Tag: M.W:100-200

Related Products of 215950-19-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.215950-19-9, Name is N-Methoxy-N,1-dimethylpiperidine-4-carboxamide, molecular formula is C9H18N2O2. In a Article，once mentioned of 215950-19-9

The synthesis and evaluation of structurally novel 5-HT1F receptor agonists are reported. Several fused bicyclic systems have been investigated to serve as the core structure of potent and selective 5-HT 1F receptor agonists. Replacement of the indole nucleus in 2 with indazole and ‘inverted’ indazole provided more potent and selective 5-HT 1F receptor ligands. Indoline and 1,2-benzisoxazole systems also provided potent 5-HT1F receptor agonists, and the 5-HT1A receptor selectivity of the indoline- and 1,2-benzisoxazole-based 5-HT 1F receptor agonists could be improved with modification of the benzoyl moiety of the benzamides. Through these studies, we found that the inherent geometries of the templates, not the nature of hybridization of the linking atom, were important for the 5-HT1F receptor recognition.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H11542N – PubChem

Electric Literature of 2971-79-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.2971-79-1, Name is Methyl piperidine-4-carboxylate, molecular formula is C7H13NO2. In a Article，once mentioned of 2971-79-1

Reactions of available diethyl 1-acylamino-2,2-dichloroethenylphosphonates with amino acids esters were studied, which in the case of esters of proline, nipecotic and isonipecotic acids resulted in N-substituted derivatives of 5-amino-4-diethoxyphosphoryloxazol in high yields. Their behavior in the acidic and alkaline media was investigated by the example of methyl N-(4-diethoxyphosphoryl-2-R-oxazol-5-yl)isonipecotinate.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H8034N – PubChem

Related Products of 3433-37-2, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.3433-37-2, Name is 2-(Hydroxymethyl)piperidine, molecular formula is C6H13NO. In a Patent，once mentioned of 3433-37-2

The invention relates to the use of certain heterocyclic compounds which act as kappa receptor agonists in the treatment of cerebral ischaemia.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H2749N – PubChem

Related Products of 37675-18-6, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 37675-18-6, Name is (S)-Ethyl piperidine-3-carboxylate,introducing its new discovery.

The construction of a library of benzothiaoxazepine-1,1?-dioxides utilizing a one-pot, SNAr diversification-ODCT50 scavenging protocol is reported. This protocol combines microwave irradiation to facilitate the reaction, in conjunction with a soluble ROMP-derived scavenger (ODCT) to afford the desired products in good overall purity. Utilizing this protocol, a 78-member library was successfully synthesized and submitted for biological evaluation.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H8933N – PubChem

Reference of 1484-84-0, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.1484-84-0, Name is 2-Piperidineethanol, molecular formula is C7H15NO. In a article，once mentioned of 1484-84-0

Treatment of 2-(2′-alkenyl)-piperidine boranes with iodine or triflic acid induces internal hydroboration with high regiocontrol, even with a terminal alkene (R H). Good stereocontrol is possible for the N-benzyl substrates. Comparisons with acyclic model structures show that the source of regiocontrol with the terminal alkene is due to a steric effect of the axial piperidine C(3,5) hydrogens that destabilize the competing bridged bicyclic transition state.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H5485N – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. HPLC of Formula: C7H13NO2. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 177-11-7

The present invention is directed to novel trisubstituted thiophene derivatives, pharmaceutical compositions containing them and their use in the treatment or prevention of disorders and diseases mediated by agonists and antagonists of the progesterone receptor. The clinical usage of these compounds are related to hormonal contraception, the treatment and/or prevention of secondary dysmenorrhea, amenorrhea, dysfunctional uterine bleeding, uterine leiomyomata, endometriosis; polycystic ovary syndrome, carcinomas and adenocarcinomas of the endometrium, ovary, breast, colon or prostate. Additional uses of the invention include stimulation of food intake.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H7349N – PubChem

Reference of 27578-60-5, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.27578-60-5, Name is N-(2-Aminoethyl)piperidine, molecular formula is C7H16N2. In a Patent，once mentioned of 27578-60-5

The invention relates to the field of pharmaceutical chemistry, relates to isoflavone amide derivatives, its preparation process and medical application, in particular to a group of general formula (I) of the amide derivatives of isoflavone, process for their preparation, pharmaceutical compositions containing these compounds and their medical use, especially as the prevention or treatment of hyperlipidemia, obesity or diabetes type II the use of the medicament. (by machine translation)

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H4273N – PubChem

Reference of 50533-97-6, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 50533-97-6, Name is N,N-Dimethylpiperidin-4-amine, molecular formula is C7H16N2. In a Article，once mentioned of 50533-97-6

In present study, we described the synthesis and biological evaluation of a new class of EGFR inhibitors containing 2,9-disubstituted 8-phenylthio/phenylsulfinyl-9H-purine scaffold. Thirty-one compounds were synthesized. Among them, compound C9 displayed the IC50 of 29.4 nM against HCC827 cell line and 1.9 nM against EGFRL858R. Compound C12 showed moderate inhibitory activity against EGFRL858R/T790M/C797S (IC50 = 114 nM). Western bolt assay suggested that compound C9 significantly inhibited EGFR phosphorylation. In vivo test, compound C9 remarkably exhibited inhibitory effect on tumor growth at 5.0 mg/kg by oral administration in established nude mouse HCC827 xenograft model. These results indicate that the 2,9-disubstituted 8-phenylsulfinyl/phenylsulfinyl-9H-purine derivatives can act as potent EGFR(L858R) inhibitors and effective anticancer agents. Additionally, optimization of compound C12 may result in discovering the fourth-generation EGFR-TKIs.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H3905N – PubChem

Application of 177-11-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.177-11-7, Name is 1,4-Dioxa-8-azaspiro[4.5]decane, molecular formula is C7H13NO2. In a Article，once mentioned of 177-11-7

Stereospecific introduction of a methyl group to the indole-3-side chain enhanced activity in our tryptamine-derived series of GnRH receptor antagonists. Further improvements were achieved by variation of the bicyclic amino moiety of the tertiary amide and by adjustment of the tether length to a pyridine or pyridone terminus. These modifications culminated in analogue 24, which had oral activity in a rat model and acceptable oral bioavailability and half-life in dogs and monkeys.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 177-11-7 is helpful to your research. Application of 177-11-7

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7477N – PubChem

Synthetic Route of 3040-44-6, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 3040-44-6, Name is 1-(2-Hydroxyethyl)piperidine, molecular formula is C7H15NO. In a Patent，once mentioned of 3040-44-6

The present invention provides a 1,2,4-triazolone derivative represented by Formula (1A) having an antagonistic activity on the arginine-vasopressin 1b receptor or a pharmaceutically acceptable salt thereof and provides a pharmaceutical composition comprising the compound or the salt as an active ingredient, in particular, a therapeutic or preventive agent exhibiting favorable pharmacokinetics in a disease such as mood disorder, anxiety disorder, schizophrenia, Alzheimer’s disease, Parkinson’s disease, Huntington’s chorea, eating disorder, hypertension, gastrointestinal disease, drug addiction, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, head injury, inflammation, immune-related disease, or alopecia.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H5212N – PubChem