Tag: M.W:100-200

71985-80-3, 1-Methylpiperidine-4-carboxylic acid hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,71985-80-3

Example 252; 1 -Methyl-piperidine-4-carboxylic acid ((S)-I -{2-[6-cyano-3-(4-methoxy- benzenesulfonyl)-2-oxo-2,3-dihydro-benzoimidazol-1 -yl]-2 -phenyl -acetyl}- pyrrolidin-3-yl)-amide; compound with trifluoroacetic acid; A mixture of i-methylpiperidine-4-carboxylic acid hydrochloride (16 mg, 0.09 mmol), 1-hydroxybenzotriazole (15 mg, 0.11 mmol) and PS-carbodiimide resin (Argonaut; 1.25 mmol/g; 72 mg, 0.09 mmol) in CH2CI2 (3 ml.) was agitated for 10 min at room temperature. Then, 3-[2-((S)-3-amino-pyrrolidin-1 -yl)-2-oxo-1 -phenyl-ethyl]-1 -(4- methoxy-benzenesulfonyl)-2-oxo-2,3-dihydro-1 H-benzoimidazole-5-carbonitrile (40 mg, 0.08 mmol) was added and the reaction mixture was agitated at room temperature overnight. To this was then added MP-carbonate resin (Argonaut; 3.08 mmol/g; 73 mg, 0.23 mmol) and the reaction mixture was agitated for another 2 hours, filtered and concentrated in vacuo. The residue was purified by preparative RP-HPLC (eluent: gradient from 10% to 80% acetonitrile in water, 0.1% trifluoroacetic acid as modulator) to afford 1 -methyl-piperidine-4-carboxylic acid ((S)- 1-{2-[6-cyano-3-(4-methoxy-benzenesulfonyl)-2-oxo-2,3-dihydro-benzoimidazol-1-yl]- 2-phenyl-acetyl}-pyrrolidin-3-yl)-amide; compound with trifluoroacetic acid (13 mg, 21%) as a white solid.1H-NMR (500 MHz, DMSOd6): delta 1.61-2.04 (m, 5H), 2.15-2.33 (m, 1 H), 2.77 (m, 3H), 2.90 (m, 2H), 3.11 (m, 1 H), 3.27 (m, 1 H), 3.42-3.98 (m, 6H), 3.87 (s, 3H), 6.32-6.42 (m, 1 H), 6.97-7.10 (m, 1 H), 7.20 (dd, 9.1 Hz, 2.4 Hz, 2H), 7.22-7.30 (m, 2H), 7.39 (m, 3H), 7.61-7.65 (m, 1 H), 7.97 (dd, 8.5 Hz, 4.7 Hz, 1 H), 7.99-8.03 (m, 2H). MS (API-ES, pos) m/z = 657.20 [M+H]+.

As the paragraph descriping shows that 71985-80-3 is playing an increasingly important role.

Reference：
Patent; ABBOTT GMBH & CO. KG; WO2008/25736; (2008); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

86542-94-1, 1-(Piperidin-4-yl)propan-1-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

86542-94-1, General procedure: HOBt*H2O (969 mg, 7.17 mmol), EDCI*HCl(1.37 g, 7.17 mmol), 2,2,6,6-tetramethylpiperidin-4-amine (2.49 mL,3.00 mmol) and Et3N (3.31 mL, 13.9 mmol) were added to a solution of 2-(benzo[d][1,3]dioxol-5-ylamino)-2-oxoacetic acid (1.00 g, 4.78 mmol) in DMF(23.9 mL) at 0 C. The reaction mixture was heated to room temperature and stirred for 20 h. Subsequently, the reaction mixture was concentrated under reduced pressure. Saturated aqueous NaHCO3 was added to the residue, andthe mixture was extracted with CHCl3 (150 mL 3), then washed with brineand dried over MgSO4. Concentration under reduced pressure followed by column chromatography (MeOH/CHCl3, 1/10) provided the title compound 5 (1.46 g, 88% yield) as white powder.

86542-94-1 1-(Piperidin-4-yl)propan-1-one 18620952, apiperidines compound, is more and more widely used in various fields.

Reference：
Article; Mizuguchi, Takaaki; Harada, Shigeyoshi; Miura, Tomoyuki; Ohashi, Nami; Narumi, Tetsuo; Mori, Hiromi; Irahara, Yu; Yamada, Yuko; Nomura, Wataru; Matsushita, Shuzo; Yoshimura, Kazuhisa; Tamamura, Hirokazu; Bioorganic and Medicinal Chemistry Letters; vol. 26; 2; (2016); p. 397 – 400;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10338-57-5,4-(Piperidin-1-yl)benzaldehyde,as a common compound, the synthetic route is as follows.

General procedure: A mixture of the appropriate aromatic aldehydes 2b-d (12 mmol) and compound 1 (10 mmol, 2.15 g) dissolved in ethanol (50 ml) was added slowly to an aqueous solution of sodium hydroxide (12.8 mmol) in water (10 ml). The reaction mixture was stirred at 20-25 C for 4 h. The mixture was filtrated and the solid was washed with cold water. The product was crystallized from ethanol to give 3b-d., 10338-57-5

10338-57-5 4-(Piperidin-1-yl)benzaldehyde 291354, apiperidines compound, is more and more widely used in various fields.

Reference：
Article; Abdel-Wahab, Bakr F.; Abdel-Latif, Ehab; Mohamed, Hanan A.; Awad, Ghada E.A.; European Journal of Medicinal Chemistry; vol. 52; (2012); p. 263 – 268;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

10338-57-5, 4-(Piperidin-1-yl)benzaldehyde is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The synthesis of compounds 5, 14-23 and 26-31 follows a multi-component procedure described by Groebke et al.1 N-Cyclohexyl-2-(4-morpholinophenyl)imidazo[1,2-a]pyridin-3- amine 17: 0.30 g (3.1 mmol) 2-aminopyridine and 0.60 g (3.1 mmol) 4-morpholinobenzaldehyde were stirred with glacial acetic acid and 35 mL anhydrous MeOH, then 0.35 g (3.1 mmol) cyclohexyl isocyanide was added. After 18 h the reaction mixture was quenched with 5 mL 2N HCl to destroy the residual isocyanide. MeOH was removed under reduced pressure and 50 mL saturated NaHCO3 solution was added. The product was extracted with EtOAc (3 x 40 mL) and the solvent was removed under reduced pressure. The purification was completed by recrystallization from EtOAc/MeOH yielding 0.50 g (42.2%) yellow solid.

10338-57-5, The synthetic route of 10338-57-5 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Hieke, Martina; Roedl, Carmen B.; Wisniewska, Joanna M.; La Buscato, Estel.; Stark, Holger; Schubert-Zsilavecz, Manfred; Steinhilber, Dieter; Hofmann, Bettina; Proschak, Ewgenij; Bioorganic and Medicinal Chemistry Letters; vol. 22; 5; (2012); p. 1969 – 1975;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

6258-28-2, 2-(2,6-Dioxopiperidin-4-yl)acetic acid is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,6258-28-2

Example 14 4-{2-[4-(2-tert-Butylphenyl)piperazin-1-yl]-2-oxoethyl}piperidine-2,6-dione A mixture of 1-(2-tert-butylphenyl)piperazine dihydrochloride obtained in Reference Example 1 (500 mg), (2,6-dioxopiperidin-4-yl)acetic acid (311 mg), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (403 mg), 1-hydroxy-1H-benzotriazole monohydrate (322 mg), triethylamine (0.627 mL), and N,N-dimethylformamide (5 mL) was stirred at room temperature for over-night. Water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was subjected to purification by high performance liquid chromatography [Column: Gilson, Ltd. High throughput purification system, YMC Combiprep ODS-A, S-5 mum, 50 mm*20 mm; Gradient cycle: H2O (contains 0.1% CF3COOH)-acetonitrile (contains 0.1% CF3COOH), 90:10 (0 min)-90:10 (1 min)-10:90 (4.2 min)-10:90 (5.4 min)-90:10 (5.5 min)-90:10 (5.6 min); Flow rate: 25 mL/min; detection wavelength: UV 220 nm] to give the title compound (47 mg, 13%) as a white solid. 1H NMR (300 MHz, DMSO-d6) delta 1.41 (s, 9H), 2.35-2.74 (m, 12H), 3.20-3.31 (m, 1H), 3.85-3.98 (m, 1H), 4.40-4.50 (m, 1H), 7.13-7.21 (m, 2H), 7.30-7.34 (m, 2H), 10.72 (br, 1H).

6258-28-2 2-(2,6-Dioxopiperidin-4-yl)acetic acid 234331, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; Kasai, Shizuo; McGee, JR., Kevin Francis; US2012/71489; (2012); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.690261-64-4,2-(Piperidin-4-yl)pyrimidine hydrochloride,as a common compound, the synthetic route is as follows.

EXAMPLE 82; The hydrochloride salt of the pyrimidyl piperidine (Intermediate 8) (67 mg, 0.34 mmol) was combined with Intermediate 4 (100 mg, 0.28 mmol), triethylamine (46 muL, 0.35 mmol), and 4 powdered molecular sieves (100 mg) in DCM. After 15 minutes at room temperature, sodium triacetoxyborohydride (240 mg, 1.13 mmol) was added and the resulting mixture was stirred for 3 days before being filtered through celite, diluted with DCM and washed with saturated sodium bicarbonate and brine. The organic layer was dried over MgSO4, filtered and concentrated under reduced pressure to give a crude oil that was purified by preparative TLC (silica gel, 0.3% NH4OH/2.7% MeOH/97% DCM) to give 110 mg of a colorless oil. Resolution of the individual diastereomers was accomplished by HPLC using a ChiralPak AD column eluting with 30% isopropanol/hexanes to give 2 single diastereomers and a single mixture of the 2 other diastereomers.First peak 10 mg: ESI-MS calc. for C28H35F3N4O: 500.28; found 504 (M+H).Second peak 11 mg: ESI-MS calc. for C28H35F3N4O: 500.28; found 504 (M+H).Third peak 7.0 mg ESI-MS calc. for C28H35F3N4O: 500.28; found 504 (M+H)., 690261-64-4

As the paragraph descriping shows that 690261-64-4 is playing an increasingly important role.

Reference：
Patent; Butora, Gabor; Goble, Stephen D.; Pastemak, Alexander; Yang, Lihu; Zhou, Changyou; Moyes, Christopher R.; US2008/81803; (2008); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

5773-58-0, 3-Methylpiperidin-4-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5773-58-0

3-Methylpiperidin-4-one (1.34 g, 11.9 mmol) was dissolved in dichloromethane (30 ml), Et3N (6.12 ml) was added followed by 4-chlorobenzyl bromide (2.46 g, 12 mmol) and the reaction mixture was stirred at room temperature over night, partitioned between dichloromethane and water. The organic layer was dried over Na2SO4, filtered and the filtrate was concentrated in vacuo. The residue was dissolved in pyridine (30 ml), NH2OH HCl (1.53 g) was added and the mixture was stirred at room temperature over night, partitioned between ethyl acetate and water. The organic layer was washed with water, dried over Na2SO4, filtered and the filtrate was concentrated in vacuo to give l-(4- chlorobenzyl)-3-methylpiperidin-4-one-oxime (2.1 g). 1H-NMR (CDCl3, 400 MHz): 58.39 (br.s, IH); 7.28 (s, 4H); 3.47 (m, 2H); 3.00 (m, IH); 2.77 (m, 2H); 2.58 (m, IH); 2.26 (m, 2H); 2.05 (dd, J= 9.2, 11.0 Hz, IH); 1.08 (d, J= 6.6 Hz, 3H). APCI-MS : m/z 253 (MH+).

5773-58-0 3-Methylpiperidin-4-one 12284277, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; ASTRAZENECA AB; WO2007/53082; (2007); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.948894-26-6,4-Methylpiperidine-4-carbonitrile hydrochloride,as a common compound, the synthetic route is as follows.

948894-26-6, The mixture of 4-methylpiperidine-4-carbonitrile (200 mg, 696 mupiiotaomicron, 1 equiv) and 3- chloro-4-((5-chloro-3-methylpyrazin-2-yl)thio)pyridin-2-amine (112 mg, 696 mupiiotaomicron, 1 equiv) in DIPEA (2.00 mL) was stirred at 120 C under an inert atmosphere for 2 hours. The reaction mixture was then poured into H20 (5 mL), and the aqueous phase was extracted with EtOAc (3 x 5 mL). The combined organic extracts were washed with brine (1 mL), dried with anhydrous Na2SC”4, filtered, and concentrated under reduced pressure. The crude residue was then purified by column chromatography to give l-(5-((2-amino-3-chloropyridin-4-yl)thio)-6-methylpyrazin- 2-yl)-4-methylpiperidine-4-carbonitrile (100 mg, 266 mupiiotaomicron, 38% yield) as a white solid. 1H NMR (400 MHz, chloroform-i ) delta 8.05 (s, 1H), 7.67 (d, J= 5.29 Hz, 1H), 5.87 (d, J= 5.51 Hz, 1 H), 4.84 (br s, 2H), 4.43 (br d, J = 13.01 Hz, 2H), 3.26 (br t, J = 12.24 Hz, 2H), 2.47 (s, 3H), 2.07 (br s, 1H), 1.41 – 1.47 (m, 4H).

As the paragraph descriping shows that 948894-26-6 is playing an increasingly important role.

Reference：
Patent; REVOLUTION MEDICINES, INC.; JOGALEKAR, Ash; WON, Walter; KOLTUN, Elena S.; GILL, Adrian; MELLEM, Kevin; AAY, Naing; BUCKL, Andreas; SEMKO, Christopher; KISS, Gert; (496 pag.)WO2018/13597; (2018); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1187173-43-8,2,7-Diazaspiro[4.5]decan-1-one hydrochloride,as a common compound, the synthetic route is as follows.

2,7-Diazaspiro[4.5]decan-1 -one hydrogen chloride (100 mg, 0.524 mmol) was dissolved in dichloromethane (10 mL) and triethylamine (0.219 mL, 1 .573 mmol). Then, 3-fluoro-5-(trifluoromethyl)benzenesulfonyl chloride (165 mg, 0.629 mmol) was added and stirred for 17 h. The mixture was concentrated in vacuo and the resulting residue was purified by MDAP to give 7-{[3-fluoro-5-(trifluoromethyl)phenyl]sulfonyl}- 2,7-diazaspiro[4.5]decan-1 -one (87.9 mg, 0.226 mmol, 43% yield) as a white solid. 1 H NMR (400 MHz, DMSO-d6) delta ppm 1.39 – 1 .49 (m, 2 H) 1.52 – 1 .64 (m, 1 H) 1.66 – 1 .75 (m, 1 H) 1.87 – 1.97 (m, 1 H) 1.99 – 2.09 (m, 1 H) 2.29 – 2.41 (m, 2 H) 3.14 – 3.24 (m, 2 H) 3.41 (d, J=1 1 .73 Hz, 1 H) 3.68 (d, J=1 1 .89 Hz, 1 H) 7.76 (s, 1 H) 7.84 (s, 1 H) 8.01 (d, J=7.84 Hz, 1 H) 8.16 (d, J=8.55 Hz, 1 H). MS ES+ve m/z 381 (M+H)., 1187173-43-8

1187173-43-8 2,7-Diazaspiro[4.5]decan-1-one hydrochloride 45074126, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; CONVERGENCE PHARMACEUTICALS LIMITED; GLEAVE, Robert James; HACHISU, Shuji; PAGE, Lee William; BESWICK, Paul John; WO2011/141728; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

53617-36-0, 1-Methyl-4-(piperidin-4-yl)piperazine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

53617-36-0, 3h) (R)-1-(4-methyl-2-oxo-2,3-dihydro-benzoxazol-6-ylmethyl -2-[4-(4-methyl-piperazin-1-yl)-piperidin-1-yl]-2-oxo-ethyl 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylate A solution of 510 mg (1.0 mmol) (R)-1-carboxy-2-(4-methyl-2-oxo-2,3-dihydrobenz-oxazol-6-yl)-ethyl 4-(2-oxo-1,2,4,5,-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylate, 365 mg (1.12 mmol) TBTU, 230 muL (1.31 mmol) ethyldiisopropylamine in 80 mL THF was stirred for 30 min at RT, then combined with 210 mg (1.12 mmol) 1-methyl-4-piperidin-4-yl-piperazine and stirred for 22 h at RT. To complete the reaction the mixture was again combined with 100 mg (0.3 mmol) TBTU and 50 mg (0.27 mmol) 1-methyl-4-piperidin-4-yl-piperazine and 40 mL THF and stirred for a further 4 h at RT. The reaction solution was diluted with 250 mL EtOAc and extracted twice with 60 mL saturated NaHCO3 solution. The organic phase was dried over Na2SO4, filtered and evaporated down i.vac. The residue was purified by chromatography (Alox, DCM/MeOH 50:1 to 25:1), the fractions containing the product were combined, evaporated down i.vac., combined with diethyl ether, filtered off and dried. Yield: 440 mg (65percent of theory) ESI-MS: (M+H)+=674 Rf=0.46 (Polygram-Alox, DCM/MeOH 25:1)

The synthetic route of 53617-36-0 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Boehringer Ingelheim International GmbH; US2005/256099; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem