Tag: M.W:100-200

5570-78-5, 1-Isopropylpiperidin-4-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5570-78-5, To a solution of l-(l-methylethyl)piperidin-4-ol (103 mg, 0.724 mmol) in THF (3 ml) under an atmosphere of nitrogen was added KO1Bu (136 mg, 1.21 mmol). The mixture was stirred for 15 min at room temperature before 2-chloro-6-methyl-5,6,7,8-tetrahydro-l,6- naphthyridine-3-carbonitrile (100 mg, 0.483 mmol) was added. The resulting mixture was heated to 90 0C by microwave irradiation and stirred for 15 min. After cooling to RT, the reaction mixture was quenched by pouring onto saturated aqueous NaHCO3 , extracted with EtOAc (3 x 20 ml), dried (Na2SO4), filtered and concentrated at reduced pressure. The residue was purified by FCC (SiO2, eluting with 95:5 chloroform / MeOH) to give the title compound (36 mg, 24 %) as yellow oil. LCMS data: Calculated MH+ (315); Found 94 % (MH+) m/z 315, Rt = 4.78 min.1H NMR (400 MHz, MeOD) delta ppm 7.73 (1 H, s), 5.29 – 5.36 (1 H, m), 3.55 (2 H, s), 2.93 – 3.07 (5 H, m), 2.78 – 2.84 (4 H, m), 2.48 (3 H, s), 2.10 – 2.20 (2 H, m), 1.95 – 2.04 (2 H, m), 1.20 (6 H, d, J=6.6 Hz).

As the paragraph descriping shows that 5570-78-5 is playing an increasingly important role.

Reference£º
Patent; EVOTEC NEUROSCIENCES GMBH; WO2009/121812; (2009); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.160357-94-8,1-Acetyl-4-aminopiperidine,as a common compound, the synthetic route is as follows.

Example 102 N-(1-acetyl-piperidin-4-y)-4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-3-methoxy-benzamide (I-102) A mixture of 0.045 g (0.1 mmole) of 4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-3-methoxybenzoic acid (I-22), 0.042 g (0.110 mmole) of 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium-3-oxide hexafluorophosphate, 0.052 ml (0.300 mmole) of ethyldiisopropyl amine and 1.0 mL of dimethylformamide was stirred for 5 minutes and then 0.017 g (0.12 mmole) of 1-(4-Amino-piperidin-1-yl)-ethanone was added. The mixture was stirred for 3 hours, then diluted with 10 mL of water plus 2 mL of saturated aqueous sodium bicarbonate and then extracted 3 times with 10 mL of ethyl acetate. The combined extracts were washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The residue was purified by reverse phase silica gel chromatography, eluding with water-acetonitrile (gradient, 0:100-80:20) to give 0.05 g of N-(1-acetyl-piperidin-4-yl)-4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-3-methoxy-benzamide (I-102) as a white solid., 160357-94-8

160357-94-8 1-Acetyl-4-aminopiperidine 4962477, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Cai, Jianping; Chen, Shaoqing; Chu, Xin-Jie; Luk, Kin-Chun; Mischke, Steven Gregory; Sun, Hongmao; Wovkulich, Peter Michael; US2009/318408; (2009); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

138007-24-6, tert-Butyl piperidine-4-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

tert-Butyl piperidine-4-carboxylate (2.84 g, 15.33 mmol) and 2-(1-oxo-1,3- dihydroisobenzofuran-5-yl)acetaldehyde(4.05 g, 22.99 mmol) were dissolved in DCE (120m1) then sodium triacetoxyborohydride (9.75 g, 46.0 mmol) was added and and the mixtue was stirred for 16 hrs. The reaction mixture was poured into aqueous NaHCO3 solution and extractedwith DCM. The organic layer was separated and dried over Na2504, filtered and concentrated. The crude residue was chromatographed through a 330g ISCO Redi-sep column and eluted with 5percent (NHOH: MeOH 1:9) in 95percent DCM to yield tert-butyl 1-(2-(1-oxo-1,3- dihydroisobenzofuran-5-yl)ethyl)piperidine-4-carboxylate. LC-MS (IE, m/z): 346 [M + 1]¡À; lHNMR (500 MHz, CDC13) oe ppm 7.859 (d, J= 7.9 Hz, 1H), 7.394 (d, J= 8.0 Hz, 1H), 7.352 (s,1H), 5.311 (s, 2H), 2.965 (b, 4H), 2.641 (b, 2H), 2.234 (b, 1H), 2.139 (b, 2H), 1.925(d, J 9.5 Hz, 2H), 1 .788( t, J 11.5 Hz, 2H,) 1.447 (s, 9H)., 138007-24-6

138007-24-6 tert-Butyl piperidine-4-carboxylate 1512676, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; PASTERNAK, Alexander; TANG, Haifeng; FRIE, Jessica; FERGUSON, Ronald Dale; GUO, Zhiqiang; SHI, Zhi-Cai; CATO, Brian; FU, Qinghong; WO2015/65866; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

5325-94-0, Ethyl piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In nitrogen atmosphere, to a 500 ml three-neck flask, 16.7 g (77.6 mmol) of 4-bromo-2,6-dimethylanisole, and 150 ml of dehydrated diethyl ether were added. While the mixture was cooled in a methanol/dry ice bath, 49.7 ml (81.5 mmol) of a n-butyllithium/hexane solution (1.64 M) was gradually added. While the temperature was gradually elevated to room temperature, the mixture was stirred for 16 hours. While the mixture was cooled in an ice bath, a solution composed of 4.83 g (30.7 mmol) of N-carboethoxypiperidine and 50 ml of dehydrated diethyl ether was gradually added with a dropping funnel over a period of 20 minutes. The mixture was stirred for 1 hour at room temperature, and stirred for 2 hours under heating to reflux. Thereto, in an ice bath, 100 ml of 2N hydrochloric acid was gradually added. The resultant two-layer solution was transferred to a 500 ml separating funnel. The resultant solution was shaken several times. Thereafter, the aqueous layer was removed. Subsequently, the organic layer was washed two times with 100 ml of water, one time with 100 ml of a saturated aqueous sodium bicarbonate solution, and one time with 100 ml of a saturated saline solution, and dried over anhydrous magnesium sulfate for 30 minutes. After the solvent was distilled off under reduced pressure, a small amount of hexane was added to perform recrystallization to give a solid. This solid was washed with a small amount of hexane, and dried under reduced pressure. As a result, 6.83 g (22.9 mmol, 74.5%) of 4,4′-dimethoxy-3,3′,5,5′-tetramethylbenzophenone was obtained as a white solid. 4,4′-Dimethoxy-3,3′,5,5′-tetramethylbenzophenone was identified by 1H NMR spectrum. Measured values thereof are shown below. 1H NMR spectrum (270 MHz, CDCl3): delta/ppm 7.44 (s, 4H), 3.77 (s, 6H), 2.31 (s, 12H), 5325-94-0

5325-94-0 Ethyl piperidine-1-carboxylate 21399, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; MITSUI CHEMICALS, INC.; Endo, Koji; Hiwara, Mayumi; Matsuura, Sadahiko; Kosugi, Yoko; Yamamura, Yuichi; Mizobuchi, Yusuke; (50 pag.)US9969827; (2018); B2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

37675-20-0, (R)-(Piperidin-3-yl)methanol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

TEA (1.76 g, 17.4 mmol, 2.42 mL) was added to a solution of [(3R)-3 -piped dyl]methanol (1.0 g, 8.68 mmol) in THF (25.0 mL), followed by the addition of a solution of B0C2O (1.89 g, 8.68 mmol, 1.99 mL) in THF (5 mL) at 15 C. The mixture was stirred at 15 C for 12 hours. The solvent was removed under vacuum and the residue dissolved in ethyl acetate (50 ml) and H2O (30 mL). The solution was acidified with HC1 (6 M) to pH~6 and the layers separated. The organics were washed with brine (3 x 50 mL) and the combined organics concentrated to dryness to give tert- butyl (3R)-3-(hydroxymethyl)piperidine-l-carboxylate (1.68 g, 7.80 mmol, 89.9% yield, 100% purity) as colorless crystals. MR (400MHz, chloroform-d) delta = 3.73 (br s, 2H), 3.51 (br d, J = 6.8 Hz, 2H), 3.05 (br s, 2H), 1.83 – 1.71 (m, 2H), 1.62 (br s, 1H), 1.46 (s, 9H), 1.44 – 1.37 (m, 1H), 1.35 – 1.22 (m, 1H).

37675-20-0, The synthetic route of 37675-20-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MIRATI THERAPEUTICS, INC.; ARRAY BIOPHARMA, INC.; FISCHER, John, P.; FELL, Jay, Bradford; BLAKE, James, F.; HINKLIN, Ronald, Jay; MEJIA, Macedonio, J.; HICKEN, Erik, James; CHICARELLI, Mark, Joseph; GAUDINO, John, J.; VIGERS, Guy, P.A.; BURGESS, Laurence, E.; MARX, Matthew, Arnold; CHRISTENSEN, James, Gail; LEE, Matthew, Randolf; SAVECHENKOV, Pavel; ZECCA, Henry, J.; (529 pag.)WO2017/201161; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

19889-77-1, Piperidine-2-carboxamide is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(d) I-Isobutylpiperidine-2-carboxamide. To a solution of piperidine-2-carboxamide (4.52 g, 35 mmol, Bionet-Inter) in DCE (100 mL) was added isobutyraldehyde (9.6 mL, 106 mmol, Aldrich). The mixture was stirred at room temperature for 10 min, sodium triacetoxyborohydride (22.26 g, 105 mmol, Aldrich) was added, and the stirring was continued for 1 h. The reaction mixture was evaporated in vacuo and the residue was dissolved in EtOAc. The EtOAc solution was washed with sat. aqueous solution of NaHCO3, H2O and brine, dried over Na2SO4, filtered, and evaporated under reduced pressure. Purification of the residue by silica gel column chromatography [gradient: 0-2% (2 N NH3 in MeOH)/DCM] afforded the title compound as yellow oil. (ESI, pos. ion.) m/z: 185 (M+1).

19889-77-1, As the paragraph descriping shows that 19889-77-1 is playing an increasingly important role.

Reference£º
Patent; Doherty, Elizabeth M.; Liao, Hongyu; Norman, Mark H.; Retz, Daniel M.; US2006/235036; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.37675-18-6,(S)-Ethyl piperidine-3-carboxylate,as a common compound, the synthetic route is as follows.,37675-18-6

[1495] LAH (118 mL, 1.0 M in Et2O, 1.0 eq.) was added to a solution of the product from Step A (18.5 g, 0.125 mmol) in THF (250 mL) at 0 C. over 20 minutes. The resulting solution was warmed slowly to room temperature and then heated at reflux 2 hours. The reaction was cooled to room temperature and quenched by the slow addition of saturated Na2SO4. The resulting slurry was dried by the addition of Na2SO4, filtered through Celite and concentrated to give a colorless oil (13.7 g, 98% crude yield). CIMS: MH+=116; [alpha]20D=-8.4 (5.0 mg in 2 mL MeOH).

The synthetic route of 37675-18-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Zhu, Hugh Y.; Njoroge, F. George; Cooper, Alan B.; Guzi, Timothy; Rane, Dinanath F.; Minor, Keith P.; Doll, Ronald J.; Girijavallabhan, Viyyoor M.; Santhanam, Bama; Pinto, Patrick A.; Vibulbhan, Bancha; Keertikar, Kartik M.; Alvarez, Carmen S.; Baldwin, John J.; Li, Ge; Huang, Chia-Yu; James, Ray A.; Bishop, W. Robert; Wang, James J-S; Desai, Jagdish A.; US2003/229099; (2003); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

60407-35-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.60407-35-4,1-Benzylpiperidin-3-amine,as a common compound, the synthetic route is as follows.

A mbdure of sodium (E-3-(1 (3-1dimethylamino,?propyl)-2-methyl-1H-indoI-3-yt)acrylate(200 mg, 0.65 mmol), i-benzylpiperidin-3-amine (104 mg, 0.65 mmol), EDCI (248 mg,1 35 mmol), HOBt (88 mg, 0 65 mmol) and TEA (136 mg, 1 35 rnrnol) in DCM (15 mL)was stirred at room temperature overnight. The reaction mixture was washed with saturated Na2CO3, dried over Na2SO4 and concentrated. The crude product was purified by preparative TLC to give a solid (63 mg, 21 %).1H NMR (400 MHz.. CDCI3): 5 7.96-7.92 (m, 2H), 7.40-7.25 (m, 8H), 7.46 (d, J =15.6 Hz, IH), 4.34 (br s, 1H), 4.23 (1, J = 7.2 Hz, 2H), 3.63 (br s, 2H), 276-2.60 (rn,3H) 2 58 (s, 3H) 2 41-2 32 (m 9H) 2 04-1 97 ,m 2H) 1 90-1 62 (m, 4H) LCMS ma459.1 [M+H]

60407-35-4 1-Benzylpiperidin-3-amine 12275357, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; NOVOGEN LTD; JAMES, Ian; DIXON, Ian; BU, Xian; WO2015/74124; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

106-52-5, 1-Methylpiperidin-4-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1-Methyl-4-piperidyl para-toluenesulphonate may be obtained in the following manner: para-toluenesulphonyl chloride (19.60 g) is added in the course of approximately 1 hour 30 minutes to a solution, cooled to 0 C., of 4-hydroxy-1-methylpiperidine (11.50 g) in pyridine (50 cc), and the mixture is stirred for 4 hours at 0 C. and then 12 hours at a temperature in the region of 20 C. After the addition of triethylamine (14.10 g) and stirring for a further 15 minutes, distilled water (300 cc) and ethyl acetate (300 cc) are added., 106-52-5

As the paragraph descriping shows that 106-52-5 is playing an increasingly important role.

Reference£º
Patent; Rhone-Poulenc Sante; US5086051; (1992); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5382-17-2,Piperidin-4-ol hydrochloride,as a common compound, the synthetic route is as follows.

a 4-Benzyl-5-bromo-2-(4-hydroxypiperidino)pyridine A mixture of 550 mg of 4-benzyl-5-bromo-2-pyridyl trifluoromethanesulfonate (Production Example 1), 600 mg of 4-hydroxypiperidine hydrochloride, 1 ml of triethylamine and 2 ml of N,N-dimethylformamide was heated under stirring for 3 hours in an oil bath kept at 100 C. in a nitrogen atmosphere. After cooling as it was, the reaction mixture was extracted with ethyl acetate/water. The organic phase was washed with water and brine, dried over anhydrous magnesium sulfate and evaporated. The residue was subjected to silica gel column chromatography and eluted with 50% ethyl acetate/hexane, to give 270 mg of the target compound. 1H-NMR (CDCl3) delta=1.44-1.60 (2H, m), 1.88-1.97 (2H, m), 3.03-3.12 (2H, m), 3.75-3.96 (3H, m), 3.99 (2H, s), 6.41 (1H, s), 7.19 (2H, d, J=7 Hz), 7.25 (1H, t, J=7 Hz), 7.32 (2H, t, J=7 Hz), 8.20 (1H, s)., 5382-17-2

The synthetic route of 5382-17-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Eisai Co., Ltd.; US6599917; (2003); B1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem