Tag: M.W:100-200

Lai, Zeng-Wei; Li, Chunhong; Liu, Jun; Kong, Lingyi; Wen, Xiaoan; Sun, Hongbin published an article about the compound: (S)-Piperidin-3-amine dihydrochloride( cas:334618-07-4,SMILESS:Cl.Cl.N[C@H]1CCCNC1 ).COA of Formula: C5H14Cl2N2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:334618-07-4) through the article.

Highly potent DPP-4 inhibitors have been identified by hybrid compound design based on linagliptin and alogliptin. The most promising compound I (IC50 = 0.31 nM) exhibited 8.5-fold and 2.5-fold more potent activity than that of alogliptin (IC50 = 2.63 nM) and linagliptin (IC50 = 0.77 nM), resp. Compound I had a good inhibition selectivity for DPP-4 over DPP-8/9 and thus was selected for further biol. evaluation, including oral glucose tolerance, plasma DPP-4 inhibitory activity, pharmacokinetic profile, acute toxicity and hERG inhibition. The assay results showed that I displayed significant in vivo glucose-lowering effect and low risk of toxicity. Further studies are expected to confirm I as a potential drug candidate for the treatment of type 2 diabetes.

From this literature《Discovery of highly potent DPP-4 inhibitors by hybrid compound design based on linagliptin and alogliptin》,we know some information about this compound(334618-07-4)COA of Formula: C5H14Cl2N2, but this is not all information, there are many literatures related to this compound(334618-07-4).

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Related Products of 23794-15-2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1-(2-chloropyridine-4-yl)ethanone, is researched, Molecular C7H6ClNO, CAS is 23794-15-2, about Visible-Light Photocatalytic Difluoroalkylation-Induced 1, 2-Heteroarene Migration of Allylic Alcohols in Batch and Flow. Author is Wei, Xiao-Jing; Noel, Timothy.

A convenient method for the preparation of sp3-rich heterocycles is reported. The method comprises a photocatalytic difluoroalkylation-induced 1,2-heteroarene migration of allylic alcs. Here we describe for the first time the benefits of using flow to facilitate such migration reactions, including shorter reaction times, higher selectivities, and opportunities to scale the chem.

From this literature《Visible-Light Photocatalytic Difluoroalkylation-Induced 1, 2-Heteroarene Migration of Allylic Alcohols in Batch and Flow》,we know some information about this compound(23794-15-2)Related Products of 23794-15-2, but this is not all information, there are many literatures related to this compound(23794-15-2).

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Centimeter-Sized Single Crystals of Two-Dimensional Hybrid Iodide Double Perovskite (4,4-Difluoropiperidinium)4AgBiI8 for High-Temperature Ferroelectricity and Efficient X-Ray Detection, published in 2021-03-29, which mentions a compound: 144230-52-4, Name is 4,4-Difluoropiperidine hydrochloride, Molecular C5H10ClF2N, Related Products of 144230-52-4.

Ferroelectricity and X-ray detection property have been recently implemented for the first time in hybrid bromide double perovskites. It sheds a light on achieving photosensitive and ferroelec. multifunctional materials based on 2D lead-free hybrid halide double perovskites. However, the low Tc, small Ps, and relatively low X-ray sensitivity in the reported bromide double perovskites hinder practical applications. Herein, the authors demonstrate a novel 2D lead-free iodide double perovskite (4,4-difluoropiperidinium)4AgBiI8 (1) for high-performance X-ray sensitive ferroelec. devices. Centimeter-sized single crystal of 1 is obtained and exhibits an excellent ferroelectricity including a high Tc up to 422 K and a large Ps of 10.5 μC cm-2. Moreover, due to a large X-ray attenuation and efficient charge carrier mobility (μ)-charge carrier lifetime (τ) product, the crystal 1 also exhibits promising X-ray response with a high sensitivity up to 188 μC·Gyair-1 cm-2 and a detection limit below 3.13 μGyair·s-1. Therefore, this finding is a step further toward practical applications of lead-free halide perovskite in high-performance photoelectronic devices. It will afford a promising platform for exploring novel photosensitive ferroelec. multifunctional materials based on lead-free double perovskites.

If you want to learn more about this compound(4,4-Difluoropiperidine hydrochloride)Related Products of 144230-52-4, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(144230-52-4).

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

SDS of cas: 144230-52-4. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 4,4-Difluoropiperidine hydrochloride, is researched, Molecular C5H10ClF2N, CAS is 144230-52-4, about Structure-Activity Relationship Studies of Pyrimidine-4-Carboxamides as Inhibitors of N-Acylphosphatidylethanolamine Phospholipase D. Author is Mock, Elliot D.; Kotsogianni, Ioli; Driever, Wouter P. F.; Fonseca, Carmen S.; Vooijs, Jelle M.; den Dulk, Hans; van Boeckel, Constant A. A.; van der Stelt, Mario.

N-Acylphosphatidylethanolamine phospholipase D (NAPE-PLD) is regarded as the main enzyme responsible for the biosynthesis of N-acylethanolamines (NAEs), a family of bioactive lipid mediators. Previously, we reported N-(cyclopropylmethyl)-6-((S)-3-hydroxypyrrolidin-1-yl)-2-((S)-3-phenylpiperidin-1-yl)pyrimidine-4-carboxamide (1, LEI-401)(I) as the first potent and selective NAPE-PLD inhibitor that decreased NAEs in the brains of freely moving mice and modulated emotional behavior []. Here, we describe the structure-activity relationship (SAR) of a library of pyrimidine-4-carboxamides as inhibitors of NAPE-PLD that led to the identification of LEI-401. A high-throughput screening hit was modified at three different substituents to optimize its potency and lipophilicity. Conformational restriction of an N-methylphenethylamine group by replacement with an (S)-3-phenylpiperidine increased the inhibitory potency 3-fold. Exchange of a morpholine substituent for an (S)-3-hydroxypyrrolidine reduced the lipophilicity and further increased activity by 10-fold, affording LEI-401 as a nanomolar potent inhibitor with drug-like properties. LEI-401 is a suitable pharmacol. tool compound to investigate NAPE-PLD function in vitro and in vivo.

If you want to learn more about this compound(4,4-Difluoropiperidine hydrochloride)SDS of cas: 144230-52-4, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(144230-52-4).

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3612-20-2,1-Benzylpiperidin-4-one,as a common compound, the synthetic route is as follows.

Sodium hydride (4.20 g, 175.0 mmol) was suspended in THF (200 mL), and a solution of the piperidone (18.9 g, 99.9 mmol) and methyl iodide (17.9 g, 126.1 mmol) in THF (20 mL) was added dropwise at room temperature over 5 minutes. The mixture was then heated to 60 C and stirred for 5 hours. The reaction was then filtered and the filtrate concentrated. The concentrate was poured into 150 mL of water and extracted with 120 mL portions of EtOAc three times. The extract was washed with brine, dried, and concentrated. The crude product was purified by column chromatography (gradient: 12% EtOAc in hexanes to 50% EtOAc in hexanes over 1200 mL). Both mono and di methylation occurred. Separation of both isomers by chromatography was quite facile. 3.53 g of the dimethylated product (16%) was obtained. MS (EI) : m/z 218.1 (M + 1). 5.91 g (29%) of the monomethylated product was obtained. MS (EI) : m/z 204.0 (M + 1)., 3612-20-2

As the paragraph descriping shows that 3612-20-2 is playing an increasingly important role.

Reference：
Patent; WARNER-LAMBERT COMPANY LLC; WO2005/26145; (2005); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.25137-01-3,(R)-Ethyl piperidine-3-carboxylate,as a common compound, the synthetic route is as follows.

A mixture of 4-fluoro-1-naphthonitrile (300 mg), (R)-ethyl nipecotate (551 mg), potassium carbonate (485 mg), and dimethylsulfoxide (3.0 mL) was stirred at 100 C for 3 hours. After cooling to room temperature, the reactant was poured into water, and then extracted with ethyl acetate. The extracts were washed with water, dried and concentrated. The obtained residue was purified by silica gel column chromatography to obtain ethyl (3R)-1-(4-cyano-1-naphthyl)-3-piperidinecarboxylate (451 mg) (Compound 32). [?]D=-56.4 (c=0.475, MeOH).1H-NMR (200 MHz, CDCl3) ?: 1.26 (3H, t, J=7.0 Hz), 1.70-2.03 (3H, m), 2.14-2.20 (1H, m), 2.79-2.95 (2H, m), 3.07 (1H, t, J=10.6 Hz), 3.35-3.41 (1H, m), 3.57-3.62 (1H, m), 4.17 (2H, q, J=7.0 Hz), 7.06 (1H, d, J=8.2 Hz), 7.54-7.70 (2H, m), 7.84 (1H, d, J=8.2 Hz), 8.13-8.23 (2H, m). IR (KBr) 2216, 1730, 1574 cm-1, 25137-01-3

25137-01-3 (R)-Ethyl piperidine-3-carboxylate 185582, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; Takeda Pharmaceutical Company Limited; EP1553074; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.138377-80-7,3-Aminopiperidin-2-one hydrochloride,as a common compound, the synthetic route is as follows.

[Preparation Example 116] Preparation of 3-[(benzylsulfonyl)(methyl)amino]-N-((1S,2S,4R)-2-{[tert- butyl(dimethyl)silyl]oxy}-1-isobutyl-4-methyl-5-oxo-5-{[(3R or 3S)-2- OXOPIPERIDINYL] AMMO} PENTVBENZAMIDE 91 mg (0. 15 mmol) of the compound obtained in Preparation Example 58 was dissolved in 5 ml of N, N-DIMETHYLFORMAMIDE and cooled to 0°C, then 34 mg (0.225 mmol) obtained in Preparation Example 115 and 86 mg (0.225 mmol) of HATU were added thereto. 0.5 ml (excess amount) of N, N-diisopropylethylamine was then added thereto and heated to room temperature, followed by stirring for 3 hours. After removing solvent by distillation under reduced pressure, the residue was dissolved in ethyl acetate and washed with water, 0.5 N hydrochloride solution, saturated sodium bicarbonate solution and sodium chloride solution. After removing solvent by distillation under reduced pressure, the product was purified by column chromatography using a 5: 95 mixture of methanol and dichloromethane to obtain 21 mg of the title compound at 20percent yield. 1H NMR (400 MHz, CDC) ; 7.82 (1H, s), 7.59 (1H, d), 7.45-7. 33 (7H, m), 6.79 (1H, d), 6.27 (1H, d), 5.48 (1H, s), 4.50-4. 20 (4H, m), 3.80 (1H, m), 3.23 (3H, s), 3.22-3. 12 (2H, m), 2.54 (1H, m), 2.28 (1H, m), 1.97 (1H, m), 1.92-1. 48 (6H, m), 1.39 (1H, m), 1.17 (3H, d), 0.98 (3H, d), 0.97 (3H, d), 0.91 (9H, s), 0.12 (3H, s), 0.11 (3H, s), 138377-80-7

As the paragraph descriping shows that 138377-80-7 is playing an increasingly important role.

Reference：
Patent; LG Life Sciences Ltd.; ProMediTech, Inc.; WO2005/30709; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2905-56-8,1-Benzylpiperidine,as a common compound, the synthetic route is as follows.

In the reaction tube is sequentially added 1n (0.5 mmol, 88 mg), 2a (0.6 mmol, 90 mg), acetonitrile (3 ml), copper bromide (0.05 mmol, 11 mg) and di-tert-butyl peroxide (1 mmol, 183 mul), in air (1 atm) atmosphere at 60 C stirring reaction 24 h. Then add 10 ml saturated salt water quenching reaction, extracted with ethyl acetate (10 ml × 3), combined with the organic phase, dried with anhydrous sodium sulfate. Filtering, turns on lathe does, too separating by silica gel column (petroleum ether/ethyl acetate=5/1) to get the yellow solid product 3n (71 mg, 51%)., 2905-56-8

The synthetic route of 2905-56-8 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Henan Normal University; Fan Xuesen; Shi Xiaonan; Zhang Xinying; Chen Qian; (19 pag.)CN108516952; (2018); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

10338-57-5, 4-(Piperidin-1-yl)benzaldehyde is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of appropriate p-aminobenzaldehyde 1a-n (20 mmol) and cyanoacetamide (20 mmol) in ethanol (20 ml) a few drops of potassium hydroxide solution (10% in water) at 50 C was added. The solution was set aside for seven hours at room temperature. The precipitatewas filtered off and recrystallized from ethanol., 10338-57-5

As the paragraph descriping shows that 10338-57-5 is playing an increasingly important role.

Reference：
Article; Pietrzak, Marek; Bajorek, Agnieszka; Dyes and Pigments; vol. 96; 1; (2013); p. 63 – 70;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1187173-43-8,2,7-Diazaspiro[4.5]decan-1-one hydrochloride,as a common compound, the synthetic route is as follows.,1187173-43-8

To a solution of 2,7-diazaspiro[4.5]decan-1 -one hydrochloride (0.572 g, 3 mmol) and triethylamine (0.836 ml_, 6.00 mmol) in dichloromethane (15 ml_), cooled in an ice- water bath, was added 4-bromo-3-(trifluoromethyl)benzenesulfonyl chloride (0.971 g, 3.00 mmol). The reaction was allowed to warm to room temperature and stirred for 18 hours. The reaction was diluted with dichloromethane (35 ml_), washed with water (30 ml_), passed through a hydrophobic frit and reduced in vacuo. The residue was purified by silica chromatography (Biotage SP4) eluting with 60% EtOAc in iso- hexanes (3 column volumes), a gradient from 60 – 100% EtOAc (over 9 column volumes) then EtOAc (3 column volumes) to yield 7-{[4-bromo-3- (trifluoromethyl)phenyl]sulfonyl}-2,7-diazaspiro[4.5]decan-1 -one (1.022 g, 2.316 mmol, 77% yield) as a white solid. 1 H NMR (250 MHz, CHLOROFORM-d) delta ppm 1 .59 – 1 .86 (m, 4 H) 2.00 – 2.14 (m, 1 H) 2.24 – 2.51 (m, 3 H) 3.31 – 3.51 (m, 2 H) 3.52 – 3.60 (m, 1 H) 3.86 (dd, J=10.39, 1.96 Hz, 1 H) 5.67 (br. s., 1 H) 7.72 (dd, J=8.30, 1 .92 Hz, 1 H) 7.90 (d, J=8.37 Hz, 1 H) 8.02 (d, J=2.13 Hz, 1 H). MS ES+ve m/z 443 (M+H).

As the paragraph descriping shows that 1187173-43-8 is playing an increasingly important role.

Reference：
Patent; CONVERGENCE PHARMACEUTICALS LIMITED; GLEAVE, Robert James; HACHISU, Shuji; PAGE, Lee William; BESWICK, Paul John; WO2011/141728; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem