Tag: M.W:100-200

Simple exploration of 159635-49-1

As the paragraph descriping shows that 159635-49-1 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.159635-49-1,tert-Butyl 4-methylenepiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

159635-49-1, m-Chloroperbenzoic acid (1 .14 g, 6.6 mmol) was added to a solution of tert-butyl 4- methylenepiperidine-1-carboxylate (1 g, 5.1 mmol) in CH2CI2(30 ml.) at 0¡ãC. The reaction mixture was stirred for 15 h at rt, diluted with CH2CI2, washed with a saturated aqueous solution of NaHC03and brine, dried (Na2S04), and evaporated to afford 1.1 g of the title compound which was used without further purification. H-NMR (400 MHz, CDCI3) delta ppm 3.74-3.65 (m, 2 H), 3.45-3.38 (m, 2 H), 2.68 (s, 2 H), 1.82-1.75 (m, 2 H), 1.48-1.41 (m, 2 H), 1.46 (s, 9 H).

As the paragraph descriping shows that 159635-49-1 is playing an increasingly important role.

Reference£º
Patent; NOVARTIS AG; FURET, Pascal; GUAGNANO, Vito; HOLZER, Philipp; MAH, Robert; MASUYA, Keiichi; SCHLAPBACH, Achim; STUTZ, Stefan; VAUPEL, Andrea; WO2013/80141; (2013); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

Downstream synthetic route of 142752-12-3

The synthetic route of 142752-12-3 has been constantly updated, and we look forward to future research findings.

142752-12-3, 1-(4-Aminophenyl)piperidin-4-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 141-{4-fluoro-2-[4-(4-hydroxypiperidin-1-yl)phenylamino]benzyl}-3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethylimidazolidine-2,4-dione; hydrochloride; 0.16 g of compound 3.2 was admixed with 0.10 g of 1-(4-aminophenyl)-piperidin-4-ol, 8 mg of palladium(II) acetate, 39 mg of 9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene and 0.33 g of cesium carbonate, before 10 ml of dry dioxane were added under an argon atmosphere. The mixture was stirred at 80 C. for 6 h. The cooled reaction mixture was filtered with suction, the filtrate was concentrated under reduced pressure and the residue was purified by chromatography (method [RP1]). The eluates were concentrated, admixed with hydrochloric acid in dioxane and freeze-dried. This afforded 1-{4-fluoro-2-[4-(4-hydroxypiperidin-1-yl)phenylamino]benzyl}-3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl imidazolidine-2,4-dione as the hydrochloride (14). Molecular weight (free base) 588.21 (C30H29F5N4O3); retention time Rt=3.91 min. [D]; MS (ESI): 589.52 (MH+)., 142752-12-3

The synthetic route of 142752-12-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SANOFI-AVENTIS; US2011/46105; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

New learning discoveries about 4842-86-8

4842-86-8, 4842-86-8 Ethyl 3-piperidinecarboxylate hydrochloride 12896004, apiperidines compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4842-86-8,Ethyl 3-piperidinecarboxylate hydrochloride,as a common compound, the synthetic route is as follows.

Example 12 5-[(3-Ethoxycarbonyl)piperidyl]-1-(3-ethoxy-4-methoxyphenyl)-1-penten-3-one hydrochloride Compound No. 12 0.387g (2.0mmol) of 3-ethoxycarbonylpiperidine hydrochloride and 0.4g (14mmol) of paraformaldehyde were dissolved in anhydrous ethanol (5ml). The pH value of the solution was adjusted to pH =2-3 with concentrated hydrochloric acid and the reaction mixture was refluxed and stirred for 2hr. After the solid was dissolved, 0.44g (2.0mmol) of 4-(3-ethoxy-4-methoxyphenyl)-3-buten-2-one (prepared as described in preparation 4) was added to the above reaction mixture. The solution was further refluxed and stirred for 11hr. TLC showed the reaction was completed, after staying overnight at room temperature, the precipitated solid was collected by filtration and then recrystallized from 95% ethanol and dried to give 0.26g of crystals, yield: 30.1 %, mp: 158-160C. 1H-NMR deltappm (DMSO-d6): 1.21(t, 3H, J=7.2 Hz, OCH2CH3), 1.33(t, 3H, J=7.2 Hz, COOCH2CH3), 2.26-2.71(brs, 5H, (CH2)2CH), 3.30-3.40(m, 8H, 3NCH2+COCH2), 3.80(s, 3H, OCH3), 4.10 (d, d, 4H, J=7.2 Hz, J=7.2 Hz, COOCH2CH3, OCH2CH3), 6.82(d, 1H, J=16.2Hz =CHCO), 7.02 (d, 1H, J=9.0Hz, ArH), 7.27(d, J=8.1Hz, 1H, ArH), 7.32(s, 1H, ArH), 7.63(d, 1H, J=16.2Hz, CH=). MS (m/z): 389(M+, 15), 344(M+-45, 12), 232(M+-156+H, 45), 316(M+-73, 3).

4842-86-8, 4842-86-8 Ethyl 3-piperidinecarboxylate hydrochloride 12896004, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES; EP1783115; (2007); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

Brief introduction of 276872-89-0

276872-89-0, 276872-89-0 N-Boc-3-Methylenepiperidine 11252594, apiperidines compound, is more and more widely used in various fields.

276872-89-0, N-Boc-3-Methylenepiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of N-Boc-3-methylenepyrazdine (0.4 g) and 9-BBN (12 ml) was cooled to 0 C. for 30 min, and then warmed to room temperature for 2 h. Dioxane (20 ml), PdCl2 (0.05 g), K3PO4 (0.32 g) and 4-chloro-2-(4-chlorophenyl)-thieno[2,3-d]pyridzaine-7-carboxylic acid ethyl ester were heated at 90 C. over night. The reaction mixture was cooled, diluted with ethyl acetate and washed with water. The organic layer was washed with brine, dried over anhydrous Na2SO4 and evaporated. The residue was purified by flash chromatography (silica gel, PE_EA=5:10) to obtain 4-(1-Boc-3-piperidinemethy)-2-(4-chlorophenyl)-thieno[2,3-d]pyridazine-7-carboxylic acid ethyl ester as a solid (0.3 g). 1H-NMR (400 MHz, DMSO), delta 8.90 (s, 1H), 8.03 (m, 2H), 7.63 (m, 2H), 4.54 (m, 2H), 3.73 (s, 2H), 3.32 (m, 2H), 3.28 (m, 1H), 2.82 (m, 2H), 2.09 (s, 1H), 1.78 (s, 1H), 1.64 (s, 1H), 1.44 (m, 3H), 1.39 (s, 1H), 1.32 (s, 9H). MS (EI): 515 (M+), 486, 458, 442, 414, 334, 332, 306, 304, 149, 57.

276872-89-0, 276872-89-0 N-Boc-3-Methylenepiperidine 11252594, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Wu, Zhanggui; US2009/275585; (2009); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

Brief introduction of 672883-95-3

672883-95-3 (S)-5-Aminopiperidin-2-one hydrochloride 42614518, apiperidines compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.672883-95-3,(S)-5-Aminopiperidin-2-one hydrochloride,as a common compound, the synthetic route is as follows.,672883-95-3

A mixture of (-S -5-((4-chloro-5-((4-(3-(3-(4-fluoropiperidin-l-yl)propoxy)-2- methylphenyl)-2,3-dihydro-lH-inden-l-yl)oxy)-2-formylphenoxy)methyl)isophthalonitrile (50.0 mg, 0.074 mmol) and (Patent; CHEMOCENTRYX, INC.; LANGE, Christopher; MALATHONG, Viengkham; MALI, Venkat Reddy; MCMAHON, Jeffrey; MCMURTRIE, Darren J.; PUNNA, Sreenivas; ROTH, Howard S.; SINGH, Rajinder; WANG, Yu; YANG, Ju; ZHANG, Penglie; (164 pag.)WO2019/23575; (2019); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

Simple exploration of 7149-42-0

The synthetic route of 7149-42-0 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7149-42-0,(1-Methylpiperidin-4-yl)methanamine,as a common compound, the synthetic route is as follows.

12. Scheme for the Synthesis of 7-29 . Scheme 613. Synthesis of N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy) phenyl imidazofi ,2-blpyridazin-6-amine (Compound 7-29):[0148] To the toluene (5 mL) solvent was added 7-12 (40 mg, 0.128 mmol), (1-methylpiperidin-4-yl)methanamine (24.53 0.191 mmol), ligand (7.53 mg, 0.019 mmol), Pd2(dba)3 (8.76, 9.56 mmol) and NaOfBu (17.40 mg, 0.181 mmol). The resulting reaction mixture was degassed for 10 min under argon and then was heated to reflux overnight (12 h). The crude product was EPO concentration and preparative TLC was performed with 10% MeOH/DCM solvent system afforded 17.6 mg of 7-23 (50%)., 7149-42-0

The synthetic route of 7149-42-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SUPERGEN, INC.; WO2008/58126; (2008); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

Some tips on 5382-16-1

5382-16-1, As the paragraph descriping shows that 5382-16-1 is playing an increasingly important role.

5382-16-1, 4-Piperidinol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(d) A solution containing 4-piperidinol (5 g) and triethylamine (7 ml) in dichloromethane (50 ml) was treated with benzyl chloroformate (7.5 ml), added dropwise, and the resulting mixture was allowed to stand for 2 hours. The mixture was diluted with dichloromethane (50 ml) and washed with water (2*50 ml) and with saturated brine (50 ml). The organic solution was dried (MgSO4) and concentrated. The residue was purified by column chromatography, eluding with ether/hexane (50%, then 75%) followed by ether, to give 1-(benzyloxycarbonyl)piperidin-4-ol (7.5 g) as a colourless oil; NMR Spectrum 1.2-1.4 (2H, m); 1.6-1.8 (2H, m); 3.0-3.2 (2H, m); 3.6-3.8 (3H, m); 4.7 (1H, d); 5.05 (2H, s); 7.3-7.4 (5H, m).

5382-16-1, As the paragraph descriping shows that 5382-16-1 is playing an increasingly important role.

Reference£º
Patent; Zeneca Limited; US5612373; (1997); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

New learning discoveries about 58333-75-8

58333-75-8, 58333-75-8 4-(2-Methoxyphenyl)piperidine 544738, apiperidines compound, is more and more widely used in various fields.

58333-75-8, 4-(2-Methoxyphenyl)piperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To 26 mmol 4-(2-methoxyphenyl)-piperidine (Maybridge) in 100 ml dry DICHLOROMETHANE were added 28.6 mmol triethylamine and 78 mmol ETHYLCHLOROFONNATE at 0 The solution was stirred at room temperature overnight, washed twice with 0.5 M HC1 (125 ml) then dried over MGS04 and evaporated. The product was sufficiently pure to be used in the following steps.

58333-75-8, 58333-75-8 4-(2-Methoxyphenyl)piperidine 544738, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; H. LUNDBECK A/S; WO2004/87155; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

Analyzing the synthesis route of 79099-07-3

79099-07-3 1-Boc-4-Piperidone 735900, apiperidines compound, is more and more widely used in various fields.

79099-07-3, 1-Boc-4-Piperidone is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation 21 t-Butyl-3-[(dimethylamino)methylidene]-4-oxopiperidine-1-carboxylate A solution of N-Boc-4-piperidone (10 g, 50.19 mmol) and DMF-dimethylacetal (20.16 ml, 150.57 mmol) in 1,4-dioxane (100 ml) was heated at reflux for 20 hours. The reaction mixture was concentrated and the residue was eluted through a flash column (silica gel 60, 230-400 mesh, 7% MeOH in EtOAc) to give the title compound as an orange oil which crystallized on standing (10.51 g, 82%)., 79099-07-3

79099-07-3 1-Boc-4-Piperidone 735900, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; ALLERGAN, INC.; Hull, III, Clarence E.; Malone, Thomas C.; US2013/237538; (2013); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

New learning discoveries about 106-52-5

106-52-5, 106-52-5 1-Methylpiperidin-4-ol 66048, apiperidines compound, is more and more widely used in various fields.

106-52-5, 1-Methylpiperidin-4-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-((3-chloro-4′-nitro-[1,1′-biphenyl]-4-yl)oxy)-1-methylpiperidine (25e): Diisopropylazo dicarboxylate (2.40 mmol) was added to a solution of phenol (1.20 mmol), PPh3 (2.40 mmol) and 4-hydroxy N-methyl piperidine (2.40 mmol) in THF (8 mL) at room temperature. The reaction mixture was stirred for 18 hours before the removal of solvent under reduced pressure. The remaining residue was purified by silica gel column chromatography (eluting with methylene chloride:methanol = 99:1 to 20:1) to yield a yellow amorphous solid (83%). 1H NMR (500 MHz, CDCl3) delta 8.22 (d, J = 8.8 Hz, 2H), 7.77- 7.52 (m, 3H), 7.46 (dd, J = 8.5, 2.4 Hz, 1H), 7.06 (d, J = 8.6 Hz, 1H), 4.81 (m, 1H), 3.49- 3.37 (m, 2H), 3.23 (m, 2H), 2.87 (s, 3H), 2.32 (m, 2H), 2.24- 2.10 (m, 2H). 13C NMR (126 MHz, CDCl3+CH3OH) delta 147.99, 142.90, 141.28, 129.32, 125.35, 123.24, 123.19, 122.97, 120.71, 120.08, 120.04, 111.82, 67.46, 54.11, 44.12, 26.76. HRMS (ESI+) m/z [M+H+] calcd for C18H19ClN2O3 347.1163; found 347.1159.

106-52-5, 106-52-5 1-Methylpiperidin-4-ol 66048, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; THE UNIVERSITY OF KANSAS; BLAGG, Brian, S.J.; ZHAO, Huiping; WO2015/70091; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem