Tag: M.W:100-200

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 4,4-Difluoropiperidine hydrochloride, is researched, Molecular C5H10ClF2N, CAS is 144230-52-4, about Observation of Vortex Domains in a Two-Dimensional Lead Iodide Perovskite Ferroelectric, the main research direction is lead iodide two dimensional perovskite ferroelec vortex domain.Application of 144230-52-4.

Topol. defects, such as vortices and skyrmions, provide a wealth of splendid possibilities for new nanoscale devices because of their marvelous electronic, magnetic, and mech. behaviors. Recently, great advances have been made in the study of the ferroelec. vortex in conventional perovskite oxides, such as BaTiO3 and BiFeO3. Despite extensive interest, however, no intriguing ferroelec. vortex structures have yet been found in organic-inorganic hybrid perovskites (OIHPs), which are desirable for their mech. flexibility, ease of fabrication, and low acoustical impedance. We observed the robust vortex-antivortex topol. configurations in a two-dimensional (2D) layered OIHP ferroelec. (4,4-DFPD)2PbI4 (4,4-DFPD is 4,4-difluoropiperidinium). This provides future directions for the study of perovskites and makes it a promising alternative for nanoscale ferroelec. devices in medical, micromech., and biomech. applications.

As far as I know, this compound(144230-52-4)Application of 144230-52-4 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis, anticonvulsant activity and QSAR studies of some new pyrazolyl pyridines, published in 2016-08-31, which mentions a compound: 23794-15-2, mainly applied to anticonvulsant epilepsy QSAR pyrazole pyridine, Safety of 1-(2-chloropyridine-4-yl)ethanone.

Twenty-one new 3,5-bipyridinyl-1H-pyrazole derivatives (pyrazolyl pyridines) have been synthesized and evaluated for their anticonvulsant activity in animal models of epilepsy. The pyrazolyl pyridines I [R1 = H, Cl, Ph, etc.; R2 = H, Cl, Ph, etc.] were obtained through a general one-pot synthesis, from ketones and acid chlorides via formation of 1,3-diketones in situ carried out in hydrocarbon solvent and LiHMDS base. The profile of anticonvulsant activity of final compounds was established in the maximal electroshock (MES) and s.c. pentylenetetrazole (s.c. PTZ) tests, after i.p. injection in rats and mice, resp., at doses of 30, 100, and 300 mg/kg. An observation was carried out at two different time intervals-0.5 and 4 h. Phenytoin was used as a standard antiepileptic against MES convulsions and valproic acid against s.c. PTZ convulsions. Furthermore, in addition to the primary anticonvulsant screening, the acute neurol. toxicity was determined in mice by the rotarod test and in rats by positional sense test. The compounds showed anticonvulsant activity exclusively against MES convulsions. The compounds were found especially active in 100 mg/kg dose at both the time points, i.e., 0.5 and 4 h, depending upon the lipophilicity of mols. as indicated by statistically significant reduction in the time spent in tonic extension phase (p < 0.001). Further, the newly synthesized compounds were subjected to two-dimensional quant. structure-activity relationship (2D QSAR) anal. through multiple linear regression, principal component regression, and partial least square regression anal., and three-dimensional quant. structure-activity relationship (3D QSAR) anal. by k-nearest neighbor mol. field anal. in conjunction with stepwise forward-backward, genetic algorithm, and simulated annealing variable selection methods using the software VLife MDS. The structure-activity relationship (SAR) as well as quant. structure-activity relationship (QSAR) studies for anticonvulsant activity confirmed the crucial role of 3,5-bipyridinyl-1H-pyrazole core fragment for anticonvulsant activity. As far as I know, this compound(23794-15-2)Safety of 1-(2-chloropyridine-4-yl)ethanone can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Formula: C7H6ClNO. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1-(2-chloropyridine-4-yl)ethanone, is researched, Molecular C7H6ClNO, CAS is 23794-15-2, about Structural Optimization of a Pyridinylimidazole Scaffold: Shifting the Selectivity from p38α Mitogen-Activated Protein Kinase to c-Jun N-Terminal Kinase 3. Author is Ansideri, Francesco; Macedo, Joana T.; Eitel, Michael; El-Gokha, Ahmed; Zinad, Dhafer S.; Scarpellini, Camilla; Kudolo, Mark; Schollmeyer, Dieter; Boeckler, Frank M.; Blaum, Baerbel S.; Laufer, Stefan A.; Koch, Pierre.

Starting from known p38α mitogen-activated protein kinase (MAPK) inhibitors, a series of inhibitors of the c-Jun N-terminal kinase (JNK) 3 was obtained. Altering the substitution pattern of the pyridinylimidazole scaffold proved to be effective in shifting the inhibitory activity from the original target p38α MAPK to the closely related JNK3. In particular, a significant improvement for JNK3 selectivity could be achieved by addressing the hydrophobic region I with a small Me group. Furthermore, addnl. structural modifications permitted to explore structure-activity relationships. The most potent inhibitor 4-(4-methyl-2-(methylthio)-1H-imidazol-5-yl)-N-(4-morpholinophenyl)pyridin-2-amine showed an IC50 value for the JNK3 in the low triple digit nanomolar range and its binding mode was confirmed by x-ray crystallog.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Journal of Medicinal Chemistry called 1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors: From Hit Generation to Orally Bioavailable Brain Penetrant Leads, Author is Rombouts, Frederik J. R.; Tresadern, Gary; Delgado, Oscar; Martinez-Lamenca, Carolina; Van Gool, Michiel; Garcia-Molina, Aranzazu; Alonso de Diego, Sergio A.; Oehlrich, Daniel; Prokopcova, Hana; Alonso, Jose Manuel; Austin, Nigel; Borghys, Herman; Van Brandt, Sven; Surkyn, Michel; De Cleyn, Michel; Vos, Ann; Alexander, Richard; Macdonald, Gregor; Moechars, Dieder; Gijsen, Harrie; Trabanco, Andres A., which mentions a compound: 23794-15-2, SMILESS is CC(=O)C1=CC(Cl)=NC=C1, Molecular C7H6ClNO, Quality Control of 1-(2-chloropyridine-4-yl)ethanone.

1,4-Oxazines are presented, which show good in vitro inhibition in enzymic and cellular BACE1 assays. We describe lead optimization focused on reducing the amidine pKa while optimizing interactions in the BACE1 active site. Our strategy permitted modulation of properties such as permeation and especially P-glycoprotein efflux. This led to compounds which were orally bioavailable, centrally active, and which demonstrated robust lowering of brain and CSF Aβ levels, resp., in mouse and dog models. The amyloid lowering potential of these mols. makes them valuable leads in the search for new BACE1 inhibitors for the treatment of Alzheimer’s disease.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Synthetic Route of C5H10ClF2N. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 4,4-Difluoropiperidine hydrochloride, is researched, Molecular C5H10ClF2N, CAS is 144230-52-4, about A Structure-Activity Relationship Study of Novel Hydroxamic Acid Inhibitors around the S1 Subsite of Human Aminopeptidase N. Author is Lee, Jisook; Drinkwater, Nyssa; McGowan, Sheena; Scammells, Peter.

Aminopeptidase N (APN/CD13) is a zinc-dependent ubiquitous transmembrane ectoenzyme that is widely present in different types of cells. APN is one of the most extensively studied metalloaminopeptidases as an anti-cancer target due to its significant role in the regulation of metastasis and angiogenesis. Previously, we identified a potent and selective APN inhibitor, N-(2-(Hydroxyamino)-2-oxo-1-(3′,4′,5′-trifluoro-[1,1′-biphenyl]-4-yl)ethyl)-4-(methylsulfonamido)benzamide (3). Herein, we report the further modifications performed to explore SAR around the S1 subsite of APN and to improve the physicochem. properties. A series of hydroxamic acid analogs were synthesized, and the pharmacol. activities were evaluated in vitro. N-(1-(3′-Fluoro-[1,1′-biphenyl]-4-yl)-2-(hydroxyamino)-2-oxoethyl)-4-(methylsulfonamido)benzamide (6 f) was found to display an extremely potent inhibitory activity in the sub-nanomolar range.

As far as I know, this compound(144230-52-4)Synthetic Route of C5H10ClF2N can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-(2-chloropyridine-4-yl)ethanone(SMILESS: CC(=O)C1=CC(Cl)=NC=C1,cas:23794-15-2) is researched.Product Details of 3230-65-7. The article 《Iron-Catalyzed Arylation of Heterocycles via Directed C-H Bond Activation [Erratum to document cited in CA160:248695]》 in relation to this compound, is published in Organic Letters. Let’s take a look at the latest research on this compound (cas:23794-15-2).

On page 868, Scheme 1 contained inverted references; the corrected scheme is given. On page 870, the text accompanying Table 3 contained an incorrect substrate name; the correct substrate is 4-methylthiophene. On page 871, reference 6b contained misspelled names; the corrected reference is given.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Angewandte Chemie, International Edition called Chirality-Dependent Second-Order Nonlinear Optical Effect in 1D Organic-Inorganic Hybrid Perovskite Bulk Single Crystal, Author is Fu, Dongying; Xin, Jianli; He, Yueyue; Wu, Shichao; Zhang, Xinyuan; Zhang, Xian-Ming; Luo, Junhua, which mentions a compound: 334618-07-4, SMILESS is Cl.Cl.N[C@H]1CCCNC1, Molecular C5H14Cl2N2, Name: (S)-Piperidin-3-amine dihydrochloride.

The introduction of chirality into organic-inorganic hybrid perovskites (OIHPs) is expected to achieve excellent photoelec. and nonlinear materials related to CD. Owing to the existence of asym. center and intrinsic chirality in the chiral OIHPs, the different efficiencies of second harmonic generation (SHG) signal occurs when the circularly polarized light (CPL) with different phases passes through the chiral crystal, which is defined as second harmonic generation CD (SHG-CD). Here, the SHG-CD effect is developed in bulk single crystals of chiral one-dimensional (1D) [(R/S)-3-aminopiperidine]PbI4. It is the first time that CPL is distinguished using chirality-dependent SHG-CD effect in OIHPs bulk single crystals. Such SHG-CD technol. extends the detection range to near IR region (NIR). In this way, the anisotropy factor (gSHG-CD) through SHG-CD signal is as high as 0.21.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Discovery of 8-azabicyclo[3.2.1]octan-3-yloxy-benzamides as selective antagonists of the kappa opioid receptor. Part 1, published in 2010-10-01, which mentions a compound: 23794-15-2, Name is 1-(2-chloropyridine-4-yl)ethanone, Molecular C7H6ClNO, Category: piperidines.

Initial high throughput screening efforts identified highly potent and selective kappa opioid receptor antagonist 3 (κ IC50 = 77 nM; μ:κ and δ:κ IC50 ratios >400) which lacked CNS exposure in vivo. Modification of this scaffold resulted in development of a series of 8-azabicyclo[3.2.1]octan-3-yloxy-benzamides showing potent and selectivity κ antagonism as well as good brain exposure. Analog 6c (I) (κ IC50 = 20 nM; μ:κ = 36, δ:κ = 415) was also shown to reverse κ-agonist induced rat diuresis in vivo.

There is still a lot of research devoted to this compound(SMILES：CC(=O)C1=CC(Cl)=NC=C1)Category: piperidines, and with the development of science, more effects of this compound(23794-15-2) can be discovered.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Quality Control of (S)-Piperidin-3-amine dihydrochloride. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (S)-Piperidin-3-amine dihydrochloride, is researched, Molecular C5H14Cl2N2, CAS is 334618-07-4, about A triple exon-skipping luciferase reporter assay identifies a new CLK inhibitor pharmacophore. Author is Shi, Yihui; Park, Jaehyeon; Lagisetti, Chandraiah; Zhou, Wei; Sambucetti, Lidia C.; Webb, Thomas R..

The splicing of pre-mRNA is a critical process in normal cells and is deregulated in cancer. Compounds that modulate this process have recently been shown to target a specific vulnerability in tumors. We have developed a novel cell-based assay that specifically activates luciferase in cells exposed to SF3B1 targeted compounds, such as sudemycin D6. This assay was used to screen a combined collection of approved drugs and bioactive compounds This screening approach identified several active hits, the most potent of which were CGP-74514A and aminopurvalanol A, both have been reported to be cyclin-dependent kinases (CDKs) inhibitors. We found that these compounds, and their analogs, show significant cdc2-like kinase (CLK) inhibition and clear structure-activity relationships (SAR) at CLKs. We prepared a set of analogs and were able to ‘dial out’ the CDK activity and simultaneously developed CLK inhibitors with low nanomolar activity. Thus, we have demonstrated the utility of our exon-skipping assay and identified new mols. that exhibit potency and selectivity for CLK, as well as some structurally related dual CLK/CDK inhibitors.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Application In Synthesis of 4,4-Difluoropiperidine hydrochloride. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 4,4-Difluoropiperidine hydrochloride, is researched, Molecular C5H10ClF2N, CAS is 144230-52-4, about Synthesis of 4-oxotetrahydropyrimidine-1(2H)-carboxamides derivatives as capsid assembly modulators of hepatitis B virus.

We report herein the synthesis and evaluation of Ph ureas derived from 4-oxotetrahydropyrimidine as novel capsid assembly modulators of hepatitis B virus (HBV). Among the derivatives, compound 27 (58031) and several analogs showed an activity of submicromolar EC50 against HBV and low cytotoxicities (>50 μM). Structure-activity relationship studies revealed a tolerance for an addnl. group at position 5 of 4-oxotetrahydropyrimidine. The mechanism study indicates that compound 27 (58031) is a type II core protein allosteric modulator (CpAMs), which induces core protein dimers to assemble empty capsids with fast electrophoresis mobility in native agarose gel. These compounds may thus serve as leads for future developments of novel antivirals against HBV.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem