New learning discoveries about 53617-36-0

53617-36-0, 53617-36-0 1-Methyl-4-(piperidin-4-yl)piperazine 795707, apiperidines compound, is more and more widely used in various fields.

53617-36-0, 1-Methyl-4-(piperidin-4-yl)piperazine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2g) (R)-1-(4-amino-3-methyl-5-nitro-benzyl)-2-[4-(4-methyl-piperazin-1-yl)-piperidin-1-yl]-2-oxo-ethyl 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylate A solution of 780 mg (1.5 mmol) (R)-2-(4-amino-3-methyl-5-nitro-phenyl)-1-carboxy-ethyl 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylate, 520 mg (1.6 mmol) TBTU, 350 muL (2.1 mmol) ethyldiisopropylamine in 30 mL THF and 5 mL DMF was stirred for 1 h at RT, then combined with 300 mg (1.6 mmol) 1-methyl-4-piperidin-4-yl-piperazine and stirred for 4 h at RT. The reaction solution was combined with 100 mL semisaturated NaHCO3 solution and extracted twice with 50 mL EtOAc. The organic phases were dried over Na2SO4, filtered and evaporated down i.vac. The residue was dissolved in a little DCM, combined with diethyl ether, the precipitate was suction filtered and dried. Yield: 1.0 g (97percent of theory) ESI-MS: (M+H)+=677 Rf=0.46 (Polygram-Alox, DCM/MeOH 25:1)

53617-36-0, 53617-36-0 1-Methyl-4-(piperidin-4-yl)piperazine 795707, apiperidines compound, is more and more widely used in various fields.

Reference:
Patent; Boehringer Ingelheim International GmbH; US2005/256099; (2005); A1;,
Piperidine – Wikipedia
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Analyzing the synthesis route of 1187173-43-8

As the paragraph descriping shows that 1187173-43-8 is playing an increasingly important role.

1187173-43-8, 2,7-Diazaspiro[4.5]decan-1-one hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2,7-Diazaspiro[4.5]decan-1 -one (150 mg, 0.973 mmol) was dissolved in a mixture of triethylamine (0.542 mL, 3.89 mmol) and dichloromethane (10 mL), and 3-chloro-4- [(trifluoromethyl)oxy]benzenesulfonyl chloride (344 mg, 1.167 mmol) was added. After 16 h the reaction mixture was concentrated in vacuo and the resulting residue was purified by silica column chromatography on SP4 (gradient elution: 0 – 20% MeOH – DCM) to give 7-({3-chloro-4-[(trifluoromethyl)oxy]phenyl}sulfonyl)-2,7- diazaspiro[4.5]decan-1 -one (350 mg, 0.839 mmol, 86% yield) as a white solid. 1 H NMR (400 MHz, DMSO-d6) delta ppm 1 .37 – 1.49 (m, 2 H) 1.49 – 1.65 (m, 1 H) 1.65 – 1 .76 (m, 1 H) 1.88 – 2.08 (m, 2 H) 2.27 – 2.40 (m, 2 H) 3.19 (t, J=6.63 Hz, 2 H) 3.36 (d, J=1 1 .51 Hz, 1 H) 3.64 (d, J=1 1 .62 Hz, 1 H) 7.77 (s, 1 H) 7.80 – 7.87 (m, 2 H) 8.06 (dd, J=1.59, 0.82 Hz, 1 H). MS ES+ve m/z 413 (M+H)., 1187173-43-8

As the paragraph descriping shows that 1187173-43-8 is playing an increasingly important role.

Reference:
Patent; CONVERGENCE PHARMACEUTICALS LIMITED; GLEAVE, Robert James; HACHISU, Shuji; PAGE, Lee William; BESWICK, Paul John; WO2011/141728; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

Downstream synthetic route of 3612-20-2

3612-20-2, 3612-20-2 1-Benzylpiperidin-4-one 19220, apiperidines compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3612-20-2,1-Benzylpiperidin-4-one,as a common compound, the synthetic route is as follows.

Step 1 A mixture of 1-benzyl-4-piperidone (XXV, Chart G, 24.5 mL, 0.1295 mol), N-methylamine hydrochloride (44.75 g, 0.6628 mol) and methanol (50 ml) is stirred for 35 minutes at 20-25, at which time additional methanol (10 ml) is added. The mixture is then cooled in an ice bath and a solution of sodium cyanoborohydride (9.1749 g, 0.1460 mol) in methanol (68 ml) is added to the mixture. The mixture is stirred for 5 min and then is allowed to warm to 20-25. After 1.25 hr the mixture is concentrated under reduced pressure and saturated aqueous sodium bicarbonate is added. After stirring for 1 hr, the mixture is extracted with dichloromethane and the organic phases are combined, backwashed with saline, dried with magnesium sulfate and concentrated under reduced pressure to give (XXVII). The material is upgraded by forming the dihydrochloride salt and collecting the resulting solids. The dihydrochloride salt is further upgraded by trituration with dichloromethane. The free base (XXVII) is recovered by slurrying the dihydrochloride salt (7.5204 g, 0.02713 mol) in dichloromethane and adding enough saturated sodium bicarbonate to dissolve all the solids and then extracting the aqueous layer exhaustively with dichloromethane to obtain N-(1-benzylpiperidin-4-yl)-N-methylamine (XXVII), MS (m/z) 204; IR (neat) 2942, 2796, 2775, 743 and 2749 cm-1.

3612-20-2, 3612-20-2 1-Benzylpiperidin-4-one 19220, apiperidines compound, is more and more widely used in various fields.

Reference:
Patent; Pharmacia & Upjohn Company; US5877317; (1999); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

New learning discoveries about 690261-64-4

690261-64-4 2-(Piperidin-4-yl)pyrimidine hydrochloride 56965759, apiperidines compound, is more and more widely used in various fields.

690261-64-4, 2-(Piperidin-4-yl)pyrimidine hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

690261-64-4, The hydrochloride salt of the PYRIMIDYL PIPERIDINE (Intermediate 8) (67 mg, 0.34 mmol) was combined with Intermediate 4 (100 mg, 0.28 MMOL), triethylamine (46 P. L, 0.35 MMOL), and 4 A powdered molecular sieves (100 mg) in DCM. After 15 minutes at room temperature, sodium triacetoxyborohydride (240 mg, 1.13 mmol) was added and the resulting mixture was stirred for 3 days before being filtered through celite, diluted with DCM and washed with saturated sodium bicarbonate and brine. The organic layer was dried over MGS04, filtered and concentrated under reduced pressure to give a crude oil that was purified by preparative TLC (silica gel, 0.3 % NH40H/2. 7 % MeOH/97 % DCM) to give 110 mg of a colorless oil. Resolution of the individual diastereomers was accomplished by HPLC using a ChiralPak AD column eluting with 30 % isopropanol/hexanes to give 2 single diastereomers and a single mixture of the 2 other diastereomers. First peak 10 mg: ESI-MS calc. for C28H35F3N40: 500.28 ; found 504 (M+H). Second peak 11 mg: ESI-MS calc. for C28H35F3N40: 500.28 ; found 504 (M+H). Third peak 7.0 mg ESI-MS calc. for C28H35F3N40: 500.28 ; found 504 (M+H).

690261-64-4 2-(Piperidin-4-yl)pyrimidine hydrochloride 56965759, apiperidines compound, is more and more widely used in various fields.

Reference:
Patent; MERCK & CO., INC.; MERCK SHARP & DOHME LIMITED; WO2004/94371; (2004); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

Brief introduction of 1187173-43-8

As the paragraph descriping shows that 1187173-43-8 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1187173-43-8,2,7-Diazaspiro[4.5]decan-1-one hydrochloride,as a common compound, the synthetic route is as follows.,1187173-43-8

2,7-Diazaspiro[4.5]decan-1 -one hydrogen chloride (80 mg, 0.420 mmol) was dissolved in dichloromethane (4 mL) and triethylamine (0.1 17 ml_, 0.839 mmol) before the addition of 3,5-bis(trifluoromethyl)benzenesulfonyl chloride (144 mg, 0.462 mmol). After stirring for 20 h the reaction mixture was concentrated in vacuo and the resulting residue was purified by MDAP to give 7-{[3,5-bis(trifluoromethyl)phenyl]- sulfonyl}-2,7-diazaspiro[4.5]decan-1 -one (14 mg, 0.032 mmol, 8% yield) as a white solid. 1 H NMR (400 MHz, DMSO-d6) delta ppm 1 .32 – 1 .63 (m, 3 H) 1.66 – 1 .76 (m, 1 H) 1 .87 – 1 .97 (m, 1 H) 2.00 – 2.08 (m, 1 H) 2.35 – 2.47 (m, 2 H) 3.15 – 3.24 (m, 2 H) 3.47 (d, J=1 1 .45 Hz, 1 H) 3.71 (d, J=1 1 .67 Hz, 1 H) 7.75 (s, 1 H) 8.32 (s, 2 H) 8.55 (s, 1 H). MS ES+ve m/z 431 (M+H).

As the paragraph descriping shows that 1187173-43-8 is playing an increasingly important role.

Reference:
Patent; CONVERGENCE PHARMACEUTICALS LIMITED; GLEAVE, Robert James; HACHISU, Shuji; PAGE, Lee William; BESWICK, Paul John; WO2011/141728; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

Downstream synthetic route of 768-66-1

As the paragraph descriping shows that 768-66-1 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.768-66-1,2,2,6,6-Tetramethylpiperidine,as a common compound, the synthetic route is as follows.,768-66-1

A solution of2,2,6,6-tetramethylpiperidine (1.6 mL, 9.6 mmol) in THF (10 mL) was treated withn-BuLi (6.0 mL, 1.60 M in hexane, 9.6 mmol) at 0 C. After stirring for 1 h at 0 C thesolution was added to a solution of compound 3 (1.81 g, 4.00 mmol) in THF (8 mL) at-78 C. After stirring for 30 min at -78 C and 3 h at -30 C the reaction mixture wastransferred to a suspension of ZnCl2 (1.09 g, 8.00 mmol) in THF (8 mL) at -78 C.Stirring was continued at -78 C for 30 min before the mixture was warmed to roomtemperature, where stirring was maintained for 30 min. To the resulting solution wasadded a solution of 1-bromo-3,5-di-t-butylbenzene (1.18 g, 4.40 mmol) and [Pd(PPh3)4](0.23 g, 0.20 mmol) in THF (8 mL). The reaction mixture was heated to 60 C for 10hours, before the reaction was quenched with a saturated aqueous ammonium chloride solution. The reaction mixture was extracted with hexane and the combined organicphases were washed with water and dried over MgSO4. After filtration, the filtrate wasevaporated to dryness under reduced pressure and the obtained residue was purified bycolumn chromatography on silica gel (hexane). Washing the resulting solid with smallamount of methanol to give compound 4 (1.99 g, 3.10 mmol, 78%). 4: orange solid, m.p.139-141 C. 1H NMR (300 MHz, CDCl3) delta 1.39 (s, 36H), 4.14 (s, 5H), 4.59 (s, 2H),7.35 (t, J = 1.8 Hz, 1H), 7.62 (d, J = 1.8 Hz, 2H); 13C NMR (75 MHz, CDCl3) delta 31.5 (q),34.9 (s), 67.0 (d), 73.5 (d), 79.7 (s), 88.6 (s), 120.9 (d), 124.4 (d), 135.5 (s), 149.8 (s).Anal. Calcd for C38H49BrFe: C, 71.14; H, 7.70%. Found: C, 71.30; H, 7.66%.

As the paragraph descriping shows that 768-66-1 is playing an increasingly important role.

Reference:
Article; Sasamori, Takahiro; Suzuki, Yuko; Sakagami, Michiyasu; Miyake, Hideaki; Tokitoh, Norihiro; Chemistry Letters; vol. 43; 9; (2014); p. 1464 – 1466;,
Piperidine – Wikipedia
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New learning discoveries about 768-66-1

As the paragraph descriping shows that 768-66-1 is playing an increasingly important role.

768-66-1, 2,2,6,6-Tetramethylpiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,768-66-1

In a 300 ml flask purged with nitrogen, 7.88 g (55.8 mmol) of 2,2,6,6-tetramethylpiperidine, 2.77 g of lithium chloride (65.3 mmol: 2,2,6,6-tetramethylpiperidine To 1.17 equivalents) THF was added, 24.2 g (58.2 mmol) of a 15% n-butyllithium hexane solution was dropped at -10 C. to obtain lithium 2,2,6,6-tetramethyl Piperidide solution was prepared. After cooling this solution to -50 C., 10.93 g (58.2 mmol) of triisopropoxyborane was added dropwise, followed by dropwise addition of 4.98 g (48.3 mmol) of benzonitrile, followed by aging at the same temperature for 3 hours did. Analysis of the reaction liquid by HPLC revealed that the area% of 2-cyanophenylboronic acid was 98.6%, the area% was 1.38%, 1-phenyl-1- (2,2,6,6-tetramethylpiperidine -1-yl) methyl imine as by-product was confirmed. This reaction solution was added to 38 ml of 3N HCl and hydrolyzed. 150 ml of ethyl acetate was added and stirred, The acid phase was separated. The organic phase was washed with 50 ml of 0.2 N HCl and the resultant organic phase solution was subjected to quantitative determination of 2-cyanophenylboronic acid using HPLC. As a result, 2-cyanophenylboronic acid was obtained in a yield of 95.0 % Confirmed that it was obtained. Further, it contained 0.45% of 1-phenyl- (2,2,6,6-tetramethylpiperidin-1-yl) methylimine in area%.

As the paragraph descriping shows that 768-66-1 is playing an increasingly important role.

Reference:
Patent; TOSOH FINECHEM CORPORATION; HATTORI, YU; KANEKO, TOSHIYUKI; (13 pag.)JP2015/160823; (2015); A;,
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Piperidine | C5H11N – PubChem

 

New learning discoveries about 4801-58-5

4801-58-5, As the paragraph descriping shows that 4801-58-5 is playing an increasingly important role.

4801-58-5, Piperidin-1-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

PREPARATION 16 (3R,S)-Hydroxy-1-(3-methoxyphenethyl)piperidine This was prepared as described in Preparation 15 from (3R,S)-hydroxypiperidine and 3-methoxyphenethyl bromide. The title compound was obtained as a pale yellow oil (1.63 g, 72%) which was characterised by its 1 H-n.m.r. spectrum; (CDCl3): delta=7.21 (1H, dd, J=8 and 7 Hz); 6.72-6.83 (3H, m); 3.78-3.88 (1H, m); 3.81 (3H, s); 2.30-2.84 (9H, m) and 1.47-1.90 (4H, m).

4801-58-5, As the paragraph descriping shows that 4801-58-5 is playing an increasingly important role.

Reference:
Patent; Pfizer Inc.; US5089505; (1992); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

New learning discoveries about 1445-73-4

The synthetic route of 1445-73-4 has been constantly updated, and we look forward to future research findings.

1445-73-4, 1-Methyl-4-piperidone is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a typical experiment, complex 1 (6.1 mg, 10 tmol) and H[BAr?4].(Et2O)2 (10.1 mg, 10 tmol) were dissolved in THF (2.0 mE) in a 100 mE thick-walled glass vessel equipped with a TEFLON stopcock and a stir bar. The substrate (0.5 mmol) to be hydrogenated was then added. The vessel was degassed by freeze-pump-thaw and then hydrogen (1 or 4 atm) was added. The resulting solution was stirred at the desired temperature (25-60 C.) for the indicated reaction time. At the end of the reaction, the solvent was evaporated and the residue was passed through silica gel in a pipette. The solvent was removed under vacuum and the ?H NMR spectrum of the crude product mixture was recorded in CDC13. Hydrogenation products were then isolated by column chromatography or preparative thin layer chromatography (?TLC?) using n-hexane/ethyl acetate (3:1, v/v) as an eluent. Isolated products were characterized by ?H NMR and GCMS, with spectra matching those reported in the literature or authentic samples., 1445-73-4

The synthetic route of 1445-73-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LOS ALAMOS NATIONAL SECURITY, LLC; Vasudevan, Kalyan V.; Zhang, Guoqi; Hanson, Susan K.; US2015/336862; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

New learning discoveries about 5166-67-6

5166-67-6 Ethyl N-methylpiperidine-3-carboxylate 97981, apiperidines compound, is more and more widely used in various fields.

5166-67-6,5166-67-6, Ethyl N-methylpiperidine-3-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 9 Reduction of Ethyl 1-methylnipecotate To a cooled solution of filtered or unfiltered LiAlH4 (2 mole) under argon was added ethyl 1-methylnipecotate (1 mole) in THF. After addition was complete, reaction was heated to 40 to 50 C. for 2 hr and then stirred overnight at room temperature. The reaction was quenched by adding H2O, and aqueous NaOH using cooling as required. The solution was then filtered and solids were washed with fresh THF. Yields were determined by GC analysis of crude filtered reaction solutions using nonane as an internal standard. Essentially no difference in yields was observed with filtered or unfiltered LiAlH4 solutions.

5166-67-6 Ethyl N-methylpiperidine-3-carboxylate 97981, apiperidines compound, is more and more widely used in various fields.

Reference:
Patent; FMC Corporation; US6444190; (2002); B2;; ; Patent; PAUTARD-COOPER, ANNE; ENGEL, JOHN F.; GRANGER, ERIC J.; SIMS, PHILIP F.; SCHWINDEMAN, JAMES A.; RATHMAN, TERRY L.; US2001/51729; (2001); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem