Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.71985-80-3,1-Methylpiperidine-4-carboxylic acid hydrochloride,as a common compound, the synthetic route is as follows.

Example A10; N-[[3-(4-amino-1-methyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-7-yl)phenyl]methyl]-1-methyl-4-piperidinecarboxamide; A mixture of A9.3 (13 mg; 0.03 mmol), 1-methylpiperidine-4-carboxylic acid hydrochloride salt (8 mg; 0.04 mmol), EDC (12 mg; 0.06 mmol), 1-hydroxybenztriazole (6 mg; 0.04 mmol) and diisopropylethylamine (0.028 ml; 0.15 mmol) in MDF (0.5 ml) was heated to 60 C. for 0.5 hrs. After the volatiles were removed in vacuo, the residue was dissolved in a small volume of TFA and heated to 60 C. for 2 hrs. After removing the volatiles in vacuo, the residue was purified by preparative HPLC to afford 15 mg (94%) of A10 as a light yellow solid. 1H-NMR (DMSO-d6) delta: 8.74 (2H, brs), 8.64 (1H, t, J=5.5 Hz), 8.48 (1H, s), 7.77 (1H, s), 7.73 (1H, d, J=8 Hz), 7.68 (1H, s), 7.50 (1H, t, J=7.5 Hz), 7.33 (1H, d, J=8 Hz), 4.37 (2H, d, J=5.5 Hz), 4.04 (1H, s), 3.47 (2H, m) 2.97 (2H, m), 2.78 (4H, m), 1.95 (2H, m), 1.80 (2H, m). HPLC (A): 99%, ret. time 1.10 min., LC/MS (M+H)+=435.32.

71985-80-3, As the paragraph descriping shows that 71985-80-3 is playing an increasingly important role.

Reference：
Patent; Pitts, William J.; Das, Jagabandhu; Qiu, Yuping; Spergel, Steven H.; US2006/178393; (2006); A1;,
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Piperidine | C5H11N – PubChem

25137-01-3, (R)-Ethyl piperidine-3-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The mixture of ethyl (3R)-piperidine-3-carboxylate (200 mg. 1.27 mmole), benzenesulfonyl chloride (162 muL, 1.27 mmol), and triethylamine (266 muL, 1.91 mmole) in acetonitrile (2.0 mL) was stirred at r.t. for 2 hours. The reaction was quenched with water, extracted with ethyl acetate. The extract was washed with 1N HCl solution, water, brine; dried over Na2SO4. After removal of drying agent, the solution was concentrated to give a residue which was used directly in the next step.

25137-01-3, As the paragraph descriping shows that 25137-01-3 is playing an increasingly important role.

Reference：
Patent; Yao, Wenqing; Li, Yanlong; Xu, Meizhong; Zhuo, Jincong; Zhang, Colin; Metcalf, Brian W.; US2005/288317; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

10338-57-5, 4-(Piperidin-1-yl)benzaldehyde is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Appropriate benzaldehyde (10 mmol) was dissolved in ethanol (20mL). Sodium metabisulfite (15 mmol) in 5mL water was added in portion over 5 min. The reaction mixture was stirred at room temperature for 1h and subsequently stirred at 4 C overnight. The precipitate formed was filtered and dried to afford sodium bisulfite adducts (85-98%)., 10338-57-5

10338-57-5 4-(Piperidin-1-yl)benzaldehyde 291354, apiperidines compound, is more and more widely used in various fields.

Reference：
Article; Yoon, Yeong Keng; Ali, Mohamed Ashraf; Wei, Ang Chee; Choon, Tan Soo; Osman, Hasnah; Parang, Keykavous; Shirazi, Amir Nasrolahi; Bioorganic and Medicinal Chemistry; vol. 22; 2; (2014); p. 703 – 710;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.71985-80-3,1-Methylpiperidine-4-carboxylic acid hydrochloride,as a common compound, the synthetic route is as follows.

71985-80-3, Example 8; Synthesis of 2-(benzhvdryl(methylamino)-l-(4-((l-methylpiperidin-4- yl)(phenyl)methyl)piperazin-l-yl)ethanone (compound no. 14); A. Synthesis of (l-methylpiperidin-4-yl)(phenyl)methanone[0096] l-Methylpiperidine-4-carboxylic acid hydrochloride salt 10 g (55.7mmol) was added to thionyl chloride (25 ml) and stirred at room temperature until the solid dissolved completely. The reaction mixture was stirred for another 20 minutes and concentrated. The product was used for the next step without further purification.[0097] To a cooled suspension of anhydrous aluminum chloride (20 g, 75 mmol) in benzene 30 ml at 00C was added l-methylpiperidine-4-carboxylic acid chloride in small portions and the resulting mixture was refluxed for 3 hours. The reaction mixture was then cooled down by adding to ice water. The organic phase was discarded. The aqueous solution was washed with 2×50 ml ethyl ether, basified with potassium hydroxide pellet slowly to pH >10 and extracted with ethyl ether 4×50 ml. The combined ethereal solution was dried over sodium sulfate and concentrated to give 9.5 g of desired product in 84% yield.

The synthetic route of 71985-80-3 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; NEUROMED PHARMACEUTICALS LTD.; WO2007/71035; (2007); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

1187173-43-8, 2,7-Diazaspiro[4.5]decan-1-one hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation 44: tert-butyl 1-oxo-2,7-diazaspiro[4,5]decane-7-carboxylate (P44)2,7-diazaspiro[4.5]decan-l-one hydrochloride (600 mg, 3.15 mmol), was dissolved in 30 m L of DCM. To this solution, TEA (1.98 mL, 14.18 mmol) and Boc20 (895 mg, 4.10 mmol) were added and the reaction mixture was stirred at RT for 4 hrs. Water was added and the two layers were separated; the organic layer was washed with NH4CI, dried and evaporated to obtain ferf-butyl l-oxo-2,7- diazaspiro[4.5]decane-7-carboxylate (p44, 830 mg, y= quant.), colourless oil.MS (ES) (m/z): 255.2 [M+H]+., 1187173-43-8

The synthetic route of 1187173-43-8 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; SHIRE INTERNATIONAL GMBH; SEMERARO, Teresa; TARSI, Luca; MICHELI, Fabrizio; LUKER, Tim; CREMONESI, Susanna; (122 pag.)WO2016/42451; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

10338-57-5, 4-(Piperidin-1-yl)benzaldehyde is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Appropriate 2-((5-substitutedbenzothiazol-2-yl)thio) acetohydrazide (3a-3b) (0.002 mol), 4-substitutedbenzaldehyde (0.002 mol) and glacial acetic acid (0.1 mL) were refluxed in EtOH for 2 h. The mixture was cooled down in an ice-bath, precipitated product was filtered, dried and recrystallized from EtOH., 10338-57-5

The synthetic route of 10338-57-5 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Osmaniye, Derya; Levent, Serkan; Karaduman, Abdullah Burak; Ilg?n, Sinem; Zkay, Yusuf; Kaplancikli, Zafer Asim; Molecules; vol. 23; 5; (2018);,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13096-31-6,5-Hydroxypiperidine-2-carboxylic acid,as a common compound, the synthetic route is as follows.,13096-31-6

To a mixture of 413 5-hydroxypiperidine-2-carboxylic acid (62 g, 427.13 mmol, 1 eq.) and Boc2O (102.54 g, 469.84 mmol, 107.94 mL, 1.1 eq.) in 46 dioxane (500 mL) was added 358 NaOH (34.17 g, 854.25 mmol, 2 eq.) and the mixture was stirred at 25 C. for 18 hrs. The mixture was then concentrated to remove dioxane and the pH was adjusted to 2-3 by addition of 1N HCl solution. The aqueous phase was extracted with 2-Me-THF (500 mL*3). The combined organic layers was dried over Na2SO4, filtered and concentrated to give 415 1-tert-butoxycarbonyl-5-hydroxy-piperidine-2-carboxylic acid (40 g, crude) as yellow oil. ESI [M+Na]=267.9

As the paragraph descriping shows that 13096-31-6 is playing an increasingly important role.

Reference：
Patent; Cyteir Therapeutics, Inc.; Castro, Alfredo C.; McComas, Casey Cameron; Vacca, Joseph; Maclay, Tyler; (132 pag.)US2019/77799; (2019); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10338-57-5,4-(Piperidin-1-yl)benzaldehyde,as a common compound, the synthetic route is as follows.

General procedure: Chalcones analogs were synthesized by Claisen-Schmidt condensation reaction using appropriate equimolar amounts of substituted acetophenones and benzaldehydes in MeOH. NaOH was dissolved in the least amount of water and added dropwise (3mmol) (Scheme 1). Reactions were stirred overnight. All reactions were monitored by TLC using appropriate solvent or mixture of solvents. When the reaction was complete, the obtained precipitate was filtered, washed with cold methanol and dried under vacuum. The crude products were crystallized from different solvent systems based on their solubility or purified by column chromatography to give pure crystalline compounds., 10338-57-5

The synthetic route of 10338-57-5 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Elkhalifa, Dana; Siddique, Abu Bakar; Qusa, Mohammed; Cyprian, Farhan S.; El Sayed, Khalid; Alali, Feras; Al Moustafa, Ala-Eddin; Khalil, Ashraf; European Journal of Medicinal Chemistry; vol. 187; (2020);,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10338-57-5,4-(Piperidin-1-yl)benzaldehyde,as a common compound, the synthetic route is as follows.

10338-57-5, General procedure: o-amino thiophenol (1mmol), aromatic aldehyde (1.1mmol) andwater (10mL) were mixed in 25mL single neck round bottom flask, andto this Ammonium Nickel Sulphate (10 mol %) was added. The reactionmixture was sonicated at room temperature (250C) for the appropriate time(Table 2, entries 13-25), and the progress of reaction was monitored by TLC.After completion of reaction, the mixture was extracted with ethyl acetate(2×10mL). The combined organic layer was dried over anhydrous Na2SO4 andevaporated under reduced pressure; the crude material was purified by columnchromatography over silica gel to afford products 4a-4m with high purity.

As the paragraph descriping shows that 10338-57-5 is playing an increasingly important role.

Reference：
Article; Pardeshi, Sandeep D.; Sonar, Jayant P.; Pawar, Shivaji S.; Dekhane, Deepak; Gupta, Sunil; Zine, Ashok M.; Thore, Shivaji N.; Journal of the Chilean Chemical Society; vol. 59; 1; (2014); p. 2335 – 2340;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

20691-89-8, 1-Methyl-4-piperidinemethanol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 4-[(2, 4-dichloro-5-methoxyphenyl) amino3-6-ethoxy-7-fluoro-3- quinolinecarbonitrile (200 mg, 0.49 mmol), 1-methylpiperidine-4-methanol (1888 mg, 0.98 mmol) (WO 20047212) and sodium hydride (196 mg, 4.6 mmol) in 5 mL of N, N-dimethylformamide was heated at 125C for 3 hours. The reaction mixture was poured into saturated sodium bicarbonate and stirred for 1 hour. The solid was collected by filtration, washed with water and dried in vacuo. The solid was purified by preparative thin layer chromatography, eluting with 15% methanol in dichloromethane. Trituation with diethyl ether provided 67 mg of 4-[(2,4-dichloro-5- methoxyphenyl) amino]-6-ethoxy-7- [ (1-methylpiperidin-4-yl) methoxy] quinoline-3- carbonitrile as a light brown solid, mp 182-186C. MS 513. 0 (M-H)- Analysis for C2gH28CI2N403-1. 4 H20 Calcd : C, 57.76 ; H, 5.74 ; N, 10.36. Found: C, 57.65 ; H, 5.43 ; N, 10.15., 20691-89-8

As the paragraph descriping shows that 20691-89-8 is playing an increasingly important role.

Reference：
Patent; WYETH; WO2005/47259; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem