Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3970-68-1,4-Methylpiperidin-4-ol,as a common compound, the synthetic route is as follows.

3970-68-1, Step 2: (S)-1-Phenylethyl (R)-2-(4-hydroxy-4-methylpiperidin-1-yl)-2-phenylacetate To a solution of (S)-1-phenylethyl 2-bromo-2-phenylacetate (0.464 g, 1.45 mmol) in THF (8 mL) was added triethylamine (0.61 mL, 4.35 mmol), followed by tetrabutylammonium iodide (0.215 g, 0.58 mmol). The reaction mixture was stirred at room temperature for 5 minutes and then a solution of 4-methyl-4-hydroxypiperidine (0.251 g, 2.18 mmol) in THF (2 mL) was added. The mixture was stirred for 1 hour at room temperature and then it was heated at 55-60 C. (oil bath temperature) for 4 hours. The cooled reaction mixture was then diluted with ethyl acetate (30 mL), washed (H2O*2, brine), dried (MgSO4), filtered and concentrated. The residue was purified by silica gel chromatography (0-60% ethyl acetate-hexane) to provide first the (S,R)-isomer of the title compound (0.306 g, 60%) as a white solid and then the corresponding (S,S)-isomer (0.120 g, 23%), also as a white solid. (S,R)-isomer: 1H NMR (CD3OD) delta 7.51-7.45 (m, 2H), 7.41-7.25 (m, 8H), 5.85 (q, J=6.6 Hz, 1H), 4.05 (s, 1H), 2.56-2.45 (m, 2H), 2.41-2.29 (m, 2H), 1.71-1.49 (m, 4H), 1.38 (d, J=6.6 Hz, 3H), 1.18 (s, 3H). LCMS: Anal. Calcd. for C22H27NO3: 353; found: 354 (M+H)+. (S,S)-isomer: 1H NMR (CD3OD) delta 7.41-7.30 (m, 5H), 7.20-7.14 (m, 3H), 7.06-7.00 (m, 2H), 5.85 (q, J=6.6 Hz, 1H), 4.06 (s, 1H), 2.70-2.60 (m, 1H), 2.51 (dt, J=6.6, 3.3 Hz, 1H), 2.44-2.31 (m, 2H), 1.75-1.65 (m, 1H), 1.65-1.54 (m, 3H), 1.50 (d, J=6.8 Hz, 3H), 1.20 (s, 3H). LCMS: Anal. Calcd. for C22H27NO3: 353; found: 354 (M+H)+.

3970-68-1 4-Methylpiperidin-4-ol 15649174, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Bristol-Myers Squibb Company; US2009/202483; (2009); A1;; ; Patent; Bristol-Myers Squibb Company; US2010/80772; (2010); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

50534-49-1, N,N-Dimethylpiperidin-3-amine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

50534-49-1, General procedure: Compound 265a was prepared from 3-carbamoyl-l-(2-((2-((3-chloro-2-fluorobenzyl)amino)- 2-oxoethyl)(cyclopropyl)amino)-2-oxoethyl)-lH-indazole-5-carbonyl azide (235a) (400 mg, 0.38 mmol) and N,N-dimethylpiperidin-3 -amine (97 mg, 0.76 mmol) using TEA (0.21 mL, 1.52 mmol) as base according to the procedure reported in step-4 of Scheme 129. This gave after workup, purification by flash column chromatography [silica gel (12 g), eluting with DMA80 in DCM 0 to 40%] followed by preparative HPLC [Cis column, eluting with CH3CN in water (containing 0.1% TFA) 0-100%] l-(2-((2-((3-chloro-2-fluorobenzyl)amino)-2- oxoethyl)(cyclopropyl)amino)-2-oxoethyl)-5-(3-(dimethylamino)piperidine-l-carboxamido)- lH-indazole-3-carboxamide (265a) (32 mg, 0.051 mmol, 13 % yield) white solid as a TFA salt; NMR (300 MHz, DMSO-d) delta 9.60 – 9.46 (m, 1H), 8.77 (s, 1H), 8.50 (t, J= 5.8 Hz, 1H), 8.25 – 8.18 (m, 1H), 7.66 (s, 1H), 7.56 – 7.50 (m, 2H), 7.50 – 7.42 (m, 1H), 7.32 (s, 1H), 7.27 – 7.19 (m, 1H), 7.19 – 7.08 (m, 1H), 5.61 (s, 2H), 4.33 (d, J= 5.7 Hz, 2H), 4.24 (d, J = 13.0 Hz, 2H), 3.98 (s, 2H), 3.94 – 3.88 (m, 1H), 3.33 – 3.22 (m, 1H), 3.10 – 2.97 (m, 2H), 2.86 and 2.85 and 2.82 and 2.81 (4s, 6H), 2.13 – 2.03 (m, 1H), 1.86 – 1.65 (m, 2H), 1.61 – 1.39 (m, 1H), 1.03 – 0.95 (m, 2H), 0.95 – 0.85 (m, 2H);19F NMR (282 MHz, DMSO-i) delta – 73.92 (TFA peak), -121.58; MS (ES+): 627.5 (M+1). Scheme 266 A suspension of 3-acetyl-l-(2-((2-((3-chloro-2-fluorobenzyl)amino)-2- oxoethyl)(isopropyl)amino)-2-oxoethyl)-lH-indole-5-carbonyl azide (129d) (75 mg, 0.14 mmol) in THF/Tol (24 mL, Ratio: 1 :2) was heated at reflux for 4h, cooled to room temperature and concentrated in vacuum to dryness. The residue obtained was dissolved in THF (20 mL) and ACN (10 mL) followed by the addition of cyclopropanamine (16.25 mg, 0.29 mmol) and triethylamine (0.060 mu^, 0.427 mmol). The reaction mixture was stirred at room temperature overnight, diluted with EtOAc (100 mL), washed with water (3x), dried, filtered and concentrated in vacuum. The residue was purified by column chromatography [silica (12 g), eluting with CMA80 in CHCb 0 to 40%] followed by preparative HPLC with water/ ACN to give 2-(3-acetyl-5-(3-cyclopropylureido)-lH-indol-l-yl)-N-(2-((3-chloro-2- fluorobenzyl)amino)-2-oxoethyl)-N-isopropylacetamide (129e) (6 mg, 10.79 mupiiotaomicron, 6% yield) as a white solid after lyophilization; NMR (300 MHz, DMSO-de) (a mixture of two rotamers) delta 8.84 – 8.13 (m, 4H), 7.60 – 6.90 (m, 5H), 6.27 (d, J = 2.3 Hz, 1H), 5.29 and 5.11 (2s, 2H), 4.66 – 4.50 and 4.28-4.20 (2m, 1H), 4.47 (d, J = 5.4 Hz) and 4.34 (d, J = 5.8 Hz) (2d, 2H), 4.17 and 3.84 (2s, 2H), 2.40 and 2.39 (2s, 3H), 1.24 (d, J = 6.3 Hz) and 1.00 (d, J = 6.8 Hz) (2d, 6H), 0.71 – 0.55 (m, 2H), 0.50 – 0.31 (m, 2H); 19F NMR (282 MHz, DMSO-d) delta -73.45 (TFA peak), -121.20, -121.82; MS (ES+); 578.5 (M+Na); MS (ES”): 554.5 (M-l).

50534-49-1 N,N-Dimethylpiperidin-3-amine 14459854, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; BIOCRYST PHARMACEUTICALS, INC.; KOTIAN, Pravin, L.; BABU, Yarlagadda, S.; ZHANG, Weihe; VOGETI, Lakshminarayana; WU, Minwan; CHINTAREDDY, Venkat, R.; RAMAN, Krishnan; (479 pag.)WO2017/136395; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1123-40-6,4,4-Dimethylpiperidine-2,6-dione,as a common compound, the synthetic route is as follows.

Crude 2- (2-METHOXY-5-NITRO-PHENOXY)-ETHANOL (0.43 g, 2 MMOL) was dissolved in dry THF, 4, 4-dimethylglutarimide (0.28 g, 2 mmol), triphenylphosphine (0.52 g, 2 MMOL) and diethylazodicarboxylate (1.1 ml, 2.4 MMOL) were added at 45 C. After 6 h the reaction mixture was concentrated in vacuo and purified by flash-chromatography (cyclohexane/ ethyl ether 3/7) to give 0.41 g of the title compound as a white solid. NMR (‘H, CECI3) : 8 7.88 (d, 1H), 7.73 (s, 1H), 6.85 (d, 1H), 4.30-4. 15 (m, 4H), 3.90 (s, 3H), 2.52 (s, 4H), 1.13 (s, 6H)., 1123-40-6

As the paragraph descriping shows that 1123-40-6 is playing an increasingly important role.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2004/89897; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

648921-37-3, 3,3-Dimethyl-4-piperidone Hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

648921-37-3, Preparation of 1-66: A solution of 1-65 (4.20 g, 33.07 mmol) in CH2C12 (80 mL) was charged with benzyl chloroformate (6.70 g, 39.68 mmol) followed by triethyl amine (5.00 g, 49 mmol) over 20 min at 0C. The reaction mixture was stirred at RT for 16 h. The organic layer was washed with saturated NaHCC solution (50 mL), water (100 mL) and brine (50 mL). The organic layer was concentrated under reduced pressure to afford 1-66 as a liquid. MS (MM) m/z 262.1 [M + H]+.

648921-37-3 3,3-Dimethyl-4-piperidone Hydrochloride 57358418, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; IOMET PHARMA LTD.; MERCK SHARP & DOHME CORP.; COWLEY, Phillip, M.; MCGOWAN, Meredeth Ann; BROWN, Thomas, J.; HAN, Yongxin; LIU, Kun; PU, Qinglin; WISE, Alan; ZHANG, Hongjun; ZHOU, Hua; (70 pag.)WO2017/189386; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

4897-50-1, 4-Piperidinopiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of 2-tert-butoxycarbonylamino-4-oxo-4- [4- (2-oxo-1, 4- dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-butyric acid (1.14 g, 2.55 mmol) and 4- [PIPERIDINYL-PIPERIDINE] (525 mg, 2.81 mmol) in methylene chloride (20 [ML)] was added [3- (DIETHOXYPHOSPHORYLOXY)-1,] 2,3-benzotriain-4 [(3H)-ONE] (DEPBT, 840 mg, 2.81 mmol) in one portion followed by dropwise addition of triethylamine (0.427 [ML,] 3.06 mmol). The resulted mixture was stirred at room temperature overnight (15 h). The mixture was diluted with methylene chloride and washed with sodium hydroxide (0.5 N) solution and water. The layers were separated and the organic layer was dried with sodium sulfate and concentrated [IN VACUO] to give a light yellow foam. The crude product was purified by flash column chromatography (10percent [(1M] ammonia in methanol) in methylene chloride) to give a colorless foam (1.08 g, [71percent).] [APOS;H-NMR] (400 MHz, [CDC13)] [8] 8.86-8. 55 [(1H,] br), 7.05 [(1H,] br), 6.93 [(1H,] br), 6.82 [(1H,] br), 6.72 [(1H,] d, J = 7.6 Hz), 6.10-5. 68 [(1H,] br), 5.20 [(1H,] m), 54.70-4. 40 (2H, br), 4.20 (2H, br), 4. [01-3. 82] (2H, br. ), 3.10-2. 88 (3H, br), 2.99 (3H, br), 2.53 (6H, br), 1.90-1. 10 (23H, m). Mass spec.: 597 [(MH) +.]

4897-50-1, 4897-50-1 4-Piperidinopiperidine 78607, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2003/104236; (2003); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3970-68-1,4-Methylpiperidin-4-ol,as a common compound, the synthetic route is as follows.

3970-68-1, Step 2: (S)-1-Phenylethyl (R)-2-(4-hydroxy-4-methylpiperidin-1-yl)-2-phenylacetate To a solution of (S)-1-phenylethyl 2-bromo-2-phenylacetate (0.464 g, 1.45 mmol) in THF (8 mL) was added triethylamine (0.61 mL, 4.35 mmol), followed by tetrabutylammonium iodide (0.215 g, 0.58 mmol). The reaction mixture was stirred at room temperature for 5 minutes and then a solution of 4-methyl-4-hydroxypiperidine (0.251 g, 2.18 mmol) in THF (2 mL) was added. The mixture was stirred for 1 hour at room temperature and then it was heated at 55-60 C. (oil bath temperature) for 4 hours. The cooled reaction mixture was then diluted with ethyl acetate (30 mL), washed (H2O*2, brine), dried (MgSO4), filtered and concentrated. The residue was purified by silica gel chromatography (0-60% ethyl acetate-hexane) to provide first the (S,R)-isomer of the title compound (0.306 g, 60%) as a white solid and then the corresponding (S,S)-isomer (0.120 g, 23%), also as a white solid. (S,R)-isomer: 1H NMR (CD3OD) delta 7.51-7.45 (m, 2H), 7.41-7.25 (m, 8H), 5.85 (q, J=6.6 Hz, 1H), 4.05 (s, 1H), 2.56-2.45 (m, 2H), 2.41-2.29 (m, 2H), 1.71-1.49 (m, 4H), 1.38 (d, J=6.6 Hz, 3H), 1.18 (s, 3H). LCMS: Anal. Calcd. for C22H27NO3: 353; found: 354 (M+H)+. (S,S)-isomer: 1H NMR (CD3OD) delta 7.41-7.30 (m, 5H), 7.20-7.14 (m, 3H), 7.06-7.00 (m, 2H), 5.85 (q, J=6.6 Hz, 1H), 4.06 (s, 1H), 2.70-2.60 (m, 1H), 2.51 (dt, J=6.6, 3.3 Hz, 1H), 2.44-2.31 (m, 2H), 1.75-1.65 (m, 1H), 1.65-1.54 (m, 3H), 1.50 (d, J=6.8 Hz, 3H), 1.20 (s, 3H). LCMS: Anal. Calcd. for C22H27NO3: 353; found: 354 (M+H)+.

3970-68-1 4-Methylpiperidin-4-ol 15649174, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Bristol-Myers Squibb Company; US2009/202483; (2009); A1;; ; Patent; Bristol-Myers Squibb Company; US2010/80772; (2010); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

50534-49-1, N,N-Dimethylpiperidin-3-amine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

50534-49-1, General procedure: Compound 265a was prepared from 3-carbamoyl-l-(2-((2-((3-chloro-2-fluorobenzyl)amino)- 2-oxoethyl)(cyclopropyl)amino)-2-oxoethyl)-lH-indazole-5-carbonyl azide (235a) (400 mg, 0.38 mmol) and N,N-dimethylpiperidin-3 -amine (97 mg, 0.76 mmol) using TEA (0.21 mL, 1.52 mmol) as base according to the procedure reported in step-4 of Scheme 129. This gave after workup, purification by flash column chromatography [silica gel (12 g), eluting with DMA80 in DCM 0 to 40%] followed by preparative HPLC [Cis column, eluting with CH3CN in water (containing 0.1% TFA) 0-100%] l-(2-((2-((3-chloro-2-fluorobenzyl)amino)-2- oxoethyl)(cyclopropyl)amino)-2-oxoethyl)-5-(3-(dimethylamino)piperidine-l-carboxamido)- lH-indazole-3-carboxamide (265a) (32 mg, 0.051 mmol, 13 % yield) white solid as a TFA salt; NMR (300 MHz, DMSO-d) delta 9.60 – 9.46 (m, 1H), 8.77 (s, 1H), 8.50 (t, J= 5.8 Hz, 1H), 8.25 – 8.18 (m, 1H), 7.66 (s, 1H), 7.56 – 7.50 (m, 2H), 7.50 – 7.42 (m, 1H), 7.32 (s, 1H), 7.27 – 7.19 (m, 1H), 7.19 – 7.08 (m, 1H), 5.61 (s, 2H), 4.33 (d, J= 5.7 Hz, 2H), 4.24 (d, J = 13.0 Hz, 2H), 3.98 (s, 2H), 3.94 – 3.88 (m, 1H), 3.33 – 3.22 (m, 1H), 3.10 – 2.97 (m, 2H), 2.86 and 2.85 and 2.82 and 2.81 (4s, 6H), 2.13 – 2.03 (m, 1H), 1.86 – 1.65 (m, 2H), 1.61 – 1.39 (m, 1H), 1.03 – 0.95 (m, 2H), 0.95 – 0.85 (m, 2H);19F NMR (282 MHz, DMSO-i) delta – 73.92 (TFA peak), -121.58; MS (ES+): 627.5 (M+1). Scheme 266 A suspension of 3-acetyl-l-(2-((2-((3-chloro-2-fluorobenzyl)amino)-2- oxoethyl)(isopropyl)amino)-2-oxoethyl)-lH-indole-5-carbonyl azide (129d) (75 mg, 0.14 mmol) in THF/Tol (24 mL, Ratio: 1 :2) was heated at reflux for 4h, cooled to room temperature and concentrated in vacuum to dryness. The residue obtained was dissolved in THF (20 mL) and ACN (10 mL) followed by the addition of cyclopropanamine (16.25 mg, 0.29 mmol) and triethylamine (0.060 mu^, 0.427 mmol). The reaction mixture was stirred at room temperature overnight, diluted with EtOAc (100 mL), washed with water (3x), dried, filtered and concentrated in vacuum. The residue was purified by column chromatography [silica (12 g), eluting with CMA80 in CHCb 0 to 40%] followed by preparative HPLC with water/ ACN to give 2-(3-acetyl-5-(3-cyclopropylureido)-lH-indol-l-yl)-N-(2-((3-chloro-2- fluorobenzyl)amino)-2-oxoethyl)-N-isopropylacetamide (129e) (6 mg, 10.79 mupiiotaomicron, 6% yield) as a white solid after lyophilization; NMR (300 MHz, DMSO-de) (a mixture of two rotamers) delta 8.84 – 8.13 (m, 4H), 7.60 – 6.90 (m, 5H), 6.27 (d, J = 2.3 Hz, 1H), 5.29 and 5.11 (2s, 2H), 4.66 – 4.50 and 4.28-4.20 (2m, 1H), 4.47 (d, J = 5.4 Hz) and 4.34 (d, J = 5.8 Hz) (2d, 2H), 4.17 and 3.84 (2s, 2H), 2.40 and 2.39 (2s, 3H), 1.24 (d, J = 6.3 Hz) and 1.00 (d, J = 6.8 Hz) (2d, 6H), 0.71 – 0.55 (m, 2H), 0.50 – 0.31 (m, 2H); 19F NMR (282 MHz, DMSO-d) delta -73.45 (TFA peak), -121.20, -121.82; MS (ES+); 578.5 (M+Na); MS (ES”): 554.5 (M-l).

50534-49-1 N,N-Dimethylpiperidin-3-amine 14459854, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; BIOCRYST PHARMACEUTICALS, INC.; KOTIAN, Pravin, L.; BABU, Yarlagadda, S.; ZHANG, Weihe; VOGETI, Lakshminarayana; WU, Minwan; CHINTAREDDY, Venkat, R.; RAMAN, Krishnan; (479 pag.)WO2017/136395; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1123-40-6,4,4-Dimethylpiperidine-2,6-dione,as a common compound, the synthetic route is as follows.

Crude 2- (2-METHOXY-5-NITRO-PHENOXY)-ETHANOL (0.43 g, 2 MMOL) was dissolved in dry THF, 4, 4-dimethylglutarimide (0.28 g, 2 mmol), triphenylphosphine (0.52 g, 2 MMOL) and diethylazodicarboxylate (1.1 ml, 2.4 MMOL) were added at 45 C. After 6 h the reaction mixture was concentrated in vacuo and purified by flash-chromatography (cyclohexane/ ethyl ether 3/7) to give 0.41 g of the title compound as a white solid. NMR (‘H, CECI3) : 8 7.88 (d, 1H), 7.73 (s, 1H), 6.85 (d, 1H), 4.30-4. 15 (m, 4H), 3.90 (s, 3H), 2.52 (s, 4H), 1.13 (s, 6H)., 1123-40-6

As the paragraph descriping shows that 1123-40-6 is playing an increasingly important role.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2004/89897; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

648921-37-3, 3,3-Dimethyl-4-piperidone Hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

648921-37-3, Preparation of 1-66: A solution of 1-65 (4.20 g, 33.07 mmol) in CH2C12 (80 mL) was charged with benzyl chloroformate (6.70 g, 39.68 mmol) followed by triethyl amine (5.00 g, 49 mmol) over 20 min at 0C. The reaction mixture was stirred at RT for 16 h. The organic layer was washed with saturated NaHCC solution (50 mL), water (100 mL) and brine (50 mL). The organic layer was concentrated under reduced pressure to afford 1-66 as a liquid. MS (MM) m/z 262.1 [M + H]+.

648921-37-3 3,3-Dimethyl-4-piperidone Hydrochloride 57358418, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; IOMET PHARMA LTD.; MERCK SHARP & DOHME CORP.; COWLEY, Phillip, M.; MCGOWAN, Meredeth Ann; BROWN, Thomas, J.; HAN, Yongxin; LIU, Kun; PU, Qinglin; WISE, Alan; ZHANG, Hongjun; ZHOU, Hua; (70 pag.)WO2017/189386; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

4897-50-1, 4-Piperidinopiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of 2-tert-butoxycarbonylamino-4-oxo-4- [4- (2-oxo-1, 4- dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-butyric acid (1.14 g, 2.55 mmol) and 4- [PIPERIDINYL-PIPERIDINE] (525 mg, 2.81 mmol) in methylene chloride (20 [ML)] was added [3- (DIETHOXYPHOSPHORYLOXY)-1,] 2,3-benzotriain-4 [(3H)-ONE] (DEPBT, 840 mg, 2.81 mmol) in one portion followed by dropwise addition of triethylamine (0.427 [ML,] 3.06 mmol). The resulted mixture was stirred at room temperature overnight (15 h). The mixture was diluted with methylene chloride and washed with sodium hydroxide (0.5 N) solution and water. The layers were separated and the organic layer was dried with sodium sulfate and concentrated [IN VACUO] to give a light yellow foam. The crude product was purified by flash column chromatography (10percent [(1M] ammonia in methanol) in methylene chloride) to give a colorless foam (1.08 g, [71percent).] [APOS;H-NMR] (400 MHz, [CDC13)] [8] 8.86-8. 55 [(1H,] br), 7.05 [(1H,] br), 6.93 [(1H,] br), 6.82 [(1H,] br), 6.72 [(1H,] d, J = 7.6 Hz), 6.10-5. 68 [(1H,] br), 5.20 [(1H,] m), 54.70-4. 40 (2H, br), 4.20 (2H, br), 4. [01-3. 82] (2H, br. ), 3.10-2. 88 (3H, br), 2.99 (3H, br), 2.53 (6H, br), 1.90-1. 10 (23H, m). Mass spec.: 597 [(MH) +.]

4897-50-1, 4897-50-1 4-Piperidinopiperidine 78607, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2003/104236; (2003); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem