Tag: M.W:100-200

68947-43-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.68947-43-3,1-Methylpiperidine-4-carboxylic acid,as a common compound, the synthetic route is as follows.

A mixture of 1-methylpiperidine-4-carboxylic acid (1.72 g) obtained above, tert-butyl 2-hydroxyethyl(methyl)carbamate (1.75 g) obtained in Reference Synthetic Example 1, 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide (2.30 g), 4-dimethylaminopyridine (0.24 g) and acetonitrile (50 mL) was stirred at room temperature for 16 hrs. The reaction solution was concentrated under reduced pressure, and to the residue was added saturated aqueous solution of sodium bicarbonate (50 mL), and extracted with ethyl acetate (100 mL). The ethyl acetate layeer was washed with saturated brine (50 mL), and dried over anhydrous magnesium sulfate, followed by concentrating under reduced pressure. The residue was purified with basic silica gel column chromatography (eluted with methanol : ethyl acetate = 50 : 50, then 80 : 20). To the purified material (2.73 g) was added 1 N hydrochloric acid (25 mL), and stirred at room temperature overnight. The reaction solution was concentrated under reduced pressure, and isopropanol was added, then, concentrated again under reduced pressure. The precipitated crystals were collected by filtration to give title compound as colorless solid (1.72 g).1H-NMR (DMSO-d6) : 1.70-2.20(4H,m), 2.40-3.50 (13H,m), 4.31(2H,m), 9.25(2H,br), 10.77 (1H,br).

The synthetic route of 68947-43-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Takeda Pharmaceutical Company Limited; EP1602362; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

3970-68-1, 4-Methylpiperidin-4-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,3970-68-1

[00152] Step 2: (S)- 1 -Phenylethyl (R)-2-(4-hydroxy-4-methylpiperidin- 1 -yl)-2- phenylacetate. To a solution of (S)-l -phenylethyl 2-bromo-2-phenylacetate (0.464 g, 1.45 mmol) in THF (8 mL) was added triethylamine (0.61 mL, 4.35 mmol), followed by tetrabutylammonium iodide (0.215 g, 0.58 mmol). The reaction mixture was stirred at room temperature for 5 minutes and then a solution of 4-methyl-4-hydroxypiperidine (0.251 g, 2.18 mmol) in THF (2 mL) was added. The mixture was stirred for 1 hour at room temperature and then it was heated at 55-60 C (oil bath temperature) for 4 hours. The cooled reaction mixture was then diluted with ethyl acetate (30 mL), washed (H20 x2, brine), dried (MgS04), filtered and concentrated. The residue was purified by silica gel chromatography (0-60% ethyl acetate-hexane) to provide first the (S,R)-isomer of the title compound (0.306 g, 60%) as a white solid and then the corresponding (S,S)-isomer (0.120 g, 23%), also as a white solid. (S,R)-isomer: ? NMR (CD3OD) delta 7.51-7.45 (m, 2H), 7.41-7.25 (m, 8H), 5.85 (q, J=6.6 Hz, 1H), 4.05 (s, 1H), 2.56-2.45 (m, 2H), 2.41- 2.29 (m, 2H), 1.71-1.49 (m, 4H), 1.38 (d, J=6.6 Hz, 3H), 1.18 (s, 3H). LC-MS: Anal. Calcd. for C22H27 03: 353; found: 354 (M+H)+. (S,S)-isomer: ‘H NMR (CD3OD) delta 7.41-7.30 (m, 5H), 7.20-7.14 (m, 3H), 7.06-7.00 (m, 2H), 5.85 (q, J=6.6 Hz, 1H), 4.06 (s, 1H), 2.70-2.60 (m, 1H), 2.51 (dt, J=6.6, 3.3 Hz, 1H), 2.44-2.31 (m, 2H), 1.75-1.65 (m, 1H), 1.65-1.54 (m, 3H), 1.50 (d, J=6.8 Hz, 3H), 1.20 (s, 3H). LC-MS: Anal. Calcd. for C22H27 03: 353; found: 354 (M+H)+.

3970-68-1 4-Methylpiperidin-4-ol 15649174, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; BELEMA, Makonen; ROMINE, Jeffrey, Lee; NGUYEN, Van, N.; WANG, Gan; LOPEZ, Omar, D.; ST. LAURENT, Denis, R.; CHEN, Qi; BENDER, John, A.; YANG, Zhong; HEWAWASAM, Piyasena; XU, Ningning; MEANWELL, Nicholas, A.; EASTER, John, A.; SU, Bao-Ning; SMITH, Michael, J.; WO2011/75439; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50534-49-1,N,N-Dimethylpiperidin-3-amine,as a common compound, the synthetic route is as follows.

EXAMPLE DDD86292 2,6-Dichloro-4-[2-(3-dimethylamino-pyrrolidin-1-yl)-pyridin-4-yl]-N-(1,3,5-trimethyl-1 H-pyrazol-4-yl)-benzenesulfonamide Prepared by heating the chloropyridine of intermediate 12 (250 mg, 0.58 mmol) with 3-dimethylaminopiperidine (200 mul) in EtOH (1.5 ml) at 155 C. for 1 h according to the method of DDD86213 to give the title compound as a white powder (150 mg, 0.29 mmol, 49%). deltaH (CDCl3, 300K) 8.48 (1H, d J 5.1 Hz), 7.49 (2H, s), 7.39 (1H, d J 4.7 Hz), 7.32 (1H, s), 3.76-3.46 (6H, s br), 3.63 (3H, s), 3.46-3.39 (1H, m), 2.75 (2H, s br), 2.28 (2H, s br), 2.05 (3H, s), 1.85 (3H, s), 1.56 (2H, s br). m/z (ES+, 70V) 523.2 (MH+)., 50534-49-1

As the paragraph descriping shows that 50534-49-1 is playing an increasingly important role.

Reference£º
Patent; Brand, Stephen; Wyatt, Paul; Thompson, Stephen; Smith, Victoria; Bayliss, Tracy; Harrison, Justin; Norcross, Neil; Cleghorn, Laura; Gilbert, Ian; Brenk, Ruth; US2011/312921; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

832710-65-3, 2,8-Diazaspiro[4.5]decan-1-one hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,832710-65-3

To a solution of 3-nitrosalicyclic acid (500 mg, 2.73 mmol) in dichloromethane (10 mL) is added oxalylchloride (2 M in dichloromethane, 1.50 ml, 3 mmol) and three drops of N,N-dimethylformamide. The mixture is stirred at room temperature overnight. The solvent is evaporated under vacuum to leave a crude residue, a portion of which (127 mg, 0.63 mmol) is dissolved in dichloromethane (5 mL) and the solution cooled to 0 C. Triethylamine (0.22 mL, 1.57 mmol) is added followed by 2,8-diaza-spiro[4.5]decan-1-one hydrochloride (100 mg, 0.52 mmol). The mixture is allowed to warm to room temperature and stirred overnight. Water is added, the phases separated, the organic layer dried over MgSO4 and evaporated under reduced pressure to give compound 1-1.Yield: 200 mgES mass spectrum: [M+H]+=320Retention time: 0.69 min (HPLC method 2)

832710-65-3 2,8-Diazaspiro[4.5]decan-1-one hydrochloride 42614558, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2012/329773; (2012); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

3973-62-4, 3-Phenylpiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3-phenylpiperidine (1,100 g, 621.1 mmol)Soluble in ethanol (50mL),Will be dissolved in D-camphorsulfonic acid (145.8g, 622.2mmol)A solution of ethanol (150 mL) was added dropwise to a solution of the racemic 3-phenylpiperidine in ethanol and stirred for 2 h.Filtration to obtain camphor sulfonate; then, adding methanol (5 L) to the camphor sulfonate,After heating to complete dissolution, the stirring was stopped; the temperature was slowly lowered to room temperature, and crystallization was carried out at 0 C for 2 days.Filtration gave a crude white solid, 1N aqueous sodium hydroxide (50 mL).Extracted with ethyl acetate (25 mL x 2), and the organic phases were combined.Dry over anhydrous sodium sulfate, filtered and concentrated to give a white solid.Namely (R)-3-phenylpiperidine, the yield was 19.3%., 3973-62-4

As the paragraph descriping shows that 3973-62-4 is playing an increasingly important role.

Reference£º
Patent; Shanghai Bobang Pharmaceutical Technology Co., Ltd.; Liu Zhende; Cui Xiaoyuan; Gao Heyong; (27 pag.)CN108203404; (2018); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

19365-07-2, 5-Hydroxypiperidin-2-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

PREPARATION S 2-Piperidon-5-yl p-Toluenesulfonate 2-Piperidon-5-ol (0.575 g, 5 mmoles) was dissolved in 15 ml. dimethylformamide and the solution was diluted with 50 ml. dichloromethane. The solution was cooled to 0 C. under nitrogen and 0.95 g. (5 mmoles) p-toluenesulfonyl chloride and 1.22 g. (10 mmoles) 4-dimethylaminopyridine was added. The solution was stirred at 0 C. for 3 hrs., then at 25 C. for 20 hrs. The reaction mixture was then diluted with 125 ml. dichloromethane and the solution was washed with 20 ml. 1N aqueous hydrochloric acid solution, two 20 ml. portions of water and 20 ml. saturated aqueous sodium chloride solution. The organic layer was dried over anhydrous sodium sulfate and concentrated in vacuo. Diethyl ether was added to the residue and the title compound was obtained as the resulting solid product following filtration (0.8 g, 60% yield). The NMR spectrum of the title compound as a deuterochloroform solution had peaks at 2.4 (s) and 1.67-2.6 (c) (total 7H); 3.43 (c, 2H); 4.86 (m, 1H); 6.96 (b, 1H); 7.3 (d, 2H); and 7.76 (d, 2H)ppm.

19365-07-2, The synthetic route of 19365-07-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Pfizer Inc.; US4772597; (1988); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.79099-07-3,1-Boc-4-Piperidone,as a common compound, the synthetic route is as follows.

79099-07-3, A mixture of tert-butyl 4-oxopiperidine-1-carboxylate (15.0 g, 0.075 mol) and DMFDMA (9.87 g, 0.0829 mol) in DMF (100 mL) was heated at 90 C with stirring overnight. The resulting mixture was then concentrated in vacuo and diluted with water (100 mL). The resulting mixture was extracted with EA (30 mL) for three times. The combined organic layer was washed with water, dried over anhydrous Na2SO4 and concentrated in vacuo to give the crude tert-butyl 3-(dimethylaminomethylene)-4-oxo-piperidine-1-carboxylate (13 g) as yellow oil, which was used in the next step directly.

79099-07-3 1-Boc-4-Piperidone 735900, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; CHENG, Zhanling; WANG, Jianhua; WANG, Min; YANG, Song; (84 pag.)WO2018/83106; (2018); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

79099-07-3,79099-07-3, 1-Boc-4-Piperidone is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

was carried out for 12 h at room temperature.The reaction of the starting material V was completed by TLC (dichloromethane:methanol = 10:1).Spin dry methanol,Adjust pH=9 with saturated NaOH solution,Extracted with dichloromethane (10.00 ml x 3),Dry over anhydrous sodium sulfate, filter,The solvent was evaporated to give a pale yellow oil (yield: 1.00 g).

As the paragraph descriping shows that 79099-07-3 is playing an increasingly important role.

Reference£º
Patent; China Pharmaceutical University; Xu Yungen; Ji Dezhong; Zhang Jingjing; Zhu Qihua; Liang Tingting; Bai Ying; Wang Zhibin; (31 pag.)CN109734700; (2019); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14691-88-4,4-Amino-2,2,6,6-tetramethylpiperidine 1-Oxyl,as a common compound, the synthetic route is as follows.

To a solution of 3,5-t-butyl-4-hydroxyl benzoic acid (2.50 g, 10 mmol), 4-amino-TEMPO (1.55 g, 9.1 mmol) and DMAP (0.5 g, 4 mmol) in CH2Cl2 (50 mL) At 0-5¡ã C., DCC (2.30 g, 1 mmol) in dichloromethane (50 mL) was added dropwise. After addition is complete, the mixture was stirred at room temperature overnight. The reaction mixture was filtered and the filtrate was washed with 1N HCl (20 mL) and dried over MgSO4. After MgSO4 was filtered off, the solvent was removed in vacuum to give a solid The solid was purified by column chromatography (silica gel, EtOAc/Hexane). The product is an orange solid (1.3 g). The yield was 35percent.

14691-88-4, As the paragraph descriping shows that 14691-88-4 is playing an increasingly important role.

Reference£º
Patent; Patil, Ghanshyam; Mousa, Shaker A.; US2008/200405; (2008); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7149-42-0,(1-Methylpiperidin-4-yl)methanamine,as a common compound, the synthetic route is as follows.

7149-42-0, (Z)-4-(((l -Acetyl-6-(methoxycarbonyl)-5-methyl-2-oxoindolin-3-ylidene) (phenyl)methyl)ami no)benzoic acid, trifluoroacetate adduct (Intermediate E) (75 mg,0.128 mmol) and HATU (73.2 mg, 0.192 mmol) in DMF (2 mL) were stirred at rt for 10 mm.Then Hunig?s base (179 p1, 1.02 mmol) and (1-methylpiperidin-4-yl)methanamine (32.9 mg,0.257 mmol) in DMF (0.2 mL) were added. The mixture was stirred at rt for 16 h. Piperidine(127 p1, 1.28 mmol) was added. The mixture was stirred at RT for 4 h and the reaction mixture was partitioned between DCM (25 mL) and saturated aqueous NaHCO3 solution (10 mL). The organic layer was washed with brine (10 mL) and the solvent was evaporated under reduced pressure. The crude product was purified by preparative HPLC (Method A, 20-50% MeCN in water) to afford the title compound (Z)-methyl 5-methyl-3-(((4-(((1 -methyl piperidin-4-yl)methyl)carbamoyl) phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate, formate as a light yellow solid (19 mg, 25%); Rt 1.55 mm (Method 1); mlz 539 (M+H) (ES); 1H NMR O: 1.11-1.28 (2H, overlapping m), 1.53 (1H, m), 1.60-1.73 (2H, overlapping m), 2.13 (3H, 5), 2.15-2.24 (2H, overlapping m), 2.34 (3H, 5), 2.89-3.00 (2H, overlapping m), 3.09 (2H, t), 3.75 (3H, 5), 5.61 (1H, 5), 6.87 (2H, m), 7.36 (1H, 5), 7.52 (2H, m), 7.58-7.69 (5H, overlapping m),8.17 (1H, 5), 8.36 (1H, t), 10.88 (1H, 5), 12.23 (1H, 5).

7149-42-0 (1-Methylpiperidin-4-yl)methanamine 81574, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; RESPIVERT LIMITED; WALTERS, Iain; BIRCH, Louise; COLLINGWOOD, Stephen, Paul; STEVENSON, Christopher, Scott; (110 pag.)WO2017/153748; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem