Tag: M.W:100-200

207852-63-9, 1-(4-Chloropiperidin-1-yl)ethanone is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 4 4-[(4-Fluorophenyl)-2-(4-methylthienyl)methylene]piperidine hydrochloride To a stirred solution of 4-(1-acetylpiperidinyl) chloride (50 g) in dichloromethane (690 ml), under a nitrogen atmosphere, at -25 C., was sequentially added powdered aluminium chloride (71 g) followed by a solution of 2-bromo-3-methylthiophene (50 g) in dichloromethane (300 ml) over 17 min. After 30 min. water (240 ml) was added dropwise to the reaction whilst allowing the reaction temperature to rise to about +20 C. After stirring for a further 30 min the inorganic components were removed by filtration through a pad of dicalite. The layers were separated, the organic layer was washed twice with water, dried (Na2SO4) and evaporated under reduced pressure. The crude product (73 g) was purified by chromatography to yield 2-(5-bromo-4-methylthienyl)4-(1-acetylpiperidine)methanone (62.2 g); mp 105-108.5 C. (dec).

207852-63-9, As the paragraph descriping shows that 207852-63-9 is playing an increasingly important role.

Reference：
Patent; Akzo Nobel N.V.; US6288085; (2001); B1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13096-31-6,5-Hydroxypiperidine-2-carboxylic acid,as a common compound, the synthetic route is as follows.

EXAMPLE 23 1-(3-Mercaptopropanoyl)-5-Hydroxy-L-Pipecolic Acid By substituting 5-hydroxy-L-pipecolic acid for L-proline in the procedure of Example 13 and then treating the product by the Procedure A of Example 18, 1-(3-benzoylthiopropanoyl)-5-hydroxy-L-pipecolic, and 1-(3-mercaptopropanoyl)-5-hydroxy-L-pipecolic acid are obtained.

13096-31-6, The synthetic route of 13096-31-6 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; E. R. Squibb & Sons, Inc.; US4105776; (1978); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10338-57-5,4-(Piperidin-1-yl)benzaldehyde,as a common compound, the synthetic route is as follows.

General procedure: To a solution of 5 or 7 in ethanol (3 mL/mmol) were added anaqueous solution of potassium hydroxide (50%, 5 mL/mmol) anda benzaldehyde derivative (8a-h, 1.5 equiv) The solution was stirredovernight until TLC showed complete disappearance of thestarting material. Ethanol was removed under reduced pressure.The residue was diluted into distilled water and acidified with anaqueous solution of hydrochloric acid (10%), then the mixturewas basified with saturated NaHCO3 solution to adjust the pH to7-8. The precipitate was filtered, washed with water and dried atroom temperature to afford the corresponding crude auronederivative as orange to dark red solid.

10338-57-5, As the paragraph descriping shows that 10338-57-5 is playing an increasingly important role.

Reference：
Article; Li, Yan; Qiang, Xiaoming; Luo, Li; Li, Yuxing; Xiao, Ganyuan; Tan, Zhenghuai; Deng, Yong; Bioorganic and Medicinal Chemistry; vol. 24; 10; (2016); p. 2342 – 2351;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14813-01-5,1-Benzylpiperidin-3-ol,as a common compound, the synthetic route is as follows.

1000ml three necked flask n-Benzyl-3-hydroxypiperidine (95.6 g, 0.5 mol) was added,2-butanone 478 ml of a solution of L-CSA (69.6 g, 0.3 mol) in 290 ml of 2-butanone was stirred at room temperature for 1 hour, and the precipitated solid appeared, kept at 0 C for 2 hours, filtered, washed with 2-butanone 30 ml, (S) -1-benzyl-3-hydroxypiperidine camphorsulfonate. (Ee: 75%)(Theory: 105.9G)., 14813-01-5

As the paragraph descriping shows that 14813-01-5 is playing an increasingly important role.

Reference：
Patent; ABA Chemicals Corporation; Lin, ZhiGang; Xu, Jun; Liu, YanQin; Que, limin; Jiang, yueheng; CAI, Tong; (13 pag.)CN103864673; (2016); B;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10338-57-5,4-(Piperidin-1-yl)benzaldehyde,as a common compound, the synthetic route is as follows.

(Z)-(4-(isobenzofuran-1(3H)-ylidenemethyl)phenyl)methanol(5) (190.6 mg, 0.8 mmol), 4-(piperidin-1-yl)benzaldehyde (6)(227.2 mg, 1.2 mmol), t-BuOK (0.48 mmol, 1 M in THF) and 18-crown-6 (190.4 mg, 0.72 mmol) in DMF (4 mL) were stirred at110 C under nitrogen atmosphere for 3 h. The mixture was cooledand saturated NH4Cl (aq) was added to quench the reaction. Theresulting mixture was extracted with CH2Cl2 and the organic phasewas washed with brine, dried over Na2SO4. The solvent was evaporatedand the residue was passed through column chromatography on silica gel (eluent: PE/EtOAc 10:1, v/v) toafford the crude product (4-((Z)-((Z)-3-(4-(piperidin-1-yl)benzylidene)isobenzofuran-1(3H)-ylidene)-methyl)phenyl)methanol 7(282.0 mg, 86%) without further purification [49].

10338-57-5, As the paragraph descriping shows that 10338-57-5 is playing an increasingly important role.

Reference：
Article; Shang, Xue Song; Li, Nian Tai; Guo, Zhi Qian; Liu, Pei Nian; Dyes and Pigments; vol. 132; (2016); p. 167 – 176;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.71985-80-3,1-Methylpiperidine-4-carboxylic acid hydrochloride,as a common compound, the synthetic route is as follows.,71985-80-3

48 mg (0.26 mmol) 1-methyl-piperidine-4-carboxylic acid hydrochloride were dissolved in 5 ml thionyl chloride and heated to reflux for 30 min. The excess thionyl chloride was removed by evaporation and the resulting acid chloride dissolved in 5 ml methylene chloride. This solution was added to a solution of 100 mg (0.25 mmol) 3-(3-amino-4-trifluormethoxy-phenyl) -5,5-dimethyl-1-pyridin-4-ylmethyl-imidazolidine-2,4-dione and 111 mg (0. 68mmol) huenig’s base and the mixture was stirred overnight at RT and heated to reflux for 1h. The mixture was poured on saturated sodium bicarbonate solution, extracted with ethylacetate, then dried and evaporated. The residue was was purified by preparative HPLC. (C18 reversed phase column, elution with a water (0.1% trifluoracetic acid) /acetonitrile gradient) Yield: 10 mg MS(ES+): m/e = 520 LC/MS Retention time [min] = 0.86

As the paragraph descriping shows that 71985-80-3 is playing an increasingly important role.

Reference：
Patent; Aventis Pharma S.A.; EP1621536; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

10338-57-5, 4-(Piperidin-1-yl)benzaldehyde is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a mixture of NaH (146mg, 6.08mmol) in THF (2mL) was added a solution of intermediate 11 (500mg, 1.52mmol) in THF (4mL) at 0C, and the mixture was stirred for 40min under argon. And a solution of corresponding substituted benzaldehydes (2-1b-m, 1.52mmol) in THF (1mL) was added dropwise. Then the mixture was stirred for another 4-7h under argon. After the reaction was completed, the mixture was quenched with 3mol/L HCl and basified with saturated aqueous solution of Na2CO3. Then the mixture was extracted with ethyl acetate (15mL×3) and the combined organic phases were washed with brine, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure to provide crude product, the crude product was purified on silica chromatography to afford corresponding target compounds 12b-m.

10338-57-5, As the paragraph descriping shows that 10338-57-5 is playing an increasingly important role.

Reference：
Article; Cao, Zhongcheng; Deng, Yong; Li, Wei; Shi, Yichun; Song, Qing; Yang, Xia; Zhang, Li; Bioorganic Chemistry; vol. 97; (2020);,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20691-89-8,1-Methyl-4-piperidinemethanol,as a common compound, the synthetic route is as follows.

To Example 60 (0. 78 g, 6 mmol) was added thionyl chloride (10 mL) and the mixture was heated to reflux for about 2 hours. The mixture was cooled and concentrated to dryness. The residue was washed with acetone, suspended in saturated aqueous sodium carbonate and extracted with dichloromethane. The combined organic extracts were dried (Na2SO4), filtered and concentrated under vacuum to provide the desired product. MS (ESI) : m/z 148 (M+H) +.

20691-89-8, The synthetic route of 20691-89-8 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; ABBOTT LABORATORIES; MAKOTO, Aoyama; WO2005/95387; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

1187173-43-8, 2,7-Diazaspiro[4.5]decan-1-one hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2,7-Diazaspiro[4.5]decan-1 -one hydrogen chloride (100 mg, 0.524 mmol) was dissolved in dichloromethane (10 mL) and triethylamine (0.219 mL, 1 .573 mmol), and 2,5-bis(trifluoromethyl)benzenesulfonyl chloride (197 mg, 0.629 mmol) was added. After stirring for 17 h the reaction mixture was concentrated in vacuo and the resulting residue was purified by MDAP to give 7-{[2,5-bis(trifluoromethyl)phenyl]- sulfonyl}-2,7-diazaspiro[4.5]decan-1 -one (96 mg, 0.221 mmol, 42% yield) as a white solid. 1 H NMR (400 MHz, DMSO-d6) delta ppm 1 .46 – 1 .63 (m, 3 H) 1.66 – 1 .75 (m, 1 H) 1 .85 – 2.03 (m, 2 H) 2.72 – 2.78 (m, 1 H) 2.80 (d, J=12.28 Hz, 1 H) 3.1 1 – 3.19 (m, 2 H) 3.47 (d, J=12.28 Hz, 1 H) 3.71 (d, J=1 1 .78 Hz, 1 H) 7.75 (s, 1 H) 8.24 (s, 1 H) 8.26 – 8.33 (m, 2 H). MS ES+ve m/z 431 (M+H)., 1187173-43-8

The synthetic route of 1187173-43-8 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; CONVERGENCE PHARMACEUTICALS LIMITED; GLEAVE, Robert James; HACHISU, Shuji; PAGE, Lee William; BESWICK, Paul John; WO2011/141728; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

5810-56-0,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5810-56-0,4-Acetamidopiperidine,as a common compound, the synthetic route is as follows.

EXAMPLE 3 A mixture of 0.088 mole of 4-acetamidopiperidine, 15 g of potassium carbonate, 0.088 mole of 2-chloro-6-methoxypyridine in 100 ml of dimethylsulfoxide is heated with stirring to 130 C. for 50 hours, then it is cooled, the mixture is poured into water and the suspension thus obtained is extracted with diethyl ether. The aqueous phase is extracted with methylene chloride, the organic phase is washed with water, it is dried on anhydrous sodium sulfate and evaporated to dryness. 4-acetamido-1-(6-methoxy-2-pyridyl)piperidine is thus obtained which, after crystallisation in 95% ethanol, melts at 125 to 127 C. Yield: 43% of the theoretical.

5810-56-0 4-Acetamidopiperidine 1445156, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; Sanofi; US4409228; (1983); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem