Tag: M.W:100-200

79099-07-3, 1-Boc-4-Piperidone is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,79099-07-3

Step-1: 3,3-Dimethyl-4-oxo-piperidine-1-carboxylic acid tert-butyl ester; Methyl iodide (11.8 ml, 0.19 mol) was added at 0 C. to a solution of 4-oxo-piperidine-1-carboxylic acid tert-butyl ester (18 g, 0.09 mol). Sodium tert butoxide (20.9 g, 0.22 mol) was then added at 0 C. and the resulting mixture was heated to reflux for 1 hour. The reaction mixture was concentrated under reduced pressure, diluted with water and the product was extracted with ethyl acetate. The organic layer was washed with brine, dried over sodium sulfate and concentrated Purification of the residue by column chromatography (2% ethyl acetate-hexane) afforded 7 g (37%) of 3,3-dimethyl-4-oxo-piperidine-1-carboxylic acid tert-butyl ester. 1H-NMR (400 MHz, CDCl3) delta (ppm): 3.7 (m, 2H), 3.41 (m, 2H), 2.47 (t, 2H), 1.48 (s, 9H), 1.09 (s, 6H).

79099-07-3 1-Boc-4-Piperidone 735900, apiperidines compound, is more and more widely used in various.

Reference£º
Patent; KHAMRAI, Uttam; Ronsheim, Matthew; Karak, Sumit Kumar; US2010/152160; (2010); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

1892-22-4, 3-Aminopiperidin-2-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A suspension of 4 ‘- [(25) -2- {[(GammaalphaMu5-4- {[(betaGamma-BetaupsilonIotaomicron gammaomicron ^ omicronetagamma1) alphaetaiotaetaomicron] etaiotaepsilon11iotagamma1} omicrongammaomicron1omicron1iotaepsilon gamma1) – carbonyl] amino} -3- (l / i- indazol-6-ylamino) -3-oxopropyl] -2-methylbiphenyl-4-carboxylic acid (100 mg, 0.153 mmol) in ethyl acetate (2.5 ml) was treated with 3-aminopiperidine-2-one (19.2 mg, 0:17 mmol) and N , N-diisopropylethylamine (0.08 mL, 0:46 mmol).The suspension was treated with a 2,4,6-tripropyl-l, 3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide solution (50% in DMF, 0.27 mL, 0.46 mmol) and then 3 at reflux (oil bath temperature 80 C) stirred.The reaction mixture was added with DMF (1 ml) and the ethyl acetate was removed on a rotary evaporator.The residue was mixed with a little water and acetonitrile, filtered through a Millipore filter and purified by preparative HPLC (eluent: gradient of acetonitrile / water with 0.1% trifluoroacetic acid).This gave 49.1 mg (42% d. Th.) Of the title compound., 1892-22-4

1892-22-4 3-Aminopiperidin-2-one 5200225, apiperidines compound, is more and more widely used in various.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; ROEHN, ULRIKE; ELLERMANN, MANUEL; STRASSBURGER, JULIA; WENDT, ASTRID; ROEHRIG, SUSANNE; WEBSTER, ROBERT ALAN; SCHMIDT, MARTINA VICTORIA; TERSTEEGEN, ADRIAN; BEYER, KRISTIN; SCHAEFER, MARTINA; BUCHMUELLER, ANJA; GERDES, CHRISTOPH; SPERZEL, MICHAEL; SANDMANN, STEFFEN; HEITMEIER, STEFAN; HILLISCH, ALEXANDER; ACKERSTAFF, JENS; TERJUNG, CARSTEN; (489 pag.)TW2016/5810; (2016); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem