Tag: M.W=100-150

Recently I am researching about COUPLING REACTIONS; ARYL CHLORIDES; PHOTOREDOX; AMINES; PRECATALYST; AMMONIA, Saw an article supported by the Natural Science Foundation of ShanghaiNatural Science Foundation of Shanghai [19ZR1468700]; CAS Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Han, DY; Li, SS; Xia, SQ; Su, MC; Jin, J. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane. Name: 1,4-Dioxa-8-azaspiro[4.5]decane

An efficient and operationally simple Ni-catalyzed amination protocol has been developed. This methodology features a simple Ni(II)salt, an organic base and catalytic amounts of both a pyridinium additive and Zn metal. A diverse number of (hetero)aryl halides were coupled successfully with primary and secondary alkyl amines, and anilines in good to excellent yields. Similarly, benzophenone imine gave the correspondingN-arylation product in an excellent yield.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

HPLC of Formula: C7H13NO2. In 2019 ORG LETT published article about CYANOGEN-BROMIDE; N-CYANATION; ELECTROPHILIC CYANATION; TIEMANN REARRANGEMENT; PRACTICAL SYNTHESIS; BACE1 INHIBITOR; VERUBECESTAT; AMINATION in [Kuhl, Nadine; Raval, Saurin; Cohen, Ryan D.] Merck & Co Inc, Dept Proc Res & Dev, Rahway, NJ 07065 USA in 2019, Cited 46. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

An operationally simple oxidation cyanation method for the synthesis of cyanamides is described. The procedure utilizes inexpensive and commercially available N-chlorosuccinimide and Zn(CN)(2) as reagents to avoid direct handling of toxic cyanogen halides. It is demonstrated to be amenable for the cyanation of a variety of primary and secondary amines and aniline derivatives as well as a complex synthetic intermediate en route to verubecestat (MK-8931). Additionally, kinetic measurements and other control experiments are reported to shed light onto the mechanism of this cyanation reaction.

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Piperidine | C5H7510N – PubChem

I found the field of Chemistry very interesting. Saw the article Preparation of Oxindoles via Visible-Light-Induced Amination/Cyclization of Arylacrylamides with Alkyl Amines published in 2020. Recommanded Product: 177-11-7, Reprint Addresses Yu, W; Liu, XY (corresponding author), Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China.. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

The cascade amination/cyclization ofN-arylacrylamides with alkyl amines under visible-light photoredox catalysis is realized via intermediacy of aminium radicals. The aminium radicals are generated by a two-step sequence which involves N-chlorination of alkyl amines and subsequent reductive N-Cl cleavage. This method provides a convenient access to aminated oxindoles.

Recommanded Product: 177-11-7. Bye, fridends, I hope you can learn more about C7H13NO2, If you have any questions, you can browse other blog as well. See you lster.

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Authors Lv, ZC; Wang, HM; Quan, ZC; Gao, Y; Lei, AW in ROYAL SOC CHEMISTRY published article about PALLADIUM-CATALYZED AMINATION; CARBON-SULFUR; COOPERATIVE CATALYSIS; EFFICIENT SYNTHESIS; METAL-COMPLEXES; ACTIVATION; FUNCTIONALIZATION; COBALT; BENZOXAZOLES; CYCLIZATION in [Lv, Zongchao; Wang, Huamin; Quan, Zhicong; Gao, Yuan; Lei, Aiwen] Wuhan Univ, Coll Chem & Mol Sci, Inst Adv Studies, Wuhan 430072, Hubei, Peoples R China; [Lei, Aiwen] Jiangxi Normal Univ, Natl Res Ctr Carbohydrate Synth, Nanchang 330022, Jiangxi, Peoples R China in 2019, Cited 68. HPLC of Formula: C7H13NO2. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

Research on the cleavage of C-C bonds has been well developed. By comparison with this, the activation of C-S bonds remains challenging. Herein, dioxygen-triggered oxidative cleavage of C-S bonds has been achieved, delivering a series of N-containing heterocyclic compounds that are frequently found in pesticides and pharmaceuticals. Additionally, the potential utility of this protocol was further demonstrated by a gram-scale experiment. Mechanistically, dioxygen plays a key role in the cleavage of C-S bonds towards C-N bond formation.

HPLC of Formula: C7H13NO2. Bye, fridends, I hope you can learn more about C7H13NO2, If you have any questions, you can browse other blog as well. See you lster.

Reference：
Piperidine – Wikipedia,
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Computed Properties of C7H13NO2. In 2019 TETRAHEDRON LETT published article about ASYMMETRIC-SYNTHESIS; COMPLEXES in [Li, Gang-Jian; Pan, You-Lu; Liu, Yan-Ling; Xu, Hai-Feng; Chen, Jian-Zhong] Zhejiang Univ, Coll Pharmaceut Sci, 866 Yuhangtang Rd, Hangzhou, Zhejiang, Peoples R China in 2019, Cited 40. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

It was reported to develop a simple and convenient method for the Ni/NHC-catalyzed cross-coupling of methyl sulfinates and amines without an acid/base to afford secondary or tertiary sulfinamides in moderate to good yields. The method can provide the desired products with broad substrate scope, good chemoselectivity and good functional group compatibility. The presented approach may enrich the Nil NHC catalyst system and promote the applications of methyl sulfinates in the organic sulfur chemistry. (C) 2019 Elsevier Ltd. All rights reserved.

Welcome to talk about 177-11-7, If you have any questions, you can contact Li, GJ; Pan, YL; Liu, YL; Xu, HF; Chen, JZ or send Email.. Computed Properties of C7H13NO2

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Recently I am researching about DNA INTERACTIONS; STEREOGENIC PROPERTIES; STRUCTURAL CHARACTERIZATIONS; ANTIMICROBIAL ACTIVITIES; ELECTROCHEMICAL INVESTIGATIONS; CYCLOTRIPHOSPHAZENE CORE; CHIRAL CONFIGURATIONS; DENDRIMERS; CYCLOPHOSPHAZENES; CHEMISTRY, Saw an article supported by the Scientific and Technical Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [215Z496]; Hacettepe University Scientific Research Project UnitHacettepe University [013 D04 602 004]; Turkish Academy of Sciences (TUBA)Turkish Academy of Sciences. Name: 1,4-Dioxa-8-azaspiro[4.5]decane. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Binici, A; Okumus, A; Elmas, G; Kilic, Z; Ramazanoglu, N; Acik, L; Simsek, H; Tunali, BC; Turk, M; Guzel, R; Hokelek, T. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

The reaction of N4P4Cl8 (1) with one equimolar amount of the sodium salt of an N/O donor-type bidentate ligand (2) afforded two kinds of derivatives, namely, mono-ferrocenyl-2-cis-4-dichloro-ansa- (2,4-ansa; 3) and mono-ferrocenyl-spiro- (spiro; 4) hexachlorocyclotetraphosphazenes. The reaction yield (35%) of 4 was significantly larger than that of 3 (14%). The 2,4-ansa compound (3) was reacted with excess secondary amines to produce 2-cis-4-dichloro-ansa-cyclotetraphosphazenes (3a-3d). On the other hand, the spiro compound (4) gave fully substituted mono-ferrocenyl-spiro-cyclotetraphosphazenes (4a-4d) with excess monoamines as well. The tetrameric phosphazene derivatives were characterized by ESI-MS and/or HRMS, FTIR, HSQC, HMBC, H-1, C-13, and P-31 NMR spectroscopy and X-ray crystallography (for 4). It is observed that the 2,4-ansa and spiro-cyclotetraphosphazenes have different thermal stabilities. Additionally, the CVs of the new mono-ferrocenyl pendant-armed cyclotetraphosphazenes revealed electrochemically reversible one-electron oxidation of the Fe-redox centre. The 2,4-ansa phosphazenes (3 and 3a-3d) have two different stereogenic P centers indicating that they are expected to be in racemic mixtures (RR’/SS’). The chiralities of 3a and 3c were investigated by chiral HPLC. The manuscript also deals with the antimicrobial activities against G(+)/G(-) bacteria and fungi, the interactions with plasmid DNA, the in vitro cytotoxic activities against L929 fibroblast and MCF7 breast cells, and the antituberculosis activities against Mycobacterium tuberculosis H37Rv of the cyclotetraphosphazenes.

Name: 1,4-Dioxa-8-azaspiro[4.5]decane. Welcome to talk about 177-11-7, If you have any questions, you can contact Binici, A; Okumus, A; Elmas, G; Kilic, Z; Ramazanoglu, N; Acik, L; Simsek, H; Tunali, BC; Turk, M; Guzel, R; Hokelek, T or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Recently I am researching about N-ACYL KETIMINES; ASYMMETRIC-SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; 1,3-DISUBSTITUTED ISOINDOLINES; STEREOSELECTIVE-SYNTHESIS; CATALYZED ARYLATION; MICHAEL REACTIONS; DIRECTING GROUP; 3+2 ANNULATION; ACTIVATION, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21672192, U1904212, 21472176]. Recommanded Product: 1,4-Dioxa-8-azaspiro[4.5]decane. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Li, XH; Gong, JF; Song, MP. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

A new method for the direct and stereoselective synthesis of 3-substituted isoindolinones via Rh(iii)-catalyzed chiral N-sulfinyl amide directed asymmetric [4 + 1] annulation of benzamides with acrylic esters has been developed. The reaction proceeded through an oxidative C-H olefination and a subsequent cyclization by intramolecular aza-Michael addition, producing a series of diastereoisomeric chiral isoindolinones (20 examples) in generally good yields with a dr value up to 5.5 : 1. The absolute configurations of the newly formed C-stereocenters in the major and minor diastereomers of the catalysis product have been determined by X-ray crystal diffraction analysis to be S and R, respectively. The separation of the major diastereoisomers from the catalysis products and subsequent removal of the N-sulfinyl chiral auxiliary afforded enantiomerically pure (S)-isoindolinones. The application of the obtained (S)-isoindolinones in the synthesis of several biologically active isoindolinones such as (S)-PD172938, (S)-pazinaclone and (S)-pagoclone is presented.

Recommanded Product: 1,4-Dioxa-8-azaspiro[4.5]decane. Welcome to talk about 177-11-7, If you have any questions, you can contact Li, XH; Gong, JF; Song, MP or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Name: 1,4-Dioxa-8-azaspiro[4.5]decane. In 2019 J ORG CHEM published article about BUCHWALD-HARTWIG AMINATION; C-N; ARYL CHLORIDES; REDUCTIVE AMINATION; ROOM-TEMPERATURE; AROMATIC AMINATION; ARYLATION; EFFICIENT; AMINES; MONOARYLATION in [Chen, Zicong; Chen, Xiangmeng; So, Chau Ming] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hung Hom, Kowloon, Hong Kong, Peoples R China; [So, Chau Ming] Hong Kong Polytech Univ, Shenzhen Res Inst, Shenzhen 518057, Peoples R China in 2019, Cited 81. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

The first general palladium-catalyzed amination of aryl phosphates is described. The combination of MorDalPhos with [Pd(pi-cinnamyl)Cl](2) enables the amination of electron-rich, electron-neutral, and electron-poor aryl phosphates with a board range of aromatic, aliphatic, and heterocyclic amines. Common functional groups such as ether, keto, ester, and nitrile show an excellent compatibility in this reaction condition. The solvent-free amination reactions are also successful in both solid coupling partners. The gram-scale cross-coupling is achieved by this catalytic system.

Name: 1,4-Dioxa-8-azaspiro[4.5]decane. Bye, fridends, I hope you can learn more about C7H13NO2, If you have any questions, you can browse other blog as well. See you lster.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Recommanded Product: 1,4-Dioxa-8-azaspiro[4.5]decane. In 2019 J AM CHEM SOC published article about C-H ARYLATION; TETRASUBSTITUTED HELICAL ALKENES; PALLADIUM-CATALYZED ANNULATION; REGIOSELECTIVE SYNTHESIS; FUNCTIONALIZATION; ACTIVATION; ROUTE; PD/NORBORNENE; AMIDATION in [Zhang, Bo-Sheng; Zhang, Zhe; An, Yang; Wen, Yu-Hua; Gou, Xue-Ya; Quan, Si-Qi; Wang, Xin-Gang; Liang, Yong-Min] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China; [Li, Yuke] Chinese Univ Hong Kong, Dept Chem, Shatin, Hong Kong, Peoples R China; [Li, Yuke] Chinese Univ Hong Kong, Ctr Sci Modeling & Computat, Shatin, Hong Kong, Peoples R China in 2019, Cited 83. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

Highly functionalized 4-aminoindoles were synthesized via the three-component cross-coupling of o-iodoaniline, N-benzoyloxyamines, and norbornadiene. The Catellani and retro-Diels-Alder strategy was used in this domino process. o-Iodoaniline, with electron-donating and sterically hindered protecting groups, made the reaction selective toward o-C-H amination. On the basis of density functional theory calculations, the intramolecular Buchwald coupling of this reaction underwent a dearomatization and a 1,3-palladium migration process. The reasons for the control of the chemical selectivity by the protecting groups are given. Moreover, synthetic applications toward 4-piperazinylindole and a GOT1 inhibitor were realized.

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Reference：
Piperidine – Wikipedia,
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An article Scalable electrochemical oxidant-and metal-free dehydrogenative coupling of S-H/N-H WOS:000457988200006 published article about C-H; OXIDATION; SULFENAMIDES; THIOLS; WATER; STRATEGIES; AMINES; ALKYL; BOND in [Tang, Shanyu; Li, Longjia; Ren, Xuanhe; Li, Jiao; Yang, Guanyu; Li, Heng; Yuan, Bingxin] Zhengzhou Univ, Dept Chem & Mol Engn, Zhengzhou 450001, Henan, Peoples R China; [Liu, Yan] Zhengzhou Univ, Sch Life Sci, Zhengzhou 450001, Henan, Peoples R China in 2019, Cited 44. SDS of cas: 177-11-7. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

A practical and scalable electrochemical oxidation of S-H and N-H was developed. This oxidant-and catalyst-free electrochemical process enables S-N bond formation with inexpensive nickel electrodes in an undivided cell. This procedure exhibits broad substrate scopes and good functional-group compatibility. A 50 g scale oxidative coupling augurs well for industrial applications.

SDS of cas: 177-11-7. Welcome to talk about 177-11-7, If you have any questions, you can contact Tang, SY; Liu, Y; Li, LJ; Ren, XH; Li, J; Yang, GY; Li, H; Yuan, BX or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem