Tag: M.W:100-200

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, the author is Carson, John R. and a compound is mentioned, 1484-84-0, 2-Piperidineethanol, introducing its new discovery. 1484-84-0

2-Substituted 1-Azabicycloalkanes, a New Class of Non-Opiate Antinociceptive Agents

2-Substituted 1-azabicycloalkanes (3- and 5-aryloctahydroindolizines 2 and 11, 3-cyclohexyloctahydroindolizine 12, 4-aryloctahydroquinolizines 13, and 3-arylhexahydropyrrolizines 14) constitute a new class of non-opiate antinociceptive agents.These compounds demonstrated activity in the mouse abdominal constriction test and many were active in the mouse tail-flick test. trans-3-(2-Bromophenyl)octahydroindolizine (2a) did not bind to the opiate receptor nor did it affect arachidonate metabolism. 3-Aryloctahydroindolizines were prepared by catalytic hydrogenation of 1-aryl-3-(2-pyridinyl)-2-propen-1-ones.The X-ray crystal structure of (-)-2a was determined and absolute stereochemistry assigned as 3-R,8a-R.

1484-84-0, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 1484-84-0

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H5698N – PubChem

 

Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 648921-37-3, molcular formula is C7H14ClNO, introducing its new discovery. 648921-37-3

ANTI-PULMONARY TUBERCULOSIS NITROIMIDAZOLE DERIVATIVE

Disclosed is a substituted nitroimidazole derivative, which is mainly used for treating related diseases caused by mycobacterial infections, such as Mycobacterium tuberculosis, especially being suitable for diseases caused by resistant Mycobacterium tuberculosis.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, 648921-37-3, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 648921-37-3

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Piperidine – Wikipedia,
Piperidine | C5H9373N – PubChem

 

1121-89-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1121-89-7, Name is Piperidine-2,6-dione, molecular formula is C5H7NO2. In a Article, authors is Srimontree, Watchara£¬once mentioned of 1121-89-7

Amide to Alkyne Interconversion via a Nickel/Copper-Catalyzed Deamidative Cross-Coupling of Aryl and Alkenyl Amides

A nickel-catalyzed deamidative cross-coupling reaction of amides with terminal alkynes as coupling partners was disclosed. This newly developed methodology allows the direct interconversion of amides to alkynes and enables a facile route for C(sp2)-C(sp) bond formation in a straightforward and mild fashion.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 1121-89-7

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Piperidine – Wikipedia,
Piperidine | C5H1536N – PubChem

 

50541-93-0, Name is 4-Amino-1-benzylpiperidine, belongs to piperidines compound, is a common compound. 50541-93-0. In an article, authors is Akrami, Hamidreza, once mentioned the new application about 50541-93-0.

Cytotoxic activity and DNA binding property of new aminopyrimidine derivatives

Background: Chromene and anilinopyrimidine heterocyclics are attractive anticancer compounds that have inspired many researchers to design novel derivatives bearing improved an-ticancer activity. Method: A series of pyrimidine-fused benzo[f]chromene derivatives 6a-x were synthesized as an-ticancer hybrids of 1H-benzo[f]chromenes and anilinopyrimidines. The inhibitory activity of the synthesized compounds 6a-x against cell viability of human chronic myelogenous leukemia (K562), human acute lymphoblastic leukemia (MOLT-4) and human breast adenocarcinoma (MCF-7) cell lines was evaluated using MTT assay. The interaction of the most promising compound with calf-thymus DNA was also studied using spectrometric titrations and Circular Dichro-ism (CD) spectroscopy. Results: Most compounds showed promising activity against tested cell lines. Among them, 2,4-dimethoxyanilino derivative 6g exhibited the best profile of activity against tested cell lines (IC50s = 1.6-6.1 muM) with no toxicity against NIH3T3 normal cell (IC50 >200 muM). The spectro-metric studies exhibited that compound 6g binds to DNA strongly and may change DNA conformation significantly, presumably via a groove binding mechanism. Conclusion: The results of this study suggest that the prototype compound 6g can be considered as a novel lead compound for the design and discovery of novel anticancer agents.

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Piperidine – Wikipedia,
Piperidine | C5H12559N – PubChem

 

177-11-7, Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬Which mentioned a new discovery about 177-11-7, molcular formula is C7H13NO2, introducing its new discovery.

BENZOTHIAZINETHIONE DERIVATIVES AND THEIR PREPARATIVE METHODS AND USES

The invention belongs to the medicine field, and particularly relates to benzothiazinethione derivatives and preparation methods and uses thereof. In the aspect of the present invention, novel benzothiazinethione derivatives of formula I are provided, the benzothiazinethione derivatives of the invention are new compounds obtained based on extensive screening. Experimental results show that the benzothiazinethione derivatives of formula I have obvious inhibitory effects on mycobacterium tuberculosis, with effects equivalent to or even better than that of isoniazide (MIC90=0.8muM). The benzothiazinethione derivatives of formula I have anti-mycobacterium tuberculosis activities, and provide new choices for the development and application of antitubercular agents.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 177-11-7 is helpful to your research. 177-11-7

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Piperidine – Wikipedia,
Piperidine | C5H7416N – PubChem

 

496807-97-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.496807-97-7,3,3-Difluoropiperidine hydrochloride,as a common compound, the synthetic route is as follows.

To a dichloroethane (10 mL) solution of methyl (lS)-3- oxocyclopentanecarboxylate (0.28 mL, 2.2 mmol, step A), 3,3-difluoropiperidine hydrochloride (420 mg, 2.7 mmol, 1.2 equiv.), and triethylamine (0.43 mL, 3.1 mmol, 1.4 equiv.) were added sodium triacetoxyborohydride (940 mg, 4.4 mmol, 2.0 equiv.) and acetic acid (0.25 mL, 4.4 mmol, 2.0 equiv.). The reaction mixture was stirred at room temperature for 12 hours and quenched with IN aqueous sodium hydroxide. It was extracted with dichloroethane, dried (sodium sulfate), and concentrated in vacuo to afford a crude product. Chromatography over silica gel, eluting with hexanes/ethyl acetate, afforded the title compound as a diastereomeric mixture. LC/MS = 248 [M+l].

As the paragraph descriping shows that 496807-97-7 is playing an increasingly important role.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; ALI, Amjad; GALLO, Gioconda V.; HENDERSON, Timothy J.; KUANG, Rongze; LIM, Yeon-Hee; LO, Michael Man-Chu; METZGER, Edward; RUIZ, Manuel de Lera; STAMFORD, Andrew; TEMPEST, Paul; WHITEHEAD, Brent; WU, Heping; WO2015/27431; (2015); A1;; ; Patent; MERCK SHARP & DOHME CORP.; ALI, Amjad; GALLO, Gioconda, V.; HENDERSON, Timothy, J.; KUANG, Rongze; LIM, Yeon-Hee; LO, Michael Man-Chu; METZGER, Edward; RUIZ, Manuel de Lera; STAMFORD, Andrew; TEMPEST, Paul; WHITEHEAD, Brent; WU, Heping; WO2015/31221; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

25504-47-6, Methyl 2-oxopiperidine-4-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Add Lawesson’s reagent (9.2 g, 22.7 mmol) to a solution of methyl2-oxopiperidine-4-carboxylate (6.5 g, 41.4 mmol) in toluene (83 mL) and heat to reflux for 2 hours. Cool the solution and concentrate to dryness under reduced pressure. Purify the residue by flash chromatography on silica gel, eluting with ethyl acetate :dichloromethane (gradient 5-15percent) to afford the title compound (6.95 g). lH NMR (CDCI3) delta 1.97 (m, 1H), 2.17 (m, 1H), 2.78 (m, 1H), 3.03 (m, 1H), 3.24 (m, 1H), 3.39 (m, 1H), 3.49 (m, 1H), 3.72 (s, 3H), 8.48 (bs, 1H)., 25504-47-6

The synthetic route of 25504-47-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ELI LILLY AND COMPANY; PRIETO, Lourdes; TABOADA MARTINEZ, Lorena; WO2011/82010; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22540-50-7,6-Oxopiperidine-3-carboxylic acid,as a common compound, the synthetic route is as follows.

To a solution of intermediate 5b (100 mg, 0.248 mmol) in DCM (5 mL) was added 6-oxopiperidine-3-carboxylic acid (38 mg, 0.265 mmol), EDC (51 mg, 0.266 mmol) and DMAP (2.5 mg) and the solution was stirred at room temperature for 5 h. A second addition of 6-oxopiperidine-3-carboxylic acid (38 mg), EDC (51 mg), and DMAP (2.5 mg) was performed and it was stirred over night. A third addition of 6-oxopiperidine-3-carboxylic acid (38 mg) and EDC (51 mg) was performed and it was stirred over night. The reaction mixture was diluted with DCM (50 mL) and extracted twice with water, saturated sodium bicarbonate solution and with brine. The organic layer was dried over sodium sulfate and the solvent was removed under reduced pressure

22540-50-7, The synthetic route of 22540-50-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Santhera Pharmaceuticals (Schweiz) AG; EP2439197; (2012); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3970-68-1,4-Methylpiperidin-4-ol,as a common compound, the synthetic route is as follows.

To a solution of 0.04 g (0.1 mmol) of 4-[(S)-4-(3-chloro-phenylcarbamoyl)-3-methyl-2-oxo- piperazin-l-yl]-butyric acid (intermediate 19) and 0.04 ml of triethylamine (0.3 mmol) in 0.8 ml DMF was added 0.05 g (0.12 mmol) of HATU. The mixture was shaken for 10 minutes before being added to the appropriate amine (0.12 mmol) and the mixture shaken overnight. The mixture was then directly purified by preparative HPLC.

3970-68-1, As the paragraph descriping shows that 3970-68-1 is playing an increasingly important role.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; AEBI, Johannes; BINGGELI, Alfred; GREEN, Luke; HARTMANN, Guido; MAERKI, Hans P.; MATTEI, Patrizio; WO2011/48032; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3970-68-1,4-Methylpiperidin-4-ol,as a common compound, the synthetic route is as follows.,3970-68-1

A mixture of 11 (100 mg, 0.35 mmol), 4-methylpiperidin-4-ol (202 mg, 1.7mmol), and potassium carbonate (484 mg, 3.5 mmol) in anhydrous DMSO (3 mL) was stirred at 90 C overnight. The reaction mixture was diluted with water (20 mL) and extracted with ethyl acetate (3 ¡Á 50 mL). Combined organic layers were dried over anhydrous Na2SO4 and concentrated in vacuo. The crude material was purified by flash chromatography using MeOH/DCM (1/100, v/v) to afford 13a as a yellow solid (80 mg, 60%).

3970-68-1 4-Methylpiperidin-4-ol 15649174, apiperidines compound, is more and more widely used in various fields.

Reference£º
Article; Yang, Hao; Murigi, Francis N.; Wang, Zhijian; Li, Junfeng; Jin, Hongjun; Tu, Zhude; Bioorganic and Medicinal Chemistry Letters; vol. 25; 4; (2015); p. 919 – 924;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem