Tag: M.W:100-200

Chemistry is an experimental science, name: tert-Butyl 4-methylenepiperidine-1-carboxylate, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 159635-49-1, Name is tert-Butyl 4-methylenepiperidine-1-carboxylate

A first aspect of the invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or ester thereof, (Formula (I)) wherein: R1 is -(CHz)nNR3R4, -OR5 or -(CHz)n-heterocycloalkyl, wherein said heterocycloalkyl group is optionally substituted by one or more R7 groups; R2 is selected from aryl, heteroaryl, fused aryl-heterocycloalkyl and fused hetero aryl- heterocycloalkyl each of which is substituted by at least one Rs group; R3 is H or alkyl; R4 is: (i) cycloalkyl optionally substituted by one or more -NRnR12 or NHCOR11 groups; or (ii) -(CHz)n-heterocycloalkyl, wherein said heterocycloalkyl is a 4, 5 or 6-membered nitrogen-containing group optionally containing one or more CO groups, wherein said heterocycloalkyl is optionally substituted by one or more one or more (CHz)nR7 groups; or (iii) alkyl substituted by one or more -NRUR12groups; or R3 and R4 are linked together with the nitrogen to which they are attached to form a 4, 5, 6 or 7-membered monocyclic heterocycloalkyl group or a bicyclic heterocyclic group, each of which optionally contains one or two further groups selected from CO, O, N and S, and which is optionally further substituted by one or more R7 groups; R5 is selected from alkyl, -(CHz)n-heteroaryl and – (CHz)n-heterocycloalkyl, wherein said heteroaryl and heterocycloalkyl groups are each optionally substituted by one or more R7 groups; each Rs is independently selected from – NR16R17, -OR17 and -(CHz)nR17 where each R16 is H and each R17 is independently – (CHR10)n-heteroaryl, wherein said heteroaryl group is in turn optionally substituted by one or more R7 groups; each R10, R11 and R12 is independently H or alkyl; or in the case of an – NR11R12 group, R11 and R12 may be linked together with the nitrogen to which they are attached to form a 4, 5, 6 or 7-membered monocyclic or bicyclic heterocycloalkyl group optionally containing one or two further groups selected from CO, O, N and S, and which is optionally further substituted by one or more R7 groups; each m is independently an integer from 1 to 6; and each n is independently an integer from 0 to 6. Further aspects relate to the use of said compounds in the treatment of various therapeutic disorders, and more particularly as inhibitors of PfCDPK1

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. name: tert-Butyl 4-methylenepiperidine-1-carboxylate, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 159635-49-1, in my other articles.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H13154N – PubChem

Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 2213-43-6, molcular formula is C5H12N2, introducing its new discovery. Formula: C5H12N2

The present invention discloses novel compounds of Formula I: ( I ) possessing 11beta-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, cognitive disorders, and other conditions associated with 11beta-HSD type 1 activity.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Formula: C5H12N2, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 2213-43-6

Reference：
Piperidine – Wikipedia,
Piperidine | C5H768N – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， Computed Properties of C7H16N2, Which mentioned a new discovery about 50533-97-6

1-[(3- or 4-Benzoylphenyl)-lower-alkyl]-[(CH2)n –N=B]-substituted-piperidines, useful as anti-asthmatic, anti-allergic, anti-cholinergic, bronchodilator and anti-inflammatory agents, are prepared by alkylation of an appropriate substituted piperidine with a (3- or 4-benzoylphenyl)-lower-alkyl halide or tosylate; by reaction of a 1-[2-(3- or 4-lithiophenyl)-lower-alkyl]-[(CH2)n –N=B]-substituted-piperidine with benzonitrile and hydrolysis of the resulting benzimidoyl compound; or by reduction of a 1-[alpha-(3- or 4-benzoylphenyl)-lower-alkanoyl]-[(CH2)n –N=B]-substituted-piperidine. The analogous carbinols are prepared by reduction, with an alkali metal borohydride, of the ketone.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 50533-97-6, help many people in the next few years.Computed Properties of C7H16N2

Reference：
Piperidine – Wikipedia,
Piperidine | C5H4007N – PubChem

Chemistry is an experimental science, Recommanded Product: 177-11-7, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 177-11-7, Name is 1,4-Dioxa-8-azaspiro[4.5]decane

The present invention is related to thiazole derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Recommanded Product: 177-11-7, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 177-11-7, in my other articles.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7345N – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， COA of Formula: C7H13NO2, Which mentioned a new discovery about 177-11-7

The invention provides the use of a compound for the manufacture of a medicament for the treatment of pain, wherein the compound is a compound of the formula (Vl): or a salt, solvate, tautomer or N-oxide thereof; wherein the bicydic group: is selected from the structures C1, C5 and C6: wherein n, R1, R2a, R3, R4a, R8 and R10 are as defined in the claims. The invention also provides the use of a compound of the formula (Vl) for the manufacture of a medicament for the prophylaxis or treatment of a fungal, protozoal, viral or parasitic disease state or condition (other than a disease state or condition due to Plasmodium falciparum) or for use in the prophylaxis or treatment of Ewing’s sarcoma, atherosclerosis or lupus erythematosus

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 177-11-7, help many people in the next few years.COA of Formula: C7H13NO2

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7394N – PubChem

Electric Literature of 2008-75-5, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.2008-75-5, Name is 1-(2-Chloroethyl)piperidine hydrochloride, molecular formula is C7H15Cl2N. In a Article，once mentioned of 2008-75-5

The reactions of in-situ generated PhS-, PyS- and PhSe- with 4-(2-chloroethyl)morpholine hydrochloride and 1-(2-chloroethyl)piperidine hydrochloride in N2 atmosphere have resulted in N-{2-(arylchalcogeno)ethyl}morpholine/piperidine ligands (L1-L6), which on reaction with Na2PdCl4 at room temperature result in complexes of composition [PdCl2(L)] (1-6; L = L1-L6). All the complexes except 2 have been characterized by X-ray crystallography. The geometry around Pd is nearly square planar in all the cases. The Pd-S and Pd-Se bond lengths are in the ranges 2.2598(10)-2.2795(14) and 2.3541(6)-2.3632(15) A, respectively. In 77Se{1H} NMR spectra of Pd(II)-complexes with L5 and L6 (Se ligands), the signals appear at higher frequency (up to 187 ppm) with respect to those of corresponding free ligands. Pd(II)-complexes (2, 4 and 6) have been found promising for Heck reaction of aryl bromides with methyl acrylate. The TON values are up to 18 200 and TOF up to 758 h-1 (with complex 6 as catalyst). The Pd-complexes of piperidene derivatives show little higher catalytic efficiency than those of morpholine ones. The positive Hg-test has implied that nano-sized Pd(0) species probably catalyze Heck reactions.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Electric Literature of 2008-75-5, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 2008-75-5

Reference：
Piperidine – Wikipedia,
Piperidine | C5H11014N – PubChem

Related Products of 177-11-7, In heterogeneous catalysis, the catalyst is in a different phase from the reactants. At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 177-11-7, name is 1,4-Dioxa-8-azaspiro[4.5]decane. In an article，Which mentioned a new discovery about 177-11-7

The functionalization of the naphthalene ring system by a direct amination-alkylation reaction of chiral nonracemic naphthyloxazolines is described.Chiral 1-naphthyl- and 2-naphthyloxazoline were treated with a variety of lithium amides followed by several different electrophilic quenches.The solvent and additives were varied in order to achieve optimum conditions.The combination of HMPA and THF at -78 deg C gave the best yield with excellent stereoselectivity.The present methology provides a stereospecific synthesis of novel, nonracemic, rigid beta-amino acides after hydrolytic removal of the chiral oxazoline.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.177-11-7. In my other articles, you can also check out more blogs about 177-11-7

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7422N – PubChem

Synthetic Route of 50541-93-0, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 50541-93-0, Name is 4-Amino-1-benzylpiperidine, molecular formula is C12H18N2. In a Patent，once mentioned of 50541-93-0

The present invention relates to a method for the preparation of active ester, characterized by subjecting to a reaction a mixture of a carboxylic acid, which is a starting material, reagent which forms active ester and a base or a starting material carboxylic acid.The present invention provides an active ester useful as an intermediate of pharmaceutical drugs etc. in high yield using an inexpensive reagent, in one-pot reaction, without causing isomerization, regardless of the structure of starting material carboxylic acid.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Synthetic Route of 50541-93-0, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 50541-93-0, in my other articles.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H12278N – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. Product Details of 6789-94-2. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 6789-94-2

A novel polyprenyl compound such as a polyprenyl carboxylic acid amide is disclosed. It has antithrombic and antiplatelet aggregation activity.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Product Details of 6789-94-2, you can also check out more blogs about6789-94-2

Reference：
Piperidine – Wikipedia,
Piperidine | C5H4050N – PubChem

Related Products of 2008-75-5, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.2008-75-5, Name is 1-(2-Chloroethyl)piperidine hydrochloride, molecular formula is C7H15Cl2N. In a Article，once mentioned of 2008-75-5

Noninvasive methods to modulate G protein-coupled receptors (GPCRs) with temporal and spatial precision are in great demand. Photopharmacology uses photons to control in situ the biological properties of photoswitchable small-molecule ligands, which bodes well for chemical biological precision approaches. Integrating the light-switchable configurational properties of an azobenzene into the ligand core, we developed a bidirectional antagonist toolbox for an archetypical family A GPCR, the histamine H3 receptor (H3R). From 16 newly synthesized photoswitchable compounds, VUF14738 (28) and VUF14862 (33) were selected as they swiftly and reversibly photoisomerize and show over 10-fold increased or decreased H3R binding affinities, respectively, upon illumination at 360 nm. Both ligands combine long thermal half-lives with fast and high photochemical trans-/cis conversion, allowing their use in real-time electrophysiology experiments with oocytes to confirm dynamic photomodulation of H3R activation in repeated second-scale cycles. VUF14738 and VUF14862 are robust and fatigue-resistant photoswitchable GPCR antagonists suitable for spatiotemporal studies of H3R signaling.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 2008-75-5

Reference：
Piperidine – Wikipedia,
Piperidine | C5H11234N – PubChem