Tag: M.W=100-150

Authors Zhang, YJ; Su, JY; Niu, WJ; Li, YJ in WILEY-V C H VERLAG GMBH published article about ALKENE DIAMINATION; ASYMMETRIC DIAMINATION; CATALYZED DIAMINATION; VICINAL DIAMINES; SECONDARY-AMINES; CHIRAL DIAMINES; REAGENTS; 1,2-DIAMINATION; PALLADIUM; DERIVATIVES in [Zhang, YongJian; Su, Junyi; Niu, Wenjie; Li, Yujin] Zhejiang Univ Technol, Dept Chem & Chem Engn, State Key Lab Breeding Base Green Chem Synth Tech, Hangzhou 310032, Zhejiang, Peoples R China in 2019, Cited 56. Name: 1,4-Dioxa-8-azaspiro[4.5]decane. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

Iodine-promoted direct diamination of ,-unsaturated ketone to form two C-N bonds has been developed starting from chalcone and secondary amine. This reaction was performed in THF at 50 degrees C in the presence of I-2 and K2CO3. The protocol is metal-free, operationally simple and carried out under mild conditions, providing an effective new way for directing diamination reactions.

Name: 1,4-Dioxa-8-azaspiro[4.5]decane. Bye, fridends, I hope you can learn more about C7H13NO2, If you have any questions, you can browse other blog as well. See you lster.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Copper-Catalyzed Coupling of Sulfonamides with Alkylamines: Synthesis of (E)-N-Sulfonylformamidines WOS:000516665800029 published article about ONE-POT SYNTHESIS; N-SULFONYLFORMAMIDINES; SULFONYL AMIDINES; TERTIARY-AMINES; METAL-FREE; INHIBITORS; DESIGN; ROUTE; INTERCEPTION; FORMAMIDINES in [Gou, Quan; Cao, Tuanwu; Tan, Xiaoping; Shi, Wenbing; Ran, Man] Yangtze Normal Univ, Chongqing, Peoples R China; [Liu, Zining; Cheng, Feixiang] Qujing Normal Univ, Qujing, Peoples R China; [Qn, Jun] Yunnan Univ, Kunming, Yunnan, Peoples R China in 2020, Cited 43. Category: piperidines. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

Herein, we describe an efficient copper-catalyzed coupling of sulfonamides with alkylamines to synthesize (E)-N-sulfonylformamidines. The reaction is accomplished under mild conditions without the use of a corrosive acid or base as an additive. It tolerates a broad scope of substrates and generates the products with exclusive (E)-stereoselectivity.

Category: piperidines. Bye, fridends, I hope you can learn more about C7H13NO2, If you have any questions, you can browse other blog as well. See you lster.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

SDS of cas: 177-11-7. Patil, DV; Si, T; Kim, HY; Oh, K in [Patil, Dilip, V; Si, Tengda; Oh, Kyungsoo] Chung Ang Univ, Ctr Metareceptome Res, Grad Sch Pharmaceut Sci, Seoul 06974, South Korea; [Kim, Hun Young] Chung Ang Univ, Dept Global Innovat Drugs, Seoul 06974, South Korea published Visible-Light-Induced Photoaddition of N-Nitrosoalkylamines to Alkenes: One-Pot Tandem Approach to 1,2-Diamination of Alkenes from Secondary Amines in 2021, Cited 46. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

The generation of aminium radical cation species from N-nitrosoamines is disclosed for the first time through visible-light excitation at 453 nm. The developed visible-light-promoted photoaddition reaction of N-nitrosoamines to alkenes was combined with the o-NQ-catalyzed aerobic oxidation protocol of amines to telescope the direct handling of harmful N-nitroso compounds, where the desired aamino oxime derivatives were obtained in a one-pot tandem Nnitrosation and photoaddition sequence.

SDS of cas: 177-11-7. Welcome to talk about 177-11-7, If you have any questions, you can contact Patil, DV; Si, T; Kim, HY; Oh, K or send Email.

Reference：
Piperidine – Wikipedia,
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I found the field of Pharmacology & Pharmacy very interesting. Saw the article Amide-Amine Replacement in Indole-2-carboxamides Yields Potent Mycobactericidal Agents with Improved Water Solubility published in 2021. Computed Properties of C7H13NO2, Reprint Addresses Lam, YL (corresponding author), Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore.; Go, ML (corresponding author), Natl Univ Singapore, Dept Pharm, Singapore 117543, Singapore.. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

Indolecarboxamides are potent but poorly soluble mycobactericidal agents. Here we found that modifying the incipient scaffold by amide-amine substitution and replacing the indole ring with benzothiophene or benzoselenophene led to striking (10-20-fold) improvements in solubility. Potent activity could be achieved without the carboxamide linker but not in the absence of the indole ring. The indolylmethylamine, N-cyclooctyl-6-trifluoromethylindol-2-ylmethylamine (33, MIC90Mtb , 0.13 mu M, MBC99.9Mtb, 0.63 mu M), exemplifies a promising member that is more soluble and equipotent to its carboxamide equivalent. It is also an inhibitor of the mycolate transporter MmpL3, a property shared by the methylamines of benzothiophene and benzoselenophene.

Welcome to talk about 177-11-7, If you have any questions, you can contact Tan, YJ; Li, M; Gunawan, GA; Nyantakyi, SA; Dick, T; Go, ML; Lam, YL or send Email.. Computed Properties of C7H13NO2

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Recently I am researching about POT FACILE SYNTHESIS; PEPTIDE-SYNTHESIS; HIGHLY EFFICIENT; AMIDE SYNTHESIS; CHEMISTRY; THIOACIDS; FUNCTIONALIZATION; PHOTOCATALYSIS; ALCOHOLS; ESTERS, Saw an article supported by the [ESS01/2018]. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Srivastava, V; Singh, PK; Singh, PP. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane. HPLC of Formula: C7H13NO2

A visible-light promoted photoredox catalysed, green one-pot approach for the amidation of carboxylic acids with amines has been developed for the synthesis of diverse aliphatic and aromatic amides. The proposed strategy is extendable also to biologically active amides and could represent a low-cost alternative to the common synthetic pathways. The developed strategy may hold great potential for a comprehensive display of biologically interesting peptide synthesis and amino acid modification. (C) 2018 Elsevier Ltd. All rights reserved.

HPLC of Formula: C7H13NO2. Welcome to talk about 177-11-7, If you have any questions, you can contact Srivastava, V; Singh, PK; Singh, PP or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Recently I am researching about POT FACILE SYNTHESIS; PEPTIDE-SYNTHESIS; HIGHLY EFFICIENT; AMIDE SYNTHESIS; CHEMISTRY; THIOACIDS; FUNCTIONALIZATION; PHOTOCATALYSIS; ALCOHOLS; ESTERS, Saw an article supported by the [ESS01/2018]. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Srivastava, V; Singh, PK; Singh, PP. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane. SDS of cas: 177-11-7

A visible-light promoted photoredox catalysed, green one-pot approach for the amidation of carboxylic acids with amines has been developed for the synthesis of diverse aliphatic and aromatic amides. The proposed strategy is extendable also to biologically active amides and could represent a low-cost alternative to the common synthetic pathways. The developed strategy may hold great potential for a comprehensive display of biologically interesting peptide synthesis and amino acid modification. (C) 2018 Elsevier Ltd. All rights reserved.

SDS of cas: 177-11-7. Bye, fridends, I hope you can learn more about C7H13NO2, If you have any questions, you can browse other blog as well. See you lster.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Safety of 1,4-Dioxa-8-azaspiro[4.5]decane. In 2019 CHEM-ASIAN J published article about ALKENE DIAMINATION; ASYMMETRIC DIAMINATION; CATALYZED DIAMINATION; VICINAL DIAMINES; SECONDARY-AMINES; CHIRAL DIAMINES; REAGENTS; 1,2-DIAMINATION; PALLADIUM; DERIVATIVES in [Zhang, YongJian; Su, Junyi; Niu, Wenjie; Li, Yujin] Zhejiang Univ Technol, Dept Chem & Chem Engn, State Key Lab Breeding Base Green Chem Synth Tech, Hangzhou 310032, Zhejiang, Peoples R China in 2019, Cited 56. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

Iodine-promoted direct diamination of ,-unsaturated ketone to form two C-N bonds has been developed starting from chalcone and secondary amine. This reaction was performed in THF at 50 degrees C in the presence of I-2 and K2CO3. The protocol is metal-free, operationally simple and carried out under mild conditions, providing an effective new way for directing diamination reactions.

Welcome to talk about 177-11-7, If you have any questions, you can contact Zhang, YJ; Su, JY; Niu, WJ; Li, YJ or send Email.. Safety of 1,4-Dioxa-8-azaspiro[4.5]decane

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

HPLC of Formula: C7H13NO2. In 2019 J AM CHEM SOC published article about ALLYLATION; LIGANDS; HYDROGENATION; REDUCTION; COMPLEXES; ENANTIO in [Ghorai, Samir; Chirke, Sahadev Shrihari; Xu, Wen-Bin; Chen, Jia-Feng; Li, Changkun] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai Key Lab Mol Engn Chiral Drugs, 800 Dongchuan Rd, Shanghai 200240, Peoples R China; [Li, Changkun] Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China in 2019, Cited 45. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

The first earth-abundant cobalt-catalyzed highly branched- and enantioselective allylic amination of racemic branched allylic carbonates bearing alkyl groups with both aromatic and aliphatic amines has been developed. The process allows rapid access of allylic amines in high yields with exclusively branched selectivity and excellent enantioselectivities (normally 99% ee) under mild reaction conditions.

HPLC of Formula: C7H13NO2. Welcome to talk about 177-11-7, If you have any questions, you can contact Ghorai, S; Chirke, SS; Xu, WB; Chen, JF; Li, CK or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article SuFEx Activation with Ca(NTf2)(2) : A Unified Strategy to Access Sulfamides, Sulfamates, and Sulfonamides from S(VI) Fluorides WOS:000538848600065 published article about SULFONYL FLUORIDES; CLICK CHEMISTRY; TOSYLATES; CHLORIDES; REAGENT in [Woroch, Cristian P.; Carneiro, Sabrina N.; Kwan, Sabrina C.; Khasnavis, Samuel R.; Gu, Junha; Ball, Nicholas D.] Pomona Coll, Dept Chem, Claremont, CA 91711 USA; [Mahapatra, Subham; Butler, Todd W.; Dutra, Jason K.; Vetelino, Beth C.; Bellenger, Justin; Ende, Christopher W. am] Pfizer Worldwide Res & Dev, Groton, CT 06340 USA in 2020, Cited 35. HPLC of Formula: C7H13NO2. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

A method to activate sulfamoyl fluorides, fluorosulfates, and sulfonyl fluorides with calcium triflimide and DABCO for SuFEx with amines is described. The reaction was applied to a diverse set of sulfamides, sulfamates, and sulfonamides at room temperature under mild conditions. Additionally, we highlight this transformation to parallel medicinal chemistry to generate a broad array of nitrogen-based S(VI) compounds.

HPLC of Formula: C7H13NO2. Welcome to talk about 177-11-7, If you have any questions, you can contact Mahapatra, S; Woroch, CP; Butler, TW; Carneiro, SN; Kwan, SC; Khasnavis, SR; Gu, J; Dutra, JK; Vetelino, BC; Bellenger, J; Ende, CWA; Ball, ND or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Quality Control of 1,4-Dioxa-8-azaspiro[4.5]decane. In 2019 MEDCHEMCOMM published article about NF-KAPPA-B; WATER-SOLUBLE PARTHENOLIDE; SESQUITERPENE LACTONE; IN-VITRO; AMINO-DERIVATIVES; BIOLOGICAL EVALUATION; ANTICANCER AGENTS; CRYSTAL-STRUCTURE; CANCER CELLS; FEVERFEW in [Li, Xingjian; Payne, Daniel T.; Dutton, Mark J.; Quy, Alex S.; Fossey, John S.] Univ Birmingham, Sch Chem, Birmingham B15 2TT, W Midlands, England; [Ampolu, Badarinath; Bland, Nicholas; Brown, Jane T.; Hamza, Daniel; Jones, Geraint; Lane, Rebecca; Merisor, Elena G.; Schulz-Utermoehl, Timothy; Stevenson, Brett] BioCity, Sygnat Discovery, Discovery Bldg,Pennyfoot St, Nottingham NG1 1GR, England; [Fitton, Catherine A.; Scarll, Rosanna; Stankovic, Tatjana; Agathanggelou, Angelo] Univ Birmingham, Inst Canc & Genom Sci, Birmingham B15 2TT, W Midlands, England; [Gulliver, Abigail; Hale, Lee] Univ Birmingham, Winterbourne Bot Garden, 58 Edgbaston Pk Rd, Birmingham B15 2RT, W Midlands, England; [Leach, Andrew G.] Liverpool John Moores Univ, Sch Pharm & Biomol Sci, Byrom St, Liverpool L3 3AF, Merseyside, England; [Male, Louise] Univ Birmingham, Sch Chem, Xray Crystallog Facil, Birmingham B15 2TT, W Midlands, England; [Morton, Michael J.; Roberts, Ruth] ApconiX Ltd, Alderly Pk, Nether Alderly SK10 4TG, Cheshire, England; [Roberts, Ruth] Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England in 2019, Cited 143. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

Parthenolide is a natural product that exhibits anti-leukaemic activity, however, its clinical use is limited by its poor bioavailability. It may be extracted from feverfew and protocols for growing, extracting and derivatising it are reported. A novel parthenolide derivative with good bioavailability and pharmacological properties was identified through a screening cascade based on in vitro anti-leukaemic activity and calculated drug-likeness properties, in vitro and in vivo pharmacokinetics studies and hERG liability testing. In vitro studies showed the most promising derivative to have comparable anti-leukaemic activity to DMAPT, a previously described parthenolide derivative. The newly identified compound was shown to have pro-oxidant activity and in silico molecular docking studies indicate a prodrug mode of action. A synthesis scheme is presented for the production of amine 7 used in the generation of 5f.

Welcome to talk about 177-11-7, If you have any questions, you can contact Li, XJ; Payne, DT; Ampolu, B; Bland, N; Brown, JT; Dutton, MJ; Fitton, CA; Gulliver, A; Hale, L; Hamza, D; Jones, G; Lane, R; Leach, AG; Male, L; Merisor, EG; Morton, MJ; Quy, AS; Roberts, R; Scarll, R; Schulz-Utermoehl, T; Stankovic, T; Stevenson, B; Fossey, JS; Agathanggelou, A or send Email.. Quality Control of 1,4-Dioxa-8-azaspiro[4.5]decane

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem