Tag: M.W:100-200

41373-39-1,41373-39-1, (S)-Piperidin-2-ylmethanol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 4-((6-ethoxy-6-oxohexyl)oxy)-5-methoxy-2-nitrobenzoic acid (16 ) (2.00 g, 5.60 mmol) in dichloromethane (40 mL) was charged with trimethyl amine (4.70 mL, 33.8 mmol) and 0-(7-azabenzotriazole-i-yl)-A V,A V-tetramethyluronium hexafluoro- phosphate (2.20 g, 5.90 mmol) and the resulting mixture was stirred for 2 h at room temperature. A solution of (S,)-piperidin-2-ylmethanol (647 mg, 5.63 mmol) in dichloromethane (10 mL) was then added and the resulting mixture was stirred for 16 h at room temperature. The reaction was quenched with a saturated aqueous solution of sodium hydrogen carbonate (40 mL), the phases were separated and the aqueous layer was further extracted with dichloromethane (20 mL). The combined organic extracts were washed with brine (40 mL), dried over magnesium sulfate, filtered and (1451) concentrated to give an amber oil. Purification was carried out by column (1452) chromatography (silica), eluting with ethyl acetate/ hexane (from 0percent to 100percent), to give the title compound (1.20 g, 48percent) as a colourless oil. (1453) NMR (400 MHz, CDCI3) delta 7.63-7.6o (m, iH), 6.77-6.75 (m, iH), 4.13-4.02 (m, 4H), 3-93 (s, 3H), 3-78-3-70 (m, iH), 3-68-3-39 (m, iH), 3-i8-3-H (m, 3H), 2.32 (t, J=7-6 Hz, 2H), 1.91-1.83 (m, 2H), 1.72-1.39 (m, 11H), 1.26 (t, J=7-i Hz, 3H); MS M/Z (EIMS) = 453 (M+H)+; LCMS (Method B): tR = 3.63 min.

The synthetic route of 41373-39-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; FEMTOGENIX LIMITED; JACKSON, Paul Joseph Mark; THURSTON, David Edwin; RAHMAN, Khondaker Mirazur; (243 pag.)WO2017/194960; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

64051-79-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.64051-79-2,3-Hydroxypiperidine Hydrochloride,as a common compound, the synthetic route is as follows.

10 Step 4: preparation of 3-Hydroxy-piperidine-1-carboxylic acid benzyl ester. Tosuspension of piperidin-3-ol hydrochloride (134 g, 0.974 mol) and triethylamine (276 mL, 1.98 mol) in dichloromethane (2 L) at 0 C was added a solution of benzyl chloroformate (140 mL, 0.981 mol) in dichloromethane (100 mL) drop wise over 2.5 h. The reaction was allowed to stir for an additional 30 mm at 0 C, then allowed to warm15 to ambient temperature over 16 h, after which it was quenched with 1 N hydrochloric acid (3 L) and allowed to stir for 30 mm. The organic layer was separated, dried over sodium sulfate, and concentrated in vacuo to afford the title compound (218 g, 95 %).1H-NMR (CDCI3) 67.29-7.41 (m, 5H), 5.14 (s, 2H), 3.59-3.85 (m, 3H), 3.13-3.27 (m, 2H), 2.18 (bs, 1H), 1.74-1.94 (m, 2H), 1.38-1.61 (m, 2H).

64051-79-2 3-Hydroxypiperidine Hydrochloride 2723962, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; PFIZER INC.; SPRINGER, John Robert; DEVADAS, Balekudru; GARLAND, Danny James; GRAPPERHAUS, Margaret Lanahan; HAN, Seungil; HOCKERMAN, Susan Landis; HUGHES, Robert Owen; SAIAH, Eddine; SCHNUTE, Mark Edward; SELNESS, Shaun Raj; WALKER, Daniel Patrick; WAN, Zhao-Kui; XING, Li; ZAPF, Christoph Wolfgang; SCHMIDT, Michelle, Ann; WO2014/68527; (2014); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

22990-34-7, 2-(4-Piperidyl)-2-propanol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 209 [0728] cis-Methyl 4-((E)-2-(4-fluorobenzoylimino)-6-((4-(2- hydroxypropan-2-yl)piperidin-l-yl)methyl)-2,3-dihydro-lH-benzo[d]imidazol-l- yl)cyclohexanecarboxylate. To a 0C cooled solution of cis-methyl 4-((E)-2-(4- fluorobenzoylimino)-6-(hydroxymethyl)-2,3-dihydro-lH-benzo[d]imidazol-l- yl)cyclohexanecarboxylate (1 g, 2.350 mmol) in DCM (25 mL) was added thionyl chloride (0.858 mL, 11.75 mmol) dropwise, and the reaction was stirred at 0C for 30 minutes. After 30 minutes, the solvent was removed at reduced pressure, and the residue was suspended in ACN (5 mL) and re-concentrated to remove residual thionyl chloride. The residue was resuspended in ACN (15 mL), cooled to 0C, and 2-(piperidin-4- yl)propan-2-ol (1.010 g, 7.05 mmol) and TEA (0.655 mL, 4.70 mmol) were added. The reaction was stirred overnight at RT. After 16 hours, the reaction mixture was concentrated and partitioned between EtOAc and water. The organic layer was concentrated and the residual product was purified by column chromatography, eluting with 0-100% (90:9:1 DCM/MeOH/NH4OH)/DCM to provide cis-methyl 4-((E)-2-(4- fluorobenzoylimino)-6-((4-(2-hydroxypropan-2-yl)piperidin-l-yl)methyl)-2,3-dihydro- lH-benzo[d]imidazol-l-yl)cyclohexanecarboxylate as a white powder (1.05 g, 81 % yield). .H NMR (400 MHz, DMSO-d6) delta ppm 1.03 (s, 6 H), 1.09 – 1.35 (m, 3 H), 1.56 – 1.91 (m, 8 H), 2.21 – 2.29 (m, 2 H), 2.53 – 2.64 (m, 2 H), 2.77 – 2.95 (m, 3 H), 3.50 (s, 2 H), 3.77 (s, 3 H), 3.99 (s, 1 H), 4.74 (br. s., 1 H), 7.14 (d, J=6.9 Hz, 1 H), 7.26 (dd, J=8.8 Hz, 8.8 Hz, 2 H), 7.37 – 7.58 (m, 2 H), 8.26 (dd, J=8.7, 5.9 Hz, 2 H), 12.77 (s, 1 H). MS, m/z (C31H39FN4O4): calcd, 550.3; found, 551.1 [M+H].

22990-34-7, As the paragraph descriping shows that 22990-34-7 is playing an increasingly important role.

Reference£º
Patent; AMGEN INC.; BODE, Christiane, M.; CHENG, Alan, C.; CHOQUETTE, Deborah; LEWIS, Richard, T.; POTASHMAN, Michele, H.; ROMERO, Karina; STELLWAGEN, John, C.; WHITTINGTON, Douglas, A.; WO2012/18668; (2012); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3433-37-2,2-(Hydroxymethyl)piperidine,as a common compound, the synthetic route is as follows.,3433-37-2

Example 8; 2-Hydroxymethyl-piperidine-l-carboxylic acid tert-butyl ester; Di-tert-butyl dicarbonate (8.3 g, 38.2 mmol) was added to a stirred solution of piperidinemethanol (4. 0g, 37.4 mmol) in CH2C12 (50 mL) and 1N NaOH (50 mL, 50 mmol) was added. The mixture was stirred at room temperature overnight. Reaction mixture was diluted with CH2C12 and the aqueous phase was separated. The aqueous phase was extracted with dichloromethane (3X30 mL). The combined organic phase was washed with water (30 mL) and brine (30 mL), dried (sodium sulfate), filtered and concentrated in-vacuo to give the crude product which was triturated with hexane to afford the title compound as white solid (4.8 g, 64percent).

As the paragraph descriping shows that 3433-37-2 is playing an increasingly important role.

Reference£º
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2005/80386; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

38646-68-3, 4,4-Dimethylpiperidine hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

DIPEA (1 .93ml, 1 1 .1 mmol) was added to a solution of Tricyclo[3.3.1.13,7]decane-1 – carbonyl chloride (1 ) (1 g, 5.5mmol) and 4,4-dimethylpiperidine hydrochloride (4) (828mg, 5.5mmol) in DCM (10ml) and the solution stirred at room temperature for 4 hours. At this time, TLC [15:85 EA:hexane, 20muIota_ aliquot into MTBE:1 N HCI (400muIota_:400muIota_)] showed the formation of a single chemical. The solution was washed with 0.1 N HCI (30ml), saturated NaHC03 (30ml), dried (Na2S04), filtered and the solvents removed to give crude product which was further purified by FC on silica gel using 15:85 EA:hexane to give the desired product as a crystalline white solid.

38646-68-3, As the paragraph descriping shows that 38646-68-3 is playing an increasingly important role.

Reference£º
Patent; UNILEVER PLC; UNILEVER N.V.; CONOPCO, INC., D/B/A UNILEVER; AU, Van; HARICHIAN, Bijan; CLOUDSDALE, Ian Stuart; BAJOR, John Steven; DICKSON, Jr, John Kenneth; WO2014/139965; (2014); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

6457-49-4, 4-Piperidinemethanol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6457-49-4, 1.1 Synthesis of ^Hydroxymethyl-piperidine-i-carboxylic tert-butyl ester 1Og of 4-piperidine methanol was dissolved in 10OmIs of dichloromethane and the solution treated with 14.5mls of triethylamine under nitrogen. The mixture was cooled to O0C using an ice bath and stirred. 19g of boc anhydride was added portionwise to the mixture over 15 minutes. The reaction mixture was then stirred overnight allowing the whole to warm to RT. The reaction mixture was diluted with a further 30OmIs dichloromethane and washed with 1 N HCI(aq) (250ml) followed by a wash with brine before drying over anhydrous magnesium sulphate. The dried organics were filtered and evaporated to dryness to give 17.8g of colourless crystalline solid.1H-NMR (400MHz, CD3OD) OH 4.88(2H s) 4.08(1 H d), 3.39(1 H d), 1.70(1 H d), 1.60(1 H m), 1.44(9H s), 1.08(2H m)

6457-49-4 4-Piperidinemethanol 420771, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; VERNALIS (R & D) LIMITED; WO2008/38011; (2008); A1;,
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Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.79099-07-3,1-Boc-4-Piperidone,as a common compound, the synthetic route is as follows.,79099-07-3

Prepared according to a variation of a literature procedure (J. Med. Chem., 2008, 51 , p2170): Trimethylsulfoxonium iodide (22.5 g, 102 mmol) was suspended in DME (100 mL) under N2 and potassium fe/f-butoxide (12.5 g, 1 1 1 mmol) was added. After 30 min, the mixture was cooled to 0 C and a solution of fe/f-butyl 4-oxopiperidine-1-carboxylate (20 g, 100 mmol) in DME (20 mL) was added dropwise over 45 min. The reaction was allowed to warm to RT over 16 h then quenched by the addition of water (150 mL). The mixture was extracted with Et20 (3 x 100 mL). The combined organic extracts were washed with brine (100 mL), dried over MgS04 and concentrated. The residue was dried by azeotropic distillation with toluene to give the title compound (16.5 g, 83%). 1 H NMR (300 MHz, CDCI3): delta 3.81-3.58 (m, 2H), 3.40 (ddd, 2H), 2.67 (s, 2H), 1.78 (ddd, 2H), 1.56-1.30 (m, 2H), 1.45 (s, 9H).

79099-07-3 1-Boc-4-Piperidone 735900, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; ALMAC DISCOVERY LIMITED; HEWITT, Peter; MCFARLAND, Mary Melissa; ROUNTREE, James Samuel Shane; BURKAMP, Frank; BELL, Christina; PROCTOR, Lauren; HELM, Matthew Duncan; O’DOWD, Colin; HARRISON, Timothy; (280 pag.)WO2018/20242; (2018); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3970-68-1,4-Methylpiperidin-4-ol,as a common compound, the synthetic route is as follows.

(S)-1-Phenylethyl (R)-2-(4-hydroxy-4-methylpiperidin-1-yl)- 2-phenylacetate: To a solution of (S)-1-phenylethyl 2-bromo-2-phenylacetate (0.464 g, 1.45 mmol) in THF (8 mL) was added triethylamine (0.61 mL, 4.35 mmol),followed by tetrabutylammonium iodide (0.215 g, 0.58 mmol). The reaction mixture was stirred at room temperature for5 minutes and then a solution of 4-methyl-4-hydroxypiperidine (0.251 g, 2.18 mmol) in THF (2 mL) was added. Themixture was stirred for 1 hour at room temperature and then it was heated at 55-60 C (oil bath temperature) for 4 hours.The cooled reaction mixture was then diluted with ethyl acetate (30 mL), washed (H2O x2, brine), dried (MgSO4), filteredand concentrated. The residue was purified by silica gel chromatography (0-60% ethyl acetate-hexane) to provide first the (S,R)-isomer of the title compound (0.306 g, 60%) as a white solid and then the corresponding (S,S)-isomer (0.120g, 23%), also as a white solid. (S,R)-isomer: 1H NMR (CD3OD) delta 7.51-7.45 (m, 2H), 7.41-7.25 (m, 8H), 5.85 (q, J=6.6Hz, 1H), 4.05 (s, 1H), 2.56-2.45 (m, 2H), 2.41-2.29 (m, 2H), 1.71-1.49 (m, 4H), 1.38 (d, J=6.6 Hz, 3H), 1.18 (s, 3H).LCMS: Anal. Calcd. for C22H27NO3: 353; found: 354 (M+H)+. (S,S)-isomer: 1H NMR (CD3OD) delta 7.41-7.30 (m, 5H),7.20-7.14 (m, 3H), 7.06-7.00 (m, 2H), 5.85 (q, J=6.6 Hz, 1H), 4.06 (s, 1H), 2.70-2.60 (m, 1H), 2.51 (dt, J=6.6, 3.3 Hz,1H), 2.44-2.31 (m, 2H), 1.75-1.65 (m, 1H), 1.65-1.54 (m, 3H), 1.50 (d, J=6.8 Hz, 3H), 1.20 (s, 3H). LCMS: Anal. Calcd.for C22H27NO3: 353; found: 354 (M+H)+., 3970-68-1

As the paragraph descriping shows that 3970-68-1 is playing an increasingly important role.

Reference£º
Patent; Bristol-Myers Squibb Company; BELEMA, Makonen; NGUYEN, Van N.; SERRANO-WU, Michael; ST. LAURENT, Denis R.; QIU, Yuping; DING, Min; MEANWELL, Nicholas A.; SNYDER, Lawrence B.; (149 pag.)EP2328865; (2017); B1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6859-99-0,Piperidin-3-ol,as a common compound, the synthetic route is as follows.

6859-99-0, A solution of di-tert-butyl dicarbonate (5.83 g, 26.7 mmol) in dichloromethane (10 ml) was added to a solution of 3-hydroxypiperidine (3.0 g, 29.7 mmol) in dichloromethane (30 ml) at room temperature and stirred for 15 hours. The reaction solution was concentrated, diluted with ethyl acetate, and then washed with a saturated aqueous sodium hydrogencarbonate solution, a 0.5M-aqueous potassium hydrogensulfate solution, a saturated aqueous sodium hydrogencarbonate solution and then a saturated aqueous sodium chloride solution. The organic layer was dried over anhydrous magnesium sulfate and distilled under reduced pressure to remove the solvent, and the resulting residue was crystallized by the addition of hexane, filtered, and then dried to obtain tert-butyl 3-hydroxy-1-piperidinecarboxylate (5.17 g, 87percent).1H-NMR (DMSO-d6) delta; 1.46 (9H, s, 1.99 (2H, m), 3.34-3.49 (4H, m), 4.45 (1H, m).

The synthetic route of 6859-99-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sumitomo Pharmaceuticals Company, Limited; EP1403255; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

1123-40-6, 4,4-Dimethylpiperidine-2,6-dione is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A suspension of LiAlH4 (5.5 g, 145 mmol) in diethyl ether (300 ML) was treated in portions with 3,3-dimethylglutarimide (8.5 g, 57.7 mmol), heated to reflux, stirred overnight, cooled to room temperature, and treated with 1N NaOH (70 ML).The solution was decanted and the remaining solid was washed with diethyl ether (3*200 ML).The combined organic washes were washed with brine, dried (Na2SO4), filtered, and concentrated to a volume of 200 ML. The solution was treated with 2M HCl in diethyl ether (50 ML) and the mixture was filtered and the filter cake was washed with diethyl ether (3*150 ML) to provide the desired product (6.58 g, 76%). MS (CI) m/e 114 (M+H)+., 1123-40-6

As the paragraph descriping shows that 1123-40-6 is playing an increasingly important role.

Reference£º
Patent; Elmore, Steven W.; Park, Cheol-Min; Wang, Xilu; US2003/236247; (2003); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem