Tag: M.W=100-150

Sidky, M. M. published the artcileOrganophosphorous compounds. XVII. Synthesis and isomerization of some basic phosphorothioate esters, Name: 1-Ethylpiperidin-3-ol, the publication is Egyptian Journal of Chemistry (1974), 43-52, database is CAplus.

Transesterification of (RO)3P (R = Me, Et, Me2CH) with R1OH (R1 = N-methyl- and N-ethyl-3- and -4-piperidinyl, R2CH2CH2; R2 = Me2N, Et2N, 4-methylpiperazino) at 170-80° in the presence of metallic Na gave (RO)2POR1 (I) in 83-95% yield; I [R = Et; R1 = 2-(4-methylpiperazino)ethyl, N-ethyl-3- and -4-piperidinyl] were treated with excess elemental S at -10° to give ∼90% (RO)2P(S)OR1, which isomerized to (RO)2P(O)SR1 in 50-90% yield at 80-100°.

Egyptian Journal of Chemistry published new progress about 13444-24-1. 13444-24-1 belongs to piperidines, auxiliary class Piperidine,Alcohol, name is 1-Ethylpiperidin-3-ol, and the molecular formula is C3H6O2, Name: 1-Ethylpiperidin-3-ol.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Sidky, M. M. published the artcileOrganophosphorus compounds. XVII. Synthesis and isomerization of some basic phosphorothioate esters, Related Products of piperidines, the publication is Egyptian Journal of Chemistry (1973), 43-52, database is CAplus.

Phosphites (RO)2POR1 (R = Me, Et, CHMe2; R1 = CH2CH2NMe2, CH2CH2NEt2, 1-methyl-4-piperidyl, 1-ethyl-4-piperidyl, 1-methyl-3-piperidyl, 1-ethyl-3-piperidyl, 4-methyl-piperazinoethyl) were prepared in 83-95% yield by treating (RO)3P with R1OH. (EtO)2P(S)OR1 (R1 = 4-methylpiperazinoethyl, CH2CH2NEt2, 1-ethyl-3-piperidyl, 1-ethyl-4-piperidyl) were obtained by treating (EtO)2POR1 with S and isomerized to (EtO)2P(O)SR1 on heating.

Egyptian Journal of Chemistry published new progress about 13444-24-1. 13444-24-1 belongs to piperidines, auxiliary class Piperidine,Alcohol, name is 1-Ethylpiperidin-3-ol, and the molecular formula is C6H6INO, Related Products of piperidines.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Smetanin, Ilia A. published the artcileStereoselective assembly of 3,4-epoxypyrrolines via nucleophilic addition induced domino cyclization of 6-halo-1-oxa-4-azahexatrienes, HPLC of Formula: 39546-32-2, the publication is Organic Chemistry Frontiers (2020), 7(3), 525-530, database is CAplus.

A two-step method for the preparation of 3,4-epoxypyrroline derivatives (6-oxa-3-azabicyclo[3.1.0]hex-2-enes) from 2-halo-2H-azirine-2-carboxylates, diazo keto esters and amines was developed. 6-Halo-1-oxa-4-azahexa-1,3,5-trienes, prepared in the first step from the azirines and diazo compounds under Rh(II) catalysis were subjected to nucleophile-induced tandem cyclization to afford highly functionalized rac-(1R,4R,5S)-6-oxa-3-azabicyclo[3.1.0]hex-2-enes in good yields. The stereochem. outcome of the tandem cyclization induced by the secondary amines was rationalized in terms of the structural rigidity of the betaine-type precursor due to the hydrogen bonding between the ammonium group and ester group adjacent to the halogen atom. Post-modification of the 3,4-epoxypyrrolines by the Stille cross-coupling, reduction, and UV-irradiation was also demonstrated.

Organic Chemistry Frontiers published new progress about 39546-32-2. 39546-32-2 belongs to piperidines, auxiliary class Piperidine,Amine,Amide, name is Piperidine-4-carboxamide, and the molecular formula is C14H10O4, HPLC of Formula: 39546-32-2.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Rauf, Azra published the artcileSynthesis and pharmacological evaluation of novel benzoyl derivatives of piperidine-4-carboxamide, Related Products of piperidines, the publication is International Journal of Research in Pharmacy and Chemistry (2014), 4(3), 509-516, database is CAplus.

Synthesis and pharmacol. evaluation of two novel derivatives of piperidine-4-carboxamide, I (R¹,R³,R⁵ = H; R²,R³,R⁴ = MeO; R²,R⁴ = O₂N) were reported. They were synthesized by condensing the parent mol. with substituted benzoyl chlorides. The products were then assessed on different pharmacol. parameters such as analgesic, antimicrobial, antioxidant, and anxiolytic activities. It was observed that compound I (R¹,R⁵ = H; R²,R³,R⁴ = MeO) displayed good analgesic profile. Both compounds possessed least to moderate antibacterial effects against tested strains of gram pos. and gram neg. bacteria. Compound I (R¹,R³,R⁵ = H, R²,R⁴ = O₂N) expressed moderate antifungal activity against some filamentous fungi and yeast while compound I (R¹,R⁵ = H; R²,R³,R⁴ = MeO) possessed least activity for fungi only. Both compounds were inactive as antioxidants and also failed to produce remarkable change in behavior at the dose 50 mg/Kg body weight SAR was also established.

International Journal of Research in Pharmacy and Chemistry published new progress about 39546-32-2. 39546-32-2 belongs to piperidines, auxiliary class Piperidine,Amine,Amide, name is Piperidine-4-carboxamide, and the molecular formula is C6H12N2O, Related Products of piperidines.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Zafar, Shaista published the artcileSynthesis, characterization and antimicrobial activity of piperidine derivatives, Recommanded Product: Piperidine-4-carboxamide, the publication is Journal of the Chemical Society of Pakistan (2019), 41(2), 363-367, database is CAplus.

Synthesis of various piperidine derivatives having important biol. and pharmacol. potentials has been discussed in the past. In present study we reported the synthesis of benzoyl and sulfonyl derivatives by taking Piperidine-4-carboxamide as principal mol. These compounds were characterized by various spectroscopic techniques such as NMR, FTIR and Mass spectrometry. Elemental composition was explored using CHN analyzer. Antimicrobial activity study of the synthesized compounds was performed using disk diffusion method. Dissociation constant (pKa) of the synthesized compounds were determined by potentiometric titration method. In addition The findings of the study predicted good absorption of these newly synthesized compounds Besides, compound III showed good antifungal activity which can be helpful in pharmacokinetics and pharmacodynamics approaches of antibiotics.

Journal of the Chemical Society of Pakistan published new progress about 39546-32-2. 39546-32-2 belongs to piperidines, auxiliary class Piperidine,Amine,Amide, name is Piperidine-4-carboxamide, and the molecular formula is C8H11NO, Recommanded Product: Piperidine-4-carboxamide.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Hammer, C. F. published the artcileReactions of β-substituted amines. III. Complete product study of the reactions of 3-chloro-1-ethylpiperidine and 2-(chloromethyl)-1-ethylpyrrolidine with hydroxide ion, Application of 1-Ethylpiperidin-3-ol, the publication is Tetrahedron (1973), 29(13), 1767-72, database is CAplus.

3-Chloro-1-ethylpiperidine (I) in 10% NaOH gave 1-ethyl-2-(hydroxymethyl)pyrrolidine 22, 1-ethyl-3-hydroxypiperidine 42, 2,2′-bis(N-ethyl-2-pyrrolidinomethyl) ether 16, 3-(N-ethyl-2-pyrrolidinylmethoxy)-N-ethylpiperidine 16, and 3,3′-bis(N-ethyl-3-piperidinyl) ether 2%. The products were separated by gas liquid chromatog. The MeOH solvate of 2-(chloromethyl)-1-ethylpyrrolidine hydrochloride in 25% NaOH gave the same products and 1-ethyl-2-(methoxymethyl)pyrrolidine and 1-ethyl-3-methoxypiperidine. The reaction of I with EtO- was also examined

Tetrahedron published new progress about 13444-24-1. 13444-24-1 belongs to piperidines, auxiliary class Piperidine,Alcohol, name is 1-Ethylpiperidin-3-ol, and the molecular formula is C7H15NO, Application of 1-Ethylpiperidin-3-ol.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Rizwan, Muhammad published the artcileSynthesis, characterization, HOMO-LUMO study, and antimicrobial activity of organotin(IV) complexes of 4-piperidine carboxamide and its Schiff base, HPLC of Formula: 39546-32-2, the publication is Journal of Coordination Chemistry (2014), 67(2), 341-351, database is CAplus.

A series of organotin(IV) complexes has been synthesized by reacting 4-piperidine carboxamide with CS₂ and R₂SnCl₂/R₃SnCl in 1 : 1 M/L ratio at room temperature The synthesized complexes were further treated with benzaldehyde to synthesize Schiff bases under stirring. All the complexes were characterized by elemental anal., FT-IR, ¹H and ¹³C NMR. FT-IR and semi-empirical study confirm the bidentate nature of ligand. The complexes exhibit four-coordinate geometry in solution Thermodn. parameters and mol. descriptors were calculated by using semi-empirical PM3 method. HOMO-LUMO calculations show that chlorodiorganotin complexes are more susceptible to nucleophilic attack when compared with triorganotin complexes. Neg. heats of formation at 298 K demonstrate that , and are thermodynamically stable. The antimicrobial results have shown that complexes containing Schiff base exhibit significantly better activity compared to complexes with carboxamide derivatives

Journal of Coordination Chemistry published new progress about 39546-32-2. 39546-32-2 belongs to piperidines, auxiliary class Piperidine,Amine,Amide, name is Piperidine-4-carboxamide, and the molecular formula is C6H12N2O, HPLC of Formula: 39546-32-2.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Johnson, Henry W. B. published the artcileDiscovery of Highly Selective Inhibitors of the Immunoproteasome Low Molecular Mass Polypeptide 2 (LMP2) Subunit, HPLC of Formula: 72002-30-3, the publication is ACS Medicinal Chemistry Letters (2017), 8(4), 413-417, database is CAplus and MEDLINE.

Building upon the success of bortezomib (VELCADE) and carfilzomib (KYPROLIS), the design of a next generation of inhibitors targeting specific subunits within the immunoproteasome is of interest for the treatment of autoimmune disease. There are three catalytic subunits within the immunoproteasome (low mol. mass polypeptide-7, -2, and multicatalytic endopeptidase complex subunit-1; LMP7, LMP2, and MECL-1), and a campaign was undertaken to design a potent and selective LMP2 inhibitor with sufficient properties to allow for sustained inhibition in vivo. Screening a focused library of epoxyketones revealed a series of potent dipeptides that were optimized to provide the highly selective inhibitor KZR-504 (12).

ACS Medicinal Chemistry Letters published new progress about 72002-30-3. 72002-30-3 belongs to piperidines, auxiliary class Piperidine,Chiral,Carboxylic acid,Amide, name is (R)-6-Oxopiperidine-2-carboxylic acid, and the molecular formula is C6H9NO3, HPLC of Formula: 72002-30-3.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Fries, David S. published the artcileSynthesis and preliminary pharmacological activity of aminoalkoxy isosteres of glycolate ester anticholinergics, SDS of cas: 13444-24-1, the publication is Journal of Medicinal Chemistry (1977), 20(10), 1250-4, database is CAplus and MEDLINE.

Five 2-[(dialkylamino)alkoxy]-1,1-diphenylethanols and 5 2-(N-heterocycleoxy)-1,1-diphenylethanols were prepared by the reaction of 2,2-diphenyloxirane [882-59-7] with the alkoxide form of the appropriate amino alc. Most of the compounds had moderate anticholinergic activity when tested on the isolated rat jejunum or for inhibition of perphenazine-induced catatonia in rats. The most active compounds were I [63624-24-8], II [63624-25-9], and III [63624-26-0]. Structure-activity relations are discussed.

Journal of Medicinal Chemistry published new progress about 13444-24-1. 13444-24-1 belongs to piperidines, auxiliary class Piperidine,Alcohol, name is 1-Ethylpiperidin-3-ol, and the molecular formula is C7H15NO, SDS of cas: 13444-24-1.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Vettorazzi, Marcela published the artcileAn integrative study to identify novel scaffolds for sphingosine kinase 1 inhibitors, Quality Control of 39546-32-2, the publication is European Journal of Medicinal Chemistry (2017), 461-481, database is CAplus and MEDLINE.

Sphingosine kinase 1 (SphK1), the enzyme that produces the bioactive sphingolipid metabolite, sphingosine-1-phosphate, is a promising new mol. target for therapeutic intervention in cancer and inflammatory diseases. In view of its importance, the main objective of this work was to find new and more potent inhibitors for this enzyme possessing different structural scaffolds than those of the known inhibitors. The authors’ theor. and exptl. study has allowed the authors to identify two new structural scaffolds (three new compounds), which could be used as starting structures for the design and then the development of new inhibitors of SphK1. The authors’ study was carried out in different steps: virtual screening, synthesis, bioassays and mol. modeling. From the results, the authors propose a new dihydrobenzo[b]pyrimido[5,4-f]azepine and two alkyl{3-/4-[1-hydroxy-2-(4-arylpiperazin-1-yl)ethyl]phenyl}carbamates as initial structures for the development of new inhibitors. In addition, the authors’ mol. modeling study using QTAIM calculations, allowed the authors to describe in detail the mol. interactions that stabilize the different Ligand-Receptor complexes. Such analyses indicate that the cationic head of the different compounds must be refined to obtain an increase in the binding affinity of these ligands.

European Journal of Medicinal Chemistry published new progress about 39546-32-2. 39546-32-2 belongs to piperidines, auxiliary class Piperidine,Amine,Amide, name is Piperidine-4-carboxamide, and the molecular formula is C8H11NO, Quality Control of 39546-32-2.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem