Tag: M.W:100-200

3970-68-1, 4-Methylpiperidin-4-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 13.1; 1-(4-{2-[6-(4-Methoxy-phenyl)-py?dazin-3-yloxy1-ethoxy)-benzyl)-4-methyl-piperidin-4-ol; 100 mg (0.285 mmol) 4-{2-[6-(4-Methoxy-phenyl)-pyridazin-3-yloxy]-ethoxy}-benzaldehyde (educt XII.1 ) and 35 mg (0.30 mmol) 4-methyl-pipeiotadin-4-ol are dissolved in 10 ml of THF and 0.20 ml cone, acetic acid are added. After 10 minutes 180 mg (0.855 mmol) sodium triacetoxyborohydride are added and the mixture is stirred for 20 hours at RT. After that time the mixture is filtered and the solvent is evaporated. The residue is purified by silica gel column chromatography with methylene chloride/methanol/ammonia (10:1 :0.1 ) as eluent. Yield: 50 mg (39% of theory),Rf value: 0.25 (silica gel, methylene chloride/methanol/ammonia = 10:1 :0.1 )EII mass spectrum: m/z = 450 [M+H]+

3970-68-1, The synthetic route of 3970-68-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG; WO2007/48802; (2007); A1;,
Piperidine – Wikipedia
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476014-76-3, 4-Hydroxy-2-piperidinone is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,476014-76-3

[0242] (6) 4-hydroxypiperidin-2-one (0.80g, 6.94mmol) was dissolved in DMF. DMAP (0.085g, 0.694mmol) and imidazole(0.92g, 13.88mmol) were added. After the resulting mixture was stirred evenly, the solution of TBDPS-Cl (2.3g,8.33mmol) in THF was added and stirred at room temperature overnight. After the reaction completed, the reactionmixture was dried by spinning. Column chromatography afforded colorless oily liquid 0.65g, yield 60percent.[0243] 1H NMR (300 MHz, CDCl3) delta 7.70-7.49 (m, 4H), 7.53-7.30 (m, 6H), 4.24-4.09 (dt, J = 8.9,3.0 Hz, 1H),3.62-3.49(dt, J = 13.0, 6.7 Hz, 1H),3.20-3.08 (dtd, J = 11.7, 5.6, 2.3 Hz, 1H), 2.51-2.35 (d, J = 4.8 Hz, 2H),1.83-1.69(m,2H),1.17-1.00 (s,9H).MS(ESI) m/z :[(M+1)+,158.3]

As the paragraph descriping shows that 476014-76-3 is playing an increasingly important role.

Reference£º
Patent; Shanghai Institute of Materia Medica, Chinese Academy of Sciences; Zhe Jiang Jutai Pharmaceutical Co., Ltd; YANG, Yushe; XUE, Tao; DING, Shi; GUO, Bin; EP2947085; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20845-34-5,1-Methyl-2-piperidinemethanol,as a common compound, the synthetic route is as follows.

A mixture of (1-methylpiperidin-2-yl)methanol (74a) (78 mg, 0.61 mmol, 1.3 eq), compound 4d (114 mg, 0.47 mmol), and PPh3 (162.2 mg, 0.61 mmol, 1.3 eq) in dry THF(10 mL) under N2 at 0¡ãC was treated with DIAD (0.12 mL 0.61 mmol) and the reaction mixture was stirred for two days, allowing it to warm to 20 ¡ãC. The solvent was removed under vacuum, and the residue was partitioned between CH2C12 and dil. aq. HC1 (the product did not go into the aqueous layer). The organic layer was separated and washed with aq.KOH, and dried (Na2SO4). Chromatographyon Si02 eluting with 50percent CH2C12/hexanes then50percent CH2C12/EtOAc gave 6-fluoro-2-methyl-4-(( 1 -methylazepan-2-yl)oxy)-9H-xanthen-9- one (74b) (8.0 mg 4.8percent): ?H NIVIR (CDC13) 5 8.34 (dd, J= 8.9, 6.5 Hz, 1H), 7.70 (dd, J= 1.8, 0.8Hz, 1H), 7.25 (dd, J= 9.4, 2.4 Hz, 1H), 7.12-7.07 (m, 2H), 4.62-4.56 (m, 1H), 2.98 (dd, J 13.6, 4.2 Hz, 1H), 2.88 (dd, J 13.6, 7.2 Hz, 1H), 2.75-2.69 (m, 1H), 2.64-2.59 (m, 1H), 2.46 (s, 3H), 2.44 (s, 3H), 2.25-2.17 (m, 1H), 2.02-1.94 (m, 1H), 1.89-1.75 (m, 3H), 1.67-1.58 (m, 1H)., 20845-34-5

As the paragraph descriping shows that 20845-34-5 is playing an increasingly important role.

Reference£º
Patent; AUCKLAND UNISERVICES LIMITED; MARSHALL, Andrew James; BUCHANAN, Christina Maree; REWCASTLE, Gordon William; LU, Guo-Liang; FLANAGAN, Jack Urquhart; BONNET, Muriel; SHEPHERD, Peter Robin; JAMIESON, Stephen Michael Frazer; GAMAGE, Swarnalatha Akuratiya; DENNY, William Alexander; (213 pag.)WO2018/83635; (2018); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14691-88-4,4-Amino-2,2,6,6-tetramethylpiperidine 1-Oxyl,as a common compound, the synthetic route is as follows.

To a solution of 6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid (2.50 g, 10 mmol), 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl (1.71 g, 10 mmol) and 4-4-Dimethylaminopyridine (DMAP) (0.6 g, 5 mmol) in CH2Cl2 (50 mL) at 0-5¡ã C., EDAC (2.14 g, 11 mmol) in dichloromethane (50 mL) was added dropwise. After the addition was complete, the mixture was stirred at room temperature overnight. The reaction mixture was washed with water (2*50 mL), 1N HCl (20 mL) and saturated Na2CO3 (20 mL) and dried over MgSO4. After MgSO4 was filtered off, the solvent was removed in vacuum to give a solid. The solid was purified by column chromatography (silica gel, EtOAc/Hexane 1:10). The product, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-N-(1-nitroxy-2,2,6,6-tetramethylpiperidin-4-yl)-2H-chromene-2-carboxamide, was an orange solid (2.61 g). The yield was 64.7percent. Used as is in the next step.

14691-88-4, 14691-88-4 4-Amino-2,2,6,6-tetramethylpiperidine 1-Oxyl 550942, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Patil, Ghanshyam; Mousa, Shaker A.; US2008/200405; (2008); A1;,
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Piperidine | C5H11N – PubChem

113310-52-4, 4-(Piperidin-4-yl)aniline is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Substrates NT1-003 (80 mg, 0.32 mmol) and NT1-004 (28.4 mg, 0.32 mmol) were mixed in a microwave tube with EtOH (1 mL). Then 0.1NHC1 (1 mL) was added to the tube. The vessel was sealed and heated to 150 C for 40 minutes. The solvent was removed under reduced pressure, the residue washed with DCM, and filtered to afford 5 -chloro-N2-(4-Q,iperidin-4-yl)phenyl)-1V4-((tetrahydrofuran-2-yl)methyl)pyrimidine-2,4- diamine (NT1-005) as a peach solid (90 mg, 72.0%), mp 160 C (dec.). HPLC 85.6% [R = 7.51 mm, 30% CH3OH in 0.1% TFA water 20 mm]. ?H NMR (400 MHz, Methanol-d4) oe 7.94 (s,1H), 7.49 (d, J= 8.2 Hz, 2H), 7.35 (d, J= 8.4 Hz, 2H), 4.16 (p, J= 6.2 Hz, 1H), 3.86-3.68 (m,2H), 3.65 -3.46 (m, 4H), 3.22-3.09 (m, 2H), 3.00-2.90 (m, 1H), 2.14- 1.82 (m, 8H), 1.69-1.58(m, 1H). ?3C NMR (101 MHz, Methanol-d4) oe 159.20, 151.43, 141.84, 139.72, 135.04, 127.16,122.99, 105.19, 76.74, 67.63, 45.23, 44.15, 39.15, 29.68, 28.54, 25.01. LC-MS (ESI+) m/z388.18965 (M+H) HRMS (ESI+) m/z calculated for C2oH26ClN5O(M+H)388.1899, found,388.1900.

113310-52-4, 113310-52-4 4-(Piperidin-4-yl)aniline 22047841, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.; MAHAJAN, Nupam, P.; MAHAJAN, Kiran, N.; LAWRENCE, Nicholas, J.; LAWRENCE, Harshani, R.; WO2015/21149; (2015); A1;,
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Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.71486-53-8,Methyl 4-oxopiperidine-3-carboxylate hydrochloride,as a common compound, the synthetic route is as follows.

71486-53-8, Referential Example 8 1.94 g of methyl 4-oxo-3-piperidinecarboxylate hydrochloride, 1.68 g of sodium hydrogencarbonate and 1.67 g of ethyl bromoacetate were dissolved in a mixed solvent comprising 32 ml of water and 8 ml of diethyl ether and stirred at room temperature overnight. 50 ml of ethyl acetate was added to the reaction liquid, and the organic layer was separated by liquid-liquid separation. This was dried with sodium sulfate and concentrated. The resulting residue was purified by silica gel column chromatography (using a gradient eluent of chloroform to chloroform/methanol=100/1) to obtain 1.5 g of ethyl 3-methoxycarbonyl-4-oxo-1-piperidineacetate as an oily substance. Mass spectrum (m/z): FAB (Pos) 244(M+ +1) NMR spectrum (CDCl3, TMS internal standard):

The synthetic route of 71486-53-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Yamanouchi Pharmaceutical Co., Ltd.; US5773442; (1998); A;,
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Piperidine | C5H11N – PubChem

6091-44-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6091-44-7,Piperidine hydrochloride,as a common compound, the synthetic route is as follows.

piperidine hydrochloride (4.4 mg, 0.04 mmol) was added to a solution of trans-(RS)-alpha-methyl-N-[4(2,4-dioxopiperidin-1-yl)-1-phenylcyclohexyl]-3,5-bis(trifluoromethyl)benzeneacetamide (Example 266, 20 mg, 0.04 mmol) in methanol (1 ML) and the mixture was stirred at room temperature for 48 hours.Further piperidine (4 muL, 0.04 mmol) and acetic acid (1 drop) were added and the mixture was stirred at room temperature for 20 hours.Further piperidine (4 muL, 0.04 mmol) and acetic acid (1 drop) were added and the mixture was stirred at room temperature for 96 hours.The solvent was evaporated under reduced pressure and toluene was added and evaporated under reduced pressure.The residue was dissolved in acetic acid (2 ML), palladium on carbon (5%, 20 mg) was added and the mixture was stirred under an atmosphere of hydrogen (1 Atm.) for 16 hours.The mixture was filtered and poured onto an SCX cartridge (Varian Bond Elut; 10 ML/500 mg).The cartridge was washed with methanol (4*2 ML), then eluted with methanolic ammonia (2K, 2*2 ML).The solvent was evaporated under reduced pressure and the residue was purified by preparative thin layer chromatography on silica gel, eluding with CH2Cl2/MeOH/NH3(Aq.) (200:8:1), to give the title compound as a colorless glass (1.4 mg, 6%).1H NMR (360 MHz, CD3OD) delta 0.88-4.91 (5H, m), 1.28-1.65 (10H, m), 1.86-1.94 (2H, m), 2.05-2.08 (1H, m), 2.33-2.40 (1H, m), 2.55-2.72 (4H, in), 2.77-2.81 (2H, m), 2.92-3.13 (3H, m), 3.75 (1H, q, J 7.0 Hz), 4.46 (1H, m), 7.18 (1H, t, J 7.2 Hz), 7.24-7.29 (1H, m), 7.44-7.46 (2H, m), 7.72 (2H, s), and 7.78 (1H, s).m/z (ES+) 624 (M+1).

The synthetic route of 6091-44-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Castro Pineiro, Jose Luis; Dinnell, Kevin; Elliott, Jason Matthew; Hollingworth, Gregory John; Shaw, Duncan Edward; Swain, Christopher John; US2003/236250; (2003); A1;,
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Piperidine | C5H11N – PubChem

4606-65-9, 3-(Hydroxymethyl)piperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A stirred solution of 3-(hydroxymethyl)-1-piperidine (0.500 g, 4.34 mmol, Aldrich) in 20 mL of anhydrous dichloromethane was treated with di-f-butyl dicarbonate (1.04 g, 4.77 mmol) dissolved in 10 mL of anhydrous dichloromethane. After 18 hours the solution was diluted with dichloromethane, washed with 10% aqueous citric acid (2x), saturated aqueous NaHC03 (2x), dried over Na2S04, and concentrated at reduced pressure to give a transparent, viscous oil. The crude material was subjected to flash chromatography (silica gel, hexane/EtOAc) to afford 0.88 g (95%) of f-butyl 3-(hydroxymethyl)-l-piperidinecarboxylate as a white, crystalline solid. 1H NMR (DMSO-cf6): 5 4.48 (t, 1H), 3.96 (brs, 1H), 3.77 (d, 1H), 3.26 (m, 1H), 3.17 (m, 1H), 2.67 (t, 1H), 2.43 (brs, 1H), 1.65 (m, 1H), 1.56 (m, 1H), 1.50-1.33 (m, 10H), 1.26 (m, 1H), 1.06 (m, 1H).

4606-65-9, 4606-65-9 3-(Hydroxymethyl)piperidine 107308, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2006/20415; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

1892-22-4, 3-Aminopiperidin-2-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

11.4 g of alpha-aminopentylactam was dissolved in 100 m of anhydrous tetrahydrofuran,Add 2.4 g of metal sodium,After 30 min reaction,16 g of p-vinylbenzene chloride was dissolved in 10 ml of anhydrous tetrahydrofuran,Was added dropwise to the above solution,30min drop finished.After the reaction was continued for 60 min,Steamed to remove the solvent after adding chloroform dissolved,The organic phase was washed three times with deionized water,Add anhydrous potassium carbonate for drying.After drying the solvent,20 g Compound 1 was obtained.

1892-22-4, The synthetic route of 1892-22-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sinopec Ltd.; Sinopec Beijing Research Institute of Chemical Industry; Sun, Ruliu; Cong, Lin; Chen, Jingjun; (15 pag.)CN106588754; (2017); A;,
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73579-08-5, 1-Methyl-4-(methylamino)piperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

73579-08-5, Example 95 Alternative Synthesis of 2-Chloro-4-{4-cycloheptylamino-6-[methyl-(1-methyl-piperidin-4-yl)-amino}-[1,3,5]triazin-2-ylamino)-phenol (138) To E7 (1.00 g, 2.7 mmol) dissolved in THF (25 mL) was added a solution of N-methyl-4-(methylamino)-piperidine (0.45 mL, 3.1 mmol) in THF (5 mL) followed by addition of 2.5 N NaOH (1.1 mL, 2.7 mmol) and 2.5 mL of water. The reaction mixture was stirred and heated at reflux overnight. The reaction mixture was extracted three times using dichloromethane, the combined organic layers were washed with a brine and dried over sodium sulfate. The sample was concentrated and the resulting solid was dried overnight under vacuum. Column chromatography (silica gel, 100percent methanol) yielded an off-white solid (138) (177 mg, 14percent); mp 68¡ã C.; HPLC: Inertsil ODS 3V C18, 40:30:30 v:v:v [KH2PO4 (0.01 M, pH 3.2):CH3OH:CH3CN], 264 nm, Rt 4.7 min, 99.6percent purity; MS (TOF ES+) m/z 460 (M+H, 55.3), 251 (100), 224 (51.1).

73579-08-5 1-Methyl-4-(methylamino)piperidine 566323, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Timmer, Richard T.; Alexander, Christopher W.; Pillarisetti, Sivaram; Saxena, Uday; Yeleswarapu, Koteswar Rao; Pal, Manojit; Reddy, Jangalgar Tirupathy; Krlshna Reddy, Velagala Venkata Rama Murali; Sridevi, Bhatlapenumarthy Sesha; Kumar, Potlapally Rajender; Reddy, Gaddam Om; US2004/209880; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem