Tag: M.W=100-150

HPLC of Formula: C7H13NO2. In 2021 ACS MED CHEM LETT published article about BIOLOGICAL EVALUATION; MMPL3; INHIBITION in [Tan, Yu Jia; Gunawan, Gregory Adrian; Lam, Yulin] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore; [Li, Ming; Nyantakyi, Samuel Agyei; Go, Mei-Lin] Natl Univ Singapore, Dept Pharm, Singapore 117543, Singapore; [Dick, Thomas] Hackensack Meridian Hlth, Ctr Discovery & Innovat, Hackensack Meridian Sch Med, Nutley, NJ 07110 USA; [Dick, Thomas] Georgetown Univ, Dept Microbiol & Immunol, Washington, DC 20057 USA in 2021, Cited 19. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

Indolecarboxamides are potent but poorly soluble mycobactericidal agents. Here we found that modifying the incipient scaffold by amide-amine substitution and replacing the indole ring with benzothiophene or benzoselenophene led to striking (10-20-fold) improvements in solubility. Potent activity could be achieved without the carboxamide linker but not in the absence of the indole ring. The indolylmethylamine, N-cyclooctyl-6-trifluoromethylindol-2-ylmethylamine (33, MIC90Mtb , 0.13 mu M, MBC99.9Mtb, 0.63 mu M), exemplifies a promising member that is more soluble and equipotent to its carboxamide equivalent. It is also an inhibitor of the mycolate transporter MmpL3, a property shared by the methylamines of benzothiophene and benzoselenophene.

HPLC of Formula: C7H13NO2. Bye, fridends, I hope you can learn more about C7H13NO2, If you have any questions, you can browse other blog as well. See you lster.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

In 2019 ORG LETT published article about NUCLEOPHILIC TRIFLUOROMETHYLATION; ELECTROPHILIC AMINATION; TRANSFER HYDROGENATION; DIORGANOZINC REAGENTS; IMINES; AMINES; FLUORINE; ALKENES; ACCESS; ARYL in [Takata, Tatsuaki; Hirano, Koji; Miura, Masahiro] Osaka Univ, Grad Sch Engn, Dept Appl Chem, Suita, Osaka 5650871, Japan in 2019, Cited 81. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. Category: piperidines

A copper-catalyzed regioselective net hydroamination of 1-trifluoromethylalkenes with hydrosilanes and hydroxylamines has been developed. The judicious choice of ligand and additive suppresses the conceivable but undesired beta-F elimination of an alpha-CF3-substituted organocopper intermediate, leading to targeted alpha-trifluoromethylamines in good yields with excellent regioselectivity. Additionally, with an appropriate chiral bisphosphine ligand, the enantioselective reaction is also possible to deliver optically active alpha-trifluoromethylamines of high potential in medicinal and pharmaceutical chemistry.

Category: piperidines. Welcome to talk about 177-11-7, If you have any questions, you can contact Takata, T; Hirano, K; Miura, M or send Email.

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Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Copper- and Cobalt-Catalyzed Syntheses of Thiophene-Based Tertiary Amines WOS:000472974000024 published article about C-H AMINATION; CROSS-COUPLING REACTIONS; N-ARYLATION SEQUENCE; CENTER-DOT-LICL; ELECTROPHILIC AMINATION; DEPROTOMETALATION-IODINATION; ANTIPROLIFERATIVE ACTIVITY; DEPROTONATIVE METALATION; BOND FUNCTIONALIZATION; HETEROCYCLIC AMINES in [Bouarfa, Salima; Langlais, Timothy; Lassagne, Frederic; Erb, William; Roisnel, Thierry; Dorcet, Vincent; Mongin, Florence] Univ Rennes, CNRS, ISCR, UMR 6226, F-35000 Rennes, France; [Bouarfa, Salima; Bentabed-Ababsa, Ghenia] Univ Oran1 Ahmed Ben Bella, Fac Sci Exactes & Appl, Lab Synth Organ Appl, BP 1524 El MNaouer, Oran 31000, Algeria; [Grassl, Simon; Ivanova, Maria; Langlais, Timothy; Knochel, Paul] Ludwig Maximilians Univ Munchen, Dept Chem, Butenandtstr 5-13,Haus F, D-81377 Munich, Germany in 2019, Cited 105. COA of Formula: C7H13NO2. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

Thienylzinc halides and related compounds prepared by deprotonation followed by transmetalation were used in copper-catalyzed amination using N-benzoyloxy secondary amines. By extending the reaction to 1,5-naphthyridine, it was showed that the competitive dimer formation observed in the case of thiophenes was linked with the low stability of some thienylamines rather than homocoupling. Interestingly, thienylzinc halides and related compounds prepared by transmetalation of thienylmagnesium halides, either prepared from their bromo-precursors or generated by deprotometalation, were satisfactorily employed in cobalt-catalyzed aminations. Finally, aminothiophenes were involved in copper-catalyzed mono- and di-N-arylations, affording differently substituted di- and triphenylamines.

COA of Formula: C7H13NO2. Bye, fridends, I hope you can learn more about C7H13NO2, If you have any questions, you can browse other blog as well. See you lster.

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Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

I found the field of Chemistry very interesting. Saw the article Synthesis of C4-Aminated Indoles via a Catellani and Retro-Diels-Alder Strategy published in 2019. Formula: C7H13NO2, Reprint Addresses Liang, YM (corresponding author), Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China.. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

Highly functionalized 4-aminoindoles were synthesized via the three-component cross-coupling of o-iodoaniline, N-benzoyloxyamines, and norbornadiene. The Catellani and retro-Diels-Alder strategy was used in this domino process. o-Iodoaniline, with electron-donating and sterically hindered protecting groups, made the reaction selective toward o-C-H amination. On the basis of density functional theory calculations, the intramolecular Buchwald coupling of this reaction underwent a dearomatization and a 1,3-palladium migration process. The reasons for the control of the chemical selectivity by the protecting groups are given. Moreover, synthetic applications toward 4-piperazinylindole and a GOT1 inhibitor were realized.

Bye, fridends, I hope you can learn more about C7H13NO2, If you have any questions, you can browse other blog as well. See you lster.. Formula: C7H13NO2

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Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Authors Kopruluoglu, C; Dejmek, M; Sala, M; Ajani, H; Hrebabecky, H; Fanfrlik, J; Jorda, R; Dracinsky, M; Prochazkova, E; Sacha, P; Krystof, V; Hobza, P; Lepsik, M; Nencka, R in WILEY published article about SCORING FUNCTION; SMALL MOLECULES; ROSCOVITINE; POTENT; IDENTIFICATION; SITE in [Kopruluoglu, Cemal; Dejmek, Milan; Sala, Michal; Ajani, Haresh; Hrebabecky, Hubert; Fanfrlik, Jindrich; Dracinsky, Martin; Prochazkova, Eliska; Sacha, Pavel; Hobza, Pavel; Lepsik, Martin; Nencka, Radim] Czech Acad Sci, Inst Organ Chem & Biochem, Flemingovo Nam 2, Prague 16610 6, Czech Republic; [Kopruluoglu, Cemal; Ajani, Haresh; Hobza, Pavel] Palacky Univ, Reg Ctr Adv Technol & Mat, Dept Phys Chem, Olomouc, Czech Republic; [Jorda, Radek; Krystof, Vladimir] Palacky Univ, Fac Sci, Lab Growth Regulators, Olomouc, Czech Republic; [Jorda, Radek; Krystof, Vladimir] Czech Acad Sci, Inst Expt Bot, Olomouc, Czech Republic in 2020, Cited 45. SDS of cas: 177-11-7. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

We report on the discovery of norbornyl moiety as a novel structural motif for cyclin-dependent kinase 2 (CDK2) inhibitors which was identified by screening a carbocyclic nucleoside analogue library. Three micromolar hits were expanded by the use of medicinal chemistry methods into a series of 16 novel compounds. They had prevailingly micromolar activities against CDK2 and the best compound of the series attained IC(50)of 190 nM. The binding modes were explored in molecular details by modeling and docking. Quantum mechanics-based scoring was used to rationalize the affinities. In conclusion, the discovered 9-hydroxymethylnorbornyl moiety was shown by joint experimental-theoretical efforts to be able to serve as a novel substituent for CDK2 inhibitors. This finding opens door to the exploration of chemical space towards more effective derivatives targeting this important class of protein kinases.

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Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

SDS of cas: 177-11-7. Wu, P; Huang, W; Cheng, TJ; Lin, HX; Xu, H; Dai, HX in [Cheng, Tai-Jin; Xu, Hui; Dai, Hui-Xiong] Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China; [Dai, Hui-Xiong] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China; [Cheng, Tai-Jin; Dai, Hui-Xiong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Wu, Peng; Lin, Hai-Xia] Shanghai Univ, Innovat Drug Res Ctr, Dept Chem, Shanghai 200444, Peoples R China; [Huang, Wei] Nanchang Univ, Sch Pharm, Nanchang 330006, Jiangxi, Peoples R China published Copper-Catalyzed Oxalamide-Directed ortho-C-H Amination of Anilines with Alkylamines in 2020, Cited 56. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

A copper-catalyzed oxalamide-directed ortho-C-H amination of anilines has been developed by using 1 atm of air as the sole oxidant. The protocol shows excellent functional group tolerance, and some heterocyclic amines including indole, benzothiophene, benzothiazole, quinoline, isoquinoline, and quinoxaline could be compatible in the reaction. The late-stage diversification of medicinal drugs demonstrates the synthetic utility of this protocol.

Bye, fridends, I hope you can learn more about C7H13NO2, If you have any questions, you can browse other blog as well. See you lster.. SDS of cas: 177-11-7

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Authors An, Y; Zhang, BS; Zhang, Z; Liu, C; Gou, XY; Ding, YN; Liang, YM in ROYAL SOC CHEMISTRY published article about INTRAMOLECULAR ALKANE ARYLATION; C-H FUNCTIONALIZATION; PHENANTHRIDINE DERIVATIVES; OXIDATIVE CYCLIZATION; ARYL IODIDES; METAL-FREE; BOND; CONSTITUENTS; ALKALOIDS; AMINATION in [An, Yang; Zhang, Bo-Sheng; Zhang, Zhe; Liu, Ce; Gou, Xue-Ya; Ding, Ya-Nan; Liang, Yong-Min] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China in 2020, Cited 69. Recommanded Product: 1,4-Dioxa-8-azaspiro[4.5]decane. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

This report describes a carboxylate-assisted palladium-catalysed Catellani reaction, which is compatible with ortho-amination and unactivated C(sp(2))-H arylation. This method was used to synthesize a series of 1-amino substituted dihydrophenanthridines, phenanthridines and 6H-benzo[c]chromenes. Based on kinetic isotope experiments, the kinetic curve proves that pivalic acid accelerates the reaction rate of unactivated C(sp(2))-H activation, and thus this rate can keep up with the five membered aryl-norbornene-palladacycle (ANP) intermediate.

Recommanded Product: 1,4-Dioxa-8-azaspiro[4.5]decane. Welcome to talk about 177-11-7, If you have any questions, you can contact An, Y; Zhang, BS; Zhang, Z; Liu, C; Gou, XY; Ding, YN; Liang, YM or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Copper-Catalyzed Oxalamide-Directed ortho-C-H Amination of Anilines with Alkylamines WOS:000547468700027 published article about BINAPHTHOL DERIVATIVES; C(SP(3))-H BONDS; ARENES; HYDROXYLATION; C(SP(2))-H; FUNCTIONALIZATION; MECHANISM; MILD in [Cheng, Tai-Jin; Xu, Hui; Dai, Hui-Xiong] Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China; [Dai, Hui-Xiong] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China; [Cheng, Tai-Jin; Dai, Hui-Xiong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Wu, Peng; Lin, Hai-Xia] Shanghai Univ, Innovat Drug Res Ctr, Dept Chem, Shanghai 200444, Peoples R China; [Huang, Wei] Nanchang Univ, Sch Pharm, Nanchang 330006, Jiangxi, Peoples R China in 2020, Cited 56. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. Formula: C7H13NO2

A copper-catalyzed oxalamide-directed ortho-C-H amination of anilines has been developed by using 1 atm of air as the sole oxidant. The protocol shows excellent functional group tolerance, and some heterocyclic amines including indole, benzothiophene, benzothiazole, quinoline, isoquinoline, and quinoxaline could be compatible in the reaction. The late-stage diversification of medicinal drugs demonstrates the synthetic utility of this protocol.

Welcome to talk about 177-11-7, If you have any questions, you can contact Wu, P; Huang, W; Cheng, TJ; Lin, HX; Xu, H; Dai, HX or send Email.. Formula: C7H13NO2

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Category: piperidines. Recently I am researching about PHOSPHORUS-NITROGEN COMPOUNDS; DNA INTERACTIONS; STEREOGENIC PROPERTIES; BIOLOGICAL-ACTIVITIES; CYTOTOXIC ACTIVITIES; ELECTROCHEMICAL INVESTIGATIONS; ANTIMICROBIAL ACTIVITIES; CRYSTAL-STRUCTURES; ANTITUBERCULOSIS; MONO, Saw an article supported by the . Published in TAYLOR & FRANCIS LTD in ABINGDON ,Authors: Elmas, G. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

The Cl exchange reaction of hexachlorocyclotriphosphazene, N3P3Cl6 (1), with one equimolar amount of sodium salt of N/O donor type bidentate ligand containing a 2-pyridyl pendant arm (2) afforded, regioselectively, the partly substituted 2-pyridyl(N/O)spirocyclotriphosphazene (3; with a yield of 65%) in THF. The reactions of 3 with excess pyrrolidine, morpholine and 1,4-dioxa-8-azaspiro[4,5]decane (DASD) led to the formation of the tetraamino-2-pyridyl(N/O)spirocyclotriphosphazenes (3a-3c) in high yields. Compound 3 also gave both tetrapiperidino (3d) and gem-bispiperidino (3e) products with excess piperidine. The structures of all the compounds were determined by elemental analyses, ESI-MS, FTIR, HSQC, HMBC and H-1, C-13, and P-31 NMR techniques. The crystal structure of 3c was identified by single crystal X-ray crystallography. Besides, the compound 3e had one stereogenic P atom, and its chirality was verified by P-31 NMR spectroscopy in the presence of (S)-(+)-2,2,2-trifluoro-1-(9′-anthryl)-ethanol (CSA).

Category: piperidines. Bye, fridends, I hope you can learn more about C7H13NO2, If you have any questions, you can browse other blog as well. See you lster.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

I found the field of Chemistry very interesting. Saw the article Visible light photoredox catalysed amidation of carboxylic acids with amines published in 2019. SDS of cas: 177-11-7, Reprint Addresses Singh, PP (corresponding author), United Coll Engn & Res, Dept Chem, Allahabad 211010, Uttar Pradesh, India.. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

A visible-light promoted photoredox catalysed, green one-pot approach for the amidation of carboxylic acids with amines has been developed for the synthesis of diverse aliphatic and aromatic amides. The proposed strategy is extendable also to biologically active amides and could represent a low-cost alternative to the common synthetic pathways. The developed strategy may hold great potential for a comprehensive display of biologically interesting peptide synthesis and amino acid modification. (C) 2018 Elsevier Ltd. All rights reserved.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem