Tag: M.W:100-200

37675-18-6, (S)-Ethyl piperidine-3-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Reference Example 5 To a mixture of (S)-ethyl nipecotate (1.15 g) and tetrahydrofuran (16 ml) was added lithium aluminum hydride (278 mg) at 0C. The mixture was stirred for 3 hours with elevating the temperature to room temperature. Water (0.28 ml), 25% potassium hydroxide solution (0.28 ml) and water (0.84 ml) were added thereto in this order, and the mixture was stirred for 15 hours. The insolubles were filtered off using celite and the mother liquor was concentrated, to give (S)-3-(hydroxymethyl)piperidine (797 mg). [alpha]D = -11.3 (c = 0.730, MeOH). 1H-NMR (300 Hz, CDCl3) delta: 1.07-1.20 (1H, m), 1.40-1.54 (1H, m), 1.61-1.82 (3H, m), 2.39 (1H, dd, J=12.0 and 9.9 Hz), 2.54-2.62 (3H, m), 2.95-3.01 (1H, m), 3.13-3.18 (1H, m), 3.40-3.54 (2H, m).

37675-18-6, The synthetic route of 37675-18-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Takeda Pharmaceutical Company Limited; EP1553074; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

50585-89-2, Methyl piperidine-3-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

50585-89-2, Potassium 3-methoxycarbonyl-piperidine-1-carbodithioate (13 Kmpc) was prepared by the dropwise addition of 14 CS2 (1.2mL, 20mmol) into a solution of methyl nipecotate (2.8mL, 20mmol) in 15 methanol (30mL) in the presence of 16 KOH (1.2g, 20mmol), stirring the reaction mixture for 1h. The yellow solid which separated was filtered off, washed with ethanol and thereafter with ether and dried (Scheme 2 ). Yield: 80%; m.p. 202C. Anal. Found: C, 37.15; H, 4.88; N, 5.70; S, 24.58%. Calc. for C8H12NO2S2K (257.40): C, 37.32; H, 4.70; N, 5.44; S, 24.91%. IR (KBr, cm-1): nu(C-H) 2944, 2857; nu(C=O) 1658; nu(CN) 1565; nu(C=S) 1012. 1H NMR (CDCl3: delta, ppm): 1.68-2.43 (m, H-3, H-4, H-5), 2.64 (t, 2H, H-6axial), 2.91 (d, 2H, H6-equatorial), 2.82 (t, 2H, H-2axial), 3.13 (d, 2H, H-2equatorial), 4.09 (s, 3H, -OCH3). 13C NMR (CDCl3: delta, ppm): 23.88-49.99 (piperidine ring), 51.01 (-OCH3), 173.50 (C=O), 212.46 (C=S).

The synthetic route of 50585-89-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Nath, Paras; Bharty; Kushawaha; Maiti; Polyhedron; vol. 151; (2018); p. 503 – 509;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24211-55-0,(S)-Piperidin-3-ol,as a common compound, the synthetic route is as follows.

2,3′-difluoro-4′-((1-(2-fluoro-2-methylpropyl)piperidin-4-yl)methoxy)biphenyl-4-carboxylic acid (0.04 g, 0.10 mmol) and (S)-piperidin-3-ol (0.02 g, 0.19 mmol) were dissolved in DMF 2 mL. DIPEA (0.08 mL, 0.48 mmol), EDCI (0.04 g, 0.19 mmol) and HOBt (0.03 g, 0.19 mmol) were added thereto slowly, following with stirring at 60 C. for 3 hours. After the completion of the reaction, excess amount of water was added to the reaction mixture. The resulting precipitate was filtered, and dissolved in CH2Cl2. The solution was concentrated under reduced pressure. The obtained concentrate was purified by column chromatography (40 g ISCO silica gel cartridge, 0-20% MeOHCH2Cl2) to yield the title compound as light-yellow solid (0.02 g, 42%). 1H NMR (400 MHz, CDCl3) delta 7.40 (t, 1H, J=5.8 Hz), 7.29-7.21 (m, 4H), 6.99 (t, 1H, J=6.4 Hz), 3.88 (d, 2H, J=4.6 Hz), 3.78-3.27 (m, 4H), 2.97 (d, 2H, J=8.2 Hz), 2.45 (s, 1H), 2.40 (s, 1H), 2.16 (t, 2H, J=8.5 Hz), 1.91-1.65 (m, 7H), 1.45-1.23 (m, 8H); MS (ESI) mz 505 (M++H)

24211-55-0, The synthetic route of 24211-55-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CHONG KUN DANG PHARMACEUTICAL CORP.; Lee, ChangSik; Jang, TaegSu; Choi, DaeKyu; Ko, MooSung; Kim, DoHoon; Kim, SoYoung; Min, JaeKi; Kim, WooSik; Lim, YoungTae; US2015/166480; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

4606-65-9, 3-(Hydroxymethyl)piperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Scheme 6, step B. To a solution ofpiperidin-3-ylmethanol (2.10 g, 0.018 mol) inCHzCh (20 mL) is added triethylamine (5.53 g, 0.0547 mol) followed by tbutyldimethylchlorosilane( 4.127 g, 0.0275 mol) and the reaction mixture is stirred atroom temperature. After 24 hours, the reaction mixture is washed with water, saturated solution ofNaHC03, and brine. The combined organic layers are combined and dried25over sodium sulfate, filtered, and concentrated under reduced pressure. The resultingresidue is purified by flash chromatography (silica gel) over a gradient using 0-10%MeOH in dichloromethane to afford the title compound (2.50 g, 60 %). Mass spectrum(m/z): 231.2 (M+1)., 4606-65-9

The synthetic route of 4606-65-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ELI LILLY AND COMPANY; BLANCO-PILLADO, Maria-Jesus; VETMAN, Tatiana Natali; FISHER, Matthew Joseph; KUKLISH, Steven Lee; WO2014/4230; (2014); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

496807-97-7, 3,3-Difluoropiperidine hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,496807-97-7

General procedure: To a solution of 1 -benzyl-1 H-pyrazole-4-carboxylic acid [5-(3-formyl-phenyl)-1 – (toluene-4-sulfonyl)-1 H-pyrrolo[2,3-b]pyridin-3-yl]-amide (100mg, 0.17mmol) in MeOH (1 ml_) was added 4A molecular sieves followed by dimethylamine, 2.0M solution in THF (4ml_, 8mmol) and the reaction stirred for 3 hours at RT. Sodium triacetoxyborohydride (72.1 mg, 0.34mmol) was added and the reaction stirred 18 hours at RT. The inorganic material was separated via filtration and the filtrate was diluted with DCM. The solution was washed with aqueous saturated sodium bicarbonate solution, dried (MgSO4) and concentrated in vacuo. The residue was purified using automated column chromatography eluting with DCM to 10% MeOH/DCM. Fractions containing pure compound were combined and concentrated in vacuo to give the desired compound as a colourless glass, 61 mg, 58.0%.

The synthetic route of 496807-97-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; VERNALIS (R&D) LIMITED; STOKES, Stephen; GRAHAM, Christoper John; RAY, Stuart Christopher; STEFANIAK, Emma Jayne; WO2013/114113; (2013); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.177-11-7,1,4-Dioxa-8-azaspiro[4.5]decane,as a common compound, the synthetic route is as follows.

a) 8-(6-Methylpyrimidin-4-yl)-1,4-dioxa-8-azaspiro[4.5]decane; A solution of 1,4-dioxa-8-azaspiro[4.5]decane (3.04 g, 2.72 mL, 21.2 mmol), 4-chloro-6-methylpyrimidine (3.00 g, 23.4 mmol) and N,N-diisopropylethylamine (4.12 g, 5.56 mL, 31.8 mmol) in dioxane (50 mL) was heated to 140 C. in the microwave for 40 minutes. The reaction mixture was concentrated, then directly purified by flash chromatography (silica gel, 70 g, 0% to 15% MeOH/NH4OH (9:1) in dichloromethane). The title compound was obtained as orange oil (4.64 g, 93%).MS ISP (m/e): 236.2 (100) [(M+H)+].1H NMR (CDCl3, 300 MHz): delta (ppm)=8.52-8.51 (m, 1H), 6.42 (m, 1H), 4.01 (s, 4H), 3.83-3.79 (m, 4H), 2.45 (s, 3H), 1.79-1.75 (m, 4H)., 177-11-7

As the paragraph descriping shows that 177-11-7 is playing an increasingly important role.

Reference£º
Patent; Baumann, Karlheinz; Flohr, Alexander; Goetschi, Erwin; Green, Luke; Jolidon, Synese; Knust, Henner; Limberg, Anja; Luebbers, Thomas; Thomas, Andrew; US2011/201605; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21987-29-1,4,4-Difluoropiperidine,as a common compound, the synthetic route is as follows.

Step 8: N-(cis-3-{[(4,4-Difluoropiperidin-1-yl)sulfonyl]methyl}cyclobutyl)-N-methyl-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine To a mixture of 4,4-difluoropiperidine (77 mg, 0.64 mmol) and triethylamine (97 mg, 0.96 mmol) in tetrahydrofuran (20 mL) at 0¡ã C. was added dropwise a solution of cis-[3-(methyl{7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)cyclobutyl]methanesulfonyl chloride (150 mg, 0.320 mmol) in tetrahydrofuran (10 mL). The mixture was allowed to warm to room temperature overnight. The solvent was evaporated and the residue was taken up in ethyl acetate (80 mL). The solution was washed with brine (30 mL), dried over sodium sulfate and concentrated to afford the crude title compound (134 mg) as a white solid. LC/MS (exact mass) calculated for C24H29F2N5O4S2; 553.651. found (M+H+); 554.3., 21987-29-1

As the paragraph descriping shows that 21987-29-1 is playing an increasingly important role.

Reference£º
Patent; Pfizer Inc.; Brown, Matthew Frank; Fenwick, Ashley Edward; Flanagan, Mark Edward; Gonzales, Andrea; Johnson, Timothy Allan; Kaila, Neelu; Mitton-Fry, Mark J.; Strohbach, Joseph Walter; TenBrink, Ruth E.; Trzupek, John David; Unwalla, Rayomand Jal; Vazquez, Michael L.; US2014/243312; (2014); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

4138-26-5, Piperidine-3-carboxamide is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,4138-26-5

Piperidine-3-carboxylic acid amide 1a (25 g, 0.195 mol) was added portionwise to a stirred solution of lithium aluminum hydride (14.8 g, 0.39 mol, 2.0 equiv) in dry THF (0.6 L). When the initial effervescence had subsided, the reaction was heated at reflux under N2 at rt for 24 h. The reaction was quenched by dropwise addition of saturated sodium sulfate solution with stirring until no further effervescence was observed. The suspension was filtered through a celite plug, washed with THF (400 mL), and the filtrate concentrated under reduced pressure. The crude residue was distilled to yield pure product 1b as a colorless oil (12.4 g, 55percent).

4138-26-5 Piperidine-3-carboxamide 92980, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Du Bois, Daisy Joe; Mao, Long; Rogers, Daniel Harry; Williams, John Patrick; US2004/14775; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3433-37-2,2-(Hydroxymethyl)piperidine,as a common compound, the synthetic route is as follows.

3433-37-2, A. (l-Benzylpiperidin-2-yl)methanol (compound 13) To a stirred solution of piperidine-2 -methanol (12; 6 g, 52.09 mmol) in dimethylformamide (DMF, 50 mL) were added successively K2CO3 (10.78 g, 78.14 mmol) and benzyl bromide (6.85 mL, 57.30 mmol) at 0¡ãC and the mixture stirred at rt for 16 hours. The reaction mixture was then filtered and the filtrate was concentrated. The residue was dissolved in EtOAc and the organic layer was washed with water and brine solution. The organic layer was dried over Na2S04, filtered and concentrated. The crude material was purified by chromatography on 230-400 mesh silica gel eluting with 30percent EtOAc-hexane to provide compound 13. Yield: 6.0 g (56.6percent); 1H-NMR (400 MHz, CDC13): delta 7.37-7.21 (m, 5H), 4.05 (d, J= 13 Hz, 1H), 3.85 (dd, J= 11, 4 Hz, 1H), 3.50 (dd, J= 11, 4 Hz, 1H), 3.30 (d, J= 13 Hz, 1H), 2.88-2.83 (m, 1H), 2.69 (brs, 1H), 2.47-2.43 (m, 1H), 2.17-2.11 (m, 1H), 1.70-1.54 (m, 4H), 1.40-1.33 (m, 2H).

The synthetic route of 3433-37-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ENDO PHARMACEUTICALS INC.; GUPTA, Sandeep; PRIESTLEY, Tony; LAPING, Nicholas, James; WO2014/28675; (2014); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

79099-07-3,79099-07-3, 1-Boc-4-Piperidone is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Acetonitrile (2.06 g, 50.18 mmol) was added to tetrahydrofuran (30.00 mL); added dropwise with n-butyl lithium (2.5 M, 20.07 mL) at -78 C and under nitrogen protection,and stirred at -78 C for 1 hour. 4-oxoperidine-1-formic acid tert-butyl ester (5.00g, 25.09 mmol) was added to the reaction solution under nitrogen protection at -78-25 C, and the reaction mixture was stirred at -78-25 C for 9 hours. TLC showed that new products appeared but the raw materials were not completely consumed. The reaction solution was concentrated, added with ethyl acetate (10 mL) and water (20 mL), and then extracted with ethyl acetate (20 mL) three times. The combined organic phases were dried over anhydrous sodium sulfate (5 g), concentrated, separated and purified by column chromatography (PE: EA = 5:1 to 2:1) to give compound 11A. 1H NMR (400MHz, deuterated chloroform) delta = 3.91 (br s, 2H), 3.15 (br t, J=11.6 Hz, 2H), 2.54 (s, 2H), 1.77 – 1.70 (m, 2H), 1.67 – 1.60 (m, 2H), 1.46 (s, 9H).

The synthetic route of 79099-07-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Medshine Discovery Inc.; LIU, Xile; DING, Charles Z.; CHEN, Shuhui; WU, Lingyun; HU, Lihong; WAN, Haiwen; (118 pag.)EP3567030; (2019); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem