Tag: M.W:100-200

4897-50-1,4897-50-1, 4-Piperidinopiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of triphosgene (8 g, 26.9 mmol) in dry dichloromethane (40 mL) at -7 C were added dry triethylamine (1 mL, 7.1 mmol) and dropwise a solution of 1,4′-dipiperidine (5 g, 29.7 mmol) in dry dichloromethane (35 mL) over a period of 50 min. Then the solution was stirred at room temperature for 8 h, at which time the reaction was completed, the solution was filtered, the filtrate was concentrated, the residue was reacted with 23-hydroxybetulinic acid directly without further purification.

As the paragraph descriping shows that 4897-50-1 is playing an increasingly important role.

Reference£º
Article; Lan, Ping; Wang, Jiao; Zhang, Dong-Mei; Shu, Chang; Cao, Hui-Hui; Sun, Ping-Hua; Wu, Xiao-Ming; Ye, Wen-Cai; Chen, Wei-Min; European Journal of Medicinal Chemistry; vol. 46; 6; (2011); p. 2490 – 2502;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.54012-73-6,Piperidin-3-amine,as a common compound, the synthetic route is as follows.

54012-73-6, In a sample bottle with stopper with a volume of 20 ml,1.00 g (10.0 mmol) of racemic 3-aminopiperidine,2.65 g (10.0 mmol) of N-p-toluyl-D-glutamic acid,5.55 g of methanol,And 0.97 g of water, and the mixture was heated to 60 C. for dissolution,10 mg of N-p-toluyl-D-glutamate of (S) -3-aminopiperidine was added.After cooling to 10 C.,After filtering the precipitated crystals,And dried to obtain 1.57 g of a salt.The optical purity of 3-aminopiperidine contained in the salt was 95.5% e. E. (S form).A portion of this salt was collected to quantify 3-aminopiperidine,The content rate is 27.5%This salt,It was confirmed to be a 1: 1 salt of 3-aminopiperidine and Np-toluyl-D-glutamic acid.Yield 43%.

The synthetic route of 54012-73-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; TORAY FINE CHEMICALS CO LTD; FUJINO, TOSHIHIRO; HIRAGA, HISAFUMI; (9 pag.)JP5838590; (2016); B2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

3970-68-1, 4-Methylpiperidin-4-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 7 4-Methyl-1-[3-[3-(trifluoromethyl)phenyl]sulfonyl-8-quinolyl]piperidin-4-ol Hydrochloride 4-Methylpiperidin-4-ol (292 mg, 2.53 mmol), 8-fluoro-3-(3-(trifluoromethyl)phenyl-sulfonyl)quinoline (200 mg, 0.563 mmol) and K2CO3 (311 mg, 2.252 mmol) were suspended in NMP (2 ml) and stirred in the Microwave at 225 C. for 35 min. The reaction mixture was diluted with ethyl acetate and washed 4* with water, dried and concentrated. The product was obtained by preparative HPLC chromatography on a reversed phase column. Finally the HCl salt was formed by adding one equivalent HCl to give 4-methyl-1-(3-(3-(trifluoromethyl)phenylsulfonyl)quinolin-8-yl)piperidin-4-ol hydrochloride (97 mg, yield 35.4%). LCMS (ESI+) m/z [M+H]+: 451.10 1H NMR (DMSO-d6, 500 MHz): delta=9.56 (d, J=2.1 Hz, 1H), 9.44 (d, J=2.1 Hz, 1H), 8.43-8.53 (m, 3H), 8.32 (d, J=8.2 Hz, 1H), 8.17 (d, J=7.9 Hz, 1H), 7.97 (t, J=7.9 Hz, 1H), 7.91 (t, J=7.9 Hz, 1H), 5.32-5.41 (m, broad, 1H), 4.04 (br s, 2H), 3.63 (s, 1H), 3.61 (s, 1H), 2.21 (m, 2H), 1.83 (m, 2H), 1.31 ppm (s, 3H)., 3970-68-1

The synthetic route of 3970-68-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Abbvie Deutschland GmbH & Co. KG; GENESTE, Herve; HAUPT, Andreas; POHLKI, Frauke; RELO, Ana Lucia; UNGER, Liliane; WICKE, Karsten; (53 pag.)US2017/260158; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.214147-48-5,1-(4-Aminopiperidin-1-yl)ethanone hydrochloride,as a common compound, the synthetic route is as follows.

The sealed tube is charged with 7-bromo-5-chloroquinoxaline (50 mg; 0.21 mmol; 1.00 eq.), 1 -(4-aminopiperidin-1 -yl)ethan-1-one hydrochloride (38 mg; 0.27 mmol; 1.30 eq.), NaOtBu (59 mg; 0.62 mmol; 3.00 eqf.), BrettPhos Pd G1 (3.3 mg; 0.00 mmol; 0.02 eq.), BrettPhos (4.4 mg; 0.01 mmol; 0.04 eq.) and sealed with silicone PTFE coated cap. The air from the vessel is evacuated in vacuo thorough syringe and backfilled with argon. The cycle is repeated 3 times and anhydrous [1 ,4]-dioxane (1 .00 ml) is added thorough syringe. RM is heated and stirred for 1 h at 120C. Then RM is diluted with EtOAc and filtered through celite pad. Filtrate is evaporated resulted oily residue is purified by FCC (MeOH/DCM, gradient). 1-{4-[(8-Chloroquinoxalin- 6-yl)amino]piperidin-1-yl}ethan-1 -one (6.9 mg; 0.02 mmol; yield 10.4%;94% by UPLC) is obtained as brown glass.

214147-48-5, 214147-48-5 1-(4-Aminopiperidin-1-yl)ethanone hydrochloride 17221642, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; SELVITA S.A.; FABRITIUS, Charles-Henry Robert Yves; NOWAK, Mateusz Oktawian; WIKLIK, Katarzyna Anna; SABINIARZ, Aleksandra Barbara; BIE?, Marcin Dominik; BUDA, Anna Ma?gorzata; GUZIK, Pawel Szczepan; JAKUBIEC, Krzysztof Roman; MACIUSZEK, Monika; KWIECI?SKA, Katarzyna; TOMCZYK, Mateusz Micha?; GA??ZOWSKI, Micha? Miko?aj; GONDELA, Andrzej; DUDEK, ?ukasz Piotr; (681 pag.)WO2016/180536; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

24666-56-6, 3-Aminopiperidine-2,6-dione hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 3-aminopiperidine-2,6-dione (2.00 g, 12.1 mmol, HCl) and methyl 4-bromo-2-(bromomethyl)benzoate (5.10 g, 16.5 mmol) in DMF (50.0 mL) was added TEA (4.92 g, 48.6 mmol). The reaction mixture was stirred at 75 C. for 12 hrs. On completion, the reaction mixture was diluted with water (200 mL) and filtered. The filtered cake was collected. The reaction mixture was concentrated in vacuo. The residue was triturated with EA_H2O=1:1 (50 mL) to give the title compound (1.70 g, 39% yield) as blue solid. 1H NMR (400 MHz, DMSO-d6) delta 10.99 (s, 1H), 7.90 (s, 1H), 7.74-7.66 (m, 2H), 5.14-5.09 (m, 1H), 4.50-4.33 (m, 2H), 2.95-2.86 (m, 1H), 2.70-2.61 (m, 1H), 2.42-2.36 (m, 1H), 2.04-2.01 (m, 1H).

24666-56-6, As the paragraph descriping shows that 24666-56-6 is playing an increasingly important role.

Reference£º
Patent; Kymera Therapeutics, Inc.; Mainolfi, Nello; Ji, Nan; Kluge, Arthur F.; Weiss, Matthew M.; Zhang, Yi; (1443 pag.)US2019/192668; (2019); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

2971-79-1, Methyl piperidine-4-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of {3-(5-Chloro-2-difluoromethoxyphenyl)-4-[(pyrazolo[1,5-a]pyrimidine-3-carbonyl)amino]pyrazol-1-yl}acetic acid (500 mg, 1.08 mmol) in DMF (5 mL) was added methyl piperidine-4-carboxylate (232.1 mg, 1.62 mmol), DIEA (279.2 mg, 2.16 mmol), HATU (493.5 mg, 1.30 mmol). The resulting solution was stirred at room temperature overnight. The resulting mixture was concentrated under vacuum. The residue was purified by flash chromatography on silica gel eluting with 3% MeOH in DCM. This resulted in 500 mg (79%) of methyl 1-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperidine-4-carboxylate as yellow oil. LCMS (Method 25) [M+H]+=588.1, RT=0.87 min.

2971-79-1, As the paragraph descriping shows that 2971-79-1 is playing an increasingly important role.

Reference£º
Patent; Genentech, Inc.; Zak, Mark Edward; Ray, Nicholas Charles; Goodacre, Simon Charles; Mendonca, Rohan; Kellar, Terry; Cheng, Yun-Xing; Li, Wei; Yuen, Po-Wai; US2015/336962; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

159635-49-1, tert-Butyl 4-methylenepiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,159635-49-1

To a degassed, cooled (0¡ãC) sample of 11 (1.7 g) was added 9-BBN (17.5 mL of a 0.5 M in THF). The cooling bath was removed and the solution was stirred for 1.5 h at RT. The resulting solution was added, at RT, to a mixture of the sulfone 10 (0.27 g), Pd(dppf)Cl2 (20 mg), triphenyl arsine (25 mg), DMF (2.0 mL), water (0.18 mL) and Cs2CO3 (0.33 g). The resulting mixture was heated at 60¡ãC for 3 h 45 min. After cooling to RT and pouring into water, the pH was adjusted to 11 with 10 percent NaOH and mixture was extracted with EtOAc (3 * 25 mL). The combined organic extracts were dried with brine and MgSO4, filtered and evaporated to give a crude which was further purified by preparative plate chromatography (2000 muM plate; silica adsorbent; 1:1 EtOAc:hexanes eluant) to give the product 12 as a white foam (0.28 g) in 77 percent yield.

159635-49-1 tert-Butyl 4-methylenepiperidine-1-carboxylate 2756808, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; SCHERING CORPORATION; EP1091956; (2004); B1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.832715-51-2,Isopropyl 4-hydroxypiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

832715-51-2, Step 3: 1 -Methylethyl 4-({7-[6-(methylthio)-3-pyridinyl]-6,7-dihydro-5H-pyrrolo[2,3- c/]pyrimidin-4-yl}oxy)-1 -piperidinecarboxylate (206) To a stirred solution of 205 (1.31 g, 4.71 mmol) and 1 -methylethyl 4-hydroxy-1- piperidinecarboxylate 9 (1.06 g, 5.65 mmol) in THF (47 ml.) was added NaH (60% dispersion in mineral oil, 565 mg, 14.13 mmol) in one portion at RT. The reaction mixture was heated to reflux for 18 h, cooled to RT, and quenched with water (10 ml_). The mixture was extracted with EtOAc (3 x 75 ml_), dried over MgSO4, filtered, and concentrated under reduced pressure. The crude oil was purified using SiO2 flash chromatography (40% EtOAc in hexanes) to give 500 mg (25%) of the title product 206 as a colorless oil. 1H NMR (400 MHz, CDCI3): delta 8.58 (d, J = 2.7 Hz, 1 H), 8.41 – 8.37 (m, 1 H), 8.27 (s, 1 H), 7.21 (d, J = 8.8 Hz, 1 H), 5.32 (septuplet, J = 3.9 Hz, 1 H), 4.91 (app. quintuplet, J = 6.1 Hz, 1 H), 4.05 (t, J = 8.8 Hz, 2 H), 3.82 – 3.75 (m, 2 H), 3.35 – 3.28 (m, 2 H), 3.08 (t, J = 8.8 Hz, 2 H), 2.59 (s, 3 H), 2.00 – 1.93 (m, 2 H), 1.75 – 1.67 (m, 2 H), 1.24 (d, J = 6.8 Hz, 6 H); LCMS (ESI): m/z 430 (M + H)+.

832715-51-2 Isopropyl 4-hydroxypiperidine-1-carboxylate 16745126, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2008/8895; (2008); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3970-68-1,4-Methylpiperidin-4-ol,as a common compound, the synthetic route is as follows.

l-(6-Chloropyrazin-2-yl)-3,3-dimethyl-6-(2-methylpyrimidin-5-yl)indolin-2-one (52 mg, 142 mupiiotaomicron, Eq: 1, Example 6a), 4-methylpiperidin-4-ol (24.6 mg, 213 mupiiotaomicron, Eq: 1.5) and potassium carbonate (39.3 mg, 284 mupiiotaomicron, Eq: 2) were combined with acetonitrile (711 mu). The reaction mixture was heated to 100 C and stirred for 3 days until no starting material was left. The residue was purified by chromatography on silica gel to afford the desired product as a light yellow foam (63 mg, 99 %). MS (m/z) = 445.2 [M + H]+.

3970-68-1, As the paragraph descriping shows that 3970-68-1 is playing an increasingly important role.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; GAUFRETEAU, Delphine; KOLCZEWSKI, Sabine; PLANCHER, Jean-Marc; STOLL, Theodor; (99 pag.)WO2017/76842; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

79099-07-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.79099-07-3,1-Boc-4-Piperidone,as a common compound, the synthetic route is as follows.

To a stirred solution of tert-butyl 4-oxopiperidine-l-carboxylate (step 1, 6.0 g, 30.15 mmol, 1.0 eq) in DCM (60 mL) was added diethylaminosulfmtrifiuoride (DAST) (5.97 mL, 45.22 mmol, 1.5 eq) at 0 C. The reaction mixture was stirred at same temperature for about 6 hours. TLC indicated starting material was consumed and the desired product was observed. The reaction mixture was poured into ice cold water and extracted with DCM. The organic layer was washed with water, brine solution and the organic layer was dried with Na2S04. The filtrate was concentrated to get the crude residue which was purified by column chromatography by using 10% EtOAc and hexane as an eluent to obtain the desired product (6.0 g, yield: 90.0%) as a white solid. 1H NMR (DMSO-d6, 300 MHz): delta 3.45-3.41 (m, 4H), 1.98-1.85 (m, 4H) and 1.40 (s, 9H); Mass: [M+H]+222.53 (20%).

The synthetic route of 79099-07-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; HETERO LABS LIMITED; BANDI, Parthasaradhi Reddy; KURA, Rathnakar Reddy; GAZULA LEVI, David Krupadanam; ADULLA, Panduranga Reddy; MUKKERA, Venkati; NEELA, Sudhakar; (77 pag.)WO2017/149518; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem