Tag: M.W:100-200

768-66-1, 2,2,6,6-Tetramethylpiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,768-66-1

A dry and argon-flushed 500 mL Schlenk flask, equipped with a magnetic stirring bar and a rubber septum, was charged with i-PrMgCl·LiCl(1.31 M in THF, 229 mL, 300 mmol). Then, TMPH (52.0 mL, 306 mmol,1.02 equiv) was added and the mixture was stirred until gas evolution ceased (48 h). The freshly prepared TMPMgCl·LiCl (5) solution was titrated prior to use at 0 C with benzoic acid and by using 4-(phenylazo)diphenylamine as indicator.

768-66-1 2,2,6,6-Tetramethylpiperidine 13035, apiperidines compound, is more and more widely used in various fields.

Reference：
Article; Ziegler, Dorothee S.; Klier, Lydia; Mueller, Nicolas; Karaghiosoff, Konstantin; Knochel, Paul; Synthesis; vol. 50; 22; (2018); p. 4383 – 4394;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

85908-96-9, N-Boc-2-Piperidone is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

85908-96-9, Step 2 tert-butyl 3,3-diallyl-2-oxopiperidine-l-carboxylate [0360] To a solution of tert-butyl 2-oxopiperidine- 1 -carboxylate (8.22 g, 41.3 mmol) in anhydrous THF (80 mL) was added LiHMDS (1.0 M in THF, 103 mL, 103 mmol) dropwise under nitrogen atmosphere at -78 C. The reaction mixture was stirred for 20 min and 3- bromoprop-l-ene (10.7 mL, 124 mmol) was added. The resulting mixture was stirred for 15 min, and then allowed to warm to rt, and quenched with water (15 mL), concentrated in vacuo. The residue was diluted with water (30 mL) and extracted with EtOAc (50 mL x 3). The combined organic phases were washed with brine (50 mL), then dried over anhydrous Na2S04, filtered and concentrated in vacuo. The residue was purified by silica gel column chromatography (EtOAc/PE (v/v) = 1/50) to give the title compound as yellow oil (3.95 g, 35%). MS (ESI, pos. ion) m/z: 224.2 [(M-C4H8)+H]+; NMR (600 MHz, CDCb): delta (ppm) 5.72 (ddt, J =16.5, 10.5, 7.0 Hz, 2H), 5.06 (d, J = 10.5 Hz, 2H), 5.03 (d, J= 16.5 Hz, 2H), 3.55 (t, J = 5.8 Hz, 2H), 2.46 (dd, J = 13.6, 7.0 Hz, 2H), 2.21 (dd, J = 13.6, 7.0 Hz, 2H), 1.75 (m, 4H), 1.48 (s, 9H).

As the paragraph descriping shows that 85908-96-9 is playing an increasingly important role.

Reference：
Patent; CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD; XI, Ning; LI, Minxiong; HU, Haiyang; DAI, Weilong; LI, Xiaobo; WANG, Tingjin; WU, Yanjun; (136 pag.)WO2016/190847; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14813-01-5,1-Benzylpiperidin-3-ol,as a common compound, the synthetic route is as follows.

To a solution of 0.50 g (2.62 mmol) of rac-2 in 1 ml of dry pyridine cooled to 0 C, 0.35 ml (3.70 mmol) of acetic anhydride was added under nitrogen. The resulting mixture was stirred overnight at room temperature. The reaction mixture was diluted with toluene (3 x 3 ml) and concentrated under reduced pressure to give 0.57 g (2.45 mmol) of rac-4 as a pale yellow oil (94% yield). 1H NMR (300 MHz, CDCl3, d ppm): 1.46-1.94 (m, 4H); 2.04 (s,3H); 2.10-2.21 (m, 2H); 2.45-2.79 (m, 2H); 3.57 (s, 2H); 4.84 (s,1H); 7.22-7.45 (m, 5H); TLC Rf = 0.59.

14813-01-5, 14813-01-5 1-Benzylpiperidin-3-ol 85773, apiperidines compound, is more and more widely used in various fields.

Reference：
Article; Tofani, Giorgio; Petri, Antonella; Piccolo, Oreste; Tetrahedron Asymmetry; vol. 26; 12-13; (2015); p. 638 – 643;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

768-66-1, 2,2,6,6-Tetramethylpiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

768-66-1, 0.71 g (5.0 mmol) 2,2,6,6-tetramethylpiperidine and 0.95 g (5.0 mmol) p-toluenesulfonic acid monohydrate were mixed in 15 mL acetone, the mixture was stirred for 30 mins at room temperature (15-20C), evaporation of the solvent gave the crude product, which was washed with 30 mL n-hexane to give a pure 2,2,6,6-tetramethylpiperidinium tosylate (1.63 g) as a white crystal, the yield is 98%. m.p.: 219.4-220.1C (reference4m.p. = 218-219C); 1H NMR (400 MHz, CDCl3) delta 8.00 (br, 2H), 7.77 (d, J = 8.0 Hz, 2H), 7.19 (d, J= 8.0 Hz, 2H), 2.37 (s, 3H), 1.69-1.58 (m, 6H), 1.49 (s, 12H) ppm; 13C NMR (100 MHz, CDCl3) delta 142.69, 139.95, 128.78, 125.89, 56.78, 34.52, 27.22, 21.34, 16.32 ppm; IR (KBr): 3425, 2997, 2924, 2872, 2838, 2505, 1614, 1485, 1389, 1275, 1227, 1161, 1120, 1034, 1009, 833 cm-1.

768-66-1 2,2,6,6-Tetramethylpiperidine 13035, apiperidines compound, is more and more widely used in various fields.

Reference：
Article; Gao, Lan; Liu, Taoping; Tao, Xiaochun; Huang, Yongmin; Tetrahedron Letters; vol. 57; 44; (2016); p. 4905 – 4909;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3518-83-0,N-Ethyl-4-hydroxypiperidine,as a common compound, the synthetic route is as follows.

Example 11 In a 200-ml three-necked flask equipped with dropping funnel, thermometer and reflux condenser, there were placed 4.80 g of N-ethyl-4-hydroxypiperidine, 3.23 g of pyridine and 50 ml of benzene, and 11.60 g of farnesylacetyl chloride was added dropwise under reflux. After completion of the dropping, the mixture was refluxed for a subsequent 2 hour period and then cooled. Addition of 30 ml of 20% aqueous solution of sodium hydroxide, stirring, phase separation and silica gel column chromatography of the upper layer yielded 2.4 g of N-ethyl-4-farnesylacetoxy-piperidine as a pale-yellow liquid.

3518-83-0, The synthetic route of 3518-83-0 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Kuraray Co., Ltd.; US4289786; (1981); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

768-66-1, 2,2,6,6-Tetramethylpiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,768-66-1

General procedure: Compound 4 0.2 g (0.41 mmol) and 25 muL piperdine (0.82 mmol) was added to the 1.0 mL dried CH2Cl2.Anhydrous Na2CO3 20 mg was then added to the mixture, which was stirred for 12 h. The mixturewas washed with the distilled water, the organic phase was separated and dried over anhydrousNa2SO4, and then concentrated viarotary evaporation. The crude product was purified by silica gelchromatography with petroleum ether-acetone-strong ammonia water (v/v/v, 8/1/0.1) as the eluentto gain 0.18 g yellow solid compound 5a in 90% yield.

768-66-1 2,2,6,6-Tetramethylpiperidine 13035, apiperidines compound, is more and more widely used in various fields.

Reference：
Article; Feng, Xiu E.; Wang, Qin Jin; Gao, Jie; Ban, Shu Rong; Li, Qing Shan; Molecules; vol. 22; 12; (2017);,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10338-57-5,4-(Piperidin-1-yl)benzaldehyde,as a common compound, the synthetic route is as follows.

General procedure: Appropriate benzaldehyde (10 mmol) was dissolved in ethanol(20 mL). Sodium metabisulfite (15 mmol) in 5 mL water was addedin portion over 5 min. The reaction mixture was stirred at roomtemperature for 1 h and subsequently stirred at 4?C overnight.The precipitate formed was filtered and dried to afford sodiumbisulfite adducts (55-90%)., 10338-57-5

The synthetic route of 10338-57-5 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Yoon, Yeong Keng; Ali, Mohamed Ashraf; Wei, Ang Chee; Choon, Tan Soo; Khaw, Kooi-Yeong; Murugaiyah, Vikneswaran; Osman, Hasnah; Masand, Vijay H.; Bioorganic Chemistry; vol. 49; (2013); p. 33 – 39;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3612-20-2,1-Benzylpiperidin-4-one,as a common compound, the synthetic route is as follows.

To a solution of ammonium chloride (5.7 g, 105.6 mmol) and potassium cyanide (6.9 mg, 105.6 mmol) in water (155 mL) was added 1-benzyl-4-piperidone (5 g, 26.4 mmol) and the mixture was stirred for 6 days. It was cooled to 0 C. and pH was adjusted to 11 by adding K2CO3. The reaction mixture was extracted with ethyl acetate three times. The combined organic layer was dried over MgSO4, filtered and evaporated to give the oil (5 g), which was a mixture of the desired aminonitrile, cyanohydrin and starting ketone. The crude mixture was used in next step without further purification. 1H NMR (400 MHz, CDCl3) delta 7.36-7.25 (m, 5H), 2.77-2.74 (m, 2H), 2.48-2.31 (m, 4H), 2.13-2.08 (m, 2H), 1.81-1.74 (m, 2H).

3612-20-2, As the paragraph descriping shows that 3612-20-2 is playing an increasingly important role.

Reference：
Patent; Cumbre Inc.; US2005/277633; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

85908-96-9, N-Boc-2-Piperidone is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

85908-96-9, [0151] N-Boc-lactam 2a-1 (300 mg, 1.50 mmol) was dissolved in THF (3 mL), a THF solution of phenylmagnesium bromide (1 mol/L solution, 1.5 mL, 1.50 mmol) was added at 0 C., and the mixture was stirred at 0 C. for 1 hr. Water (1.0 mL) was added, anhydrous sodium sulfate was added, water in the reaction system was removed, and the mixture was filtered through cotton. The obtained filtrate was concentrated by a rotary evaporator. The obtained crude product was purified by silica gel column chromatography (solvent :hexane and ethyl acetate) to give N-Boc-aminoketone 3a-1 (313 mg, 1.13 mmol) as a colorless liquid (yield 75%). MS: m/z 278 ([M+1], C16H23NO3

As the paragraph descriping shows that 85908-96-9 is playing an increasingly important role.

Reference：
Patent; SEED RESEARCH INSTITUTE CO., LTD.; ISHIKAWA, Teruhiko; IWAMI, Morita; (10 pag.)US2017/327513; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3612-20-2,1-Benzylpiperidin-4-one,as a common compound, the synthetic route is as follows.

8-benzyl-1,3,8-triazaspiro[4.5]decane-2,4-dione1-Benzylpiperidin-4-one (49A) (20.0 g, 105.68 mmol)Soluble in ethanol (140mL), add potassium cyanide with stirring(14.3 g, 219.6 mmol) and water (140 mL),The mixture was stirred at 85 C for 36 hours.The reaction solution was cooled to room temperature, filtered, and the filter cake was washed with hot water (100 mL×3).The filter cake is dried to a white solid8-benzyl-1,3,8-triazaspiro[4.5]decane-2,4-dione (49B)(24.3 g, yield: 88.68%)., 3612-20-2

As the paragraph descriping shows that 3612-20-2 is playing an increasingly important role.

Reference：
Patent; Sichuan Hai Sike Pharmaceutical Co., Ltd.; Fan Jiang; Zhu Fengfei; Chen Qingping; Wang Chengtao; (251 pag.)CN109206417; (2019); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem