Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.37675-18-6,(S)-Ethyl piperidine-3-carboxylate,as a common compound, the synthetic route is as follows.

4.3.40 Ethyl (S)-1-(ethoxymethyl)piperidine-3-carboxylate, (S)-10 K2CO3 (2.8?g, 20?mmol) was added to a solution of ethyl nipecotate (3.2?mL, 20?mmol) in EtOH (7.0?mL, 0.12?mol) at 0?C. After 15?min paraformaldehyde (PFA) (0.63?g, 20?mmol) was added, and the mixture was stirred at 25?C for 6?h. The mixture was diluted with Et2O and filtered. The filtrate was concentrated under reduced pressure. The crude product was purified by distillation (Kugelrohr distillation) at 130?C (0.4?Torr) to obtain the product N,O-acetal (rac-10) as a colorless oil (3.1?g, 71%). Analytical data corresponds to those of rac-10 except [alpha]D 20 = +13.3 (c?=?2.0, DCM).

37675-18-6, 37675-18-6 (S)-Ethyl piperidine-3-carboxylate 187784, apiperidines compound, is more and more widely used in various fields.

Reference£º
Article; Toth, Krisztian; Hoefner, Georg; Wanner, Klaus T.; Bioorganic and Medicinal Chemistry; vol. 26; 22; (2018); p. 5944 – 5961;,
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2971-79-1, Methyl piperidine-4-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of Example 340F (9.5 g, 25.1 mmol) and methyl isonipecotate (7.19 g, 50.2 mmol) in DMF (70 ML) was added EDC (9.64 g, 50.2 mmol), HOBt (6.78 g, 50.2 mmol) and triethylamine (7.0 ML, 50.2 mmol).The reaction mixture was stirred at room temperature for 15 hours.ethyl acetate (800 ML) was added, and the mixture was washed with brine, and concentrated.The residue was purified by flash chromatography (60% EtOAc in hexane) to give example 340G as white powder (10.86 g, 94%). MS (ESI+) m/z 503 (M+H)+., 2971-79-1

2971-79-1 Methyl piperidine-4-carboxylate 424914, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Abbott Laboratories; US2004/116518; (2004); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.79099-07-3,1-Boc-4-Piperidone,as a common compound, the synthetic route is as follows.

79099-07-3, 3, 3-DIMETHVL-4-OXO-PIPERIDINE-1-CARBOXYLIC acid ter-butyl ester (88 ; Scheme XXIV was prepared according the procedure described in Vice et al. J. Org. Chem. 2001,66, 2487-2492.

As the paragraph descriping shows that 79099-07-3 is playing an increasingly important role.

Reference£º
Patent; JANSSEN PHARMACEUTICA, N.V.; WO2005/33108; (2005); A1;,
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Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5382-16-1,4-Piperidinol,as a common compound, the synthetic route is as follows.,5382-16-1

b. 1-(Carbobenzyloxy)piperidin-4-ol A solution of 4-hydroxypiperidine (25.0 g, 0.247 mol) in methylene chloride (2000 mL) was cooled to 0 C. under nitrogen with overhead stirring. Triethylamine (86.1 mL, 0.618 mol, 2.5 eq) was added followed by benzyl chloroformate (35.3 mL, 0.247 mol, 1.0 eq). The reaction was warmed to room temperature over 1 h and maintained at this temperature for 5 h. A significant amount of amine hydrochloride precipitates in the course of the procedure. The organic phase was washed with 3N HCl (3*250 mL), dried over anhydrous sodium sulfate and filtered. The solvent was removed in vacuo to yield 47.0 g (81%) of the title compound as an oil. The product did not require any addition purification prior to the Swern oxidation. TLC analysis (Rf 0.17, 50% ethyl acetate in hexane). MS (CI, CH4) m/z 236 (M+1,42), 218 (4), 192 (10), 181 (9), 174 (15), 91 (100).

5382-16-1 4-Piperidinol 79341, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Zeneca Limited; US5512575; (1996); A;,
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40064-34-4, Piperidine-4,4-diol hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,40064-34-4

Step 1 To a stirred, 0 C. solution of 4-piperidinone hydrochloride hydrate (50 g; 0.33 mol) in DMF (500 mL) was added di-t-butyldicarbonate (64 g; 0.29 mol) followed by a dropwise addition of DIEA (63 mL; 0.36 mol). After the addition of DIEA was complete, the reaction was allowed to gradually warm to ambient temperature over 4 h and stirring was continued for 20 h. The DMF was removed under reduced pressure and the residue was dissolved in EtOAc (1000 mL) and washed with 5% aqueous citric acid (2*500 mL), water (250 mL), and saturated aqueous NaHCO3 (500 mL). The EtOAc layer was dried (Na2 SO4), filtered, and the EtOAc was removed under reduced pressure. The residue was boiled in ether (ca. 250 mL) until the solid had dissolved. Cooling gave N-t-butyloxycarbonyl-4-piperidinone as white crystals (47 g; 80% yield).

40064-34-4 Piperidine-4,4-diol hydrochloride 33721, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Merck & Co., Inc.; US5665719; (1997); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20845-34-5,1-Methyl-2-piperidinemethanol,as a common compound, the synthetic route is as follows.

The title compound was prepared by using Mitsunobu condition from 4-(2-hydroxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester and 1-Methyl-2-piperidinemethanol., 20845-34-5

As the paragraph descriping shows that 20845-34-5 is playing an increasingly important role.

Reference£º
Patent; Briner, Karin; Doecke, Christopher William; Mancuso, Vincent; Martinelli, Michael John; Richardson, Timothy Ivo; Rothhaar, Roger Ryan; Shi, Qing; Xie, Chaoyu; US2004/82590; (2004); A1;,
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20845-34-5, 1-Methyl-2-piperidinemethanol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Synthesis of 2-(hydroxymethyl)-1-(2-isothiocyanatoethyl)-1-methylpiperidin-1-ium trifluoromethanesulfonate: A solution of 2-Isothiocyanatoethyl trifluoromethanesulfonate (30.2 mg, 0.128 mmol) and (1-methylpiperidin-2-yl)methanol (17.4 mg, 1.05 eq.) in toluene (0.5 mL) was stirred at RT for 2 hrs. The solvent was decanted and the residual oil was dissolved in DCM (0.3 mL) and Et2O (diethyl ether) (1 mL) was added to precipitate the salt. The top solvent layer was decanted. This process repeated twice. The residue was dried in high vacuum to give 41.9 mg (89.7percent) as colorless oil. MS-ESI: 129.84 (M-CH2CH2NCS?OTf?), 215.07 (M-OTf?), 20845-34-5

The synthetic route of 20845-34-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; The Procter & Gamble Company; GARCIA-GARCIA, Jose Carlos; HAZEN, Stanley Leon; WOS, John August; (43 pag.)US2017/152222; (2017); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3197-44-2,(R)-Piperidin-2-ylmethanol,as a common compound, the synthetic route is as follows.

7-Chloro-1-(3,5-difluoropyridin-2-yl)-6-fluoro-N-(1,1,1,3,3,3-hexafluoropropan-2-yl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide (50.0 mg, 99.1 mumol) was initially charged in 1 ml of DMF, (2R)piperidin-2-ylmethanol (12.6 mg, 109 mumol) and N,N-diisopropylethylamine (8.6 mul, 50 mumol) were added and the mixture was stirred at 55 C. for 8 h. More (2R)-piperidin-2-ylmethanol (5.7 mg, 50 mumol) and N,N-diisopropylethylamine (8.6 mul, 50 mumol) were added and the mixture was stirred at 55 C. The reaction solution was cooled and purified by preparative HPLC (RP18 column, mobile phase: acetonitrile/water gradient with addition of 0.1% formic acid). The product fractions were combined and concentrated by evaporation. This gave 37 mg of the target compound (63% of theory, purity 99%). LC-MS (Method 3): Rt=2.26 min; MS (ESIpos): m/z=584 [M+H]+ 1H NMR (400 MHz, DMSO-d6) delta [ppm]: -0.149 (0.99), -0.008 (7.81), 0.008 (7.07), 0.146 (0.93), 1.339 (1.30), 1.525 (9.67), 1.545 (8.81), 1.616 (2.67), 1.647 (2.17), 1.745 (3.97), 2.328 (1.86), 2.367 (0.68), 2.670 (1.98), 2.711 (0.68), 2.921 (2.17), 2.954 (1.61), 3.002 (1.74), 3.031 (0.99), 3.473 (1.74), 3.489 (3.22), 3.500 (6.02), 3.515 (7.75), 3.529 (6.20), 3.581 (2.54), 3.859 (4.59), 3.892 (4.28), 4.286 (3.16), 4.660 (3.10), 4.697 (4.90), 6.300 (1.05), 6.317 (2.67), 6.335 (3.78), 6.360 (3.91), 6.378 (2.60), 6.397 (0.99), 8.037 (9.92), 8.071 (10.23), 8.339 (4.53), 8.357 (4.09), 8.629 (16.00), 8.635 (15.32), 8.956 (9.80), 11.224 (12.84), 11.250 (12.34)., 3197-44-2

The synthetic route of 3197-44-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; TELLER, Henrik; VAKALOPOULOS, Alexandros; BOULTADAKIS ARAPINIS, Melissa; STRAUB, Alexander; TINEL, Hanna; BRECHMANN, Markus; WITTWER, Matthias Beat; KULLMANN, Maximilian Andreas; FREUDENBERGER, Till; MONDRITZKI, Thomas; MARQUARDT, Tobias; (165 pag.)US2019/263805; (2019); A1;,
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42538-31-8,42538-31-8, (S)-3-Aminopiperidin-2-one hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

ExamEleJj_(5)-3-(l’-Methylcyclohexanecarbonyl)amino-tetrahydropyridin-2-one; (S)-3-Amino-tetrah.ydropyridin-2-one hydrochloride (2 mmol) and Na2CO3 (6 mmol) in water (25 ml) were added to a solution of 1-methylcyclohexanecarbonyl chloride (2 mmol) in dichloromethane (25 ml) at ambient temperature and the reaction was stirred for 18 hours. The organic layer was then separated and the aqueous phase was extracted with additional dichloromethane. The combined organic layers were dried over Na2SO4 and reduced in vacuo. The residue was purified by silica column chromatography (EtOAc: hexanes 1:3 to MeOH : EtOAc 1:19) to give as an amorphous solid (199 mg, 42%); v^/cm”1 3335, 3269 (NH)5 1650, 1621 (CO), 1529 (NH); deltaH (500 MHz, CDCl3) 6.65 (IH5 br d, J5, NH), 6.59 (IH5 br S5 NH), 4.18 (IH5 dt, J 11.5, 5.5, CHNH), 3.30 (2H, td, J6.5, 2.5, CH2NH), 2.52 (IH, ddt, J 13, 5.5, 4.5, lactam CH2), 1.92-1.83 (4H5 m, 2 x lactam CH and 2 x cyclohexane CH2), 1.55-1.23 (9H, m, lactam CH and 8 x cyclohexane CH2) and 1.11 (3H, s, CH3); deltac (125 MHz, CDCl3) 178.0, 172.3 (CO)5 50.4 (NHCHCO), 42.6 (CH3C quat), 41.5, 35.6, 35.5, 27.0 (CH2), 26.3 (CH3), 25.7, 22.8 (chi2), 20.9 (CH2); m/z (MNa+ C13H22N2O2Na requires 261.1579) 261.1570.

42538-31-8 (S)-3-Aminopiperidin-2-one hydrochloride 45789910, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LIMITED; WO2006/134385; (2006); A2;,
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Piperidine | C5H11N – PubChem

1892-22-4, 3-Aminopiperidin-2-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 3-aminophthalic acid (0.100 g, 0.552 mmol) in DMF (1.1 mL) was added 3-aminopiperidine-2-one (0.063 g, 0.552 mmol) and the reaction was stirred at 90 C over 18 h. Volatiles were removed in vacuo and the dark-brown crude residue was purified by preparative reverse phase HPLC to give the desired product 28 (0.050 g, 35%) as an off-white powder. 1H NMR (400 MHz, DMSO) delta 7.83 (s, 1H), 7.43 (dd, J = 8.3, 7.1 Hz, 1H), 7.07 – 6.87 (m, 2H), 6.47 (br s, 2H), 4.49 (dd, J = 11.9, 6.3 Hz, 1H), 3.27 – 3.10 (m, 2H), 2.19 (dt, J = 12.0, 7.7 Hz, 1H), 2.05 – 1.72 (m, 3H). MS (ESI) m/z calcd for C13H14N3O3 [M+H]+ 260.3, found: 260.9., 1892-22-4

1892-22-4 3-Aminopiperidin-2-one 5200225, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Taiho Pharmaceutical Co., Ltd.; PARK, Eun, Sun; PELISH, Henry, E.; CLARKE, Astrid, S.; WILLIAMS, Grace, L.; CASTALDI, Maria, Paola; AREFOLOV, Alexander; RING, Jennifer, E.; SHAIR, Matthew, D.; KING, Randall, W.; (58 pag.)EP2582836; (2018); B1;,
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