Tag: M.W:100-200

768-66-1,768-66-1, 2,2,6,6-Tetramethylpiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 35 (31.7 g, 127 mmol) and THF (200 mL) were loaded into a three-necked flask, and then the mixture was cooled to -78C. A lithium 2,2,6,6-tetramethylpiperidine solution prepared in advance from a 1.55-M solution of n-BuLi in hexane (82 mL, 127 mmol), 2,2,6,6-tetramethylpiperidine (17.9 g, 127 mmol), and THF (50 mL) was added to the mixture, and then the whole was stirred at -78C under an Ar atmosphere for 2 hours. After that, triisopropyl borate (71.6 g, 381 mmol) was added to the resultant, and then the mixture was stirred at -78C for 2 hours. After that, the temperature of the mixture was slowly returned to roomtemperature, and then the mixture was left to stand overnight. After the completion of the reaction, methanol (50 mL) was added to deactivate the resultant, and then the mixture was concentrated so that its volume might be reduced by about half. CH2Cl2 (200 mL) and 2N HCl (120 mL) were added to the resultant, and then the mixture was stirred at room temperature for 2 hours. The resultant sample was transferred to a separating funnel and extracted with CH2Cl2. The solution was dried with MgSO4, and was then purified by silica gel column chromatography. The purified product was concentrated to dryness, and then the solid was subjected to dispersion washing with toluene. Thus, a white solid was obtained in an amount of 27.5 g in 74% yield.

As the paragraph descriping shows that 768-66-1 is playing an increasingly important role.

Reference：
Patent; Idemitsu Kosan Co., Ltd.; EP2301926; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

10338-57-5, 4-(Piperidin-1-yl)benzaldehyde is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The 4-alkyl(aryl)aminobenzaldehyde (1 mmol) was added to(RMe2Si)3CLi, R=H,Me (1 mmol) in THF under argon. The mixturewas reacted according to Tables 1 and 2. The reaction was quenchedwith H2O, extracted with CH2Cl2 and dried over Na2SO4. The solventwas evaporated under reduced pressure and the residue was purifiedby preparative column chromatography (n-hexane/ethylacetate) andthe corresponding products were obtained.

10338-57-5, The synthetic route of 10338-57-5 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Safa, Kazem Dindar; Nadimi, Sanaz; Alyari, Maryam; Journal of Chemical Research; vol. 38; 8; (2014); p. 498 – 501;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21168-72-9,2-(4-(Aminomethyl)piperidin-1-yl)ethanol,as a common compound, the synthetic route is as follows.

[00351 ] To the solution of compound 2-(4-(aminomethyl)piperidin-1 – yl)ethanol (150 mg, 0.95 mmol) and compound 6-chloro-3-(3- (trifluoromethoxy)phenyl)imidazo[1 ,2-b]pyridazine (200 mg, 0.64 mmol) in 3 ml_ DMSO was added DIEA (0.3 ml_, 1 .37 mmol) and 10 mg CsF, the solvent was stirred for 5 h at 120 C, Then the mixture was purified by HPLC to afford the compound 2-(4-(((3-(3-(trifluoromethoxy)phenyl)imidazo[1 ,2-b]pyridazin-6- yl)amino)methyl)cyclohexyl)ethanol (34 mg, 8.2 %) as a brown solid. [00352] 1 H-NMR (CDCI3/400 MHz): delta 8.61 (s, 1 H), 8.20 – 8.25 (m, 1 H), 7.95 – 8.05 (m, 2 H), 7.66 (t, J = 4.4 Hz, 1 H), 7.21 – 7.28 (m, 1 H), 3.80 – 3.90 (m, 2 H), 3.62 – 3.75 (m, 2 H), 3.37 (d, J = 6.4 Hz, 2 H), 3.21 (t, J = 5.2 Hz, 2 H), 2.91 – 3.09 (m, 2 H), 2.10 (d, J = 14.0 Hz, 2 H), 1 .51 – 1 .69 (m, 2 H). MS (ES+, m/z): (M+H)+: 435.5.

21168-72-9, The synthetic route of 21168-72-9 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; TOLERO PHARMACEUTICALS, INC.; XU, Yong; BRENNING, Benjamin, Gary; KULTGEN, Steven, G.; LIU, Xiaohui; SAUNDERS, Michael; HO, Koc-Kan; WO2013/13188; (2013); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.280774-03-0,(1-Isopropylpiperidin-4-yl)methanol,as a common compound, the synthetic route is as follows.

(1) Lithium aluminum hydride (1.10 g) is suspended in tetrahydrofuran (80 ml), and thereto is added a solution of ethyl 1-isopropylpiperidine-4-carboxylate (5.00 g) obtained in Reference Example 127 in tetrahydrofuran (30 ml) dropwise under ice-cooling. The reaction solution is stirred for 2 hours under the ice-cooling, and water (1.1 ml), 15 % aqueous sodium hydroxide solution (1.1 ml) and water (3.3 ml) are added dropwise successively and stirred for additional 10 minutes. To the resulting reaction solution is added potassium carbonate, and the mixture is stirred for 20 minutes, and then the insoluble materials are removed by filtration. The filtrate is concentrated under reduced pressure, and then the resulting residue is purified by NH-silica gel column chromatography (eluent: chloroform/ethyl acetate = 1/1) to give (1-isopropylpiperidin-4-yl)methanol (4.29 g). APCI-MS M/Z:158[M+H]+.(2) Oxalyl chloride (2.0 ml) is dissolved in dichloromethane (120 ml) and thereto is added dropwise a solution of dimethylsulfoxide (3.3 ml) in dichloromethane (15 ml) under dry ice-acetone cooling. After stirring for 10 minutes under ice-cooling, a solution of (1-isopropylpiperidin-4-yl)methanol (3.00 g) obtained in Reference Example 134(1) in dichloromethane (30 ml) is added dropwise over a period of 15 minutes. After addition, the reaction solution is stirred for 2 hours under ice-cooling, and thereto is added dropwise triethylamine (13.3 ml) over a period of 10 minutes. The reaction solution is stirred for one hour while it is warmed to room temperature, and then the solution is poured to saturated aqueous sodium hydrogen carbonate solution. The mixture is extracted with dichloromethane and evaporated to remove the solvent under reduced pressure. The aqueous layer is extracted with ethyl acetate, and the extract is combined with the residue obtained by removing solvent from the above dichloromethane-extract, washed with water and saturated brine and dried over sodium sulfate. The solvent is evaporated under reduced pressure to give the crude material, 1-isopropylpiperidine-4-carbaldehyde (1.96 g). APCI-MS M/Z:156[M+H]+.(3) Triethyl phosphonoacetate (7.96 g) is dissolved in tetrahydrofuran (50 ml) and thereto is added gradually 60 % sodium hydride in oil (1.45 g) under ice-cooling. After stirring for 20 minutes under ice-cooling, to the mixture is added 1-isopropylpiperidine-4-carbaldehyde (5.03 g) obtained in Reference Example 134(2) in tetrahydrofuran (25 ml). The reaction solution is stirred for 3 hours, diluted with diethyl ether, thereto is added water and the mixture is extracted with ethyl acetate. The organic layer is washed with water and saturated brine, dried over sodium sulfate and evaporated to remove the solvent under reduced pressure. The resulting residue is purified by NH-silica gel column chromatography (eluent: n-hexane/ethyl acetate = 9/1) to give ethyl 3-(1-isopropylpiperidin-4-yl)acrylate (6.87 g). APCI-MS M/Z:226[M+H]+.(4) Ethyl 3-(1-isopropylpiperidin-4-yl)acrylate (1.01 g) obtained in Reference Example 134(3) is dissolved in ethanol (20 ml), thereto is added 2 N aqueous sodium hydroxide solution (4.5 ml) and the mixture is stirred at room temperature for 24 hours. To the reaction solution is added 2 N hydrochloric acid (9 ml), and the mixture is concentrated under reduced pressure, and then the resulting residue is lyophilized to give the title compound (1.43 g). APCI-MS M/Z:198[M+H]+., 280774-03-0

280774-03-0 (1-Isopropylpiperidin-4-yl)methanol 11147855, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; Tanabe Seiyaku Co., Ltd.; EP1489078; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.85908-96-9,N-Boc-2-Piperidone,as a common compound, the synthetic route is as follows.

85908-96-9, General procedure: To a solution of compounds 15, 16, 17 (2 mmol) and diphenyl phosphoryl chloride (0.62 mL, 3 mmol) in anhydrous THF (30 mL) cooled at -78 C and under nitrogen atmosphere, was added dropwise with stirring a solution of KHMDS (6 mL, 0.5 M in toluene, 3 mmol). After 30 min at -78 C, water (20 mL) was added and the resulting mixture was extracted with Et2O (2 × 50 mL) and dried over MgSO4. Evaporation of the solvent under vacuum yielded the vinyl phosphates as yellow oils, which were used directly in the next coupling step.

85908-96-9 N-Boc-2-Piperidone 7577838, apiperidines compound, is more and more widely used in various fields.

Reference：
Article; Sallio, Romain; Lebrun, Stephane; Agbossou-Niedercorn, Francine; Michon, Christophe; Deniau, Eric; Tetrahedron Asymmetry; vol. 23; 13; (2012); p. 998 – 1004;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

53617-36-0,53617-36-0, 1-Methyl-4-(piperidin-4-yl)piperazine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 72; 4-methoxy-N,2,6-trimethyl-N-[2-[2-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]-2-oxoethoxy]ethyl]benzenesulphonamide; A suspension is prepared of 350 mg (1.06 mM) of acid obtained according to preparation III in 3 ml of DCM and 243 mg (1.27 mM) of EDCI (1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride) and 173 mg (1.27 mM) of HOAT, are added. The mixture is agitated for 30 min at ambient temperature, and 232 mg (1.27 mM) of 1-methyl-4-(4-piperidinyl)piperazine are then added. The reaction mixture is agitated for 18 hours at ambient temperature and is then poured over 10 ml of water and extracted with DCM. The organic phase is washed with water, dried and concentrated under reduced pressure. The residue is purified by silica gel chromatography in eluting with the aid of a DCM/methanol mixture (90/10; v/v). 449 mg of the product sought after are thus obtained as a yellow oil (yield=86percent). 1H NMR (300 MHz, CD3CN) delta: 6.74 (s, 2H); 4.35 (d, 1H); 4.01 (q, 2H); 3.81 (s, 3H); 3.69 (d, 1H); 3.56 (t, 2H); 3.26 (t, 2H); 2.89 (t, 1H); 2.75 (s, 3H); 2.58 (s, 6H); 2.40 (m, 10H); 2.17 (s, 3H); 1.75 (m, 2H); 1.27 (m, 2H).

53617-36-0 1-Methyl-4-(piperidin-4-yl)piperazine 795707, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; Laboratoires Fournier S.A.; US2006/178360; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

14813-01-5, 1-Benzylpiperidin-3-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

866.3 mg of the 1-benzyl-3-hydroxypiperidine crude product obtained was dissolved in 6 mL of chloroform, to which, under ice cooling, 0.95 mL of triethylamine and 0.42 mL of methanesulfonyl acid chloride were sequentially added, and stirred at the same temperature for 30 minutes. To the reaction mixture, saturated sodium bicarbonate was added, extracted with chloroform, the extract was washed with saturated saline, and dried on anhydrous sodium sulfate. The solvent was evaporated to obtain 1.15 g of methanesulfonic acid (1-benzyl-piperidin-3-yl)methylester crude product as an orange oil. Without further purification, this was used as the feed material for the next reaction.

14813-01-5, As the paragraph descriping shows that 14813-01-5 is playing an increasingly important role.

Reference：
Patent; Kitamura, Takahiro; Yamada, Hajime; Takemura, Shunji; Ashikawa, Masanori; Ishikawa, Tetsuya; Miyake, Yoshiharu; Kouketsu, Akiyasu; Sato, Seiichi; Ishiwata, Hiroyuki; Tabunoki, Yuichiro; Shibasaki, Manabu; Ozawa, Takatoshi; Shigemi, Ryota; Doi, Takeshi; Tamura, Masahiro; US2011/237590; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

32559-18-5, Methyl piperidine-2-carboxylate hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of methyl pipecolate hydrochloride (1 g, 5.57 mmol) in THF (10 ml) was added phenothiazine carbonyl chloride (1.457 g, 5.57 mmol) followed by diisopropylethylamine (2.02 ml, 11.68 mmol). The resulting solution was stirred for 16 h before being partitioned between ethyl acetate and aq. sat. NH4Cl. The organic layer was washed with brine, dried (MgSO4), filtered and evaporated. The residue was purified by flash chromatography (15% ethyl acetate in hexane) to afford the sub-title compound as a colorless oil which crystallized upon standing (1.823 g, 89%): 1H NMR (400 MHz, CDCl3) delta 1.13-1.48 (3H, m), 2.57-2.69 (2H, m), 2.16 (1H, m), 3.00 (1H, m), 3.74 (4H, s+m), 5.00 (1H, m), 7.11 (2H, t), 7.22-7.34 (4H, m), 7.76 (2H, d); 13C NMR (100 MHz, CDCl3) delta 21.3 (CH2), 24.8 (CH2), 27.3 (CH2), 44.9 (CH2), 52.5 (CH3), 55.9 (CH), 122.8 (CH), 125.5 (CH), 127.8 (CH), 128.0 (CH), 129.2 (C), 141.7 (C), 158.4 (C), 172.2 (C), 32559-18-5

As the paragraph descriping shows that 32559-18-5 is playing an increasingly important role.

Reference：
Patent; Randle, John C.R.; US2005/267101; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

1187173-43-8, 2,7-Diazaspiro[4.5]decan-1-one hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2,7-Diazaspiro[4.5]decan-1 -one hydrogen chloride (150 mg, 0.787 mmol) was dissolved in dichloromethane (4 mL) and triethylamine (0.219 mL, 1.573 mmol), and 2-chloro-4-(trifluoromethyl)benzenesulfonyl chloride (241 mg, 0.865 mmol) was added. After stirring for 18 h, the reaction mixture was concentrated in vacuo. The resulting residue was purified by MDAP to give 7-{[2-chloro-4-(trifluoromethyl)- phenyl]sulfonyl}-2,7-diazaspiro[4.5]decan-1 -one (38.2 mg, 0.094 mmol, 12% yield) as a white solid. 1 H NMR (400 MHz, DMSO-d6) delta ppm 1 .37 – 1 .64 (m, 3 H) 1.65 – 1 .75 (m, 1 H) 1.84 – 2.02 (m, 2 H) 2.72 – 2.83 (m, 2 H) 3.09 – 3.18 (m, J=7.78, 7.51 Hz, 2 H) 3.40 (d, J=12.1 1 Hz, 1 H) 3.72 (d, J=12.93 Hz, 1 H) 7.74 (s, 1 H) 7.93 (d, J=9.54 Hz, 1 H) 8.18 (d, J=7.45 Hz, 2 H). MS ES+ve m/z 397 (M+H)., 1187173-43-8

1187173-43-8 2,7-Diazaspiro[4.5]decan-1-one hydrochloride 45074126, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; CONVERGENCE PHARMACEUTICALS LIMITED; GLEAVE, Robert James; HACHISU, Shuji; PAGE, Lee William; BESWICK, Paul John; WO2011/141728; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

63921-23-3, 1-Phenylpiperidin-4-amine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

63921-23-3, (1) Preparation of phenyl N-(1-phenyl-4-piperidyl)carbamate pyridine (24 muL) and phenyl chlorocarbonate (32 muL) were added to a solution of 1-phenyl-4-piperidylamine (35 mg) in tetrahydrofuran (1 ML), and the mixture was stirred at room temperature for 12 hours.. The reaction mixture was poured into saturated aqueous sodium bicarbonate, and extracted with ethyl acetate.. The organic layer was dried over anhydrous magnesium sulfate and concentrated.. The residue was purified by column chromatography on silica gel (ethyl acetate/chloroform = 1/1) to give the title compound (37 mg).

The synthetic route of 63921-23-3 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; BANYU PHARMACEUTICAL CO., LTD.; EP1415986; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem