Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10338-57-5,4-(Piperidin-1-yl)benzaldehyde,as a common compound, the synthetic route is as follows.

General procedure: In a grinding jar, 4-(diphenylamino)benzaldehyde (0.015 mol, 4.10 g) were combined with [(4-ethenylphenyl)methyl] phosphonic acid diethyl ester (0.01 mol, 2.53 g), t-BuOK (0.02 mol, 2.76 g) and the 7 mm stainless steel balls. The grinding jar was placed in a planetary ball-mill and stirred at 550 runs per minute during 2 h at room temperature. Then 60 mL DCM was added in the jar and the mixture was washed twice with 200 mL water. The organic layer was dried over MgSO4, concentrated under vacuum. The residue was isolated by column chromatography on silica gel using petroleum ether/ethyl acetate (10:1) to afford 3.06 g of the titled compound as a light yellow needle crystal. Yield 80.2%., 10338-57-5

The synthetic route of 10338-57-5 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Huang, Jiu-Qiang; Cai, Zhi-Bin; Jin, Fan; Li, Sheng-Li; Tian, Yu-Peng; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 154; (2016); p. 164 – 170;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

1075-89-4, 8-Azaspiro[4.5]decane-7,9-dione is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 20 8-{2-[4-(2-Fluorophenyl)piperazin-1-yl]ethyl}-8-azaspiro[4.5]decane-7,9-dione (Compound 20) A mixture of 3,3-tetramethylene glutarimide (6.9 mg) and potassium carbonate (40 mg) in dimethylformamide (0.5 mL) was stirred at room temperature for 30 minutes. 1-(2-Chloroethyl)-4-(2-fluorophenyl)piperazine (10.0 mg) was added and the resulting solution was heated at 120 C. for 3 hours. The solvent was removed and the residue was purified by thin-layer chomatography (silica gel, eluding with hexane/ethyl acetate, 1:1), giving the title compound as a white solid (6.2 mg, 40%). 1H NMR (300 MHz, CDCl13) delta 7.07-6.87 (m, 4H), 3.96 (t, 2H, J=6.6 Hz), 3.05 (t, 4H, J=4.8 Hz), 2.67 (t, 4H, J=4.7 Hz), 2.59 (s, 4 H), 2.54 (t, 4H, J=6.6 Hz), 1.73-1.68 (m, 4H), 1.55-1.50 (m, 4H). ESI-MS m/z 374 (MH+).

1075-89-4, 1075-89-4 8-Azaspiro[4.5]decane-7,9-dione 136843, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; Konkel, Michael; Wetzel, John M.; Noble, Stewart A.; Gluchowski, Charles; Craig, Douglas A.; US2002/28760; (2002); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

768-66-1, 2,2,6,6-Tetramethylpiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under nitrogen, 0.62 ml (3.7 mmol) 2,2,6,6-tetramethylpiperidine was added to 20 ml anhydrous THF (-78 C.). n-Buli 1.3 ml (2.5 M, 3.33 mmol) was added and the reaction mixture was stirred for 30 minutes. Compound 91 (0.83 g, 2.16 mmol), dissolved in 10 ml THF was added and the mixture was stirred for 30 minutes., 768-66-1

As the paragraph descriping shows that 768-66-1 is playing an increasingly important role.

Reference：
Patent; STOIT, Axel; Coolen, Hein K.A.C.; Van Der Neut, Martina A. W.; Kruse, Cornelis G.; US2008/9514; (2008); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

72752-52-4, 2-Piperidinobenzonitrile is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 3-5; 4-methyl-2-(2-(1-piperidinyl)phenyl)pentanoic acid; This acid was synthesized in 3 steps from the intermediate 2-(1-piperidinyl)benzonitrile (see example 2-1). Step 1; 3-methyl-1-(2-(1-piperidinyl)phenyl)butan-1-ol; Under anhydrous atmosphere, 2-(1-piperidinyl)benzonitrile (10 g, 53.7 mmol) was solubilized in anhydrous THF (50 ml). Freshly prepared isobutylmagnesium bromide (83 ml at 3.9 mol/l in THF, 324 mmol) was added and the mixture was refluxed overnight. The mixture was hydrolyzed with water and acidified by a 1M HCl solution until pH 7. The resulting ketone was extracted by ethyl acetate, dried with magnesium sulfate (MgSO4), and evaporated. The residue was solubilized in methanol (100 ml) and the solution was cooled with an ice bath. Sodium borohydride (7.1 g, 188 mmol) was added portionwise at 0 C. and the reaction was slowly warmed to room temperature. Once the ketone was reduced, water was added and the alcohol was extracted by ethyl acetate, dried with magnesium sulfate (MgSO4) and evaporated. The expected product was purified by silica gel chromatography (cyclohexane/ethyl acetate 95/5). Yield: 60%, 72752-52-4

72752-52-4 2-Piperidinobenzonitrile 2774355, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; GENFIT; US2006/79696; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5810-56-0,4-Acetamidopiperidine,as a common compound, the synthetic route is as follows.

20.1 c lambda/-(1-{4-[2-(4-Benzyloxy-6-oxo-6/-/-pyrimidin-1-yl)-ethyl]-benzyl}-piperidin-4-yl)- acetamideTo 100 mg (0.25 mmol) 6-benzyloxy-3-[2-(4-bromomethyl-phenyl)-ethyl]-3H-pyrimidin-4-one (example 20.1 b) in 1.0 mL DCM is added 71 mg (0.50 mmol) lambda/-piperidin-4-yl-acetamide atRT. The reaction mixture is refluxed for 2 h and the solvent is evaporated. The residue is dissolved in DMF and a few drops of formic acid and is transferred to a reverse HPLC for purification (Waters symmetry, C 18; water (0.15 % formic acid)/acetonitrile 95:5 to 5:95).Yield: 75 mg (65% of theory) ESI Mass spectrum: [M+H]+ = 461Retention time HPLC: 2.2 min (method G).

5810-56-0, 5810-56-0 4-Acetamidopiperidine 1445156, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG; WO2008/22979; (2008); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3518-83-0,N-Ethyl-4-hydroxypiperidine,as a common compound, the synthetic route is as follows.

Add to the reaction flask1-ethylpiperidin-4-ol (1.0 g, 7.7 mmol), 2,5-dibromopyridine (2 g, 8.5 mmol)And dimethylsulfoxide (30 mL) were added sodium tert-butoxide (1.7 g, 15.4 mmol).The mixture was stirred at room temperature for 3 hours, water (30 mL) was added,Dichloromethane extraction (20 mL x 3) .The organic layers were combined,Washed with saturated brine (20 mL), dried over anhydrous sodium sulfate and the filtrate was concentrated in vacuo.The resulting residue was purified by column chromatography (DCM / MeOH = 10: 1)To give the title compound (702 mg, black solid) in 32% yield., 3518-83-0

As the paragraph descriping shows that 3518-83-0 is playing an increasingly important role.

Reference：
Patent; Gan & Lee Pharmaceuticals; Liu, Wenjian; Yin, Lei; Li, Heng; (94 pag.)CN106608879; (2017); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3612-20-2,1-Benzylpiperidin-4-one,as a common compound, the synthetic route is as follows.

A solution of 294.14 g 1-benzylpiperidin-4-one in 2.1 L methanol was added to a solution of 448 g ammonium carbonate in 2.1 L hot water. The yellow turbid reaction mixture was cooled with an ice bath. A solution of 77 g sodium cyanide in 200 ml water was added dropwise over 10 min (exothermic.). After the addition the ice bath was removed and the reaction mixture was stirred at ambient temperature for 3 days. The resulting precipitate was filtered, washed with water (3×) and dried in a vacuum oven at 50 C. to obtain the intermediate I.38. [0268] Yield: quantitative, 3612-20-2

3612-20-2 1-Benzylpiperidin-4-one 19220, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GmbH; Dahmann, Georg; Fiegen, Dennis; Fleck, Martin; Hoffmann, Matthias; Klicic, Jasna; East, Stephen Peter; Napier, Spencer Charles R.; Scott, John; US2013/23502; (2013); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

5810-56-0, 4-Acetamidopiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5810-56-0

Example 3; (2S)-4,4-Difluoro-1-(2-{[1-(2-pyrazinyl)piperidin-4-yl]amino}acetyl)-2-pyrrolidine carbonitrile dihydrochloride; The meaning of Rl is 2-pyrazinyl group, B means a group of formula (1), R2 and R3 mean fluorine atom in general formula (I). a. ) 1- .-4-acetamino-piperidine with (V) general formula-where Ru ils 2- pyrazinyl, Y is COCH3, B is (1) group; 0,45 ml of chloropyrazine (5 mmol) and 1,6 g of 4-acetaminopyperidine (10 mmol) are dissolved in 15 ml of 1-pentanol and heated under reflux for 14 hours. The solvent are evaporated and the residue is purified by column chromatography using ethyl acetate- methanol-25 % aqueous NH3 solution (17: 3: 1) as eluent to result 0,81 g (76 %) of the above crystalline product. M. p.: 158-160C. 1H-NMR (200 MHz, DMSO-d6) : 3 1.34 (dq, 2H), 1.78 (m, 5H), 3.03 (dt, 2H), 3.74-3. 89 (m, lH), 4.21 (td, 2H), 7.77 (d, 1H, 3′-H), 7.80 (s, 1H, NH), 8. 05 (dd, 1H, 5′-H), 8.31 (d, 1H, 6′-H).

5810-56-0 4-Acetamidopiperidine 1445156, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; SANOFI-SYNTHELABO; WO2003/74500; (2003); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10338-57-5,4-(Piperidin-1-yl)benzaldehyde,as a common compound, the synthetic route is as follows.

General procedure: A mixture of 0.208 g. (0.002 mol) of malonic acid and 0.166 g.(0.001 mol) of 4-substituted benzaldehyde Ia-g and (5 mL) of pyridinewas prepared. Malonic acid is dissolved by shaking andwarming on a steam bath. Catalytic amount of piperidine was thenadded and the mixture was heated at 80-85 C for 1 h. After whichthe mixture was heated under reflux (109-115 C) for an additional3 h. The reaction mixture was then cooled and poured intocold water. The mixture was then acidified by slow addition of concentratedhydrochloric acid with stirring. The formed light crystalswere separated by filtration and washed 4 times with cold water.The crude acid was dissolved in a solution of 5% sodium hydroxide.The resulting solution was filtered, diluted with an additionalwater, and acidified by adding concentrated hydrochloric acid.The formed solid was filtered and washed with cold water. Thesolid was further purified by using methanol as the solvent of crystallizationto yield titled compounds IIIa-g.(E)-3-(4-(Piperidin-1-yl)phenyl) acrylic acid IIIc (E) Yield 87% as reddish purple solid, mp 110 C. IR: (U max, cm-1): 1594 (C=C), 1755 (C=O, COOH), 2928-3420 (OH, COOH). 1H NMR (400 MHz)(DMSO) delta: 1.54 (m, H, piperidine H3, H4, H5), 3.39 (t, 4H, piperidine H2, H6), 6.47 (d, 1H, CH=CH-COOH, J = 16 Hz), 7.01 (d, 2H, aromatic H3, H5, J = 8.8 Hz), 7.50 (d, 1H, CH=CH-COOH, J = 15.8 Hz), 7.65 (d, 2H, aromatic H2, H6, J = 8.8 Hz). MS: m/z (%): 231 (M+, 77%), 232 (M++1, 58%) and base peak at 209 (100%). Anal. Calcd for C14H17NO2: C, 72.70; H, 7.41; N, 6.06. Found: C, 72.84; H, 7.48; N, 6.19., 10338-57-5

10338-57-5 4-(Piperidin-1-yl)benzaldehyde 291354, apiperidines compound, is more and more widely used in various fields.

Reference：
Article; Abdel-Atty, Mona M.; Farag, Nahla A.; Kassab, Shaymaa E.; Serya, Rabah A.T.; Abouzid, Khaled A.M.; Bioorganic Chemistry; vol. 57; (2014); p. 65 – 82;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

53617-36-0, 1-Methyl-4-(piperidin-4-yl)piperazine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(Example 54) N-(2-Fluoro-4-{[2-({[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl}amino)pyridin-4-yl]oxy}phenyl)-N’-phenylcyclopropane-1,1-dicarboxamide To a solution of [4-(3-fluoro-4-{[1-(phenylcarbamoyl)cyclopropanecarbonyl]amino}phenoxy)pyridin-2-yl]-N-(phenoxycarbonyl)carbamic acid phenyl ester (100 mg) in N,N-dimethylformamide (2.0 ml) was added 1-methyl-4-(piperidin-4-yl)piperazine (114 mg) at room temperature, followed by stirring for 5 hr. The reaction mixture was partitioned between ethyl acetate and water. The organic layer was washed with a saturated aqueous solution of ammonium chloride and brine in this order, and dried over anhydrous sodium sulfate. The solvent was concentrated under reduced pressure. The resultant residue was purified by silica gel column chromatography (Fuji Silysia NH, eluent; ethyl acetate, then ethyl acetate:methanol = 95:5). Fractions containing the target compound were concentrated under reduced pressure. A solid was precipitated by addition of diethyl ether to the resultant residue. The solid was collected by filtration. The solid was dried under aeration to provide the titled compound as white powder (28.3 mg, 30 percent). 1H-NMR Spectrum (CDCl3) delta (ppm): 1.40-2.00 (9H, m), 2.29 (3H, s), 2.35-2.70 (8H, m), 2.89 (2H, m), 4.05-4.15 (2H, m), 6.53 (1H, dd, J = 2.4, 5.6 Hz), 6.90-6.95 (2H, m), 7.15 (1H, m), 7.24 (1H, brs), 7.33-7.40 (2H, m), 7.50-7.55 (2H, m), 7.63 (1H, d, J = 2.4 Hz), 8.05 (1H, d, J = 5.6 Hz), 8.22 (1H, m), 8.94 (1H, brs), 9.09 (1H, brs). ESI-MS (m/z): 638 [M+Na]+.

53617-36-0, The synthetic route of 53617-36-0 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Eisai R&D Management Co., Ltd.; EP1889836; (2008); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem