Tag: M.W:100-200

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， Computed Properties of C7H15Cl2N, Which mentioned a new discovery about 2008-75-5

Four novel 4-(1H-imidazo[4,5-f]-1,10-phenanthrolin-2-yl)phenol derivatives 1-4 have been synthesized, and their G-quadruplex DNA-binding interactions, telomerase inhibition, antiproliferative activity, cell cycle arrest, and apoptotic induction were studied. All compounds show the preferential h-telo, c-myc, and c-kit2 G-quadruplex binding affinity and the G-quadruplex versus duplex selectivity. In the case of the same G-quadruplex target, the compound 1 exhibits better stabilization effect (DeltaTm) than the other three compounds and also gives 80.2% inhibition of telomerase activity at 7.5 muM. All compounds can promote selectively the formation of parallel G-quadruplex structure of both c-myc and c-kit2 without addition of any cations. Four compounds display the cytotoxicity activities against HeLa and HepG2 cells by MTT assay with IC50 values of about 10-6 and 10 -5 M, respectively, and cause a substantial decrease in the G 2/M-phase cell population and a significant increase in the number of apoptotic cells.

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, Computed Properties of C7H15Cl2N, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 2008-75-5

Reference：
Piperidine – Wikipedia,
Piperidine | C5H11283N – PubChem

Synthetic Route of 111153-74-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.111153-74-3, Name is 1-Phenylpiperidine-4-carbaldehyde, molecular formula is C12H15NO. In a Article，once mentioned of 111153-74-3

2-{4-[(7-Chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid (XK469) is among the most highly and broadly active antitumor agents to have been evaluated in our laboratories and is currently scheduled to enter clinical trials in 2001. The mechanism or mechanisms of action of XK469 remain to be elaborated. Accordingly, an effort was initiated to establish a pharmacophore hypothesis to delineate the requirements of the active site, via a comprehensive program of synthesis of analogues of XK469 and evaluation of the effects of structural modification(s) on solid tumor activity. The strategy formulated chose to dissect the two-dimensional parent structure into three regions – I, ring A of quinoxaline; II, the hydroquinone connector linkage; and III, the lactic acid moiety – to determine the resultant in vitro and in vivo effects of chemical alterations in each region. Neither the A-ring unsubstituted nor the B-ring 3-chloro-regioisomer of XK469 showed antitumor activity. The modulating antitumor effect(s) of substituents of differing electronegativities, located at the several sites comprising the A-ring of region I, were next ascertained. Thus, a halogen substituent, located at the 7-position of a 2-{4-[(2-quinoxalinyl)oxy]phenoxy}propionic acid, generated the most highly and broadly active antitumor agents. A methyl, methoxy, or an azido substituent at this site generated a much less active structure, whereas 5-, 6-, 8-chloro-, 6-, 7-nitro, and 7-amino derivatives all proved to be essentially inactive. When the connector linkage (region II) of 1 was changed from that of a hydroquinone to either a resorcinol or a catechol derivative, all antitumor activity was lost. Of the carboxylic acid derivatives of XK469 (region III), i.e., CONH2, CONHCH3, CON(CH3)2, CONHOH, CONHNH2, CN, or CN4H (tetrazole), only the monomethyl- and N,N-dimethylamides proved to be active.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 111153-74-3

Reference：
Piperidine – Wikipedia,
Piperidine | C5H11801N – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Recommanded Product: 39546-32-2, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 39546-32-2, Name is Piperidine-4-carboxamide, molecular formula is C6H12N2O. In a Article, authors is Cen, Xiaobo，once mentioned of 39546-32-2

A series of novel tetrahydropyridine derivatives were prepared and evaluated using cell-based measurements. Systematic optimization of general structure G-1 led to the identification of compound 35 (EC50 = 4.9 nM) and 37 (EC50 = 8.8 nM) with high GPR119 agonism activity and moderate clog P. Through single and long-term pharmacodynamic experiments, we found that compound 35 showed a hypoglycemic effect and may have an effect on improving basal metabolic rate in DIO mice. Both in vitro and in vivo tests indicated that compound 35 was a potential potent GPR119 agonist in allusion to T2DM treatment.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H3613N – PubChem

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 3040-44-6, name is 1-(2-Hydroxyethyl)piperidine, introducing its new discovery. name: 1-(2-Hydroxyethyl)piperidine

The improved synthesis of 1H-imidazo[1,2-b]pyrazole 1 and of mono- and disubstituted derivatives is described and representative experimental procedures are given. Namely, 2-, 3-, 7- and 6-monosubstituted (2-15k), 2,3- and 6,7-disubstituted (16,17) compounds are prepared and characterized.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 3040-44-6 is helpful to your research. name: 1-(2-Hydroxyethyl)piperidine

Reference：
Piperidine – Wikipedia,
Piperidine | C5H5245N – PubChem

Related Products of 2008-75-5, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 2008-75-5, Name is 1-(2-Chloroethyl)piperidine hydrochloride, molecular formula is C7H15Cl2N. In a Patent，once mentioned of 2008-75-5

The present invention provides compounds useful in the synthesis of biologically active compounds, and processes for their production, the compounds having the formula: STR1 wherein: R 1 and R 2 are, independently, selected from H; C 1-C 12 alkyl or C 1-C. sub.6 perfluorinated alkyl; X represents a leaving group; A is O or S; m is an integer from 1 to 3, preferably 2; R 3, R 4, R 5, and R. sup. 6 are independently selected from H, halogen,–NO. sub.2, alkyl, alkoxy, C 1-C 6 perfluorinated alkyl, OH or the C. sub.1-C 4 esters or alkyl ethers thereof,–CN,–O–R 1,–O–Ar,–S–R. sup.1,–S–Ar,–SO–R 1,–SO–Ar,–SO 2–R 1,–SO. sub. 2–Ar,–CO–R 1,–CO–Ar,–CO 2–R 1, or–CO 2–Ar; and Y is selected from a) the moiety: STR2 wherein R. sub.7 and R 8 are independently selected from the group of H, C 1-C. sub.6 alkyl, or phenyl; or b) an optionally substituted five-, six-or seven-membered saturated, unsaturated or partially unsaturated heterocycle or bicyclic heterocycle containing up to two heteroatoms selected from the group consisting of–O–,–NH–,–N(C 1 C 4 alkyl)–,–N=, and–S(O). sub.n–.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Related Products of 2008-75-5, you can also check out more blogs about2008-75-5

Reference：
Piperidine – Wikipedia,
Piperidine | C5H11076N – PubChem

Application of 308087-58-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.308087-58-3, Name is 1-(4-Methylenepiperidin-1-yl)ethanone, molecular formula is C8H13NO. In a Article，once mentioned of 308087-58-3

Cross-coupling of alkyl halides with alkyl Grignard reagents proceeds with extremely high TONs of up to 1230000 using a Cu/unsaturated hydrocarbon catalytic system. Alkyl fluorides, chlorides, bromides, and tosylates are all suitable electrophiles, and a TOF as high as 31200 h-1 was attained using an alkyl iodide. Side reactions of this catalytic system, i.e., reduction, dehydrohalogenation (elimination), and the homocoupling of alkyl halides, occur in the absence of additives. It appears that the reaction involves the beta-hydrogen elimination of alkylcopper intermediates, giving rise to olefins and Cu-H species, and that this process triggers both side reactions and the degradation of the Cu catalyst. The formed Cu-H promotes the reduction of alkyl halides to give alkanes and Cu-X or the generation of Cu(0), probably by disproportionation, which can oxidatively add to alkyl halides to yield olefins and, in some cases, homocoupling products. Unsaturated hydrocarbon additives such as 1,3-butadiene and phenylpropyne play important roles in achieving highly efficient cross-coupling by suppressing beta-hydrogen elimination, which inhibits both the degradation of the Cu catalyst and undesirable side reactions.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H6452N – PubChem

Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 73415-84-6, molcular formula is C7H14ClNO2, introducing its new discovery. Recommanded Product: 2-(Piperidin-4yl)acetic acid hydrochloride

The present invention relates to hydroxyindalpine derivatives of formula (I) as defined herein and pharmaceutical compositions comprising these compounds, as well as their medical use, particularly in the treatment or prevention of gastrointestinal diseases/disorders, such as constipation and functional dyspepsia.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H10874N – PubChem

Synthetic Route of 27578-60-5, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.27578-60-5, Name is N-(2-Aminoethyl)piperidine, molecular formula is C7H16N2. In a article，once mentioned of 27578-60-5

The present invention relates to compounds of general formula (I), in which X1, X2, R1, R2, R4, R5, R7, and R8 are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H4201N – PubChem

Reference of 22990-77-8, In heterogeneous catalysis, the catalyst is in a different phase from the reactants. At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 22990-77-8, name is 2-Piperidylmethylamine. In an article，Which mentioned a new discovery about 22990-77-8

The complex trans,cis-[RuCl2(PPh3)2(ampi)] (2) was prepared by reaction of RuCl2(PPh3)3 with 2-aminomethylpiperidine(ampi) (1). [RuCl2(PPh 2(CH2)nPPh2)(ampi) (n = 3, 4, 5)] (3-5) were synthesized by displacement of two PPh3 with chelating phosphine ligands. All complexes (2-5) were characterized by 1 H, 13C, 31P NMR, IR and UV-visible spectroscopy and elemental analysis. They were found to be efficient catalysts for transfer hydrogen reactions. Copyright

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.22990-77-8. In my other articles, you can also check out more blogs about 22990-77-8

Reference：
Piperidine – Wikipedia,
Piperidine | C5H2166N – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Application In Synthesis of N-(2-Aminoethyl)piperidine, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 27578-60-5, Name is N-(2-Aminoethyl)piperidine, molecular formula is C7H16N2. In a Patent, authors is ，once mentioned of 27578-60-5

Novel pyrrolidine, piperidine and homopiperidinecarboxamide and thiocarboxamide compounds having the formula: STR1 wherein X is –S–, –S(O)– or –S(O)2 –; A is a loweralkalene chain and A1 and A2 are alkalene chains when p and d are one; R, R1 and R2 are hydrogen, loweralkyl, phenyl cycloalkyl or phenylalkyl and R1 and R2 may form a heterocyclic residue with the adjacent nitrogen atom; Q is a selected aromatic radical, and the pharmaceutically acceptable acid addition salts useful as cardiac antiarrhythmia agents are disclosed. Novel chemical intermediates, unsubstituted on pyrrolidine, piperidine and homopiperidine nitrogen but with –(A2)p –X–(A2)d –Q side chain are also disclosed.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 27578-60-5, help many people in the next few years.Application In Synthesis of N-(2-Aminoethyl)piperidine

Reference：
Piperidine – Wikipedia,
Piperidine | C5H4448N – PubChem