before chlorination engendered in a reduce in the concentration of total disinfection byproducts (DBPs) at pH 8.5. A feasible reaction pathway of DBPs formation was examined with d. functional theory (DFT) calculation The findings provide a new routine for effective PMS activation.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Qu, Ruijuan team published research on Environmental Science & Technology in 2018 | 2403-88-5

Product Details of C9H19NO, 2,2,6,6-Tetramethyl-4-piperidinol(TEMPO) is a useful research compound. Its molecular formula is C9H19NO and its molecular weight is 157.25 g/mol. The purity is usually 95%.
TEMPO is an intermediate used in the preparation of Piperidinyloxy free radical derivatives.
TEMPO is an organic compound that acts as a radical scavenger. It is stable in the presence of water and air and can be used for the inhibition of bacterial growth. TEMPO reacts with reactive intermediates to form non-reactive substances and terminate chain reactions. This process is optimal at temperatures between 0°C and 40°C and pH values between 3.5 and 7.5. TEMPO has been shown to inhibit the growth of bacteria by reacting with reactive molecules such as amines, chlorides, or low energy radicals in aqueous solution. TEMPO also has genotoxic activity that inhibits DNA synthesis in bacterial cells through oxidation of guanine residues on DNA molecules., 2403-88-5.

Qu, Ruijuan;Li, Chenguang;Liu, Jiaoqin;Xiao, Ruiyang;Pan, Xiaoxue;Zeng, Xiaolan;Wang, Zunyao;Wu, Jichun research published 《 Hydroxyl Radical Based Photocatalytic Degradation of Halogenated Organic Contaminants and Paraffin on Silica Gel》, the research content is summarized as follows. Photochem. materials are of scientific and practical importance in the field of photocatalysis. In this study, the photochem. of several organic contaminants, including decabromodiphenyl ether (BDE-209), halogenated phenols (C₆X₅OH, X = F, Cl, Br) and paraffin, on silica gel (SG) surface was investigated under simulated solar irradiation conditions. Photolysis of these compounds at the solid/air interface proceeds with different rates yielding various hydroxylation products, and hydroxyl radical was determined as the major reactive species. According to d. functional theory (DFT) calculations, the reaction of phys. adsorbed water with reactive silanone sites (>Si=O) on silica was indispensable for the generation of ^•OH radical, where the required energy matches well with the irradiation energy of visible light. Then, the BDE-209 was selected as a representative compound to evaluate the photocatalytic performance of SG under different conditions. The SG material showed good stability in the photodegradation process, and was able to effectively eliminate BDE-209 under natural sunlight. These findings provide new insights into the potential application of SG as a solid surface photocatalyst for contaminants removal.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Rayaroth, Manoj P. team published research on Journal of Colloid and Interface Science in 2021 | 2403-88-5

Piperidine the name comes from the genus name Piper, which is the Latin word for pepper. 2403-88-5, formula is C9H19NO, Name is 2,2,6,6-Tetramethyl-4-piperidinol. Although piperidine is a common organic compound, it is best known as a representative structure element within many pharmaceuticals and alkaloids, such as natural-occurring solenopsins. Name: 2,2,6,6-Tetramethyl-4-piperidinol.

Rayaroth, Manoj P.;Oh, Dasom;Lee, Chung-Seop;Kumari, Nitee;Lee, In Su;Chang, Yoon-Seok research published 《 Carbon-nitride-based micromotor driven by chromate-hydrogen peroxide redox system: Application for removal of sulfamethaxazole》, the research content is summarized as follows. In this study, a Janus Fe/C₃N₄ micromotor driven by a chromate-hydrogen peroxide (Cr(VI)/H₂O₂) redox system was developed and its movement was analyzed. The motion of the micromotor was tracked via nanoparticle tracking anal. (NTA) and the corresponding diffusion coefficients (D) were determined The NTA results revealed that D = 0 in water in the absence of additives (Cr(VI) or H₂O₂). The addition of H₂O₂ resulted in an increase in D from 0 to 12 x 106 nm² s^-1, which further increased to 20 x 10⁶, 26.5 x 10⁶, 29 x 10⁶, and 44 x 10⁶ nm² s^-1 with the addition of 0.5, 1, 2, and 5 ppm of Cr(VI), resp. Cr(VI) alone did not efficiently propel the Fe/C₃N₄-based micromotor. Therefore, it was proposed that the Cr(VI)/H₂O₂ redox system generates O₂, which plays a major role in the movement of the C₃N₄-based micromotor. In addition, the formation of reactive species, such as ·OH and ¹O₂, was confirmed through ESR experiments The reactive species efficiently degraded sulfamethaxazole (SMX), an organic pollutant, as demonstrated through degradation studies and product analyses. The effects of various parameters, such as H₂O₂ concentration, Cr(VI) concentration, and initial pH on the movement of micromotor and degradation of SMX were also documented.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Ren, Wei team published research on Environmental Science & Technology in 2019 | 2403-88-5

Ren, Wei;Xiong, Liangliang;Yuan, Xuehong;Yu, Ziwei;Zhang, Hui;Duan, Xiaoguang;Wang, Shaobin research published 《 Activation of Peroxydisulfate on Carbon Nanotubes: Electron-Transfer Mechanism》, the research content is summarized as follows. This study proposed an electrochem. technique for studying the nonradical oxidation pathway of organics in C nanotubes (CNTs)-catalyzed peroxydisulfate (PDS) activation. The half-wave potentials of twelve phenolic compounds (PCs) were evaluated and correlated to their kinetic rate constants in the PDS/CNTs system. Integrated with quant. structure-activity relations (QSARs), EPR and radical scavenging tests, the nature of nonradical pathway was unveiled to be an electron-transfer regime without singlet oxygenation process. The QSARs accurately predicted the oxidation process of PCs according to their standard electrode potentials, reactive pH and temperature A novel electrochem. anal. method (transient open circuit potential combined with chronoamperometry) was employed to probe the mechanism, suggesting that PDS was firstly catalyzed by CNTs to form a surface-confined CNTs-PDS^* complex with a high redox potential. Then, the CNTs-PDS^* selectively abstracted electrons from the co-adsorbed PCs to initiate the oxidation Finally, a comparison of PDS/CNTs and graphite anodic oxidation under constant potentials was comprehensively analyzed to unveil the relative activity of the nonradical CNTs-PDS complexes toward different PCs, which was determined by the oxidative potentials of the CNTs-PDS^* complex and the adsorbed organics

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Minkus, Susanne team published research on Analytical Methods in 2021 | 2403-88-5

Electric Literature of 2403-88-5, 2,2,6,6-Tetramethyl-4-piperidinol(TEMPO) is a useful research compound. Its molecular formula is C9H19NO and its molecular weight is 157.25 g/mol. The purity is usually 95%.
TEMPO is an intermediate used in the preparation of Piperidinyloxy free radical derivatives.
TEMPO is an organic compound that acts as a radical scavenger. It is stable in the presence of water and air and can be used for the inhibition of bacterial growth. TEMPO reacts with reactive intermediates to form non-reactive substances and terminate chain reactions. This process is optimal at temperatures between 0°C and 40°C and pH values between 3.5 and 7.5. TEMPO has been shown to inhibit the growth of bacteria by reacting with reactive molecules such as amines, chlorides, or low energy radicals in aqueous solution. TEMPO also has genotoxic activity that inhibits DNA synthesis in bacterial cells through oxidation of guanine residues on DNA molecules., 2403-88-5.

Minkus, Susanne;Bieber, Stefan;Letzel, Thomas research published 《 Very polar organic compounds in the Danube river basin: a non-target screening workflow and prioritization strategy for extracting highly confident features》, the research content is summarized as follows. Recently, more and more research has been focused on the anal. of polar organic compounds as they tend to be persistent and mobile in the aquatic environment. The serial coupling of reversed-phase and hydrophilic interaction liquid chromatog. allows the separation of analytes of an extended polarity range within a single run. The non-target screening approach was driven by high-resolution mass spectrometry and is able to detect unexpected compounds It is therefore capable of complementing regular monitoring of surface water. Non-target screening, however, can produce massive data sets. Here, a data processing method is presented focusing on unravelling tentative polar compounds from the full scan data of 51 samples of the Danube river and its tributaries. The feature extraction method was optimized to 34 reference compounds at two concentration levels and was then applied to real samples. Features were matched by accurate mass with anthropogenic substances stored in the compound database STOFF-IDENT located on the FOR-IDENT platform. In order to extract polar candidates, the retention time interval corresponding to the HILIC separation was connected to compounds with a neg. log D value. As a result, 67 candidates were detected which were found to be plausible. Finally, features were prioritized based on an identification certainty classification system as well as their frequency of occurrence. Therefore, several feature-candidate compound pairs could be suggested for confirmation via reference materials. The presented non-target screening strategy followed by a database query is transferrable to other sample sets and other data evaluation tools.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Peng, Wei team published research on Korean Journal of Chemical Engineering in 2018 | 2403-88-5

Peng, Wei;Liu, Jie;Li, Chenxu;Zong, Fuxing;Xu, Wensi;Zhang, Xing;Fang, Zhendong research published 《 A multipath peroxymonosulfate activation process over supported by magnetic CuO-Fe₃O₄ nanoparticles for efficient degradation of 4-chlorophenol》, the research content is summarized as follows. Heterogeneous catalysts with low cost, environmentally friendly, highly effective and ready separation from aqueous solution are highly desirable. Magnetic CuO-Fe₃O₄ nanoparticles, a type of non-toxic bimetallic transition metal oxide, is a promising heterogeneous catalyst for activation of peroxymonosulfate (PMS) to generate reactive oxygen species (ROS) that has not been previously investigated. In this study, the activation of PMS by CuO-Fe₃O₄ nanoparticles was evaluated using the degradation of 4-chlorophenol as a model reaction. Several critical factors such as pH, catalyst dosage and PMS concentration were investigated. CuO-Fe₃O₄/PMS system demonstrated a wide effective pH range to degrade 4-chlorophenol, namely 5.5 to 9.5. With the increase of the catalyst dosage, the degradation efficiency of 4-chlorophenol appeared to increase first and then decrease, that the inflection point was 0.5 g/L. Elevated PMS concentration obviously improved the decomposition of 4-chlorophenol; however, the plateau was reached when the PMS concentration was 8 mM. Further increase in PMS concentration would not significantly improve the removal efficiency. Through examining the effects of scavengers and ESR (ESR) analyses, CuO-Fe₃O₄ nanoparticles were proven to activate PMS through a non-radical and radical pathway to generate singlet oxygen, sulfate radicals and hydroxyl radicals.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Liu, Yani team published research on ACS Catalysis in 2020 | 2403-88-5

Piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. This gave the compound its name. 2403-88-5, formula is C9H19NO, Name is 2,2,6,6-Tetramethyl-4-piperidinol. Other examples are the fire ant toxin solenopsin, the nicotine analog anabasine of tree tobacco (Nicotiana glauca), lobeline of Indian tobacco. Application In Synthesis of 2403-88-5.

Liu, Yani;Luo, Jun;Tang, Lin;Feng, Chengyang;Wang, Jiajia;Deng, Yaocheng;Liu, Haoyu;Yu, Jiangfang;Feng, Haopeng;Wang, Jingjing research published 《 Origin of the enhanced reusability and electron transfer of the carbon-coated Mn₃O₄ nanocube for persulfate activation》, the research content is summarized as follows. Manganese oxides and carbon materials are both desirable catalysts for persulfate (PS) advanced oxidation processes in environmental remediation. Nevertheless, manganese oxides suffer from low reusability while carbon materials face the problem of limited catalytic efficiency. For the purpose of making full use of the advantages of the two materials as well as avoiding their shortcomings, carbon-coated Mn₃O₄ composites (Mn₃O₄/C) with a regular nanocube structure were designed to activate PS for the removal of organics, and the catalytic processes were deeply investigated. The catalyst prepared at 400°C with a precursor ratio (glucose/KMnO₄) of 0.5 exhibited the best catalytic performance along with satisfactory reusability owing to the protection of the outer carbon layer. According to exptl. results and d. functional theory calculation, there were van der Waals interaction and a part of the strong attraction between the interface of PS and Mn₃O₄/C, which could be enhanced by inner Mn₃O₄ and thus promoted the electron transfer between PS and carbon shell, and the defective edges of the carbon layer with hydroxyl (C-OH) groups could act as active sites for PS activation. Radical (SO₄^•-, ^•OH) and nonradical (¹O₂) oxidation processes both participated in the degradation of 2,4-dichlorophenol, in which ^•OH was dominating. This study not only proposed a promising catalyst for the degradation of pollutants but also expanded research ideas for future PS activation mechanism studies by integrating the experiment and simulation.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem