Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.479195-19-2,2-Oxa-8-azaspiro[4.5]decane hydrochloride,as a common compound, the synthetic route is as follows.

To a solution 2-oxa-8-azaspiro[4.5]decane, HC1 (1 g, 5.63 mmol) and DIEA (2.9 mL, 16.9 mmol) in anhydrous CH3CN (35 mL) was added isopropyl 2-(5-bromo-4- chloro-2,6-dimethylpyridin-3-yl)-2-oxoacetate (1.9 g, 5.63 mmol) at rt. The resulting mixture was placed in a pre-heated oil bath (80 C) and stirred for 18 h; cooled, and concentrated. The crude product was charged (DCM) to a 80 g ISCO silica gel cartridge and gradient elution (5 – 35% EtOAc/hexanes) using an Isolera chromatography station to give isopropyl 2-(5-bromo-2,6-dimethyl-4-(2-oxa-8-azaspiro[4.5]decan-8-yl)pyridin-3- yl)-2-oxoacetate 990 mg (40%). 1H NMR (500 MHz, CDC13) delta 5.08-5.05 (m, 1H), 3.75 (t, J=7.3 Hz, 2H), 3.37 (s, 2H), 3.36-3.34 (m, 4H), 2.61 (s, 3H), 2.30 (s, 3H), 1.73-1.71 (m, 2H), 1.50 (br. s, 4H), 1.29 (d, J=6.2 Hz, 6H). UPLC (M+H) = 441.1.

479195-19-2, 479195-19-2 2-Oxa-8-azaspiro[4.5]decane hydrochloride 21955264, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; KADOW, John F.; NAIDU, B. Narasimhulu; ROMINE, Jeffrey Lee; SIVAPRAKASAM, Prasanna; ST. LAURENT, Denis R.; (204 pag.)WO2017/25864; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4138-26-5,Piperidine-3-carboxamide,as a common compound, the synthetic route is as follows.,4138-26-5

(1) 2-[(3RS)-3-Carbamoylpiperidin-1-yl]-2-iminoethylchloride hydrochloride 1.28 g of (3RS)-3-carbamoylpiperidine were added to a solution of 1.44 g of methyl 2-chloroacetimidate hydrochloride in 5 ml of anhydrous methanol, and the mixture was stirred at room temperature for 2 hours.

The synthetic route of 4138-26-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SANKYO COMPANY LIMITED; EP202048; (1991); B1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2971-79-1,Methyl piperidine-4-carboxylate,as a common compound, the synthetic route is as follows.

Methyl 1-(4-methoxybenzyl)piperidine-4-carboxylate; 4-Methoxybenzyl chloride (1.10 g, 6.98 mmol) was added dropwise to a solution of isonipecotic acid methyl ester (1.00 g, 6.98 mmol) and triethylamine (1.40 g, 14 mmol) in THF (30 ml), and stirring was carried out for 72 h at 60 C. 5% sodium hydrogen carbonate solution (50 ml) was then added to the reaction mixture, and extraction with ethyl acetate (3¡Á50 ml) was carried out. The combined organic phases were dried over sodium sulfate and concentrated in vacuo. The residue was purified by flash chromatography with cyclohexane/ethyl acetate (2:1).Yield: 1.23 g (67%) of methyl 1-(4-methoxybenzyl)piperidine-4-carboxylate1H-NMR (DMSO-d6): 1.53 (dq, 2H); 1.77 (dd, 2H); 1.93 (dt, 2H); 2.28 (tt, 1H); 2.71 (td, 2H); 3.35 (s, 2H); 3.58 (s, 3H); 3.72 (s, 3H); 6.86 (d, 2H); 7.17 (d, 2H)., 2971-79-1

The synthetic route of 2971-79-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Gruenenthal GmbH; US2008/312231; (2008); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

4897-50-1, 4-Piperidinopiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 3 PREPARATION OF 4-PIPERIDINOPIPERIDINE CARBAMOYL CHLORIDE 150 g of 4-piperidinopiperidine was dissolved in 10.5 L of dichloromethane and the solution was cooled to about 0¡ã C. A solution of triphosgene (94.8 g of triphosgene in 1.2 L of dichloromethane) was added slowly to the solution at about 5¡ã C. over a period of 45 minutes under a nitrogen atmosphere with simultaneous stirring. The resultant reaction mixture was stirred at 27¡ã C. for 12 hours. The reaction mixture was filtered and then the filtrate was washed with 1.2 L of 7percent sodium bicarbonate solution. The organic layer was separated and concentrated completely at about 40¡ã C. under a vacuum of 580 mm Hg to afford title compound. Purity: 97.2percent by GC.

4897-50-1, 4897-50-1 4-Piperidinopiperidine 78607, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Palle, Venkata Raghavendra Acharyulu; Nariyam, Sekhar Munaswamy; Matti, Lankeshwararao; Vinjamuri, Raghupati Rama Subrahmanyam; US2007/208050; (2007); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.106-52-5,1-Methylpiperidin-4-ol,as a common compound, the synthetic route is as follows.

1-Methylpiperidin-4-ol (4 g, 34.7 mmol) was dissolved in CH2Cl2 (70 ml) at 0 C. followed by the addition of Et3N (10 ml, 69.4 mmol, 2 eq.) and methanesulfonyl chloride (2.7 ml, 34.7 mmol, 1 eq.). The mixture was stirred at RT for 3 h and quenched and extracted as in Intermediate Example 5(a). The solvent was distilled off to afford the crude product (6.7 g).

106-52-5, As the paragraph descriping shows that 106-52-5 is playing an increasingly important role.

Reference£º
Patent; Linnanen, Tero; Wohlfahrt, Gerd; Nanduri, Srinivas; Ujjinamatada, Ravi; Rajagopalan, Srinivasan; Mukherjee, Subhendu; US2015/11548; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

5984-56-5,5984-56-5, Piperidine-4-carboxylic acid hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of piperidine-4-carboxylic acid hydrochloride (500 mg, 2.26 mmol) and triethylamine (2.29 g, 22.6 mmol) in 1,2-dichloroethane (50 mL) was added methyl2-(chlorosulfonyl)acetate (1.17 g, 6.78 mmol) at 0 C under nitrogen atmosphere. After stirred at 0 C for 4 hours, the mixture was poured into water (40 mL) and extracted with dichloromethane (50 mL) for three times. The combined organic layers were washed with brine (100 mL) twice, dried over Na2SO4(), filtered and concentrated under reduced pressure to give a residue, which was purified by silica gel columnchromatography (petroleum ether: ethyl acetate = 9 : ito 3 : 1) to give the title compound (475 mg, 65 % yield) as yellow solids. ?H NIVII{ (400 1VIHz, CDC13) 3.92 (s, 2H), 3.79 (s, 3H), 3.75 – 3.70 (m, 2H), 3.04 – 2.98 (m, 2H), 2.39 – 2.32 (m, 1H), 1.98 -1.92 (m, 2H), 1.81 – 1.71 (m, 2H), 1.44 (s, 9H).

The synthetic route of 5984-56-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; JANSSEN PHARMACEUTICA NV; JOHNSON & JOHNSON (CHINA) INVESTMENT LTD.; WAN, Zhao-Kui; JIANG, Yimin; DAI, Xuedong; LIU, Qian; CHEUNG, Wing Shun; DENG, Gang; FU, Liqiang; (547 pag.)WO2019/1420; (2019); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4897-50-1,4-Piperidinopiperidine,as a common compound, the synthetic route is as follows.

Example 61; 7-(l,4′-bipiperidin-r-ylV5-chloro-l-(2,6-difluorophenylV3,4-dihvdropyrimido[4.5- ^pyrimidin-2(‘l.H)-one )To a solution of 5-chloro- 1 -(2,6-difluorophenyl)-7-(methylsulfinyl)-3 ,A- dihydropyrimido[4,5-d]pvrimidin-2(lH)-one (200 mg, 0.56 mmol) in DCM (10 mL) were added 1 ,4’-bipiperidine (270 mg, 1.61 mmol) and AzetaN-diisopropylethylamine (0.3 mL, 1.7 mmol). The resultant solution was stirred at room temperature over night. The result mixture was concentrated. CombiFlash chromatography (mobile phase DCM/DCM[90]+MeOH[7]+NuH4OH[3]) provided the title compound as a white solid (298 mg, 83 percent). LC-MS m/z 463 (M + H)+.

4897-50-1, As the paragraph descriping shows that 4897-50-1 is playing an increasingly important role.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2006/104917; (2006); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3970-68-1,4-Methylpiperidin-4-ol,as a common compound, the synthetic route is as follows.,3970-68-1

Compound 13-6 (0.250g, 0.5mmol), 4- hydroxypiperidine (0.125g, 1.1mmol) was dissolved in 1,2-dichloroethane (12ml), the protection purged with nitrogen, stirred 30min, was added NaBH (OAc 3(1.151g, 5.4mmol), reacted at room temperature overnight. TLC showed the reaction of the starting material was completed, and saturated sodium bicarbonate solution and DCM (50ml / 40ml) were added, and the aqueous phase was extracted with DCM (50ml ¡Á 2). The phase was dried over anhydrous sodium sulfate, concentrated, and then purified by thin layer chromatography to yield 0.090 g of pure product, yield: 32%.

The synthetic route of 3970-68-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Suzhou Yuanzhi Pharmaceutical Technology Co., Ltd.; Chen Li; Zhao Jian; (48 pag.)CN109896991; (2019); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

54012-73-6,54012-73-6, Piperidin-3-amine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The steps will be a 3 – amino piperidine (50.1g) soluble in the 2L of in DMF, by adding 1, 2 – diphenyl vinylidene carbonate (119.1g), triethylamine (1L), for ice water bath stirring to the reaction is complete (about 30min) after, adding ethyl acetate, the combined organic layer, dried with anhydrous sodium sulfate, to remove the organic solvent. The resulting product is dissolved in the 1L trifluoroacetic in, as for 20 C stirring for 2 hours, concentrated in vacuo, to remove the surplus trifluoro acetic acid, to obtain a product of formula Chinese (148.5g, yield 92.3%)

The synthetic route of 54012-73-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Borui Bio-pharmaceutical (Suzhou) Co., Ltd.; Yuan Jiandong; (12 pag.)CN103450201; (2017); B;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

3970-68-1, 4-Methylpiperidin-4-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 2; (S)- 1 -Phenylethyl (R)-2-(4-hydroxy-4-methylpiperidin- 1 -yl)- 2- phenylacetate: To a solution of (S)-I -phenylethyl 2-bromo-2-phenylacetate (0.464 g, 1.45 mmol) in THF (8 mL) was added triethylamine (0.61 mL, 4.35 mmol), followed by tetrabutylammonium iodide (0.215 g, 0.58 mmol). The reaction mixture was stirred at room temperature for 5 minutes and then a solution of 4-methyl-4- hydroxypiperidine (0.251 g, 2.18 mmol) in THF (2 mL) was added. The mixture was stirred for 1 hour at room temperature and then it was heated at 55-60 0C (oil bath temperature) for 4 hours. The cooled reaction mixture was then diluted with ethyl acetate (30 mL), washed (H2O x2, brine), dried (MgSO4), filtered and concentrated. The residue was purified by silica gel chromatography (0-60% ethyl acetate-hexane) to provide first the (S,R)-isomer of the title compound (0.306 g, 60%) as a white solid and then the corresponding (S,S)-isomer (0.120 g, 23%), also as a white solid. (S,R)-isomer: 1HNMR (CD3OD) delta 7.51-7.45 (m, 2H), 7.41-7.25 (m, 8H), 5.85 (q, J = 6.6 Hz, IH), 4.05 (s, IH), 2.56-2.45 (m, 2H), 2.41-2.29 (m, 2H), 1.71-1.49 (m, 4H), 1.38 (d, J = 6.6 Hz, 3H), 1.18 (s, 3H). LCMS: Anal. Calcd. for C22H27NO3: 353; found: 354 (M+H)+. (S,S)-isomer: 1HNMR (CD3OD) delta 7.41-7.30 (m, 5H), 7.20-7.14 (m, 3H), 7.06-7.00 (m, 2H), 5.85 (q, J = 6.6 Hz, IH), 4.06 (s, IH), 2.70- 2.60 (m, IH), 2.51 (dt, J = 6.6, 3.3 Hz, IH), 2.44-2.31 (m, 2H), 1.75-1.65 (m, IH), 1.65-1.54 (m, 3H), 1.50 (d, J = 6.8 Hz, 3H), 1.20 (s, 3H). LCMS: Anal. Calcd. for C22H27NO3: 353; found: 354 (M+H)+.

3970-68-1, As the paragraph descriping shows that 3970-68-1 is playing an increasingly important role.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2009/102318; (2009); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem