Tag: M.W:100-200

7149-42-0, (1-Methylpiperidin-4-yl)methanamine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7149-42-0, A solution of the appropriate chloride (1 eq) (ex: 5-chloro-6-methyl-3-(3- trifluoromethoxy-phenyl)-7,8-dihydro-6H-9-oxa-1 ,2,3a,4,6-pentaaza-cyclopenta- (ajnaphthalene) and the appropriate amine (3 to 5 eq) (ex: 1-methyl-piperidin-4- ylamine) in nBuOH (15 mL/mmol) was heated up to 180- 185C under microwave irradiation for 5 h – 10 h (or 24 h at 160-180C in a silicon bath). The solvent was evaporated under vacuum and the residue was purified by flash chromatography (Isolute/Flash, Sill, 2.5% MeOH with 7N ammonia in DCM) or by semi-preparative HPLC (Gemini C18 (150 10 mm; 5 m), Solvent A: water with 0.1 % formic acid; Solvent B: acetonitrile with 0.1 % formic acid. Gradient: 40% of A to 0% of A).The NH-BOC-protected amines got deprotected in the reaction conditions and reacted giving a mixture of regioisomers. Amine: (1-methyl-4-piperidinyl)methanamineHPLC-MS (method 1): Rt=2.74 min, [ +H]+m/z 419.2.1H NMR (300 MHz, eOD) delta 8.80 (s, 1 H), 8.46 (d, J = 8.1 , 1 H), 8.34 (s, 1 H), 7.73 (d, J = 7.7, 1 H), 7.60 (t, J = 7.9, 1H), 4.43 – 4.35 (m, 2H), 3.44 (d, J = 12.1, 2H), 3.28 (d, J = 6.9, 2H), 3.19 – 3.14 (m, 2H), 3.00 (t, J = 11.5, 2H), 2.76 (s, 3H), 2.68 (s, 3H), 2.24 (s, 1 H), 2.08 (d, J = 10.8, 2H), 1.51 (d, J = 11.7, 2H).

7149-42-0 (1-Methylpiperidin-4-yl)methanamine 81574, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO); GARCIA COLLAZO, Ana Maria; PASTOR FERNANDEZ, Joaquin; BLANCO APARICIO, Carmen; RODRIGUEZ HERGUETA, Antonio; MARTIN HERNANDO, Jose Ignacio; RAMOS LIMA, Francisco Javier; HERNANDEZ HIGUERAS, Ana Isabel; SALUSTE, Carl-Gustave Pierre; GONZALEZ CANTALAPIEDRA, Esther; MARTINEZ GONZALEZ, Sonia; SALGADO SERRANO, Antonio; NOYA MARINO, Beatriz; WO2011/80510; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3040-44-6,1-(2-Hydroxyethyl)piperidine,as a common compound, the synthetic route is as follows.

2) Synthesis of 5-phenyl-4-[2-(1-piperidyl)ethoxy]thieno[2,3-d]pyrimidine (Example 369) Sodium hydride (8 mg, 0.16 mmol) was suspended in dry THF (0.5 mL). To this was added 2-(1-piperidyl)ethanol (16 muL, 0.12 mmol) and the reaction stirred for 10 min until effervescence had ceased. Then 4-chloro-5-phenyl-thieno[2,3-d]pyrimidine (20 mg, 0.08 mmol) in dry THF (0.5 mL) was added and the reaction left to stir at room temperature for 72 hrs. The reaction mixture was diluted with water and extracted with DCM. The organic layers were concentrated and the residue purified by preparative TLC (eluent 10% MeOH in DCM) to give 5-phenyl-4-[2-(1-piperidyl)ethoxy]thieno[2,3-d]pyrimidine as a yellow oil (19.4 mg, 72%). LCMS RT=3.03 min. M+1=340., 3040-44-6

3040-44-6 1-(2-Hydroxyethyl)piperidine 18232, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Madge, David; Chan, Fiona; John, Derek Edward; Edwards, Simon D.; Blunt, Richard; Hartzoulakis, Basil; Brown, Lindsay; US2014/371203; (2014); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4138-26-5,Piperidine-3-carboxamide,as a common compound, the synthetic route is as follows.,4138-26-5

General procedure: During the purification and characterization of amidase from Cupriavidus sp. KNK-J915, an enzyme assay was performed with (R,S)-BNPD as a substrate. The standard reaction mixture (0.2 mL) contained 100 mM potassium phosphate buffer (pH 7.0), 45.8 mM BNPD, and an appropriate amount of the enzyme. After the reaction was performed at 30C for 0.5-1 h, the amount of BNPA was determined using HPLC. One unit of the enzyme was defined as the amount catalyzing the formation of 1 mol of BNPA per minute under the aforementioned condition. Protein content was determined by the Bradford method [11] with BSA as a standard using a kit from Bio-Rad Laboratories Ltd. (Tokyo, Japan).

The synthetic route of 4138-26-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Nojiri, Masutoshi; Taoka, Naoaki; Yasohara, Yoshihiko; Journal of Molecular Catalysis B: Enzymatic; vol. 109; (2014); p. 136 – 142;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.79099-07-3,1-Boc-4-Piperidone,as a common compound, the synthetic route is as follows.,79099-07-3

[Reference Example 1] Synthesis of 6-aza-1-oxaspiro[2.5]octane-6-carboxylic acidtert-butyl ester After dissolving 60percent NaH-in-oil (5.28 g, 132 mmol) in DMSO (dimethylsulfoxide) (250 mL) cooled to 0¡ãC, trimethylsulfonium iodide (29.0 g, 132 mmol) was added. The reaction mixture was then raised to room temperature and the mixture was stirred for 40 minutes. N-Boc-piperidone (Boc = tert-butoxycarbonyl) (25.0 g, 125 mmol) was added to the reaction mixture, which was then stirred at room temperature for 1 hour and then at 55¡ãC for 1.5 hours. Next, the reaction mixture was poured into ice-cooled water (500 mL) and was extracted with AcOEt (ethyl acetate) (500 ml x 3 times). The organic layer obtained by combining the ethyl acetate layers was washed with water and then with saturated brine, and then dried over anhydrous Na2SO4. After filtration, the filtrate was concentrated to obtain 6-aza-1-oxaspiro[2.5]octane-6-carboxylic acid tert-butyl ester. The compound was identified by 1H-NMR. The yield was 26.4 g (99percent). 1H-NMR (270 MHz, CDCl3): 1.40-1.49(m,2H), 1.46(s,9H), 1.74-1.85(m,2H), 2.69(s,2H), 3.37-3.48(m,2H), 3.68-3.77(m,2H).

As the paragraph descriping shows that 79099-07-3 is playing an increasingly important role.

Reference£º
Patent; TEIJIN LIMITED; EP1505067; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

4897-50-1, 4-Piperidinopiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

tert-Butyi 4-(6-ami -3-pyridyl)piperazine-l-carboxylate (0500) The compound was prepared as described in WO 2010/020675 Al . (0501) (0502) To 5-bromo-2-nitropyridine (1.2 g, 5.9 mmole) in DMSO (4 mL) was added l -(4- piperidyl)piperidine (1.0 g, 5.9 mmole) and triethylamine (0.99 mL, 7.1 mmole). The contents were heated to 120 C in a CEM Discovery microwave system for 3 hours. The crude reaction was then loaded over a silica gel column and eluted with DCM/methanol (0-20%) to afford 2- nitro-5-[4-(l-piperidyl)-l -piperidyl]pyridine as an oil (457 mg). NMR (600 MHz, DMSO-c e) delta ppm 1.26 – 1.36 (m, 2 H) 1.43 (m, 6 H) 1.76 (m, 2 H) 2.37 (m, 5 H) 2.94 (t, J=12.74 Hz, 2 H) 4.06 (d, J=13.47 Hz, 2 H) 7.41 (dd, J=9.37, 2.64 Hz, 1 H) 8.08 (d, J=9.37 Hz, 1 H) 8.20 (d, J=2.64 Hz, 1 H)

4897-50-1, The synthetic route of 4897-50-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; G1 THERAPEUTICS, INC.; STRUM, Jay, Copelnad; (156 pag.)WO2018/5863; (2018); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.160357-94-8,1-Acetyl-4-aminopiperidine,as a common compound, the synthetic route is as follows.

160357-94-8, A mixture of (S)-6-chloro-N-(2-hydroxy-3-(3-phenyl-6,7-dihydro- 1 Hpyrazolo [4,3-c]pyridin-5 (4H)-yl)propyl)pyrimidine-4-carboxamide (100 mg, 0.24 mmol), 1-(4-aminopiperidin-1-yl) ethanone (45 mg, 0.32 mmol), and triethylamine (0.1 mL) in 2-propanol (10 mL) was stirred at 80 C for 12 h. The solvent was evaporated and the resultingresidue was purified by preparative HPLC to give the TFA salt of the title compound (91 mg,73%) as white solid. ?H-NMR (400 MHz, CD3OD, ): 8.65 – 8.54 (m, 1 H), 7.59 – 7.54 (m,2 H), 7.53 -7.48 (m, 2 H), 7.46 – 7.40 (m, 1 H), 7.33 -7.09 (m, 1 H), 4.78 – 4.57 (m, 2 H),4.55 -4.46 (m, 1 H), 4.44- 4.24 (m, 2 H), 4.20 – 3.88 (m, 2 H), 3.86 – 3.46 (m, 5 H), 3.43 -3.35 (m, 1 H), 3.25 – 3.14 (m, 2 H), 2.96 -2.81 (m, 1 H), 2.18 -2.14 (m, 3 H), 2.05 (s, 2 H),1.63 – 1.44 (m, 2 H). LCMS (mlz): 519.2 (M+1).

As the paragraph descriping shows that 160357-94-8 is playing an increasingly important role.

Reference£º
Patent; EPIZYME, INC.; DUNCAN, Kenneth, W.; CHESWORTH, Richard; MUNCHHOF, Michael, John; SHAPIRO, Gideon; (393 pag.)WO2015/200677; (2015); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24666-56-6,3-Aminopiperidine-2,6-dione hydrochloride,as a common compound, the synthetic route is as follows.,24666-56-6

3-nitrophthalic anhydride (I, 44.0 g, 0.23 mol), 3-amino-2,6-piperidinedione hydrochloride(II, 37.9 g, 0.23 mol) was dissolved in 600 mL of tetrahydrofuran (THF)Triethylamine (23.27 g, 0.23 mol) was then added dropwise to the system,The temperature of the control system was <20¡ãC . After the dropwise addition, the reaction was carried out for 30 min at room temperature, and the filter cake was filtered through THF (30 mL x 3) and dried in vacuo to give the intermediate 67.20 g in 91.0percent yield. As the paragraph descriping shows that 24666-56-6 is playing an increasingly important role. Reference£º
Patent; Shanghai Institute of Pharmaceutical Industry; China Institute of Pharmaceutical Industry; LI, JIAN QI; HUANG, DAO WEI; ZHOU, AI NAN; LIU, YU; ZHU, MIN YU; (9 pag.)CN103724323; (2016); B;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.160357-94-8,1-Acetyl-4-aminopiperidine,as a common compound, the synthetic route is as follows.

Step 3 Preparation of N-Acetyl-1-(3-(4-Fluorophenoxy)propyl)-4-Aminopiperidine N-Acetyl-4-aminopiperidine (5.80 g, 41 mmol) and O-(p-toluenesulfonyl)-3-(4-fluorophenoxy)propanol (13.24 g, 41 mmol) were converted to the title compound by the procedure of Preparation 2, Step 3 to give a crude product which was recrystallized from ethyl acetate to give 7.82 g of the title compound. Yield: 65%. m.p. 134 C.-136 C. EA calculated for C16 H23 N2 O2 F: C, 65.28; H, 7.88; N, 9.52. Found: C, 65.49; H, 7.91; N, 9.54. MS(FD) M+1 295., 160357-94-8

160357-94-8 1-Acetyl-4-aminopiperidine 4962477, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Eli Lilly and Company; US6069152; (2000); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.373603-88-4,3,3-Dimethylpiperidin-4-ol,as a common compound, the synthetic route is as follows.

General procedure: In an oven-dried RB flask, compound 6c (250mg, 1.01mmol) and formaldehyde solution, 37-41wt.% in water (0.15mL, 2.02mmol) were mixed in glacial acetic acid (5mL). Morpholine (220.4mg, 2.53mmol) was added drop wise at 0C. The resulting mixture was stirred at room temperature for 12h. After completion of the reaction, the excess solvent was evaporated to dryness under reduced pressure. The residue was neutralized with 10% NaHCO3 solution, the solid formed was collected by filtration, washed with water and dried. The crude product was purified by silica gel column chromatography to provide title compound.

373603-88-4, The synthetic route of 373603-88-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Jose, Gilish; Kumara, T. H. Suresha; Nagendrappa, Gopalpur; Sowmya; Jasinski, Jerry P.; Millikan, Sean P.; More, Sunil S.; Janardhan, Bhavya; Harish; Chandrika; Journal of Molecular Structure; vol. 1081; (2015); p. 85 – 95;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

1465-76-5, 1-(tert-Butyl)piperidin-4-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1465-76-5, Step A: 1-tert-Butylpiperidin-4-ol To a 0 C. solution of 1.0 g of 1-tert-butylpiperidin-4-one (COMPOUND PPA-1) in 2 mL of TBF was added 6.4 mL of a 1M solution of lithium aluminum hydride in THF dropwise. The mixture was stirred 10 min at rt, then quenched by careful addition of 0.2 mL of water, 0.2 mL of 15% aqueous NaOH, and 0.6 mL of water. The mixture was stirred vigorously for 30 min, then filtered and concentrated to yield the title compound.

As the paragraph descriping shows that 1465-76-5 is playing an increasingly important role.

Reference£º
Patent; Doherty, James B.; Stelmach, John E.; Chen, Meng-Hsin; Liu, Luping; Hunt, Julianne A.; Ruzck, Rowena D.; Goulet, Joung L.; Wisnoski, David D.; Natarajan, Swaminathan Ravi; Rupprecht, Kathleen M.; Bao, Jianming; Miao, Shouwu; Hong, Xingfang; Sinclair, Peter J.; Kallashi, Florida; US2003/92712; (2003); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem