Tag: M.W:100-200

657-36-3,657-36-3, 4-Trifluoromethylpiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a stirred solution of 3 (4, 5) (0.10 mmol) in DMSO (10 ml) were added ZH (0.12 mmol) and K2CO3 (27.6 mg 0.20 mmol). After stirring at 80 ¡ãC for 8 hours, the mixture was cooled to room temperature and poured into water, the precipitation was filtered and dried directly for next step. To a solution of above solid (0.10 mmol) in dry THF (10 ml) was added LiAlH4 (11.4 mg, 0.30 mmol) at 0 ¡ãC. After stirring at room temperature for 4 h, the mixture was quenched with water and extracted by CH2Cl2 (10 ml). The extraction was dried over anhydrous MgSO4 and filtered. The filtration was concentrated for next step. To a solution of above crude solid (0.12 mmol) in dry CH2Cl2 (10 ml) were added compound 6 (7-11) (0.10 mmol), TEA (22.2mg, 0.22 mmol) and BopCl (30.4 mg, 0.12 mmol). After stirring at room temperature for 12 h, the mixture was washed with brine and dried over anhydrous MgSO4, filtered and concentrated. The residue was purified by silica gel column (CH2Cl2 : MeOH = 100 : 1) to yield compounds 1, 2, A, B, C.

The synthetic route of 657-36-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wang, Hongjian; Lv, Kai; Li, Xiaoning; Wang, Bo; Wang, Apeng; Tao, Zeyu; Geng, Yunhe; Wang, Bin; Huang, Menghao; Liu, Mingliang; Guo, Huiyuan; Lu, Yu; Chinese Chemical Letters; vol. 30; 2; (2019); p. 413 – 416;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.73579-08-5,1-Methyl-4-(methylamino)piperidine,as a common compound, the synthetic route is as follows.

To a mixture of Scheme 43 compound 1 (1.0 g, 4.90 mmol), Scheme 43 compound 2 (630 mg, 4.90 mmol), Cs2C03 (4.8 g, 14.80 mmol) and Xantphos (286 mg, 0.49 mmol) in dry toluene (10 mL) was added Pd(OAc)2 (111 mg, 0.49 mmol) and the reaction mixture was heated to 100 ¡ãC for 4 h. After TLC showed the starting material was completely consumed, the reaction mixture was cooled to RT, passed through a pad of celite and washed with EtOAc. The filtrate was washed with water and brine, dried over Na2S04 and concentrated to give a residue which was purified by flash chromatography on silica gel (eluting with CH2Cl2/MeOH 100/0 gradually increasing to 95/5) to give Scheme 43 compound 3 (1.0 g, 83percent) as a yellow solid. MS [ESI, MH+] = 251.15., 73579-08-5

The synthetic route of 73579-08-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MANNKIND CORPORATION; TOLERO PHARMACEUTICALS, INC.; ZENG, Qingping; FARIS, Mary; MOLLARD, Alexis; WARNER, Steven L.; FLYNN, Gary A.; WO2014/52365; (2014); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

290328-55-1, 4-(Methylsulfonyl)piperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 3 Preparation of (S)-benzyl 4-((1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-5a,5b,8,8,11a-pentamethyl-3a-((2-(4-(methylsulfonyl)piperidin-1-yl)ethyl)amino)-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysen-9-yl)cyclohex-3-enecarboxylate To a flask containing a suspension of (S)-benzyl 4-((1R,3 aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-(aziridin-1-yl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysen-9-yl)cyclohex-3-enecarboxylate (0.044 g, 0.067 mmol) in 1,4-dioxane (2 mL) was added Hunig’s base (0.070 mL, 0.402 mmol) followed by 4-(methylsulfonyl)piperidine, HCl (0.067 g, 0.335 mmol). The flask attached to a reflux condensor and was heated to 95 C. for 15 h, then was cooled to rt. The crude mixture was adsorbed to silica gel and was purified by flash chromatography using a 10-75% ethyl acetate in hexanes gradient and a 12 g silica gel column. The fractions containing the expected product were combined and concentrated under reduced pressure to give (S)-benzyl 4-((1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-5a,5b,8,8,11a-pentamethyl-3a-((2-(4-(methylsulfonyl)piperidin-1-yl)ethyl)amino)-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysen-9-yl)cyclohex-3-enecarboxylate (0.033 g, 0.041 mmol, 60.6% yield) as a clear, colorless film. LCMS: m/e 813.8 (M+H)+, 2.17 min (method 1). 1H NMR (500 MHz, chloroform-d) delta=7.40-7.29 (m, 5H), 5.37-5.33 (m, 1H), 5.16 (dd, J=6.1, 1.7 Hz, 1H), 5.14 (s, 2H), 4.71 (d, J=1.7 Hz, 1H), 4.59 (s, 1H), 3.17-3.06 (m, 2H), 2.83 (s, 3H), 2.86-2.78 (m, 1H), 2.65-2.53 (m, 4H), 2.49-2.42 (m, 2H), 2.38-2.30 (m, 2H), 2.19-2.12 (m, 4H), 1.69 (s, 3H), 1.08 (s, 3H), 0.96 (s, 6H), 0.89 (s, 3H), 0.85 (s, 3H), 2.12-0.82 (m, 29H)., 290328-55-1

290328-55-1 4-(Methylsulfonyl)piperidine 22275038, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; Swidorski, Jacob; Meanwell, Nicholas A.; Regueiro-Ren, Alicia; Sit, Sing-Yuen; Chen, Jie; Chen, Yan; US2013/210787; (2013); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

496807-97-7, 3,3-Difluoropiperidine hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

496807-97-7, Step 2:; To a solution of 37a2 (100 mg, 0.18 mmol) and 3,3-difluoropiperidine hydrochloride (31 mg, 0.20 mmol) in DCE (1.5 ml.) is added NaBH(OAc)3 (52 mg, 0.25 mmol). The mixture is stirred at RT overnight, then water is added. The mixture is extracted with DCM (3x), the organics are dried and concentrated under reduced pressure. Purification by combiflash (15% EtOAc in hex) gives 37a3.

The synthetic route of 496807-97-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GmbH; WO2009/76747; (2009); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

24537-50-6, 2-Oxopiperidine-4-carboxylic acid is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 2-oxopiperidine-4-carboxylic acid (21.3 g) in tetrahydrofuran (300 mL) was added 60% sodium hydride (18 g, containing mineral oil) under cooling to 0C. The reaction mixture was stirred for 30 min under cooling to 0C. To the reaction mixture was added dropwise 1- (bromomethyl) -2, 4-bis (trifluoromethyl) benzene (46 g) under cooling to 0C, and the mixture was further stirred at 80C for 2 days. Water was added to the reaction mixture under cooling to 0C, and the mixture was extracted with ethyl acetate. To the aqueous layer was further added 10% hydrochloric acid, and the mixture was extracted with ethyl acetate. The extract was dried over sodium sulfate, and the solvent was evaporated under reduced pressure to give the title compound (32 g) .? NMR (400 MHz, CDC13) delta 2.03-2.09 (1H, m) , 2.18-2.24 (1H, m) , 2.81-2.82 (2H, m) , 2.97-3.01 (1H, m) , 3.28-3.31 (2H, m) , 4.66 (1H, d, J = 16.0 Hz), 5.10 (1H, d, J = 16.0 Hz), 7.50 (1H, d, J = 8.0 Hz), 7.78 (1H, d, J = 8.0 Hz), 7.91 (1H, s) .MS (ESI+) : [M+H]+ 370., 24537-50-6

24537-50-6 2-Oxopiperidine-4-carboxylic acid 55286080, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; MATSUMOTO, Shigemitsu; ONO, Koji; TOMINARI, Yusuke; KATOH, Taisuke; MIWA, Kazuhiro; HASUOKA, Atsushi; IMAMURA, Shinichi; WO2013/18929; (2013); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

3230-23-7, 4-Ethylpiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: B: Standard reaction procedure terminal alkyne: SeO2 (1.0 mmol) was added to a solutionof terminal alkyne (1.0 mmol) in dioxan (1 ml) followed by the addition of 10mol% of H2SO4 and amine (1.0 mmol). The reaction mixturewas then heated at 80oC for 10-12 h and the product formation wasmonitored by TLC. After completion, reaction mixture was partioned with waterethyl acetate, extracted with ethyl acetate (3 x 50ml). The combined organiclayers were washed with brine solution, concentrated on rotary evaporator andpurified by column chromatography using ethyl acetate and hexane to affordcorresponding pure products.

3230-23-7, 3230-23-7 4-Ethylpiperidine 76704, apiperidines compound, is more and more widely used in various fields.

Reference£º
Article; Meena, Samdarshi; Singh, Rohit; Vishwakarma, Ram A.; Aga, Mushtaq A.; Jain, Shreyans K.; Tetrahedron Letters; vol. 57; 33; (2016); p. 3715 – 3717;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

832715-51-2, Isopropyl 4-hydroxypiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

832715-51-2, Step 3: 1 -Methylethyl 4-({7-[5-(methylthio)-2-pyridinyl]-6,7-dihydro-5H-pyrrolo[2,3- c/]pyrimidin-4-yl}oxy)-1 -piperidinecarboxylate (201) To a stirred solution of 200 (652 mg, 2.35 mmol) and 1 -methylethyl 4-hydroxy-1- piperidinecarboxylate 9 (526 mg, 2.81 mmol) in THF (24 mL) was added NaH (60% dispersion in mineral oil, 282 mg, 7.05 mmol) in one portion at RT. The reaction mixture was heated to reflux for 18 h, cooled to RT, and quenched with water (20 mL). The mixture was extracted with EtOAc (3 x 50 mL), dried over MgSO4, filtered, and concentrated under reduced pressure. The crude oil was purified using SiO2 flash chromatography (40% EtOAc in hexanes) to give 373 mg (37%) of the title product 201 as a colorless oil. 1H NMR (400 MHz, CDCI3): delta 8.73 – 8.66 (m, 1 H), 8.42 – 8.39 (m, 1 H), 8.30 (d, J = 2.4 Hz, 1 H), 8.77 – 8.70 (m, 1 H), 5.39 – 5.32 (m, 1 H), 4.92 (septuplet, J = 6.1 Hz, 1 H), 4.46 – 4.36 (m, 2 H), 3.85 – 3.76 (m, 2 H), 3.36 – 3.30 (m, 2 H), 3.12 – 3.05 (m, 2 H), 2.48 (s, 3 H), 2.03 – 1.95 (m, 2 H), 1.79 – 1.70 (m, 2 H), 1.25 (d, J = 6.4 Hz, 6 H); LCMS (ESI): m/z 430 (M + H)+.

The synthetic route of 832715-51-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2008/8895; (2008); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

106-52-5, 1-Methylpiperidin-4-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-((2′-chloro-4′-nitro-[1,1′-biphenyl]-4-yl)oxy)-1-methylpiperidine (28e): Diisopropylazo dicarboxylate (2.40 mmol) was added to a solution of phenol (1.20 mmol), PPh3 (2.40 mmol) and 4-hydroxy N-methyl piperidine (2.40 mmol) in THF (8 mL) at room temperature. The reaction mixture was stirred for 18 hours before the removal of solvent under reduced pressure. The remaining residue was purified by silica gel column chromatography (eluting with methylene chloride:methanol = 99:1 to 20:1) to yield a yellow amorphous solid (81%). 1H NMR (500 MHz, chloroform-d) delta 8.35 (d, J = 2.3 Hz, 1H), 8.15 (dt, J = 8.4, 2.2 Hz, 1H), 7.51 (d, J = 8.5 Hz, 1H), 7.43- 7.34 (m, 2H), 7.05- 6.94 (m, 2H), 4.41 (dt, J = 7.2, 3.7 Hz, 1H), 2.83- 2.65 (m, 2H), 2.34 (s, 3H), 2.07 (ddd, J = 13.9, 7.1, 3.5 Hz, 2H), 1.92 (ddd, J = 13.2, 7.9, 3.7 Hz, 2H). 13C NMR (126 MHz, CDCl3) delta 158.01, 146.90, 146.62, 133.42, 131.78, 130.57, 129.47, 125.32, 121.80, 115.58, 71.98, 52.60, 46.17, 30.74. HRMS (ESI+) m/z [M+H+] calcd for C18H19ClN2O3347.1163, found 347.1136.

106-52-5, 106-52-5 1-Methylpiperidin-4-ol 66048, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; THE UNIVERSITY OF KANSAS; BLAGG, Brian, S.J.; ZHAO, Huiping; WO2015/70091; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.832715-51-2,Isopropyl 4-hydroxypiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

832715-51-2, 4,6-Dichloro-5-methylpyrimidine (1) (2.4235 Kg, 1.000 equivalents) and 4-hydroxypiperidine-1-carboxylic acid isopropyl ester (2) (2.8182 Kg, 1.012 equivalents) were dissolved in tetrahydrofuran (THF, 25.0028 Kg), and the resulting solution was cooled to -15 to -10 C. To the cold solution, potassium-tert-butoxide in tetrahydrofuran (1 M, 12.6051 Kg, 0.9399 equivalents) was added at a rate sufficiently slow to maintain the reaction mixture below 0 C. with reactor jacket cooling. The reaction mixture was then stirred at about -5 C. for about 2 hours before an additional portion of potassium-tert-butoxide in tetrahydrofuran (1 M, 0.5692 Kg, 0.0424 equivalents) was added to achieve >97% conversion of the pyrimidine after an additional hour of stirring at about -5 C. Most of the solvent was then removed by distillation at 30-65 C., 80 torr. Addition of water (19.9681 Kg) to the evaporation residue precipitated the product. Distillative removal of THF was then completed at 30-65 C., 80 torr, and the resulting stirred slurry was cooled to 0 C. for an hour. The solids were then collected by suction filtration, washed with water (8.011 Kg, 4 C.), and vacuum dried to constant weight at 50 C., 40 torr to provide product (3) (4.491 Kg, 96.3% yield).

As the paragraph descriping shows that 832715-51-2 is playing an increasingly important role.

Reference£º
Patent; Gharbaoui, Tawfik; Fritch, John R.; Krishnan, Ashwin M.; Throop, Beverly Wolgast; Kato, Naomi S.; US2006/155129; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.104-58-5,3-(Piperidin-1-yl)propan-1-ol,as a common compound, the synthetic route is as follows.

General procedure: Sodium (1.2 mmol) was added to a solution of an alcohol (1.0 mmol) in dry THF and the mixture was stirred at rt for 1 h. 4-Chloroquinazoline [22] (6, 1.0 mmol) was then added, and the resultant solution was stirred at rt for 24 h. The mixture was diluted with ethyl acetate (10 mL), washed with brine (10 mL) and dried over sodium sulfate. The products were purified by column chromatography (hexane-ethyl acetate 8:2).

104-58-5, As the paragraph descriping shows that 104-58-5 is playing an increasingly important role.

Reference£º
Article; ?pulak, Marcel; Pourova, Jana; Vopr?alova, Marie; Miku?ek, Ji?i; Kune?, Ji?i; Vacek, Jan; Ghavre, Mukund; Gathergood, Nicholas; Pour, Milan; European Journal of Medicinal Chemistry; vol. 74; (2014); p. 65 – 72;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem