Tag: M.W=100-150

An article Rhodium-Catalyzed Asymmetric Hydroamination of Allyl Amines WOS:000456350300004 published article about ANTI-MARKOVNIKOV HYDROAMINATION; INTERMOLECULAR HYDROAMINATION; ALKENES; DISCOVERY; ALDEHYDES in [Vanable, Evan P.; Kennemur, Jennifer L.; Hull, Kami L.] Univ Illinois, Dept Chem, 600 S Mathews, Urbana, IL 61801 USA; [Joyce, Leo A.; Ruck, Rebecca T.; Schultz, Danielle M.] Merck & Co Inc, Dept Proc Res & Dev, Rahway, NJ 07065 USA; [Kennemur, Jennifer L.] Max Planck Inst Kohlenforsch, Kaiser Wilhelm Pl 1, D-45470 Mulheim, Germany; [Hull, Kami L.] Univ Texas Austin, 105 E 24th St, Austin, TX 78712 USA in 2019, Cited 36. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. Category: piperidines

A Rh-catalyzed enantioselective hydroamination of allylamines using a chiral BIPHEP-type ligand is reported. Enantioenriched 1,2-diamines are formed in good yields and with excellent enantioselectivities. A diverse array of nucleophiles and amine directing groups are demonstrated, including deprotectable motifs. Finally, the methodology was demonstrated toward the rapid synthesis of 2-methyl-moclobemide.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Vanable, EP; Kennemur, JL; Joyce, LA; Ruck, RT; Schultz, DM; Hull, KL or concate me.. Category: piperidines

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Recommanded Product: 177-11-7. In 2020 ADV SYNTH CATAL published article about COUPLING REACTIONS; ACTIVATED ALKENES; N-ARYLACRYLAMIDES; PHOTOREDOX; RADICALS; NITROGEN; OLEFINS; BOND; AMINATION; FUNCTIONALIZATION in [Wang, Yu-Zhao; Lin, Wu-Jie; Zou, Jian-Yu; Yu, Wei; Liu, Xue-Yuan] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China in 2020, Cited 68. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

The cascade amination/cyclization ofN-arylacrylamides with alkyl amines under visible-light photoredox catalysis is realized via intermediacy of aminium radicals. The aminium radicals are generated by a two-step sequence which involves N-chlorination of alkyl amines and subsequent reductive N-Cl cleavage. This method provides a convenient access to aminated oxindoles.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Wang, YZ; Lin, WJ; Zou, JY; Yu, W; Liu, XY or concate me.. Recommanded Product: 177-11-7

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Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Discovery and development of extreme selective inhibitors of the ITD and D835Y mutant FLT3 kinases WOS:000501660900022 published article about ACUTE MYELOID-LEUKEMIA; RISK MYELODYSPLASTIC SYNDROME; ACUTE MYELOGENOUS LEUKEMIA; TYROSINE KINASE; ACTIVATING MUTATION; TANDEM DUPLICATION; WILD-TYPE; IN-VITRO; PHASE-I; RECEPTOR in [Baska, Ferenc; Sipos, Anna; Nemes, Zoltan; Dobos, Judit; Szantai-Kis, Csaba; Garamvolgyi, Rita; Orfi, Laszlo] Vichem Chem Res Ltd, H-1022 Budapest, Hungary; [Orfi, Zoltan] Max Planck Inst Biochem, Dept Mol Biol, D-82152 Martinsried, Germany; [Szabo, Eszter] Semmelweis Univ, Dept Paediat 1, H-1083 Budapest, Hungary; [Szenasi, Gabor; Dezsi, Laszlo; Hamar, Peter] Semmelweis Univ, Inst Pathophysiol, H-1089 Budapest, Hungary; [Dezsi, Laszlo] Semmelweis Univ, Nanomed Res & Educ Ctr, H-1089 Budapest, Hungary; [Cserepes, Mihaly T.; Tovari, Jozsef] Natl Inst Oncol, Dept Expt Pharmacol, H-1122 Budapest, Hungary; [Kreko, Marcell; Orfi, Laszlo] Semmelweis Univ, Dept Pharmaceut Chem, Hogyes Endre U 9, H-1085 Budapest, Hungary; [Orfi, Laszlo] Drug Res Co, Batthyany U 92, H-1161 Budapest, Hungary in 2019, Cited 62. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. Recommanded Product: 177-11-7

Aberrant activation of FMS-like tyrosine receptor kinase 3 (FLT3) is implicated in the pathogenesis of acute myeloid leukemia (AML) in 20-30% of patients. In this study we identified a highly selective (phenylethenyl)quinazoline compound family as novel potent inhibitors of the FLT3-ITD and FLT3-D835Y kinases. Their prominent effects were confirmed by biochemical and cellular proliferation assays followed by mice xenograft studies. Our modelling experiments and the chemical structures of the compounds predict the possibility of covalent inhibition. The most effective compounds triggered apoptosis in FLT3-ITD AML cells but had either weak or no effect in FLT3-independent leukemic and non-leukemic cell lines. Our results strongly suggest that our compounds may become therapeutics in relapsing and refractory AML disease harboring various ITD and tyrosine kinase domain mutations, by their ability to overcome drug resistance. (C) 2019 Elsevier Masson SAS. All rights reserved.

Recommanded Product: 177-11-7. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Baska, F; Sipos, A; Orfi, Z; Nemes, Z; Dobos, J; Szantai-Kis, C; Szabo, E; Szenasi, G; Dezsi, L; Hamar, P; Cserepes, MT; Tovari, J; Garamvolgyi, R; Kreko, M; Orfi, L or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Rhodium-Catalyzed Asymmetric Hydroamination of Allyl Amines WOS:000456350300004 published article about ANTI-MARKOVNIKOV HYDROAMINATION; INTERMOLECULAR HYDROAMINATION; ALKENES; DISCOVERY; ALDEHYDES in [Vanable, Evan P.; Kennemur, Jennifer L.; Hull, Kami L.] Univ Illinois, Dept Chem, 600 S Mathews, Urbana, IL 61801 USA; [Joyce, Leo A.; Ruck, Rebecca T.; Schultz, Danielle M.] Merck & Co Inc, Dept Proc Res & Dev, Rahway, NJ 07065 USA; [Kennemur, Jennifer L.] Max Planck Inst Kohlenforsch, Kaiser Wilhelm Pl 1, D-45470 Mulheim, Germany; [Hull, Kami L.] Univ Texas Austin, 105 E 24th St, Austin, TX 78712 USA in 2019, Cited 36. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. HPLC of Formula: C7H13NO2

A Rh-catalyzed enantioselective hydroamination of allylamines using a chiral BIPHEP-type ligand is reported. Enantioenriched 1,2-diamines are formed in good yields and with excellent enantioselectivities. A diverse array of nucleophiles and amine directing groups are demonstrated, including deprotectable motifs. Finally, the methodology was demonstrated toward the rapid synthesis of 2-methyl-moclobemide.

HPLC of Formula: C7H13NO2. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Vanable, EP; Kennemur, JL; Joyce, LA; Ruck, RT; Schultz, DM; Hull, KL or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Product Details of 177-11-7. Authors Wu, J; Zheng, CM; Li, BY; Hawkins, JM; Scott, SL in ROYAL SOC CHEMISTRY published article about in [Wu, Jing; Zheng, Chunming; Scott, Susannah L.] Univ Calif Santa Barbara, Dept Chem Engn, Santa Barbara, CA 93106 USA; [Li, Bryan] Pfizer Global Res & Dev, Chem R&D La Jolla Lab, San Diego, CA 92121 USA; [Hawkins, Joel M.] Pfizer Global Res & Dev, Groton, CT 06371 USA; [Scott, Susannah L.] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA in 2021, Cited 64. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

N-Boc deprotection (deBoc) is a common reaction in pharmaceutical research and development, as well as pharma manufacturing. Use of a catalyst lowers the required reaction temperature, and heterogeneous catalysts allow the reaction to be conducted in a continuous flow reactor with a low-boiling solvent, facilitating product separation and enhancing efficiency and productivity relative to a batch process. In this study, we explore the use of simple solid Bronsted acid catalysts to achieve continuous N-Boc deprotection of amines, without additional workup steps. Using THF as the solvent, H-BEA zeolite affords high yields of a variety of aromatic and aliphatic amines, often in residence times of less than a minute at 140 degrees C. The same catalyst/solvent combination is ineffective in batch conditions, due to the much lower temperature of refluxing THF. Boc-protected p-chloroaniline was deprotected with a throughput of 18 mmol p-chloroaniline per h per g(cat), sustained over 9 h. The active sites of the zeolite do not appear to be directly associated with the Al framework substitution in the micropores, since partially ion-exchanged Na/H-BEA shows activity similar to H-BEA. The strong Bronsted acid sites (framework [Si(OH)Al]), are likely poisoned by the amine product. Moderate Bronsted acid sites associated with silanol defects near Al on or near the external surface (and not susceptible to Na+-exchange) are presumably the active sites, since they are not poisoned even by more basic aliphatic amines.

Product Details of 177-11-7. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Wu, J; Zheng, CM; Li, BY; Hawkins, JM; Scott, SL or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Category: piperidines. Recently I am researching about METAL; NITROSAMINES; AMINATION; NITRO, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [11972195, 11702141, 21771108]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Zhao, JP; Ding, LJ; Wang, PC; Liu, Y; Huang, MJ; Zhou, XL; Lu, M. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

An acid-free N-nitrosation/nitration of the N-H bonds in secondary amines with Fe(NO3)(3)center dot 9H(2)O as the nitroso/nitro source through an electrocatalyzed radical coupling reaction was developed. Cyclic aliphatic amines and N-heteroaromatic compounds were N-nitrosated and N-nitrated, respectively, under mild conditions. Control and competition experiments, as well as kinetic studies, demonstrate that N-nitrosation and N-nitration involve two different radical reaction pathways involving N+ and N-center dot radicals. Moreover, the electrocatalysis method enables the preferential activation of the N-H bond over the electrode and thus provides high selectivity for specific N atoms. Finally, this strategy exhibits a broad scope and provides a green and straightforward approach to generate useful N-nitroso/nitro compounds in good yields.

Category: piperidines. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Zhao, JP; Ding, LJ; Wang, PC; Liu, Y; Huang, MJ; Zhou, XL; Lu, M or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Name: 1,4-Dioxa-8-azaspiro[4.5]decane. Recently I am researching about BIOLOGICAL EVALUATION; MMPL3; INHIBITION, Saw an article supported by the Ministry of Education (MoE) Academic Research FundMinistry of Education, Singapore [R148000234114, R148000286114]; Ministry of Health National Medical Research Council (Singapore)Ministry of Health-SingaporeNational Medical Research Council, Singapore [NMRC/TCR/011-NUHS/2014]; National Institute of Allergy and Infectious Diseases of the National Institutes of Health (USA)United States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Institute of Allergy & Infectious Diseases (NIAID) [R01AI132374]; MoE SingaporeMinistry of Education, Singapore. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Tan, YJ; Li, M; Gunawan, GA; Nyantakyi, SA; Dick, T; Go, ML; Lam, YL. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

Indolecarboxamides are potent but poorly soluble mycobactericidal agents. Here we found that modifying the incipient scaffold by amide-amine substitution and replacing the indole ring with benzothiophene or benzoselenophene led to striking (10-20-fold) improvements in solubility. Potent activity could be achieved without the carboxamide linker but not in the absence of the indole ring. The indolylmethylamine, N-cyclooctyl-6-trifluoromethylindol-2-ylmethylamine (33, MIC90Mtb , 0.13 mu M, MBC99.9Mtb, 0.63 mu M), exemplifies a promising member that is more soluble and equipotent to its carboxamide equivalent. It is also an inhibitor of the mycolate transporter MmpL3, a property shared by the methylamines of benzothiophene and benzoselenophene.

Name: 1,4-Dioxa-8-azaspiro[4.5]decane. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Tan, YJ; Li, M; Gunawan, GA; Nyantakyi, SA; Dick, T; Go, ML; Lam, YL or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

In 2019 TETRAHEDRON LETT published article about POT FACILE SYNTHESIS; PEPTIDE-SYNTHESIS; HIGHLY EFFICIENT; AMIDE SYNTHESIS; CHEMISTRY; THIOACIDS; FUNCTIONALIZATION; PHOTOCATALYSIS; ALCOHOLS; ESTERS in [Srivastava, Vishal; Singh, Pravin K.] Univ Allahabad, CMP Degree Coll, Dept Chem, Allahabad 211002, Uttar Pradesh, India; [Singh, Praveen P.] United Coll Engn & Res, Dept Chem, Allahabad 211010, Uttar Pradesh, India in 2019, Cited 68. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. Product Details of 177-11-7

A visible-light promoted photoredox catalysed, green one-pot approach for the amidation of carboxylic acids with amines has been developed for the synthesis of diverse aliphatic and aromatic amides. The proposed strategy is extendable also to biologically active amides and could represent a low-cost alternative to the common synthetic pathways. The developed strategy may hold great potential for a comprehensive display of biologically interesting peptide synthesis and amino acid modification. (C) 2018 Elsevier Ltd. All rights reserved.

Product Details of 177-11-7. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Srivastava, V; Singh, PK; Singh, PP or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

In 2019 ORG LETT published article about CATALYTIC HYDRATION; CHEMISTRY; PURIFICATION in [Fu, Wai Chung; Jamison, Timothy F.] MIT, Dept Chem, 77 Massachusetts Ave, Cambridge, MA 02139 USA in 2019, Cited 33. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. Category: piperidines

A modular continuous flow synthesis of imatinib and analogues is reported. Structural y diverse imatinib analogues are rapidly generated using three readily available building blocks via a flow hydration/chemoselective C-N coupling sequence. The newly developed continuous flow hydration and amidation modules each exhibit a broad scope with good to excellent yields. Overall, the method described does not require solvent switches, in-line purifications, or packed-bed apparatuses due to the judicious manipulation of flow setups and solvent mixtures.

Welcome to talk about 177-11-7, If you have any questions, you can contact Fu, WC; Jamison, TF or send Email.. Category: piperidines

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Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article DMAP and PivOH-promoted amination/allenization reaction WOS:000558045700027 published article about C-H FUNCTIONALIZATION; ARYL IODIDES; BOND FUNCTIONALIZATIONS; ARYLATION; PD/NORBORNENE; AMINATION; ALKYLATION; ANILINES; PD; MECHANISM in [Zhang, Bo-Sheng] Northwest Normal Univ, Coll Chem & Chem Engn, Lanzhou 730070, Gansu, Peoples R China; [Zhang, Bo-Sheng; Gou, Xue-Ya; Zhang, Zhe; An, Yang; Wang, Xin-Gang; Liang, Yong-Min] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China; [Li, Yuke] Chinese Univ Hong Kong, Dept Chem, Shatin, Hong Kong, Peoples R China; [Li, Yuke] Chinese Univ Hong Kong, Ctr Sci Modeling & Computat, Shatin, Hong Kong, Peoples R China in 2020, Cited 47. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. Recommanded Product: 1,4-Dioxa-8-azaspiro[4.5]decane

This report described the first DMAP and PivOH-promotedortho-C-H amination andipso-allenization reaction of iodobenzenes realized by Pd/norbornene cooperative catalysis. Based on control experiments and DFT calculations, we speculated that the three ligands have different functions and mechanism paths in the reaction.

Welcome to talk about 177-11-7, If you have any questions, you can contact Zhang, BS; Li, YK; Gou, XY; Zhang, Z; An, Y; Wang, XG; Liang, YM or send Email.. Recommanded Product: 1,4-Dioxa-8-azaspiro[4.5]decane

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem