Tag: M.W:100-200

496807-97-7,496807-97-7, 3,3-Difluoropiperidine hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 3,3-difluoropiperidine hydrochloride (518 mg) in DMF (15 mL) was added cesium carbonate (3.21 g) and (3-bromopropoxy)-tert-butyldimethylsilane (0.838 mL). The resulting reaction mixture was heated to 50 C. for 1.5 hours before cooling back to room temperature. Water and ethyl acetate were added to the reaction mixture. The mixture was extracted with ethyl acetate (2¡Á). The combined organics were washed with water (2¡Á), brine, dried over magnesium sulfate, filtered and concentrated. Purification by flash chromatography (ISCO, 0 to 40% ethyl acetate in hexanes with 1% triethylamine) gave the desired product (612 mg). 1H NMR (400 MHz, CDCl3): delta (ppm) 4.20 (t, 1H), 3.71-3.64 (m, 2H), 3.46 (t, 1H), 2.62 (t, 1H), 2.50-2.47 (m, 1H), 2.44-2.42 (m, 1H), 2.05-1.98 (m, 1H), 1.91-1.82 (m, 2H), 1.77-1.67 (m, 4H), 0.89 (d, 9H), 0.05 (s, 3H), 0.04 (s, 3H).

As the paragraph descriping shows that 496807-97-7 is playing an increasingly important role.

Reference£º
Patent; MSD Italia S.R.L.; Merck Sharp & Dohme Corp.; Rudd, Michael T.; McCauley, John; Liverton, Nigel; Grise-Bard, Christiane; Brochu, Marie-Christine; Charron, Sylvie; Aulakh, Virender; Bachand, Benoit; Beaulieu, Patrick; Zaghdane, Helmi; Han, Yongxin; Ferrara, Marco; Harper, Steven; Summa, Vincenzo; Chackalamannil, Samuel; Venkatraman, Srikanth; Shah, Unmesh; Velazquez, Francisco; (211 pag.)US9328138; (2016); B2;,
Piperidine – Wikipedia
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3970-68-1, 4-Methylpiperidin-4-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To 5-mL microwave vials, secondary amines (0.164 mmol) (commercially available, known from the literature) and K2CO3 solid (37.7 mg, 0.273 mmol) were added followed by addition of 1 mL DMF solution of the mixture of 3-bromo-N,N-bis(4- methoxybenzyl)-2-(l -(4-methoxybenzyl)- lH-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfonamide and 3-bromo-N,N-bis(4-methoxybenzyl)-2-(2-(4- methoxybenzyl)-2H-tetrazol-5-yl)-6-(trifluoromethyl)benzenesulfonamide from Reference Example 24 (40 mg, 0.055mmol). The vials were capped and heated at 140C with stirring for 2 hr. After the vials were cooled to room temperature, the solvent was removed in a GeneVac. Into each residue was added 500 of 3 N HC1 and 2 mL of EtOAc. The organic layers were transferred into 2 dram vials. The organic solvent was removed in GeneVac to afford the crude intermediates which were deprotected without further purification in the subsequent step., 3970-68-1

As the paragraph descriping shows that 3970-68-1 is playing an increasingly important role.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; MANDAL, Mihir; TANG, Haifeng; XIAO, Li; SU, Jing; LI, Guoqing; YANG, Shu-Wei; PAN, Weidong; TANG, Haiqun; DEJESUS, Reynalda; HICKS, Jacqueline; LOMBARDO, Matthew; CHU, Hong; HAGMANN, William; PASTERNAK, Alex; GU, Xin; JIANG, Jinlong; DONG, Shuzhi; DING, Fa-Xiang; LONDON, Clare; BISWAS, Dipshikha; YOUNG, Katherine; HUNTER, David, N.; ZHAO, Zhiqiang; YANG, Dexi; WO2015/112441; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

1037834-62-0, 6-Azaspiro[2.5]octane hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6-(chloroacetyl)-6-azaspiro[2.5]octane; Dissolved 6-azoniaspiro[2.5]octane chloride (1.1g, 7.5 mmol) and 2N sodium carbonate (9.3 ml, 19 mmol) in DCM (10 ml) while stirring in an ice bath. Slowly added 2- chloroacetyl chloride (0.712 ml, 9 mmol) dropwise and stirred cold for 30 minutes. The reaction mixture was stirred at room temperature for 1 h, and subsequently was diluted with dichloromethane (DCM, 20 ml) and water (20 ml). Separated layers and extracted aqueous layer twice with DCM. Combined organics were washed with brine, dried over sodium sulfate, filtered, and concentrated to yield pale-yellow oil (1 ,39g, 99%).Experimental Data; LCMS 50% H2O, Retention time 1.916 min., Parent C9Hi4CINO, MW 187.08; Found APCI+ 188.1 (M+1); 1H NMR (CDCI3) delta 4.05 (s, 2H), 3.7-3.4 (m, 4H), 1.50-1.30 (m, 4H), 0.35 (s, 4H)., 1037834-62-0

1037834-62-0 6-Azaspiro[2.5]octane hydrochloride 54593187, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; PFIZER PRODUCTS INC.; WO2008/84300; (2008); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7149-42-0,(1-Methylpiperidin-4-yl)methanamine,as a common compound, the synthetic route is as follows.

7149-42-0, A solution of the appropriate chloride (1 eq) (ex: 5-chloro-6-methyl-3-(3- trifluoromethoxy-phenyl)-7,8-dihydro-6H-9-oxa-1 ,2,3a,4,6-pentaaza-cyclopenta- (ajnaphthalene) and the appropriate amine (3 to 5 eq) (ex: 1-methyl-piperidin-4- ylamine) in nBuOH (15 mL/mmol) was heated up to 180- 185C under microwave irradiation for 5 h – 10 h (or 24 h at 160-180C in a silicon bath). The solvent was evaporated under vacuum and the residue was purified by flash chromatography (Isolute/Flash, Sill, 2.5% MeOH with 7N ammonia in DCM) or by semi-preparative HPLC (Gemini C18 (150 10 mm; 5 m), Solvent A: water with 0.1 % formic acid; Solvent B: acetonitrile with 0.1 % formic acid. Gradient: 40% of A to 0% of A).The NH-BOC-protected amines got deprotected in the reaction conditions and reacted giving a mixture of regioisomers. Amine: (1-methyl-4-piperidinyl)methylamineHPLC-MS (method 1 ): Rt = 3.28 min, [M+H]+ m/z 492.1. NMR (300 MHz, DMSO-d6) delta 8.58 (s, 1 H), 8.43 (d, J = 7.9 Hz, 1 H), 8.20 (s, 1 H), 7.69 (m, 1 H), 7.49 (m, 1 H), 6.91 (s, 1H), 4.46 (m, 1 H), 3.20 (m, 4H), 2.80 (m, 2H), 2.70 (s, 3H), 2.17 (s, 3H), 1.89 (m, 3H), 1.72 (m, 2H), 1.46 (d, J = 6.2 Hz, 3H), 1.25 (m, 2H).

As the paragraph descriping shows that 7149-42-0 is playing an increasingly important role.

Reference£º
Patent; CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO); GARCIA COLLAZO, Ana Maria; PASTOR FERNANDEZ, Joaquin; BLANCO APARICIO, Carmen; RODRIGUEZ HERGUETA, Antonio; MARTIN HERNANDO, Jose Ignacio; RAMOS LIMA, Francisco Javier; HERNANDEZ HIGUERAS, Ana Isabel; SALUSTE, Carl-Gustave Pierre; GONZALEZ CANTALAPIEDRA, Esther; MARTINEZ GONZALEZ, Sonia; SALGADO SERRANO, Antonio; NOYA MARINO, Beatriz; WO2011/80510; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.54012-73-6,Piperidin-3-amine,as a common compound, the synthetic route is as follows.

The steps will be a 2, 3 – diphenyl maleic anhydride (125g) and 3 – amino piperidine (50.1g) mixing, adding 1L dichloromethane, stirring at room temperature for 1 hour, the solvent is removed. Residue by adding acetic anhydride and sodium acetate mixture, heating to reflux 2 hours, after the reaction is complete, cooling, adding water and ethyl acetate extraction, to obtain the compound of formula d (150.5g, yield 90.6%)., 54012-73-6

The synthetic route of 54012-73-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Borui Bio-pharmaceutical (Suzhou) Co., Ltd.; Yuan Jiandong; (12 pag.)CN103450201; (2017); B;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24666-56-6,3-Aminopiperidine-2,6-dione hydrochloride,as a common compound, the synthetic route is as follows.

3-Hydroxyphthalic anhydride (1.641 g, 10 mmol, 1 eq) and 3-aminopiperidine-2,6- dione hydrochloride (1.646 g, 10 mmol, 1 eq) were dissolved in pyridine (40 mL, 0.25 M) and heated to 110 C. After 14 hours, the mixture was cooled to room temperature and concentrated under reduced pressure. Purification by column chromatography (ISCO, 24 g silica column, 0-10% MeOH/DCM) afforded the desired product as a tan solid (2.424 g, 8.84 mmol, 88%)., 24666-56-6

The synthetic route of 24666-56-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; DANA-FARBER CANCER INSTITUTE, INC.; BUCKLEY, Dennis; BRADNER, James; REMILLARD, David Ian; (212 pag.)WO2017/223452; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.657-36-3,4-Trifluoromethylpiperidine,as a common compound, the synthetic route is as follows.

General procedure: To a stirred solution of heterocyclic amines (1.1 mmol) and compound 23 (257.1 mg, 1 mmol) in anhydrous toluene (10 mL) wasadded Cs2CO3 (489.0 mg, 1.5 mmol), (¡À)-2,2′-Bis(diphenylphosphino)-1,1′-binaphthalene (62.0 mg, 0.1 mmol) and Palladium(II)acetate (25.0 mg, 0.1 mmol) at room temperature under argon. The mixture was refluxed for overnight, and then cooled to roomtemperature and filtered. The filtrate was diluted by EtOAc and washed with brine. The organic layer was concentrated and purified byFlash column chromatography (DCM/MeOH, 0-10%) to afford the crude target compounds 24b-j (50-64% yield).

657-36-3, As the paragraph descriping shows that 657-36-3 is playing an increasingly important role.

Reference£º
Article; Li; Wang; Wang, Bin; Liu, Mingliang; Lv, Kai; Tao, Zeyu; Ma, Chao; Ma; Han, Bing; Wang, Aoyu; Lu, Yu; Chinese Chemical Letters; (2019);,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

79099-07-3, 1-Boc-4-Piperidone is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

79099-07-3, In a reaction flask, 20 g (0.1 mol) of N-Boc-4-piperidone was added to 200 mL of toluene,Then 18 g (0.2 mol) of dimethyl carbonate and 22 g (0.2 mol) of potassium tert-butoxide were added, and the mixture was heated to 70 ¡ã C. for 1 hour,Cooled to room temperature, quenched with water 100mL,The reaction solution was adjusted to pH 7 with 1 mol / L HCl,Extracted with ethyl acetate, dried over anhydrous sodium sulfate,Dried to give N-Boc-3-methyl-4-piperidone as a yellow oil 25 g;

The synthetic route of 79099-07-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Wang Erxia; (19 pag.)CN107266442; (2017); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.78056-60-7,1-Acetyl-4-piperidineacetic acid,as a common compound, the synthetic route is as follows.

Reference Example 28 To a THF solution of (1-acetylpiperidin-4-yl)acetic acid were added under room temperature triethylamine and pivaloyl chloride, followed by stirring at room temperature for 1 hour. The reaction mixture was filtered and concentrated. Then, 3-cyclohexanecarbonyl-2-ethylamino-6-methylpyridine was added to the residue, followed bystirring at 150C for 14 hours. Ethanol and sodium methoxide were added to the product obtained by working up the reaction mixture, and the whole was heated under reflux for 1 hour. Thereafter, the reaction mixture was worked up and purified in a usual manner to obtain 3-(1-acetylpyridin-4-yl)-4-cyclohexyl-1-ethyl-7-methyl-1,8-naphthyridin-2(1H)-one as a colorless solid. MS: 396., 78056-60-7

The synthetic route of 78056-60-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; YAMANOUCHI PHARMACEUTICAL CO. LTD.; EP1225173; (2002); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3970-68-1,4-Methylpiperidin-4-ol,as a common compound, the synthetic route is as follows.

Preparation of the amide: The acid chloride obtained above was dissolved in 3 ml of anhydrous THF, and 40 mg (0.340 mmol) of 4-methylpiperidine-4-ol [commercially available;Lit. example:.. JM McManus et al, J. Med Chem 1965, 8 (6), 766-776] and 100 mu (0.570 mmol) of N, N-diisopropylethylamine was added. Subsequently, the reaction mixture was stirred for about 16 h at RT.After the mixture was evaporated on a rotary evaporator to dryness, the crude product was purified by preparative HPLC (Method 5).After combining the product fractions, evaporation and drying of the residue under high vacuum, 113 mg (88% of theory..) Of the title compound, 3970-68-1

3970-68-1 4-Methylpiperidin-4-ol 15649174, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; HAERTER, MICHAEL; DELBECK, MARTINA; KALTHOF, BERND; LUSTIG, KLEMENS; LINDNER, NIELS; KAST, RAIMUND; WASNAIRE, PIERRE; SUESSMEIER, FRANK; (372 pag.)TW2016/7950; (2016); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem