Tag: M.W:100-200

41373-39-1, (S)-Piperidin-2-ylmethanol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Into a 50-mL round-bottom flask, was placed a solution of 2-methylpyridine-4-carboxylic acid (548 mg, 4.00 mmol, 1.00 equiv), (2S)-piperidin-2-ylmethanol (460 mg, 3.99 mmol, 1.00 equiv), DIEA (1.29 g, 9.98 mmol, 2.50 equiv) and HATU (1.67 g, 4.39 mmol, 1.10 equiv) in dichloromethane (20 mL). The resulted solution was stirred for 30 min at room temperature. After concentration, the residue was dissolved with 200 mL of EA. Then it was washed with 3 x 20 mL of brine, dried over anhydrous sodium sulfate and concentrated under vacuum to give a residue. The crude was purified by silica gel column eluted with dichloromethane/methanol (10:1). This resulted in 426 mg (46percent, 97percent ee) of [(2S)-l-[(2-methylpyridin-4-yl)carbonyl]- piperidin-2-yl]methanol as yellow oil., 41373-39-1

As the paragraph descriping shows that 41373-39-1 is playing an increasingly important role.

Reference£º
Patent; GLOBAL BLOOD THERAPEUTICS, INC.; LI, Zhe; HARRIS, Jason, R.; DUFU, Kobina, N.; GENG, Xin; SINHA, Uma; (101 pag.)WO2016/160755; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

22990-34-7, 2-(4-Piperidyl)-2-propanol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(1) 2-Chloro-3-methyl-5-nitropyridine (6.02g) in N, N- dimethylformamide (35) at room temperature was added 2- (4-piperidinyl) -2-propanol (5.0 g) and potassium carbonate (9.65g), and stirred for 6 hours at 80 . After the reaction, it cooled to room temperature and, after addition of water, to give a yellow solid (9.09g) collected by the precipitated solid filtered.

22990-34-7, As the paragraph descriping shows that 22990-34-7 is playing an increasingly important role.

Reference£º
Patent; Mitsubishi Tanabe Pharma Corporation; Watanabe, Masayuki; Furukawa, Hiroyuki; Hamada, Maiko; Fuji, Naoto; Ushio, Hiroyuki; Takashima, Toru; (81 pag.)KR2015/2661; (2015); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

4897-50-1, 4-Piperidinopiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 1.; Preparation of 1-chlorocarbonyl-4-piperidinopiperidine base (IRT-4):; Dissolving 4-piperdinoperidine (100g) in benzene (1580ml) under stirring for 15 to 30 minutes at room temperature, adding a solution of triphosgene (150g) in benzene (660 ml) over a period of 1 to 3 hours at a temperature of 20¡ã- 25¡ãC. Filtering the solid, washing it with benzene and drying, then dissolve the dried solid in chloroform (5900 ml) by stirring at room temperature for about 30 minutes. Charging aqueous sodium bicarbonate solution (400 ml), stirring and separating chloroform layer, washing the chloroform layer with water (1800 ml), separating chloroform layer anddistilling off chloroform under vacuum at a temperature up to below 45¡ãC to obtain 1-chlorocorbonyl-4-piperidopiperidine base (60 g).

4897-50-1, The synthetic route of 4897-50-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SHILPA MEDICARE LIMITED; WO2006/16203; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

34622-39-4, (S)-2-Piperidinone-6-carboxylic acid is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 7-5: Preparation of (S)-N-(4-methoxybenzyl)-6-oxo-N-(4-(trimethylsilyl)but-2-en-1-yl)piperidine-2-carboxamide I5.1 and (S)-tert-butyl 2-((4-methoxybenzyl)(4-(trimethylsilyl)but-2-en-1-yl)carbamoyl)-6-oxopiperidine-1-carboxylate 15.2 [0199] [0200] To a solution of (S)-6-oxopiperidine-2-carboxylic acid (1.74 g, 12.15 mmol) in DMF (120 mL) were added N-(4-methoxybenzyl)-4-(trimethylsilyl)but-2-en-1-amine 14 (3.20 g, 12.2 mmol), EDC (2.79 g, 14.6 mmol) and HOBt (2.23 g, 14.6 mmol). After 2h stirring at room temperature EtO2 (300 mL) was added to the reaction and washed with sat. aq. NaCl solution (3 ¡Á 75 mL). The organic layer was dried over MgSO4 and the solvent was removed under reduced pressure and the crude compound I5.1 was used for the next step without further purification. MS (ESI): m/z (percent) = 389.29 [M + H]+, 777.25 [2M + H]+, 34622-39-4

As the paragraph descriping shows that 34622-39-4 is playing an increasingly important role.

Reference£º
Patent; Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.; The designation of the inventor has not yet been filed; EP2899192; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24211-55-0,(S)-Piperidin-3-ol,as a common compound, the synthetic route is as follows.

4-Chloro-6-(6-(trifluoromethyl)pyridin-2-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)-1,3,5-triazin-2-amine (43 mg, 0.10 mmol) prepared in step 4 of Example 1 was dissolved in 5 mL of tetrahydrofuran, and (S)-3-hydroxypiperidine (12 mg, 0.12 mmol) and sodium carbonate (16 mg, 0.15 mmol) were added. The mixture was heated under reflux for 16 h. The resultant solution was filtered, and the filtrate was purified by column chromatography to give the title compound. 1H NMR (500MHz, DMSO-d6): delta 10.70 (br, 1H), 8.55-8.66 (m, 3H), 8.26-8.33 (m, 1H), 8.08-8.11 (m, 1H), 7.85 -7.96 (m, 1H), 4.97-4.98 (m, 1H), 4.16-4.49 (m, 2H), 3.26-3.60 (m, 3H), 1.83-1.92 (m, 2H), 1.51-1.54 (m, 2H).ES: m/z 486.1 [M+H]+., 24211-55-0

24211-55-0 (S)-Piperidin-3-ol 6950221, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Nanjing Sanhome Pharmaceutical Co., Ltd.; WANG, Yong; ZHAO, Liwen; LIU, Xiaorong; ZHANG, Yan; HUANG, Dandan; JIANG, Chunhuan; SHI, Xinsheng; GU, Hongfeng; PANG, Silin; HAI, Wei; GE, Bingyang; (71 pag.)EP3489230; (2019); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21987-29-1,4,4-Difluoropiperidine,as a common compound, the synthetic route is as follows.

A mixture of Intermediate B (879 mg, 3.30 mmol), 4,4-difluoropiperidine (400 mg, 3.30 mmol), Pd2(dba)3 (302 mg, 0.330 mmol), xantphos (382 mg, 0.660 mmol) and KO’Bu (748 mg, 6.60 mmol) in toluene (10 ml) was bubbled with argon for 10 min. The mixture was then heated at 100¡ãC for overnight. The reaction was quenched with 60percent NaHC03 aqueous solution. The aqueous phase was extracted with DCM/IPA (20 ml x3, V/V = 3/1 ). The combined organic phase was dried over anhydrous MgS04. Filtered and concentrated. The residue was purified by silica gel chromatography (eluted with 2percent MeOH in DCM) to give the title compound as yellow solid (270 mg, 31 percent yield). LCMS (method B): [M+H]+ = 265, tR = 1.79 min.

21987-29-1, 21987-29-1 4,4-Difluoropiperidine 2758352, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; NOVARTIS AG; CHEN, Chao; DENG, Haibing; GUO, Haibing; HE, Feng; JIANG, Lei; LIANG, Fang; MI, Yuan; WAN, Huixin; XU, Yao-Chang; YU, Hongping; ZHANG, Ji Yue (Jeff); WO2013/38362; (2013); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.159635-49-1,tert-Butyl 4-methylenepiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

To a solution of tert-butyl 4-methylenepiperidine-1-carboxylate (APOLLO, 10 g, 50. 7 mmol) in dioxane (130 mL) at 0 ¡ãC, a solution of HCI 4M in dioxane (ALFA-AESAR, 130mL, 507 mmol, 10 eq) was added and the mixture was stirred at rt overnight. Monitoring by UPLC and TLC showed the reaction was completed. The solvent was removed under vacuum to afford the desired compound 4-methylidenepiperidine hydrochloride which was used in the next step without further purification (7.6 g, 100percent).1H NMR (400MHz, DMSO-cfe) delta ppm: 9.19 (br s, 2H), 4.86 (s, 2H), 3.06 (t, J = 6.0 Hz, 4H), 2.41 (t, J = 6.0 Hz, 4H)., 159635-49-1

As the paragraph descriping shows that 159635-49-1 is playing an increasingly important role.

Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; BIOVERSYS AG; PORRAS DE FRANCISCO, Esther; REMUINAN-BLANCO, Modesto Jesus; BOUROTTE, Marilyne; DEPREZ, Benoit; WILLAND, Nicolas; (43 pag.)WO2019/34700; (2019); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

73579-08-5,73579-08-5, 1-Methyl-4-(methylamino)piperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-(5-Cyclohexylimino-4-methyl-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-N-methyl-N-(1-methyl-piperidin-4-yl)-benzamide To a solution of I37.1 (0.5 mmol, 200 mg) in DMF (2.5 mL), ethyl-diisopropyl-amine (1.6 mmol, 190 muL), benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate (0.6 mmol, 265 mg), 1-hydroxy-7-azabenzotriazole (0.25 mmol, 34 mg) and 1-methyl-4-(methylamino)piperidine (0.6 mmol, 87 muL) were added, and the reaction mixture was stirred at RT overnight. The solvent was distilled under reduced pressure, and the residue was poured into water before extraction with dichloromethane. The organic layer was washed with brine and then with a saturated solution of NaHCO3, dried over magnesium sulfate, filtered, and concentrated under vacuum. The residue was purified by silica gel chromatography using a gradient of dichloromethane containing 0percent to 15percent methanol, to give the desired product. Yield: 93.5percent. 1H-NMR (400 MHz, DMSO) delta ppm: 1.23-1.45 (m, 5H), 1.55-1.65 (m, 1H), 1.68-1.85 (m, 6H), 1.85-2.00 (m, 2H), 2.23-2.44 (m, 5H), 2.55-2.65 (m, 1H), 2.83 (s, 3H), 3.00-3.10 (m, 2H), 3.55 (s, 3H), 3.85-4.03 (m, 1H), 7.48 (dd, 2H), 7.70 (dd, 2H). MS (m/z)/M+1=428.

As the paragraph descriping shows that 73579-08-5 is playing an increasingly important role.

Reference£º
Patent; Vergne, Fabrice; Ducrot, Pierre; Andrianjara, Charles; Bernardelli, Patrick; Lorthois, Edwige; US2003/45557; (2003); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

3970-68-1, 4-Methylpiperidin-4-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[0593] N-( 4-chloro-5-cyanopyridin-2-yl)-7-( dimethoxymethyl)-3,4-dihydro-1 ,8-naphthyridine-1 (2H)carboxamide(intermediate 21, 50 mg, 0.129 mmol) and4-methylpiperidin-4-ol (21.5 mg, 0.142 mmol) were dissolvedin DMF (1 ml) under argon. The mixture was stirred at100 C. for 16 h.[0594] An excess of 4-methylpiperidin-4-ol was added tothe mixture and stirred for 45 min at 100 C. The reactionmixture was diluted in EtOAc and washed 2x with sat. aq.NH4 Cl and brine. The organic layer was dried over Na2S04 ,filtered and concentrated under vacuum. The crude materialwas purified by normal phase chromatography ( 4 g silica gel cartridge, heptanes/EtOAc 100:0 to 0:100) to give the titlecompound as an off-white solid. (UPLC-MS 3) tR 1.08 min;ESI-MS 467.2 [M+Ht., 3970-68-1

The synthetic route of 3970-68-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Novartis AG; Buschmann, Nicole; Fairhurst, Robin Alec; Furet, Pascal; Knoepfel, Thomas; Leblanc, Catherine; Liao, Lv; Mah, Robert; Nimsgern, Pierre; Ripoche, Sebastien; Xiong, Jing; Han, Bo; Wang, Can; Zhao, Xianglin; US2015/119385; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.138007-24-6,tert-Butyl piperidine-4-carboxylate,as a common compound, the synthetic route is as follows.

Example 87Ethyl 5-chloro-6-(4-{[(4-methylbenzyl)sulfonyl]carbamoyl}piperidin-l-yl)-2-[(2- oxopyrrolidin-l-yl)methyl]nicotinate5 (a) Ethyl 6-[4-(/e^-butoxycarbonyl)piperidin-l-yl]-5-chloro-2-[(2-oxopyrrolidin-l- yl)methyl]nicotinateEthyl 5,6-dichloro-2-[(2-oxopyrrolidin-l-yl)methyl]nicotinate (Example 85(d)) (3.2 g, 9.96 mmol) and tert-bntyl piperidine-4-carboxylate (2.77 g, 15 mmol) were dissolved in DIPEA o (4.4 mL, 24.9 mmol) and iV-methyl-2-pyrrolidone (30 mL), the reaction mixture was heated at 1400C for 1.5 h. Water and DCM were added, the organic phase was washed with 0.5 M HCl, sat. NaHCO3 and water, dried (MgSO4) and concentrated in vacuo. The residue was purified by flash chromatography, DCMiMeOH 100:0 to 90:10 as eluent, to give ethyl 6-[4-(te7Y-butoxycarbonyl)piperidin-l-yl]-5-chloro-2-[(2-oxopyrrolidin-l- 5 yl)methyl]nicotinate. Yield: 3.1 g (67percent).1H-NMR (500 MHz5 CDCl3) delta 1.37 (3H, t), 1.45 (9H, s), 1.80 (2H, m), 1.95 (2H, m), 2.08 (2H, m), 2.40-2.50 (3H, m), 3.00 (2H5 m), 3.49 (2H5 m), 4.04 (2H, m), 4.32 (2H5 q), 4.87 (2H, s), 8.11 (lH, s)., 138007-24-6

As the paragraph descriping shows that 138007-24-6 is playing an increasingly important role.

Reference£º
Patent; ASTRAZENECA AB; WO2008/85119; (2008); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem